Methyl aminolevulinate (hydrochloride)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0788847
SMAD3 SMAD family member 3 0.06875
SPTBN1 spectrin, beta, non-erythrocytic 1 0.05631
AKAP12 A kinase (PRKA) anchor protein 12 0.0530028
GRB10 growth factor receptor-bound protein 10 0.0503041
FNDC3B fibronectin type III domain containing 3B 0.0499502
VMP1 vacuole membrane protein 1 0.0438696
ECT2 epithelial cell transforming 2 0.0436823
MYH9 myosin, heavy chain 9, non-muscle 0.0424396
PDE10A phosphodiesterase 10A 0.0411818
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0394326
FLNB filamin B, beta 0.0381212
MSN moesin 0.0380712
ANKRD11 ankyrin repeat domain 11 0.037931
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0362584
USP47 ubiquitin specific peptidase 47 0.0361928
DGKD diacylglycerol kinase, delta 130kDa 0.0354407
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0341202
VCL vinculin 0.0335917
FMNL2 formin-like 2 0.0334113
NRIP1 nuclear receptor interacting protein 1 0.0330206
ADAM9 ADAM metallopeptidase domain 9 0.0308873
FTH1 ferritin, heavy polypeptide 1 0.0307857
NUP58 nucleoporin 58 0.0307832
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0306728
SRRM2 serine/arginine repetitive matrix 2 0.0306611
PDLIM5 PDZ and LIM domain 5 0.0305754
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0304312
SPAG9 sperm associated antigen 9 0.0300735
ARHGAP26 Rho GTPase activating protein 26 0.0295191
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0292438
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0278117
EEF2 eukaryotic translation elongation factor 2 0.0277639
PRRC2C proline-rich coiled-coil 2C 0.0275738
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0274949
RICTOR RPTOR independent companion of MTOR, complex 2 0.0273688
SETD5 SET domain containing 5 0.0273585
TPM1 tropomyosin 1 (alpha) 0.0269764
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.02695
DSCAM Down syndrome cell adhesion molecule 0.0268656
RNF145 ring finger protein 145 0.0266779
VEGFA vascular endothelial growth factor A 0.0262699
CD44 CD44 molecule (Indian blood group) 0.0259642
AKAP13 A kinase (PRKA) anchor protein 13 0.0256451
TRIO trio Rho guanine nucleotide exchange factor 0.0248408
ELL2 elongation factor, RNA polymerase II, 2 0.0246611
PDE8A phosphodiesterase 8A 0.0242139
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0239024
TNIP1 TNFAIP3 interacting protein 1 0.023566
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0232347
AGFG1 ArfGAP with FG repeats 1 0.0232106
NAV2 neuron navigator 2 0.023122
PCM1 pericentriolar material 1 0.0229656
ITPRID2 ITPR interacting domain containing 2 0.0224706
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220856
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0218456
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0218221
CCNL1 cyclin L1 0.0215824
CHD1 chromodomain helicase DNA binding protein 1 0.0212384
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0212082
HELZ helicase with zinc finger 0.0210138
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0208993
RTN4 reticulon 4 0.0208839
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0208349
ADAM17 ADAM metallopeptidase domain 17 0.0207891
WAC WW domain containing adaptor with coiled-coil 0.0207251
ARL5B ADP-ribosylation factor-like 5B 0.020623
ATP13A3 ATPase type 13A3 0.0206126
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0206074
WDR43 WD repeat domain 43 0.0203758
SHB Src homology 2 domain containing adaptor protein B 0.0202763
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0202423
MCL1 myeloid cell leukemia 1 0.0202402
UBA6 ubiquitin-like modifier activating enzyme 6 0.0201456
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0198262
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0198112
ANO6 anoctamin 6 0.0197283
STC1 stanniocalcin 1 0.0196973
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196539
MACF1 microtubule-actin crosslinking factor 1 0.0191871
EREG epiregulin 0.0191505
USP9X ubiquitin specific peptidase 9, X-linked 0.0190559
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0189778
TFG TRK-fused gene 0.0189224
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.018885
CORO1C coronin, actin binding protein, 1C 0.0188598
DOCK5 dedicator of cytokinesis 5 0.0187945
DENND4A DENN/MADD domain containing 4A 0.018729
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0185425
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.018059
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0179133
USP3 ubiquitin specific peptidase 3 0.0177346
ERRFI1 ERBB receptor feedback inhibitor 1 0.0177321
