| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.228171 |
| MCL1 | myeloid cell leukemia 1 | 0.226744 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.196371 |
| PCBP2 | poly(rC) binding protein 2 | 0.16107 |
| EFNA5 | ephrin-A5 | 0.135578 |
| PGK1 | phosphoglycerate kinase 1 | 0.113508 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110024 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0983154 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0796458 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0750103 |
| VIM | vimentin | 0.070001 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0660871 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0659033 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0645889 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0616106 |
| CANX | calnexin | 0.0599051 |
| ENO1 | enolase 1, (alpha) | 0.0594824 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0593145 |
| RPL3 | ribosomal protein L3 | 0.0590569 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0578928 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0562527 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0558449 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0547389 |
| STC1 | stanniocalcin 1 | 0.0539096 |
| ASPH | aspartate beta-hydroxylase | 0.0537307 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0515062 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0512101 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0500971 |
| CDH13 | cadherin 13 | 0.0475572 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0473973 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0471121 |
| MYOF | myoferlin | 0.0470568 |
| PYGL | phosphorylase, glycogen, liver | 0.0465565 |
| INHBA | inhibin, beta A | 0.0458186 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0453969 |
| RPS18 | ribosomal protein S18 | 0.0444372 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0438101 |
| LDHA | lactate dehydrogenase A | 0.0429787 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.042962 |
| DNER | delta/notch-like EGF repeat containing | 0.0426396 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0421056 |
| FLNB | filamin B, beta | 0.0389548 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0389202 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0381318 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.037958 |
| APP | amyloid beta (A4) precursor protein | 0.0376721 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0374074 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0369116 |
| CALR | calreticulin | 0.0368584 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | 0.0360319 |
| COL4A6 | collagen, type IV, alpha 6 | 0.035761 |
| S100A6 | S100 calcium binding protein A6 | 0.0357199 |
| CTBP2 | C-terminal binding protein 2 | 0.035378 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.035241 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0347276 |
| HLA-A | major histocompatibility complex, class I, A | 0.0340693 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0338073 |
| PTMA | prothymosin, alpha | 0.0334627 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0333025 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0332525 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0331224 |
| LOXL2 | lysyl oxidase-like 2 | 0.0328952 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0324778 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0324301 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0322975 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0322668 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0321821 |
| DHFR | dihydrofolate reductase | 0.0321121 |
| LMNA | lamin A/C | 0.031614 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0306789 |
| GNAS | GNAS complex locus | 0.0303156 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0302009 |
| IL6 | interleukin 6 | 0.0300675 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0297612 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0296637 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0295495 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0293697 |
| CHL1 | cell adhesion molecule L1-like | 0.0287083 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0286146 |
| LAMB1 | laminin, beta 1 | 0.0284677 |
| SAR1A | secretion associated, Ras related GTPase 1A | 0.0283235 |
| SQSTM1 | sequestosome 1 | 0.0282974 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0281001 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0278857 |
| TPM3 | tropomyosin 3 | 0.0275534 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0267219 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0266871 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0266441 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0266138 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0264958 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0264425 |
| NEK7 | NIMA-related kinase 7 | 0.0257075 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0253854 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.025279 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0252724 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.025066 |
| FAM13A | family with sequence similarity 13, member A | 0.0250475 |
| CTSL | cathepsin L | 0.0247268 |
