Methyl aminolevulinate (hydrochloride)_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.148843
CSF1 colony stimulating factor 1 (macrophage) 0.0820264
APP amyloid beta (A4) precursor protein 0.0796722
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0695228
CD44 CD44 molecule (Indian blood group) 0.0670115
PDLIM5 PDZ and LIM domain 5 0.062058
CXCL8 chemokine (C-X-C motif) ligand 8 0.0618453
SMAD3 SMAD family member 3 0.0618095
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0609161
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0597376
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0597327
DDIT4 DNA-damage-inducible transcript 4 0.0594322
G0S2 G0/G1 switch 2 0.0566538
VEGFA vascular endothelial growth factor A 0.0565607
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0524894
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0522423
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0502467
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0474771
VCL vinculin 0.0466483
ANXA5 annexin A5 0.0454922
RHEB Ras homolog enriched in brain 0.0453165
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0452449
NRP2 neuropilin 2 0.0442484
FTH1 ferritin, heavy polypeptide 1 0.0441946
DENND2B DENN domain containing 2B 0.0441064
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0433383
BHLHE40 basic helix-loop-helix family, member e40 0.0424465
CRY1 cryptochrome circadian clock 1 0.0419716
FXR1 fragile X mental retardation, autosomal homolog 1 0.0404672
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0404286
ZFAND3 zinc finger, AN1-type domain 3 0.0398505
MSN moesin 0.0392633
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0392297
PTK2 protein tyrosine kinase 2 0.0384079
ANKRD33B ankyrin repeat domain 33B 0.0377358
JAK1 Janus kinase 1 0.0364079
EEF2 eukaryotic translation elongation factor 2 0.0363974
ICAM1 intercellular adhesion molecule 1 0.0362512
NRIP1 nuclear receptor interacting protein 1 0.0362365
CXCL2 chemokine (C-X-C motif) ligand 2 0.0358116
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0357105
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0352664
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0346611
LOXL2 lysyl oxidase-like 2 0.0346345
TPM3 tropomyosin 3 0.0342214
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0338961
DENND4A DENN/MADD domain containing 4A 0.0334114
FMNL2 formin-like 2 0.0333907
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0333301
MBNL1 muscleblind-like splicing regulator 1 0.0329564
MRTFA myocardin related transcription factor A 0.0317743
MARCHF6 membrane associated ring-CH-type finger 6 0.0314104
AKAP13 A kinase (PRKA) anchor protein 13 0.0307225
MATR3 matrin 3 0.0306592
TFG TRK-fused gene 0.0303782
TNIP1 TNFAIP3 interacting protein 1 0.0303229
ITGAV integrin, alpha V 0.0300267
SAMD4A sterile alpha motif domain containing 4A 0.0297243
USP12 ubiquitin specific peptidase 12 0.0295157
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0292371
WDR43 WD repeat domain 43 0.0292302
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0290083
ZMIZ1 zinc finger, MIZ-type containing 1 0.0289488
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0280527
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0276974
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0276946
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0274045
RTN4 reticulon 4 0.0272015
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0267161
NAV2 neuron navigator 2 0.0264427
FNDC3B fibronectin type III domain containing 3B 0.0255232
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0251925
ARRDC3 arrestin domain containing 3 0.025151
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0250953
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0249712
OSBPL3 oxysterol binding protein-like 3 0.0248732
SHB Src homology 2 domain containing adaptor protein B 0.0246101
RPL3 ribosomal protein L3 0.0245824
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0245244
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0245096
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0240324
ENAH enabled homolog (Drosophila) 0.0239013
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0238744
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0236463
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0232205
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0231803
CORO1C coronin, actin binding protein, 1C 0.0230458
OLA1 Obg-like ATPase 1 0.0230015
CXCL3 chemokine (C-X-C motif) ligand 3 0.0229919
COPA coatomer protein complex, subunit alpha 0.0227931
CD70 CD70 molecule 0.0227615
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0227365
ERBIN erbb2 interacting protein 0.0225626
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0225011
OSBPL9 oxysterol binding protein-like 9 0.0224808
MACF1 microtubule-actin crosslinking factor 1 0.0223834
VCAN versican 0.0223755