APP amyloid beta (A4) precursor protein 0.0176839
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0176426
TPM3 tropomyosin 3 0.0176247
KMT2C lysine (K)-specific methyltransferase 2C 0.0176012
LAMC2 laminin, gamma 2 0.0175382
MYO1B myosin IB 0.0175149
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0174266

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.233509
TMSB10 thymosin beta 10 -0.172882
ACTG1 actin gamma 1 -0.152752
FTL ferritin, light polypeptide -0.123861
VIM vimentin -0.11997
MT2A metallothionein 2A -0.108528
RPLP1 ribosomal protein, large, P1 -0.108273
RPS19 ribosomal protein S19 -0.0967684
S100A6 S100 calcium binding protein A6 -0.0663469
RPS16 ribosomal protein S16 -0.0634123
MT1X metallothionein 1X -0.0629026
RPS6 ribosomal protein S6 -0.0611407
RPL23 ribosomal protein L23 -0.0610799
TPT1 tumor protein, translationally-controlled 1 -0.0577865
RPS24 ribosomal protein S24 -0.0524133
RPL12 ribosomal protein L12 -0.0518608
EIF1 eukaryotic translation initiation factor 1 -0.0512157
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0507081
S100A10 S100 calcium binding protein A10 -0.0504718
RPS8 ribosomal protein S8 -0.0460053
RPL19 ribosomal protein L19 -0.045275
RPLP0 ribosomal protein, large, P0 -0.0433047
IGFBP4 insulin-like growth factor binding protein 4 -0.041444
RPS27A ribosomal protein S27a -0.0411485
EFNA5 ephrin-A5 -0.0392025
PTMA prothymosin, alpha -0.0384832
RPL35A ribosomal protein L35a -0.0378459
RPLP2 ribosomal protein, large, P2 -0.037212
RPL32 ribosomal protein L32 -0.035995
RPL13A ribosomal protein L13a -0.0359748
RPL26 ribosomal protein L26 -0.0359738
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0340872
RPL8 ribosomal protein L8 -0.0325075
PFN1 profilin 1 -0.032169
LOC112694756 uncharaterized LOC112694756 -0.0319857
RPL28 ribosomal protein L28 -0.0319399
RPL37A ribosomal protein L37a -0.031875
RPS11 ribosomal protein S11 -0.0312257
RPL31 ribosomal protein L31 -0.0309809
TKT transketolase -0.0309797
RPL34 ribosomal protein L34 -0.0306548
KRT81 keratin 81, type II -0.0291729
RPS14 ribosomal protein S14 -0.0288607
RPL27A ribosomal protein L27a -0.0281901
RPS4X ribosomal protein S4, X-linked -0.0277785
VDAC1 voltage-dependent anion channel 1 -0.0277647
RPL36A ribosomal protein L36a -0.027129
RPL30 ribosomal protein L30 -0.0268561
BASP1 brain abundant, membrane attached signal protein 1 -0.0268485
RPS13 ribosomal protein S13 -0.0268237
C15ORF48 chromosome 15 open reading frame 48 -0.0267962
RPS5 ribosomal protein S5 -0.0267754
RPL38 ribosomal protein L38 -0.026492
RPL9 ribosomal protein L9 -0.0264508
RPS29 ribosomal protein S29 -0.0262725
HMGA1 high mobility group AT-hook 1 -0.0259233
RPS12 ribosomal protein S12 -0.0258592
RPS23 ribosomal protein S23 -0.0257141
LMNA lamin A/C -0.0252736
RPS3 ribosomal protein S3 -0.0252203
RPL18 ribosomal protein L18 -0.0247746
RPS17 ribosomal protein S17 -0.0246268
RPS21 ribosomal protein S21 -0.0243405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0240656
RPL37 ribosomal protein L37 -0.0238515
UBC ubiquitin C -0.0238398
RPL39 ribosomal protein L39 -0.0236997
AKR1C2 aldo-keto reductase family 1, member C2 -0.0231202
KLF6 Kruppel-like factor 6 -0.0228792
TXNRD1 thioredoxin reductase 1 -0.0228683
RACK1 receptor for activated C kinase 1 -0.0226339
RPL36 ribosomal protein L36 -0.0225945
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0224684
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0224667
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214891
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0213131
LDHA lactate dehydrogenase A -0.0206418
EHBP1 EH domain binding protein 1 -0.0205719
NDRG1 N-myc downstream regulated 1 -0.020171
PKM pyruvate kinase, muscle -0.0200135
ZBTB20 zinc finger and BTB domain containing 20 -0.0197599
GNAS GNAS complex locus -0.0194338
RPL35 ribosomal protein L35 -0.0193911
RPS25 ribosomal protein S25 -0.0192987
RPL27 ribosomal protein L27 -0.0189304
RPL11 ribosomal protein L11 -0.0186539
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0185536
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0184961
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0184671
RPS27 ribosomal protein S27 -0.0182264
RPL5 ribosomal protein L5 -0.0181615
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0179386
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0175684
ASTN2 astrotactin 2 -0.017214
PGK1 phosphoglycerate kinase 1 -0.0171191
MORF4L2 mortality factor 4 like 2 -0.0169771
FBXL2 F-box and leucine-rich repeat protein 2 -0.0168771
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0167903
SQSTM1 sequestosome 1 -0.0167079
RPL7A ribosomal protein L7a -0.0165688