| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.150028 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.149727 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.147645 |
| PGK1 | phosphoglycerate kinase 1 | 0.110262 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.104479 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0946707 |
| PCBP2 | poly(rC) binding protein 2 | 0.091317 |
| CADM1 | cell adhesion molecule 1 | 0.0896162 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0873414 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0799281 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0781854 |
| FN1 | fibronectin 1 | 0.0777747 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0765251 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0764503 |
| PDE10A | phosphodiesterase 10A | 0.0746931 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0735227 |
| ADM | adrenomedullin | 0.0725426 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0667207 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0623325 |
| VCAN | versican | 0.0556707 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0550873 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0527949 |
| AHNAK | AHNAK nucleoprotein | 0.0505012 |
| FRMPD4 | FERM and PDZ domain containing 4 | 0.0503238 |
| PLIN2 | perilipin 2 | 0.0493989 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0489749 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | 0.0480327 |
| RPS18 | ribosomal protein S18 | 0.0478649 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0457881 |
| HLA-A | major histocompatibility complex, class I, A | 0.0435049 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0432925 |
| DHFR | dihydrofolate reductase | 0.0431504 |
| GLIS3 | GLIS family zinc finger 3 | 0.0431379 |
| CANX | calnexin | 0.0418972 |
| SFTPA2 | surfactant protein A2 | 0.0412569 |
| ENO1 | enolase 1, (alpha) | 0.0405525 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0403147 |
| APP | amyloid beta (A4) precursor protein | 0.0397461 |
| LOXL2 | lysyl oxidase-like 2 | 0.0374047 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0372998 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0371772 |
| FAM20C | family with sequence similarity 20, member C | 0.0369256 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0360903 |
| CEP250 | centrosomal protein 250kDa | 0.0357945 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0356068 |
| HLA-C | major histocompatibility complex, class I, C | 0.0349963 |
| PHF3 | PHD finger protein 3 | 0.0346374 |
| INHBA | inhibin, beta A | 0.0343067 |
| HLA-E | major histocompatibility complex, class I, E | 0.0342659 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0338772 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0338113 |
| LDHA | lactate dehydrogenase A | 0.0336043 |
| OGA | O-GlcNAcase | 0.0328323 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0321638 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0320113 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0319619 |
| SETD5 | SET domain containing 5 | 0.0318661 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0317492 |
| FBXO32 | F-box protein 32 | 0.0317179 |
| HMGA1 | high mobility group AT-hook 1 | 0.0316264 |
| CALR | calreticulin | 0.0314179 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0312265 |
| CAVIN1 | caveolae associated protein 1 | 0.0308691 |
| PFKP | phosphofructokinase, platelet | 0.0303125 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0299794 |
| GNAS | GNAS complex locus | 0.0294826 |
| DST | dystonin | 0.0293357 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0289547 |
| MYOF | myoferlin | 0.0285836 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0285812 |
| LMNA | lamin A/C | 0.0284962 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0284565 |
| COL5A1 | collagen, type V, alpha 1 | 0.0283859 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0281332 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0279137 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0278263 |
| RPL3 | ribosomal protein L3 | 0.0276268 |
| DIAPH2 | diaphanous-related formin 2 | 0.027361 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0273198 |
| BNC2 | basonuclin 2 | 0.0270383 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0264458 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.0263699 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0261901 |
| MLPH | melanophilin | 0.0261853 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0260678 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0257754 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.025663 |
| RAI14 | retinoic acid induced 14 | 0.0256583 |
| PCBP3 | poly(rC) binding protein 3 | 0.0256542 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0252329 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0250823 |
| PHF21A | PHD finger protein 21A | 0.0250349 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0250113 |
| AFDN | afadin, adherens junction formation factor | 0.024975 |
| CD164 | CD164 molecule, sialomucin | 0.0246643 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0245027 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0239387 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0238667 |
| ATP13A3 | ATPase type 13A3 | 0.0236864 |
