| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.279807 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0894094 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0892629 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0848768 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0821965 |
| GOLGA4 | golgin A4 | 0.0747521 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.07306 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0691282 |
| ZNF292 | zinc finger protein 292 | 0.0630401 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0623525 |
| RBM39 | RNA binding motif protein 39 | 0.0609404 |
| TMSB4X | thymosin beta 4, X-linked | 0.0607274 |
| PCBP2 | poly(rC) binding protein 2 | 0.0604978 |
| PGK1 | phosphoglycerate kinase 1 | 0.0604978 |
| PYGB | phosphorylase, glycogen; brain | 0.0588611 |
| FLNB | filamin B, beta | 0.0571166 |
| LDHA | lactate dehydrogenase A | 0.0542818 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0541827 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0531634 |
| S100A6 | S100 calcium binding protein A6 | 0.0522451 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0518649 |
| DSCAM | Down syndrome cell adhesion molecule | 0.051249 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0493768 |
| TXNRD1 | thioredoxin reductase 1 | 0.0482248 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0478875 |
| RPL3 | ribosomal protein L3 | 0.0455353 |
| RNF145 | ring finger protein 145 | 0.0453738 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0447135 |
| RPS18 | ribosomal protein S18 | 0.0445332 |
| APP | amyloid beta (A4) precursor protein | 0.0444188 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0443286 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0441266 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0440386 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0432467 |
| SQSTM1 | sequestosome 1 | 0.0424147 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0417422 |
| PTMA | prothymosin, alpha | 0.0415061 |
| NUP58 | nucleoporin 58 | 0.0405886 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0405178 |
| ANK2 | ankyrin 2, neuronal | 0.0398982 |
| COG5 | component of oligomeric golgi complex 5 | 0.039735 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0390141 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0387795 |
| EZR | ezrin | 0.0384015 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0382917 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0382233 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0380758 |
| NBAS | neuroblastoma amplified sequence | 0.0379441 |
| SMYD3 | SET and MYND domain containing 3 | 0.0360752 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0359615 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0354427 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0341506 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0336954 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.033621 |
| HDLBP | high density lipoprotein binding protein | 0.0334489 |
| RTN4 | reticulon 4 | 0.0329497 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0326405 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0322709 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0322195 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0322179 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0321687 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0316116 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0316018 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0314498 |
| HMGA1 | high mobility group AT-hook 1 | 0.0309863 |
| TXNIP | thioredoxin interacting protein | 0.0308787 |
| B2M | beta-2-microglobulin | 0.0308468 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0306708 |
| CDC73 | cell division cycle 73 | 0.0304385 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0304332 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0301846 |
| ENO1 | enolase 1, (alpha) | 0.029874 |
| SETD5 | SET domain containing 5 | 0.0297139 |
| EVI5 | ecotropic viral integration site 5 | 0.0295592 |
| MATR3 | matrin 3 | 0.0295174 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0294923 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0293304 |
| RBM26 | RNA binding motif protein 26 | 0.0288995 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.028574 |
| CCNL1 | cyclin L1 | 0.0284477 |
| PRRC2C | proline-rich coiled-coil 2C | 0.028407 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0283129 |
| TMEM41B | transmembrane protein 41B | 0.0282994 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0278685 |
| LOXL3 | lysyl oxidase-like 3 | 0.0277962 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0275369 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0270424 |
| RLF | rearranged L-myc fusion | 0.0267138 |
| TJP1 | tight junction protein 1 | 0.0265576 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0264682 |
| MSI2 | musashi RNA-binding protein 2 | 0.0262614 |
| NCKAP1 | NCK-associated protein 1 | 0.0261584 |
| TNRC6B | trinucleotide repeat containing 6B | 0.026149 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0261392 |
| MED13L | mediator complex subunit 13-like | 0.0260906 |
| AHNAK | AHNAK nucleoprotein | 0.025883 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0258781 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0258537 |
