| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.156545 |
| ZNF292 | zinc finger protein 292 | 0.122867 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.108026 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0669191 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0653624 |
| SPAG9 | sperm associated antigen 9 | 0.0649686 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0627903 |
| NTM | neurotrimin | 0.0611306 |
| COL11A1 | collagen, type XI, alpha 1 | 0.059394 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0590226 |
| WDR43 | WD repeat domain 43 | 0.0542343 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0536821 |
| MB21D2 | Mab-21 domain containing 2 | 0.0533184 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0532624 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0527534 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.049792 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.04841 |
| APP | amyloid beta (A4) precursor protein | 0.0475106 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0472635 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0470365 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0458035 |
| PCBP2 | poly(rC) binding protein 2 | 0.0452231 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0452146 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0448961 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0438904 |
| DST | dystonin | 0.0438685 |
| FAM168A | family with sequence similarity 168, member A | 0.0430686 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0428209 |
| CALR | calreticulin | 0.0419246 |
| SUCO | SUN domain containing ossification factor | 0.04154 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0411294 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0410108 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0407125 |
| COL3A1 | collagen, type III, alpha 1 | 0.0406773 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0397065 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0393774 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.0392953 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0390698 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0377719 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0375058 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0365182 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0359232 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0357322 |
| OLA1 | Obg-like ATPase 1 | 0.0356115 |
| EVI5 | ecotropic viral integration site 5 | 0.0354791 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0354375 |
| QKI | QKI, KH domain containing, RNA binding | 0.0349019 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0345604 |
| PDGFC | platelet derived growth factor C | 0.0344436 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.0343351 |
| USP12 | ubiquitin specific peptidase 12 | 0.0343249 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0342689 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0331323 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0329346 |
| FOXG1 | forkhead box G1 | 0.0328958 |
| FMNL2 | formin-like 2 | 0.032754 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.032709 |
| RPS7 | ribosomal protein S7 | 0.0324184 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0321974 |
| ATXN2 | ataxin 2 | 0.031756 |
| PTMA | prothymosin, alpha | 0.0314142 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0313135 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0311679 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0304276 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0302088 |
| FIP1L1 | factor interacting with PAPOLA and CPSF1 | 0.0299853 |
| RPS18 | ribosomal protein S18 | 0.0299072 |
| DHFR | dihydrofolate reductase | 0.0298009 |
| CCNY | cyclin Y | 0.0297772 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0296635 |
| ZFP36 | ZFP36 ring finger protein | 0.0295721 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0294454 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0283241 |
| ENAH | enabled homolog (Drosophila) | 0.0279185 |
| DENND5A | DENN/MADD domain containing 5A | 0.0279059 |
| USP15 | ubiquitin specific peptidase 15 | 0.0278206 |
| RBM33 | RNA binding motif protein 33 | 0.0272597 |
| RARS2 | arginyl-tRNA synthetase 2, mitochondrial | 0.0269313 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0268608 |
| KAT6A | K(lysine) acetyltransferase 6A | 0.0265464 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0265219 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0264185 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0262677 |
| HBP1 | HMG-box transcription factor 1 | 0.0259984 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.025998 |
| TP53BP2 | tumor protein p53 binding protein 2 | 0.0259544 |
| MEMO1 | mediator of cell motility 1 | 0.0259484 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0258388 |
| MORF4L1 | mortality factor 4 like 1 | 0.0256026 |
| GSE1 | Gse1 coiled-coil protein | 0.025576 |
| ORAI2 | ORAI calcium release-activated calcium modulator 2 | 0.0255276 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0253569 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0252298 |
| UBP1 | upstream binding protein 1 (LBP-1a) | 0.025129 |
| B3GALNT2 | beta-1,3-N-acetylgalactosaminyltransferase 2 | 0.0250789 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0250554 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.025035 |