| CD109 | CD109 molecule | 0.0246641 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0245927 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.254087 |
| TXNRD1 | thioredoxin reductase 1 | -0.111489 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0802224 |
| PDE10A | phosphodiesterase 10A | -0.0649958 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0589162 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0577143 |
| RPS6 | ribosomal protein S6 | -0.0530993 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0501007 |
| ACTG1 | actin gamma 1 | -0.0495217 |
| RPLP1 | ribosomal protein, large, P1 | -0.0469319 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0453922 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0433557 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0423904 |
| RPS24 | ribosomal protein S24 | -0.0418243 |
| GDA | guanine deaminase | -0.041361 |
| PTGR1 | prostaglandin reductase 1 | -0.0379764 |
| RPS2 | ribosomal protein S2 | -0.0362215 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | -0.0337952 |
| RPL36A | ribosomal protein L36a | -0.032255 |
| RPLP0 | ribosomal protein, large, P0 | -0.0297721 |
| RPL7A | ribosomal protein L7a | -0.0296478 |
| RPS21 | ribosomal protein S21 | -0.0296185 |
| RGS2 | regulator of G-protein signaling 2 | -0.0292004 |
| ZNF207 | zinc finger protein 207 | -0.0279554 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0278536 |
| RPL35A | ribosomal protein L35a | -0.0276713 |
| RPS23 | ribosomal protein S23 | -0.0275514 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.02743 |
| FUS | FUS RNA binding protein | -0.0269868 |
| RPLP2 | ribosomal protein, large, P2 | -0.0267195 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0265938 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0265803 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0251063 |
| PRKD3 | protein kinase D3 | -0.0250873 |
| RTN4 | reticulon 4 | -0.024112 |
| RBM39 | RNA binding motif protein 39 | -0.024074 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0240318 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0238927 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0235659 |
| RPL19 | ribosomal protein L19 | -0.0235342 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.0233694 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0223081 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.02228 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0220563 |
| RPL28 | ribosomal protein L28 | -0.0219807 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0219592 |
| RPL39 | ribosomal protein L39 | -0.0217427 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0215714 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0209952 |
| SLC38A2 | solute carrier family 38, member 2 | -0.020894 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0208572 |
| NRCAM | neuronal cell adhesion molecule | -0.0208108 |
| RAB10 | RAB10, member RAS oncogene family | -0.0207873 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0207444 |
| KYNU | kynureninase | -0.0207406 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.020729 |
| RPS15 | ribosomal protein S15 | -0.0207283 |
| RPS16 | ribosomal protein S16 | -0.0203575 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0200396 |
| TNPO1 | transportin 1 | -0.0198232 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0196875 |
| S100A10 | S100 calcium binding protein A10 | -0.0195909 |
| RPS10 | ribosomal protein S10 | -0.0192021 |
| RPS25 | ribosomal protein S25 | -0.0191911 |
| PLCB4 | phospholipase C, beta 4 | -0.0191546 |
| TUBA1B | tubulin, alpha 1b | -0.0189466 |
| JMJD1C | jumonji domain containing 1C | -0.0189016 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0188453 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0187795 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0185533 |
| RPL38 | ribosomal protein L38 | -0.0185518 |
| RPL9 | ribosomal protein L9 | -0.018343 |
| RPS8 | ribosomal protein S8 | -0.0182374 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0181707 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0181341 |
| CENPF | centromere protein F, 350/400kDa | -0.0180085 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0179726 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0178531 |
| RPL32 | ribosomal protein L32 | -0.0176489 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0174802 |
| MKI67 | marker of proliferation Ki-67 | -0.0173152 |
| TUSC3 | tumor suppressor candidate 3 | -0.0172533 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0172278 |
| TCERG1 | transcription elongation regulator 1 | -0.0172082 |
| RPL6 | ribosomal protein L6 | -0.0169532 |
| NOP58 | NOP58 ribonucleoprotein | -0.0168929 |
| CLTC | clathrin, heavy chain (Hc) | -0.016845 |
| CADM2 | cell adhesion molecule 2 | -0.0165761 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0162284 |
| RPS19 | ribosomal protein S19 | -0.0160093 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0159239 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0158812 |
| RPL5 | ribosomal protein L5 | -0.0158715 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0158111 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0157992 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0157732 |
| KIAA0825 | KIAA0825 | -0.0157675 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0156701 |
| MAP1B | microtubule-associated protein 1B | -0.015464 |
| XPO1 | exportin 1 | -0.0154282 |