| PKM | pyruvate kinase, muscle | 0.0258503 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0257991 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0902648 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0841601 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0596504 |
| BMP10 | bone morphogenetic protein 10 | -0.0571929 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0510353 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0496143 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0420615 |
| DIAPH3 | diaphanous-related formin 3 | -0.0420041 |
| RPS6 | ribosomal protein S6 | -0.0391802 |
| MKI67 | marker of proliferation Ki-67 | -0.0389497 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0358431 |
| GLI3 | GLI family zinc finger 3 | -0.0332614 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0326707 |
| FOXP1 | forkhead box P1 | -0.0324859 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0293155 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0274107 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0272804 |
| RPLP1 | ribosomal protein, large, P1 | -0.0268992 |
| RPL34 | ribosomal protein L34 | -0.0235028 |
| PDE7B | phosphodiesterase 7B | -0.0216968 |
| RPL35A | ribosomal protein L35a | -0.0215143 |
| FER1L6 | fer-1-like family member 6 | -0.0211184 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0209382 |
| ZNF438 | zinc finger protein 438 | -0.0209122 |
| RPS8 | ribosomal protein S8 | -0.0204333 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0200899 |
| CENPF | centromere protein F, 350/400kDa | -0.0200459 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.019493 |
| PKP4 | plakophilin 4 | -0.0193985 |
| TUBA1B | tubulin, alpha 1b | -0.0192995 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.019195 |
| NAV2 | neuron navigator 2 | -0.0186444 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0181369 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0177265 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0175939 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0162583 |
| EMP3 | epithelial membrane protein 3 | -0.0161829 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0160935 |
| CENPE | centromere protein E, 312kDa | -0.0159209 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0158914 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.015713 |
| ACTG1 | actin gamma 1 | -0.015393 |
| HMGB1 | high mobility group box 1 | -0.0151559 |
| MYO5C | myosin VC | -0.0149899 |
| RPL9 | ribosomal protein L9 | -0.0147041 |
| ANLN | anillin, actin binding protein | -0.0144836 |
| RPS21 | ribosomal protein S21 | -0.0144812 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0144539 |
| RRM2 | ribonucleotide reductase M2 | -0.0144473 |
| DPYD | dihydropyrimidine dehydrogenase | -0.014213 |
| MACROD2 | MACRO domain containing 2 | -0.0141579 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.0141196 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0138745 |
| TMSB10 | thymosin beta 10 | -0.0137071 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0136664 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0135926 |
| WWOX | WW domain containing oxidoreductase | -0.0134902 |
| CCND1 | cyclin D1 | -0.0134885 |
| SLC38A2 | solute carrier family 38, member 2 | -0.013351 |
| RPL28 | ribosomal protein L28 | -0.0132915 |
| ITGA10 | integrin, alpha 10 | -0.0131653 |
| RPL30 | ribosomal protein L30 | -0.0130867 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0129594 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.0128526 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0125597 |
| ASTN2 | astrotactin 2 | -0.0123944 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0123834 |
| AEBP2 | AE binding protein 2 | -0.0123439 |
| RPS11 | ribosomal protein S11 | -0.0121588 |
| CENPP | centromere protein P | -0.0121586 |
| STMN1 | stathmin 1 | -0.0120771 |
| RPLP2 | ribosomal protein, large, P2 | -0.0120116 |
| RPL7A | ribosomal protein L7a | -0.0119942 |
| FMN1 | formin 1 | -0.011969 |
| INTS6 | integrator complex subunit 6 | -0.0119356 |
| SEPTIN9 | septin 9 | -0.0119137 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0117868 |
| CUX1 | cut-like homeobox 1 | -0.0117631 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0117253 |
| TMBIM1 | transmembrane BAX inhibitor motif containing 1 | -0.011663 |
| RAN | RAN, member RAS oncogene family | -0.0116616 |
| RPS10 | ribosomal protein S10 | -0.0114467 |
| PRC1 | protein regulator of cytokinesis 1 | -0.0114418 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0114323 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0114132 |
| RPL8 | ribosomal protein L8 | -0.0112814 |
| HELLS | helicase, lymphoid-specific | -0.0112146 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.0111398 |
| RPL37A | ribosomal protein L37a | -0.0109513 |
| S100A9 | S100 calcium binding protein A9 | -0.0109448 |
| MMS22L | MMS22-like, DNA repair protein | -0.0109294 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0109129 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.0108291 |
| CCDC138 | coiled-coil domain containing 138 | -0.010751 |
| CENPK | centromere protein K | -0.0107369 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0106609 |
| RPS13 | ribosomal protein S13 | -0.0105744 |
| HJURP | Holliday junction recognition protein | -0.0105708 |
| FUS | FUS RNA binding protein | -0.0104333 |
| PCNX4 | pecanex 4 | -0.0103846 |
