| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methotrexate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.261324 |
| POTEF | POTE ankyrin domain family, member F | 0.195615 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.163536 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.143416 |
| FNDC3B | fibronectin type III domain containing 3B | 0.125098 |
| PCBP2 | poly(rC) binding protein 2 | 0.117354 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.108406 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0922014 |
| TPM3 | tropomyosin 3 | 0.0856812 |
| GRB10 | growth factor receptor-bound protein 10 | 0.083753 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0765978 |
| CALR | calreticulin | 0.0734883 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0728657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0722967 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0685269 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0681876 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0677381 |
| NDRG1 | N-myc downstream regulated 1 | 0.0670447 |
| MSN | moesin | 0.0669955 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0668811 |
| PLEC | plectin | 0.0631427 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0617144 |
| HMGA1 | high mobility group AT-hook 1 | 0.0612398 |
| UBC | ubiquitin C | 0.0610016 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0594732 |
| ASPH | aspartate beta-hydroxylase | 0.0590462 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0574475 |
| APP | amyloid beta (A4) precursor protein | 0.05555 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.054419 |
| PTK2 | protein tyrosine kinase 2 | 0.0542794 |
| RNF145 | ring finger protein 145 | 0.0523068 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0522081 |
| ENO1 | enolase 1, (alpha) | 0.0518394 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0518309 |
| DSPP | dentin sialophosphoprotein | 0.0513807 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0512031 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0507648 |
| PGK1 | phosphoglycerate kinase 1 | 0.0506874 |
| VEGFA | vascular endothelial growth factor A | 0.0485621 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0478434 |
| RPL3 | ribosomal protein L3 | 0.0472709 |
| LAMB3 | laminin, beta 3 | 0.0472377 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0462754 |
| RPS18 | ribosomal protein S18 | 0.0455435 |
| PKM | pyruvate kinase, muscle | 0.0451629 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0450622 |
| FLNB | filamin B, beta | 0.0443444 |
| PRRC2C | proline-rich coiled-coil 2C | 0.043545 |
| TMF1 | TATA element modulatory factor 1 | 0.043488 |
| MCL1 | myeloid cell leukemia 1 | 0.0434597 |
| MYO6 | myosin VI | 0.0433789 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0430272 |
| RCOR1 | REST corepressor 1 | 0.042202 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0418492 |
| PTMA | prothymosin, alpha | 0.0417449 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0408866 |
| MYO5B | myosin VB | 0.0407263 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0398474 |
| LDHA | lactate dehydrogenase A | 0.039587 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.039558 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0393138 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0392136 |
| TPM4 | tropomyosin 4 | 0.0385767 |
| SETD5 | SET domain containing 5 | 0.0384763 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0378449 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.037681 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0371287 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0368071 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0364854 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0360656 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0357559 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0353343 |
| HDGF | hepatoma-derived growth factor | 0.0351748 |
| IRF6 | interferon regulatory factor 6 | 0.0351179 |
| LAMC2 | laminin, gamma 2 | 0.0349788 |
| DHFR | dihydrofolate reductase | 0.0345576 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0341993 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0340603 |
| CD46 | CD46 molecule, complement regulatory protein | 0.034002 |
| SLMAP | sarcolemma associated protein | 0.0332267 |
| FAM13A | family with sequence similarity 13, member A | 0.0330463 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0328719 |
| KRT18 | keratin 18, type I | 0.0328444 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0328046 |
| CCNL1 | cyclin L1 | 0.0327491 |
| EZR | ezrin | 0.0325734 |
| MSI2 | musashi RNA-binding protein 2 | 0.0321279 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0320367 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0318753 |
| YTHDC1 | YTH domain containing 1 | 0.0313526 |
| CCNY | cyclin Y | 0.0313486 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0311051 |
| ADAR | adenosine deaminase, RNA-specific | 0.0309134 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0308117 |
| CANX | calnexin | 0.0305979 |
| ATP13A3 | ATPase type 13A3 | 0.0302004 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300673 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0294364 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0294091 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0288457 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.258484 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.180205 |
