| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.138039 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.115236 |
| TMSB10 | thymosin beta 10 | 0.0977661 |
| RBM39 | RNA binding motif protein 39 | 0.0935599 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0856873 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.079583 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | 0.0785714 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0779094 |
| CERS6 | ceramide synthase 6 | 0.0753901 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0753887 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0713252 |
| DTNA | dystrobrevin, alpha | 0.0691628 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0643521 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0642145 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.062334 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | 0.0622471 |
| RCOR1 | REST corepressor 1 | 0.0622008 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0618121 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0609103 |
| ZNF638 | zinc finger protein 638 | 0.06079 |
| GOLGA4 | golgin A4 | 0.0607832 |
| PARD3 | par-3 family cell polarity regulator | 0.0601014 |
| VMP1 | vacuole membrane protein 1 | 0.0600622 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0588891 |
| ADNP | activity-dependent neuroprotector homeobox | 0.05807 |
| NEBL | nebulette | 0.0575465 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0571328 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0566236 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0566089 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0560556 |
| TMEM41B | transmembrane protein 41B | 0.0552644 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0550393 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.054494 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0543601 |
| ATP13A3 | ATPase type 13A3 | 0.0543291 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0541357 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0536898 |
| DYM | dymeclin | 0.0530713 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0521974 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0515526 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.0512221 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.0510026 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.050866 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0507928 |
| SERINC5 | serine incorporator 5 | 0.0485844 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0484519 |
| USP34 | ubiquitin specific peptidase 34 | 0.0482259 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0480073 |
| RPS6 | ribosomal protein S6 | 0.0479028 |
| ZNF644 | zinc finger protein 644 | 0.0476027 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0474821 |
| SFXN1 | sideroflexin 1 | 0.0471713 |
| CABIN1 | calcineurin binding protein 1 | 0.0471563 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.047024 |
| YEATS2 | YEATS domain containing 2 | 0.0469211 |
| SERINC1 | serine incorporator 1 | 0.046126 |
| PCBP2 | poly(rC) binding protein 2 | 0.0449948 |
| YAP1 | Yes-associated protein 1 | 0.043016 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0428372 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.042523 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0424821 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0424735 |
| RHEB | Ras homolog enriched in brain | 0.0420096 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0416006 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0415833 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0412362 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.041225 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.040943 |
| SETD2 | SET domain containing 2 | 0.0408441 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0403148 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0401734 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0392554 |
| TBC1D22A | TBC1 domain family, member 22A | 0.038414 |
| SETD5 | SET domain containing 5 | 0.0384129 |
| QKI | QKI, KH domain containing, RNA binding | 0.0381245 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0374907 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0374874 |
| USP25 | ubiquitin specific peptidase 25 | 0.0373703 |
| VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 0.0373614 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0370741 |
| RPL7 | ribosomal protein L7 | 0.0370145 |
| ZNF654 | zinc finger protein 654 | 0.0369623 |
| SRPK2 | SRSF protein kinase 2 | 0.0368232 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0366747 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0362389 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0358075 |
| USP47 | ubiquitin specific peptidase 47 | 0.0352555 |
| RTN4 | reticulon 4 | 0.0348566 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.034307 |
| MEMO1 | mediator of cell motility 1 | 0.0342231 |
| HMGA1 | high mobility group AT-hook 1 | 0.0332727 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0332328 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0323581 |
| MTDH | metadherin | 0.0322816 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0318511 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0306985 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0306562 |
| MYO10 | myosin X | 0.0305101 |
| RPL12 | ribosomal protein L12 | 0.0304602 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0303496 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.201598 |
| IGF2 | insulin-like growth factor 2 | -0.17987 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.138238 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.125245 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.115404 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.113133 |
| EGFR | epidermal growth factor receptor | -0.111884 |
| FAM13A | family with sequence similarity 13, member A | -0.0978314 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0978182 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0974275 |
| PRKCA | protein kinase C, alpha | -0.0958421 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0910051 |
| ASPH | aspartate beta-hydroxylase | -0.090925 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0889044 |
| EFNA5 | ephrin-A5 | -0.0855171 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0802726 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0788737 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0786335 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0770873 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.074559 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0725487 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0704425 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0681664 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0677799 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0664917 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0657847 |
| GPC6 | glypican 6 | -0.0654119 |
| PDE10A | phosphodiesterase 10A | -0.0647783 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0636186 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0626782 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0623993 |
| SPAG9 | sperm associated antigen 9 | -0.0620189 |
| RSF1 | remodeling and spacing factor 1 | -0.0618788 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0618452 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0611812 |
| TFG | TRK-fused gene | -0.0610155 |
| COL5A2 | collagen, type V, alpha 2 | -0.0602384 |
| VIM | vimentin | -0.0595559 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0594355 |
| KYNU | kynureninase | -0.0587693 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0579625 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0568906 |
| RPL15 | ribosomal protein L15 | -0.0544885 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.052802 |
| PTMA | prothymosin, alpha | -0.0523151 |
| EXOC6B | exocyst complex component 6B | -0.0519525 |
| UBXN4 | UBX domain protein 4 | -0.0516867 |
| WASF2 | WAS protein family, member 2 | -0.0508193 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0490811 |
| FNIP1 | folliculin interacting protein 1 | -0.0488481 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.048013 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | -0.0480098 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0476994 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0466449 |
| RNF213 | ring finger protein 213 | -0.0464617 |
| ACTG1 | actin gamma 1 | -0.0443624 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0438332 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0431835 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0431069 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.042975 |
| RAB10 | RAB10, member RAS oncogene family | -0.041953 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.040637 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0405888 |
| RPS8 | ribosomal protein S8 | -0.03922 |
| ZNF292 | zinc finger protein 292 | -0.0387185 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0379705 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0371771 |
| TPD52 | tumor protein D52 | -0.0367239 |
| FRY | furry homolog (Drosophila) | -0.0366162 |
| JMJD1C | jumonji domain containing 1C | -0.0362301 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0360579 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0356716 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0351051 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0350929 |
| SMAD3 | SMAD family member 3 | -0.0340374 |
| CTBP2 | C-terminal binding protein 2 | -0.0339657 |
| RAI14 | retinoic acid induced 14 | -0.0332906 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0324388 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0321652 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0313125 |
| FMNL2 | formin-like 2 | -0.0312694 |
| MCL1 | myeloid cell leukemia 1 | -0.0308414 |
| RPL5 | ribosomal protein L5 | -0.0300212 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.029152 |
| ERBIN | erbb2 interacting protein | -0.0290073 |
| RAD51B | RAD51 paralog B | -0.0287575 |
| OGA | O-GlcNAcase | -0.0286493 |
| FTL | ferritin, light polypeptide | -0.0285707 |
| TPM3 | tropomyosin 3 | -0.0282103 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0280733 |
| FN1 | fibronectin 1 | -0.0280253 |
| CLTC | clathrin, heavy chain (Hc) | -0.0279369 |
| PRELID2 | PRELI domain containing 2 | -0.0274689 |
| GOLGB1 | golgin B1 | -0.0273836 |
| PKM | pyruvate kinase, muscle | -0.0269917 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0268566 |
| RPL23 | ribosomal protein L23 | -0.0267038 |
| PGK1 | phosphoglycerate kinase 1 | -0.0264816 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0254623 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0251124 |
