| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methotrexate perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Methotrexate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.104168 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.102613 |
| SMAD3 | SMAD family member 3 | 0.08612 |
| TXNIP | thioredoxin interacting protein | 0.0794835 |
| SMOX | spermine oxidase | 0.0759295 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0680582 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0638234 |
| TMEM156 | transmembrane protein 156 | 0.0610691 |
| AHR | aryl hydrocarbon receptor | 0.0607753 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0596659 |
| PCBP2 | poly(rC) binding protein 2 | 0.0580975 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0562322 |
| RUNX2 | runt-related transcription factor 2 | 0.0541514 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0536046 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0532777 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0525951 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0513841 |
| ETNK1 | ethanolamine kinase 1 | 0.0512199 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0499872 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0492558 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0483662 |
| NRP1 | neuropilin 1 | 0.0482469 |
| CENPF | centromere protein F, 350/400kDa | 0.0475275 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0461688 |
| RNF145 | ring finger protein 145 | 0.0451294 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0447894 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0437149 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0433639 |
| ETV6 | ets variant 6 | 0.0391595 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0385479 |
| OSMR | oncostatin M receptor | 0.0383737 |
| CD44 | CD44 molecule (Indian blood group) | 0.0370402 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.0366138 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0359071 |
| ADD3 | adducin 3 (gamma) | 0.0356689 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0353556 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0351086 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0344577 |
| PELO | pelota homolog (Drosophila) | 0.0342505 |
| APP | amyloid beta (A4) precursor protein | 0.0341018 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | 0.0340109 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.033964 |
| ENAH | enabled homolog (Drosophila) | 0.0338108 |
| CAB39 | calcium binding protein 39 | 0.0337837 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0336638 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0336361 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0333596 |
| SMYD3 | SET and MYND domain containing 3 | 0.0329804 |
| CDC73 | cell division cycle 73 | 0.0325988 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.03225 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.031612 |
| TGFB2 | transforming growth factor, beta 2 | 0.0315778 |
| GPR107 | G protein-coupled receptor 107 | 0.0314139 |
| VMP1 | vacuole membrane protein 1 | 0.0314108 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0311958 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.030727 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0306649 |
| MCTP2 | multiple C2 domains, transmembrane 2 | 0.0305392 |
| NEK7 | NIMA-related kinase 7 | 0.0304942 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0301402 |
| DHFR | dihydrofolate reductase | 0.0298723 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0295864 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0290697 |
| KSR1 | kinase suppressor of ras 1 | 0.0290262 |
| MKI67 | marker of proliferation Ki-67 | 0.0288451 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.028692 |
| WDR26 | WD repeat domain 26 | 0.0284553 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0282834 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0280239 |
| CORO1C | coronin, actin binding protein, 1C | 0.0273306 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0273222 |
| RAB8B | RAB8B, member RAS oncogene family | 0.026972 |
| FAM20C | family with sequence similarity 20, member C | 0.0269327 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0266809 |
| SEPTIN9 | septin 9 | 0.0265585 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0264873 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0264749 |
| ERBIN | erbb2 interacting protein | 0.0264551 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0263933 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0262805 |
| RPS18 | ribosomal protein S18 | 0.0261325 |
| TPR | translocated promoter region, nuclear basket protein | 0.0261103 |
| RBM39 | RNA binding motif protein 39 | 0.026075 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0259975 |
| OGA | O-GlcNAcase | 0.025987 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0257738 |
| RAB3GAP2 | RAB3 GTPase activating protein subunit 2 (non-catalytic) | 0.0256453 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0253845 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0253131 |
| RAB31 | RAB31, member RAS oncogene family | 0.0252951 |
| PTK2 | protein tyrosine kinase 2 | 0.0251081 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0250951 |
| CLTC | clathrin, heavy chain (Hc) | 0.0250862 |
| SRPK2 | SRSF protein kinase 2 | 0.0250306 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0249368 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0249223 |
| FRYL | FRY-like | 0.0246428 |