| FTL | ferritin, light polypeptide | -0.157945 |
| ACTG1 | actin gamma 1 | -0.115323 |
| TMSB10 | thymosin beta 10 | -0.0945864 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0746943 |
| RPL35A | ribosomal protein L35a | -0.0684023 |
| RPLP1 | ribosomal protein, large, P1 | -0.0679495 |
| RPL34 | ribosomal protein L34 | -0.059893 |
| S100A10 | S100 calcium binding protein A10 | -0.0465466 |
| RPL8 | ribosomal protein L8 | -0.0446927 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0388517 |
| RPLP2 | ribosomal protein, large, P2 | -0.0383109 |
| RPS19 | ribosomal protein S19 | -0.0382489 |
| RPL23 | ribosomal protein L23 | -0.0372801 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0353641 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0350187 |
| RPS8 | ribosomal protein S8 | -0.0344335 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0337687 |
| RPL30 | ribosomal protein L30 | -0.032357 |
| RPL12 | ribosomal protein L12 | -0.0318902 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.031779 |
| RPS6 | ribosomal protein S6 | -0.0317725 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0315019 |
| MT2A | metallothionein 2A | -0.0291454 |
| EFNA5 | ephrin-A5 | -0.0287998 |
| RPL32 | ribosomal protein L32 | -0.0270877 |
| RPL28 | ribosomal protein L28 | -0.0269998 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0268145 |
| RPS16 | ribosomal protein S16 | -0.0253826 |
| RPS21 | ribosomal protein S21 | -0.0252814 |
| RPL27A | ribosomal protein L27a | -0.0249981 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0245796 |
| RPL9 | ribosomal protein L9 | -0.0244889 |
| RACK1 | receptor for activated C kinase 1 | -0.0233653 |
| RPLP0 | ribosomal protein, large, P0 | -0.0232393 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0230223 |
| ARF1 | ADP-ribosylation factor 1 | -0.0220663 |
| RPS5 | ribosomal protein S5 | -0.0219497 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0218095 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0216424 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0216113 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0215826 |
| EGR1 | early growth response 1 | -0.0213626 |
| S100A9 | S100 calcium binding protein A9 | -0.0212302 |
| RPL36 | ribosomal protein L36 | -0.0209889 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0207989 |
| RPL11 | ribosomal protein L11 | -0.0207678 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0206649 |
| SP100 | SP100 nuclear antigen | -0.0206613 |
| RPL35 | ribosomal protein L35 | -0.0204856 |
| OSMR | oncostatin M receptor | -0.0203396 |
| EGFR | epidermal growth factor receptor | -0.020336 |
| RPS27A | ribosomal protein S27a | -0.0200422 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0196704 |
| RPS15 | ribosomal protein S15 | -0.0194566 |
| RPL19 | ribosomal protein L19 | -0.0190666 |
| HMGB2 | high mobility group box 2 | -0.0189458 |
| RPS10 | ribosomal protein S10 | -0.0188163 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0187795 |
| HMGB1 | high mobility group box 1 | -0.0187365 |
| TBCA | tubulin folding cofactor A | -0.0186445 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.018482 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0182748 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0182274 |
| TMEM263 | transmembrane protein 263 | -0.0180613 |
| CCNI | cyclin I | -0.0179831 |
| RPL37 | ribosomal protein L37 | -0.0178682 |
| RPS24 | ribosomal protein S24 | -0.0177805 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0175147 |
| RPS29 | ribosomal protein S29 | -0.0173825 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0172447 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0171726 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.0171368 |
| RPL4 | ribosomal protein L4 | -0.0170465 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0169881 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0169873 |
| NABP1 | nucleic acid binding protein 1 | -0.0169334 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0167371 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0162008 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0161519 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0160765 |
| RPL37A | ribosomal protein L37a | -0.0158548 |
| CTSD | cathepsin D | -0.0158082 |
| SMIM14 | small integral membrane protein 14 | -0.0156689 |
| ASTN2 | astrotactin 2 | -0.0155838 |
| RPL36AL | ribosomal protein L36a-like | -0.0155787 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0154326 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0151008 |
| RRBP1 | ribosome binding protein 1 | -0.014879 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.014825 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0147847 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0147625 |
| RPS25 | ribosomal protein S25 | -0.0146312 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.014614 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0144541 |
| RPL7A | ribosomal protein L7a | -0.014272 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0141709 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0139736 |
| RPS23 | ribosomal protein S23 | -0.0139312 |
