| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.134981 |
| PCBP2 | poly(rC) binding protein 2 | 0.0992818 |
| PTMA | prothymosin, alpha | 0.0987027 |
| LDHA | lactate dehydrogenase A | 0.0958157 |
| VIM | vimentin | 0.0814317 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0790444 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0762593 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0754499 |
| ATP13A3 | ATPase type 13A3 | 0.0670092 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0643282 |
| MSN | moesin | 0.0638342 |
| SMAD3 | SMAD family member 3 | 0.0631161 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0625814 |
| TXNRD1 | thioredoxin reductase 1 | 0.0595755 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.058864 |
| GOLGA4 | golgin A4 | 0.0576518 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0566386 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0549876 |
| PKM | pyruvate kinase, muscle | 0.0549767 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0544295 |
| ENO1 | enolase 1, (alpha) | 0.054292 |
| YAP1 | Yes-associated protein 1 | 0.0535047 |
| RBM39 | RNA binding motif protein 39 | 0.0524944 |
| SETD5 | SET domain containing 5 | 0.0521233 |
| MATR3 | matrin 3 | 0.0515598 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.051016 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0492359 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0490227 |
| EFNA5 | ephrin-A5 | 0.0487822 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0487148 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0476837 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0469814 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0462204 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0460011 |
| TPX2 | TPX2, microtubule-associated | 0.0455975 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0451878 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0446385 |
| NUP58 | nucleoporin 58 | 0.0443174 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0436585 |
| SPAG9 | sperm associated antigen 9 | 0.0434405 |
| RPS18 | ribosomal protein S18 | 0.0431567 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0424358 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0423788 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.041749 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0417476 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0413628 |
| PHF21A | PHD finger protein 21A | 0.0411751 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0411359 |
| KIF5B | kinesin family member 5B | 0.0409812 |
| SON | SON DNA binding protein | 0.040345 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0397158 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0387899 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0387614 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0386775 |
| PGK1 | phosphoglycerate kinase 1 | 0.0382975 |
| TPR | translocated promoter region, nuclear basket protein | 0.038215 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0374932 |
| CENPF | centromere protein F, 350/400kDa | 0.0366898 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0363955 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0362546 |
| CD44 | CD44 molecule (Indian blood group) | 0.0362244 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0361526 |
| SET | SET nuclear proto-oncogene | 0.0361062 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0360809 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0360304 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0358945 |
| SPTLC1 | serine palmitoyltransferase, long chain base subunit 1 | 0.0358131 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0356912 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0354674 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0353883 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0353562 |
| YBX3 | Y box binding protein 3 | 0.0353471 |
| PDS5B | PDS5 cohesin associated factor B | 0.0352716 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0351021 |
| CNTRL | centriolin | 0.0348579 |
| ZNF292 | zinc finger protein 292 | 0.0347824 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0346027 |
| RPS3 | ribosomal protein S3 | 0.0344291 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0343681 |
| CEP250 | centrosomal protein 250kDa | 0.0341131 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0339262 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0339146 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0334278 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0331762 |
| PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | 0.0330563 |
| ERGIC3 | ERGIC and golgi 3 | 0.0330531 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0328943 |
| WBP11 | WW domain binding protein 11 | 0.0326997 |
| ANO6 | anoctamin 6 | 0.0323031 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0314927 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0314159 |
| MCL1 | myeloid cell leukemia 1 | 0.0312869 |
| ALG9 | ALG9, alpha-1,2-mannosyltransferase | 0.0311879 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0310108 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | 0.0309656 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0309032 |
| HJURP | Holliday junction recognition protein | 0.0306885 |
| KIAA1328 | KIAA1328 | 0.0305889 |
| MRE11 | MRE11 homolog, double strand break repair nuclease | 0.030523 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0304667 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.270226 |
| HMGA2 | high mobility group AT-hook 2 | -0.0810159 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0745484 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0713603 |
| PRKCA | protein kinase C, alpha | -0.0620819 |
| RAD51B | RAD51 paralog B | -0.0563324 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0560634 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0548709 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0527762 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0505306 |
| INTS6 | integrator complex subunit 6 | -0.0499653 |
| AHNAK | AHNAK nucleoprotein | -0.0488563 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0441963 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0440922 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.042704 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0426485 |
| VCL | vinculin | -0.0424167 |
| TMSB10 | thymosin beta 10 | -0.0424005 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.039735 |
| RAI14 | retinoic acid induced 14 | -0.0378147 |
| NF1 | neurofibromin 1 | -0.0374317 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0366936 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0366429 |
| IGF2 | insulin-like growth factor 2 | -0.0355276 |
| PRSS23 | protease, serine, 23 | -0.0354786 |
| CCDC138 | coiled-coil domain containing 138 | -0.0354008 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0353869 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0351534 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0348917 |
| CAVIN1 | caveolae associated protein 1 | -0.0347429 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0340294 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0338249 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0335958 |
| RNF213 | ring finger protein 213 | -0.0333177 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0331428 |
| NLK | nemo-like kinase | -0.032738 |
| PRR16 | proline rich 16 | -0.0321241 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0310482 |
| OSMR | oncostatin M receptor | -0.0309416 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0307384 |
| PCED1B | PC-esterase domain containing 1B | -0.030287 |
| RANBP17 | RAN binding protein 17 | -0.0301383 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0298344 |
| GPC5 | glypican 5 | -0.0296861 |
| EGFR | epidermal growth factor receptor | -0.0293357 |
| RPLP0 | ribosomal protein, large, P0 | -0.0292914 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0286416 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0284134 |
| ZC3H6 | zinc finger CCCH-type containing 6 | -0.028294 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0279348 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0278862 |
| GNAS | GNAS complex locus | -0.0276286 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0274543 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0271543 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | -0.0268856 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0268377 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0265057 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0264434 |
| ZNF609 | zinc finger protein 609 | -0.0262835 |
| SMAD2 | SMAD family member 2 | -0.026229 |
| ASPH | aspartate beta-hydroxylase | -0.0261765 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0260793 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0260084 |
| ITGAV | integrin, alpha V | -0.0259945 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0258085 |
| PHF3 | PHD finger protein 3 | -0.0255857 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0251662 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0250866 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0248693 |
| BPTF | bromodomain PHD finger transcription factor | -0.0248504 |
| UBB | ubiquitin B | -0.0247085 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0246233 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0243263 |
| SDC4 | syndecan 4 | -0.0241791 |
| NALCN | sodium leak channel, non selective | -0.0241405 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0241168 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0239519 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0237791 |
| MT2A | metallothionein 2A | -0.0236087 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0234693 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0234329 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0233127 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.023284 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0231369 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0227925 |
| ZXDC | ZXD family zinc finger C | -0.0227073 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0226146 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0224579 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0224418 |
| DTNA | dystrobrevin, alpha | -0.0221918 |
| FMNL2 | formin-like 2 | -0.0221399 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | -0.0221339 |
| OPTN | optineurin | -0.0219189 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.0215833 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0215335 |
| NPR2 | natriuretic peptide receptor 2 | -0.021454 |
| EGR1 | early growth response 1 | -0.0213942 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0213833 |
| GOLM2 | golgi membrane protein 2 | -0.021352 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0212991 |