| FAT1 | FAT atypical cadherin 1 | 0.0245372 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0243977 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0243591 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NRG1 | neuregulin 1 | -0.222863 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.193575 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.191374 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.153126 |
| PTMA | prothymosin, alpha | -0.131571 |
| FN1 | fibronectin 1 | -0.112136 |
| FTL | ferritin, light polypeptide | -0.11124 |
| TMSB10 | thymosin beta 10 | -0.109769 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0825747 |
| HLA-B | major histocompatibility complex, class I, B | -0.0819758 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0771574 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0701762 |
| SQSTM1 | sequestosome 1 | -0.0668809 |
| NDRG1 | N-myc downstream regulated 1 | -0.0664916 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0660713 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.065581 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0627156 |
| ACTG1 | actin gamma 1 | -0.0621489 |
| RPL35A | ribosomal protein L35a | -0.0607281 |
| S100A6 | S100 calcium binding protein A6 | -0.0597412 |
| IER3 | immediate early response 3 | -0.0569761 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0568687 |
| HMGA2 | high mobility group AT-hook 2 | -0.0559979 |
| RPS6 | ribosomal protein S6 | -0.0539196 |
| TMSB4X | thymosin beta 4, X-linked | -0.0525921 |
| VIM | vimentin | -0.0521674 |
| S100A10 | S100 calcium binding protein A10 | -0.052097 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0499449 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0476497 |
| RPLP1 | ribosomal protein, large, P1 | -0.0473923 |
| ASPH | aspartate beta-hydroxylase | -0.0461218 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0452935 |
| STC2 | stanniocalcin 2 | -0.0429074 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.042435 |
| RPS8 | ribosomal protein S8 | -0.0413395 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0408445 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0404335 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0404204 |
| RPS19 | ribosomal protein S19 | -0.0397982 |
| RPL37A | ribosomal protein L37a | -0.0390119 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0377209 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0369322 |
| RPS24 | ribosomal protein S24 | -0.0367731 |
| INTS6 | integrator complex subunit 6 | -0.0366681 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0363739 |
| MT2A | metallothionein 2A | -0.0361359 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0360443 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.035427 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0353807 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0350286 |
| RPL34 | ribosomal protein L34 | -0.0350131 |
| RPL9 | ribosomal protein L9 | -0.0347199 |
| RPL26 | ribosomal protein L26 | -0.0346974 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0339266 |
| S100A9 | S100 calcium binding protein A9 | -0.0338822 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.033797 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0336156 |
| RPL28 | ribosomal protein L28 | -0.0331768 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0324661 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0321152 |
| RPS21 | ribosomal protein S21 | -0.0321123 |
| RACK1 | receptor for activated C kinase 1 | -0.0320039 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0319859 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0316275 |
| RPL23 | ribosomal protein L23 | -0.0307611 |
| CTSD | cathepsin D | -0.0305048 |
| RPL37 | ribosomal protein L37 | -0.0300315 |
| PLIN2 | perilipin 2 | -0.0296456 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.029425 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0293045 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0289485 |
| HM13 | histocompatibility (minor) 13 | -0.0288562 |
| RPS11 | ribosomal protein S11 | -0.0285537 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0282866 |
| SYT1 | synaptotagmin I | -0.0281188 |
| RPS27A | ribosomal protein S27a | -0.0278025 |
| DUSP6 | dual specificity phosphatase 6 | -0.0273718 |
| LRRC23 | leucine rich repeat containing 23 | -0.0273693 |
| RPS25 | ribosomal protein S25 | -0.0271698 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0271005 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0261074 |
| EGR1 | early growth response 1 | -0.0260558 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0259112 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0258181 |
| H1-0 | H1.0 linker histone | -0.0257374 |
| TENM4 | teneurin transmembrane protein 4 | -0.0257303 |
| RPS29 | ribosomal protein S29 | -0.0255614 |
| RPS16 | ribosomal protein S16 | -0.0254459 |
| AEBP2 | AE binding protein 2 | -0.0254327 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0253969 |
| LMNA | lamin A/C | -0.025341 |
| RPL8 | ribosomal protein L8 | -0.025048 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0249452 |
| RAI14 | retinoic acid induced 14 | -0.0249419 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0249102 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.024719 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0247153 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0243054 |
| CADM1 | cell adhesion molecule 1 | -0.0240527 |
| CUX1 | cut-like homeobox 1 | -0.0239287 |