NAP1L1 nucleosome assembly protein 1-like 1 0.0223012
RAD23B RAD23 homolog B (S. cerevisiae) 0.0222849
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.022282

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.234553
FTL ferritin, light polypeptide -0.107005
TMSB10 thymosin beta 10 -0.106067
FRMD4A FERM domain containing 4A -0.0923344
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0869458
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0858717
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0806588
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0777865
NDRG1 N-myc downstream regulated 1 -0.0714398
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0675789
IGFBP3 insulin-like growth factor binding protein 3 -0.0576831
MTDH metadherin -0.0569652
HLA-B major histocompatibility complex, class I, B -0.0568115
CP ceruloplasmin (ferroxidase) -0.0549379
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0527855
RPL35A ribosomal protein L35a -0.0520598
PLIN2 perilipin 2 -0.0518419
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0513693
RPS6 ribosomal protein S6 -0.0505223
RPS8 ribosomal protein S8 -0.0490143
CTSD cathepsin D -0.0458451
PRRC2C proline-rich coiled-coil 2C -0.0450279
TXNRD1 thioredoxin reductase 1 -0.0431646
AKAP9 A kinase (PRKA) anchor protein 9 -0.0423724
TPT1 tumor protein, translationally-controlled 1 -0.041893
SOD2 superoxide dismutase 2, mitochondrial -0.040137
RPL34 ribosomal protein L34 -0.0398157
GCC2 GRIP and coiled-coil domain containing 2 -0.0396067
S100A6 S100 calcium binding protein A6 -0.0391464
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0389463
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0388211
PFN1 profilin 1 -0.0383042
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0379968
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0376164
HM13 histocompatibility (minor) 13 -0.0375064
RPS24 ribosomal protein S24 -0.0374766
MYADM myeloid-associated differentiation marker -0.0374303
SCFD2 sec1 family domain containing 2 -0.0372992
CMIP c-Maf inducing protein -0.0357319
GARS1 glycyl-tRNA synthetase 1 -0.0354144
HLA-A major histocompatibility complex, class I, A -0.0353236
SDCBP syndecan binding protein (syntenin) -0.0351624
MRPS6 mitochondrial ribosomal protein S6 -0.0351344
LITAF lipopolysaccharide-induced TNF factor -0.0350456
RRBP1 ribosome binding protein 1 -0.0346946
RPL31 ribosomal protein L31 -0.0341648
TTC3 tetratricopeptide repeat domain 3 -0.0340624
EIF1 eukaryotic translation initiation factor 1 -0.0337969
RPL23 ribosomal protein L23 -0.0325921
UBC ubiquitin C -0.0324738
SPDYA speedy/RINGO cell cycle regulator family member A -0.0324036
RPL12 ribosomal protein L12 -0.0322756
RPLP1 ribosomal protein, large, P1 -0.0320929
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0319993
KPNB1 karyopherin (importin) beta 1 -0.0315244
TFPI2 tissue factor pathway inhibitor 2 -0.0314148
GNAS GNAS complex locus -0.0313812
MAP1B microtubule-associated protein 1B -0.0312716
HLA-E major histocompatibility complex, class I, E -0.0311916
RPL19 ribosomal protein L19 -0.031139
BIRC6 baculoviral IAP repeat containing 6 -0.0301185
CA12 carbonic anhydrase XII -0.0300712
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0296108
SLC31A1 solute carrier family 31 (copper transporter), member 1 -0.0294988
SEC31A SEC31 homolog A (S. cerevisiae) -0.0293629
RPL9 ribosomal protein L9 -0.0290751
ANXA4 annexin A4 -0.0290407
RPS19 ribosomal protein S19 -0.0287617
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0286721
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0285554
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0283271
ACTG1 actin gamma 1 -0.0282749
ADAM10 ADAM metallopeptidase domain 10 -0.0281163
EIF5B eukaryotic translation initiation factor 5B -0.0280639
MT2A metallothionein 2A -0.0278518
TKT transketolase -0.0278508
ARL4C ADP-ribosylation factor-like 4C -0.027796
GDF15 growth differentiation factor 15 -0.0276476
RPS5 ribosomal protein S5 -0.0274178
SRSF11 serine/arginine-rich splicing factor 11 -0.0271505
IFIH1 interferon induced with helicase C domain 1 -0.0270284
TPM4 tropomyosin 4 -0.0269865
LMAN1 lectin, mannose-binding, 1 -0.0269617
DLG1 discs, large homolog 1 (Drosophila) -0.0268942
GOLGA4 golgin A4 -0.0268722
CD63 CD63 molecule -0.0266011
IARS1 isoleucyl-tRNA synthetase 1 -0.0263913
PTMA prothymosin, alpha -0.0257646
RPS13 ribosomal protein S13 -0.0257561
CUX1 cut-like homeobox 1 -0.0257291
PTGR1 prostaglandin reductase 1 -0.0253822
VDAC1 voltage-dependent anion channel 1 -0.02535
HMGA1 high mobility group AT-hook 1 -0.0253368
GOLGB1 golgin B1 -0.0252984
CAVIN1 caveolae associated protein 1 -0.0251198
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.025012
BLZF1 basic leucine zipper nuclear factor 1 -0.0245734
ZMYND8 zinc finger, MYND-type containing 8 -0.0244627
NFX1 nuclear transcription factor, X-box binding 1 -0.0243095
RND3 Rho family GTPase 3 -0.0242975