| STC2 | stanniocalcin 2 | 0.0234702 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.24368 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.124706 |
| CD44 | CD44 molecule (Indian blood group) | -0.100923 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.084645 |
| RPS6 | ribosomal protein S6 | -0.0831747 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0782369 |
| HLA-B | major histocompatibility complex, class I, B | -0.072607 |
| MT2A | metallothionein 2A | -0.0584212 |
| BICC1 | BicC family RNA binding protein 1 | -0.0572619 |
| CCNL1 | cyclin L1 | -0.0518835 |
| RPS2 | ribosomal protein S2 | -0.0503425 |
| FTL | ferritin, light polypeptide | -0.0496788 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0495351 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.04758 |
| KYNU | kynureninase | -0.0473623 |
| CDCP1 | CUB domain containing protein 1 | -0.041734 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.040605 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0364231 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0362321 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0358527 |
| RPL9 | ribosomal protein L9 | -0.0355059 |
| B2M | beta-2-microglobulin | -0.0353149 |
| PLSCR1 | phospholipid scramblase 1 | -0.0352013 |
| RTN4 | reticulon 4 | -0.0342202 |
| MSN | moesin | -0.0340621 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0334938 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0332475 |
| DUSP5 | dual specificity phosphatase 5 | -0.0329981 |
| TPM1 | tropomyosin 1 (alpha) | -0.0326674 |
| RPLP1 | ribosomal protein, large, P1 | -0.03211 |
| TAPBP | TAP binding protein (tapasin) | -0.0318875 |
| RIGI | RNA sensor RIG-I | -0.0318155 |
| DSTN | destrin (actin depolymerizing factor) | -0.0317734 |
| VMP1 | vacuole membrane protein 1 | -0.0315049 |
| RPS19 | ribosomal protein S19 | -0.0308428 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.03043 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0303628 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0299763 |
| SYAP1 | synapse associated protein 1 | -0.0298846 |
| SPAG9 | sperm associated antigen 9 | -0.0298181 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0296027 |
| BPTF | bromodomain PHD finger transcription factor | -0.0294126 |
| FMN1 | formin 1 | -0.029352 |
| ARF4 | ADP-ribosylation factor 4 | -0.0290882 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.028819 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0287567 |
| MX1 | MX dynamin-like GTPase 1 | -0.0286792 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0283087 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0282576 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280842 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0279777 |
| PMP22 | peripheral myelin protein 22 | -0.0279603 |
| LAMP2 | lysosomal-associated membrane protein 2 | -0.027778 |
| RPLP2 | ribosomal protein, large, P2 | -0.0274907 |
| CTSD | cathepsin D | -0.0274076 |
| ACTG1 | actin gamma 1 | -0.0273655 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0270465 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0270095 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.026577 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0263764 |
| TBK1 | TANK-binding kinase 1 | -0.0261361 |
| TXNRD1 | thioredoxin reductase 1 | -0.0260551 |
| EGR1 | early growth response 1 | -0.0248862 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0248124 |
| SEC24A | SEC24 family member A | -0.0247477 |
| NABP1 | nucleic acid binding protein 1 | -0.0244352 |
| RPL39 | ribosomal protein L39 | -0.0242075 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0240853 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0240571 |
| RPLP0 | ribosomal protein, large, P0 | -0.0239751 |
| RPL7A | ribosomal protein L7a | -0.0237472 |
| MKI67 | marker of proliferation Ki-67 | -0.0235827 |
| RPL7 | ribosomal protein L7 | -0.0233225 |
| RPS8 | ribosomal protein S8 | -0.0232613 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0225346 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.022457 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0223201 |
| PFN1 | profilin 1 | -0.0221479 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0220128 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0219153 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0215839 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0213942 |
| RPS10 | ribosomal protein S10 | -0.021377 |
| RPL27A | ribosomal protein L27a | -0.0212594 |
| RPL8 | ribosomal protein L8 | -0.0211708 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0211333 |
| ASTN2 | astrotactin 2 | -0.0211178 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0210312 |
| RPS25 | ribosomal protein S25 | -0.0208867 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0207793 |
| UBC | ubiquitin C | -0.0204569 |
| RPL21 | ribosomal protein L21 | -0.0203534 |
| RPL19 | ribosomal protein L19 | -0.0202812 |
| PALLD | palladin, cytoskeletal associated protein | -0.020045 |
| SCFD1 | sec1 family domain containing 1 | -0.0199496 |
| RPS21 | ribosomal protein S21 | -0.0197653 |
| CALD1 | caldesmon 1 | -0.0194909 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0194774 |
| RPL36A | ribosomal protein L36a | -0.0193766 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0193466 |