| TMEM178B | transmembrane protein 178B | 0.025031 |
| USP3 | ubiquitin specific peptidase 3 | 0.0250294 |
| NUP58 | nucleoporin 58 | 0.0250082 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.192467 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.128118 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.127545 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.118286 |
| RPS6 | ribosomal protein S6 | -0.113335 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.104481 |
| TMSB10 | thymosin beta 10 | -0.0912086 |
| RPS16 | ribosomal protein S16 | -0.0886991 |
| ACTG1 | actin gamma 1 | -0.0829252 |
| CADM2 | cell adhesion molecule 2 | -0.0706637 |
| PFN1 | profilin 1 | -0.0680124 |
| RPLP0 | ribosomal protein, large, P0 | -0.0665289 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0662253 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0655191 |
| RPL23 | ribosomal protein L23 | -0.0638369 |
| CENPF | centromere protein F, 350/400kDa | -0.0609365 |
| RPS27A | ribosomal protein S27a | -0.0595187 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0584628 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0582439 |
| RPLP1 | ribosomal protein, large, P1 | -0.0546559 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0537976 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0536549 |
| RPL35A | ribosomal protein L35a | -0.0528451 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0521665 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.051778 |
| SNX6 | sorting nexin 6 | -0.0512265 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0509171 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.049593 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.049535 |
| PCDH9 | protocadherin 9 | -0.0490321 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0472689 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0461223 |
| BPTF | bromodomain PHD finger transcription factor | -0.0458226 |
| TUBA1B | tubulin, alpha 1b | -0.0446729 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0442619 |
| FTL | ferritin, light polypeptide | -0.0441243 |
| DEK | DEK proto-oncogene | -0.0437209 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0437182 |
| RPS8 | ribosomal protein S8 | -0.0436015 |
| HMGB1 | high mobility group box 1 | -0.0430292 |
| PHIP | pleckstrin homology domain interacting protein | -0.0426491 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0424358 |
| RPS19 | ribosomal protein S19 | -0.0423038 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0417918 |
| RPL37 | ribosomal protein L37 | -0.041223 |
| RACK1 | receptor for activated C kinase 1 | -0.0404942 |
| RPL30 | ribosomal protein L30 | -0.0404813 |
| FN1 | fibronectin 1 | -0.0403576 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.039748 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.037947 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0378143 |
| MAP1B | microtubule-associated protein 1B | -0.0377626 |
| ANKRD12 | ankyrin repeat domain 12 | -0.037509 |
| RPS12 | ribosomal protein S12 | -0.0367012 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0361711 |
| MKI67 | marker of proliferation Ki-67 | -0.0360486 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0359633 |
| JMJD1C | jumonji domain containing 1C | -0.0359575 |
| ITGAV | integrin, alpha V | -0.0359379 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.035715 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0352624 |
| S100A10 | S100 calcium binding protein A10 | -0.0345822 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0341566 |
| CBX3 | chromobox homolog 3 | -0.0340793 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.034005 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0337707 |
| EXOC4 | exocyst complex component 4 | -0.0328153 |
| RPL32 | ribosomal protein L32 | -0.0326292 |
| RPS13 | ribosomal protein S13 | -0.0318247 |
| RAD51B | RAD51 paralog B | -0.0317198 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0315846 |
| SEPTIN7 | septin 7 | -0.031467 |
| RPL11 | ribosomal protein L11 | -0.031392 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0310197 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0306423 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0305497 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0304826 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0297908 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0297604 |
| RPLP2 | ribosomal protein, large, P2 | -0.0297507 |
| MEIS2 | Meis homeobox 2 | -0.0296092 |
| RPL34 | ribosomal protein L34 | -0.0295902 |
| RPS24 | ribosomal protein S24 | -0.0294523 |
| TOX | thymocyte selection-associated high mobility group box | -0.0294376 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0293866 |
| GLO1 | glyoxalase I | -0.029332 |
| SGO2 | shugoshin 2 | -0.0292494 |
| NDRG1 | N-myc downstream regulated 1 | -0.0291093 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.028862 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.028756 |
| NCAM2 | neural cell adhesion molecule 2 | -0.028655 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0286487 |
| NRDC | nardilysin convertase | -0.0282846 |
| PRDX1 | peroxiredoxin 1 | -0.0282382 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0282319 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0281158 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0280782 |
| RPS5 | ribosomal protein S5 | -0.0278778 |
| ENO1 | enolase 1, (alpha) | -0.0277625 |
| UTRN | utrophin | -0.0277254 |
