Methyl aminolevulinate (hydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.114773
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0835057
CD109 CD109 molecule 0.0771718
KMT2C lysine (K)-specific methyltransferase 2C 0.0765525
COPA coatomer protein complex, subunit alpha 0.0714883
RNF145 ring finger protein 145 0.0710311
VEGFA vascular endothelial growth factor A 0.0695967
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0665815
AKAP12 A kinase (PRKA) anchor protein 12 0.0598336
SETD5 SET domain containing 5 0.057928
NUP58 nucleoporin 58 0.0572736
CABIN1 calcineurin binding protein 1 0.0566048
NDRG1 N-myc downstream regulated 1 0.0554548
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0532614
KMT2E lysine (K)-specific methyltransferase 2E 0.0517871
BHLHE40 basic helix-loop-helix family, member e40 0.0515808
FTH1 ferritin, heavy polypeptide 1 0.0452941
SRRM2 serine/arginine repetitive matrix 2 0.0430104
TPR translocated promoter region, nuclear basket protein 0.0415621
GOLGA4 golgin A4 0.0410577
VMP1 vacuole membrane protein 1 0.0405817
CALD1 caldesmon 1 0.0385866
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0376369
ESYT2 extended synaptotagmin-like protein 2 0.0368354
HILPDA hypoxia inducible lipid droplet-associated 0.0364352
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0349619
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0346638
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0339953
UBA6 ubiquitin-like modifier activating enzyme 6 0.0330963
POTEF POTE ankyrin domain family, member F 0.0327973
CALR calreticulin 0.0323252
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0321328
YBX1 Y box binding protein 1 0.0310221
CCNL1 cyclin L1 0.0305218
GDF15 growth differentiation factor 15 0.0297268
NBAS neuroblastoma amplified sequence 0.0296651
MRTFA myocardin related transcription factor A 0.0289322
SSBP3 single stranded DNA binding protein 3 0.0289107
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0286661
EEF2 eukaryotic translation elongation factor 2 0.0285201
PHF21A PHD finger protein 21A 0.0281952
PKM pyruvate kinase, muscle 0.028145
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274628
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0267769
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0262056
MIDEAS mitotic deacetylase associated SANT domain protein 0.0261551
KDM5B lysine (K)-specific demethylase 5B 0.0260342
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0257012
PPME1 protein phosphatase methylesterase 1 0.0256873
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0255839
FOSL1 FOS-like antigen 1 0.02506
CUL3 cullin 3 0.0249044
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0248238
SCARB1 scavenger receptor class B, member 1 0.0246175
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242109
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0237544
RHOA ras homolog family member A 0.023605
PLIN2 perilipin 2 0.0233099
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0231971
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0230844
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0230525
EP300 E1A binding protein p300 0.0229665
PTMS parathymosin 0.0228105
CDK19 cyclin-dependent kinase 19 0.0226534
LNPK lunapark, ER junction formation factor 0.0220284
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0218792
PTK2 protein tyrosine kinase 2 0.0218094
KTN1 kinectin 1 (kinesin receptor) 0.0216007
PRRC2C proline-rich coiled-coil 2C 0.0215714
DCAF8 DDB1 and CUL4 associated factor 8 0.0212528
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0210588
CTTNBP2 cortactin binding protein 2 0.0210143
TMEM255B transmembrane protein 255B 0.0209654
MYH9 myosin, heavy chain 9, non-muscle 0.020957
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208555
FBXO7 F-box protein 7 0.0207681
SREBF2 sterol regulatory element binding transcription factor 2 0.0206899
SOX10 SRY (sex determining region Y)-box 10 0.0205856
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0205342
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0204338
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0202828
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.020276
PTMA prothymosin, alpha 0.0202258
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0202128
TIMP2 TIMP metallopeptidase inhibitor 2 0.0201498
INSIG2 insulin induced gene 2 0.0199518
ZNF292 zinc finger protein 292 0.0198437
ZYX zyxin 0.0198108
BRWD1 bromodomain and WD repeat domain containing 1 0.0196793
RPL3 ribosomal protein L3 0.019626
WASL Wiskott-Aldrich syndrome-like 0.0195528
CDC73 cell division cycle 73 0.0195108
SET SET nuclear proto-oncogene 0.0194417
PIAS2 protein inhibitor of activated STAT, 2 0.0193925
RNMT RNA (guanine-7-) methyltransferase 0.0193151
SNX13 sorting nexin 13 0.0193049
HELZ helicase with zinc finger 0.0192943
TOP1 topoisomerase (DNA) I 0.0188062
WDR43 WD repeat domain 43 0.0187215
B2M beta-2-microglobulin 0.018499

decreased expression

Symbol Name Standardized Value
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.215121
FN1 fibronectin 1 -0.182235
GPC6 glypican 6 -0.15567
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147549
IFI16 interferon, gamma-inducible protein 16 -0.141982
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.135748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12414
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.121086
TNNC1 troponin C type 1 (slow) -0.0902898
VGF VGF nerve growth factor inducible -0.0834677
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0702595
FMN1 formin 1 -0.0662367
VIM vimentin -0.0595376
FRMD4A FERM domain containing 4A -0.0588949
HMCN1 hemicentin 1 -0.0558825
MACROD2 MACRO domain containing 2 -0.0532414
NPC1 Niemann-Pick disease, type C1 -0.0522923
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0505859
PDE10A phosphodiesterase 10A -0.0490634
PCDH7 protocadherin 7 -0.0478596
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0458494
IER3 immediate early response 3 -0.0439138
OSMR oncostatin M receptor -0.0425448
TM4SF1 transmembrane 4 L six family member 1 -0.0420448
PGK1 phosphoglycerate kinase 1 -0.0416783
ACTG1 actin gamma 1 -0.0412409
CDK14 cyclin-dependent kinase 14 -0.0396575
NAV3 neuron navigator 3 -0.038874
NPAS2 neuronal PAS domain protein 2 -0.0386528
TMSB10 thymosin beta 10 -0.0385939
ICAM1 intercellular adhesion molecule 1 -0.0385334
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0384623
LEF1 lymphoid enhancer-binding factor 1 -0.0382345
A2M alpha-2-macroglobulin -0.0379676
COL19A1 collagen, type XIX, alpha 1 -0.0376042
LRMDA leucine rich melanocyte differentiation associated -0.0370109
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0359692
FBXO32 F-box protein 32 -0.0358431
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0352376
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.034818
SDC2 syndecan 2 -0.0344552
NAMPT nicotinamide phosphoribosyltransferase -0.0342336
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0335334
NBEA neurobeachin -0.0329825
FRMD5 FERM domain containing 5 -0.0327377
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0325924
IFRD1 interferon-related developmental regulator 1 -0.0320328
NHSL1 NHS-like 1 -0.0314814
ZMYND8 zinc finger, MYND-type containing 8 -0.0314368
EXOC4 exocyst complex component 4 -0.0312436
WSB1 WD repeat and SOCS box containing 1 -0.0307419
DPYD dihydropyrimidine dehydrogenase -0.0304776
TPT1 tumor protein, translationally-controlled 1 -0.0299196
FHIT fragile histidine triad -0.029236
CAV1 caveolin 1, caveolae protein, 22kDa -0.0282752
AHNAK AHNAK nucleoprotein -0.0282228
BICD1 bicaudal D homolog 1 (Drosophila) -0.0281777
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.027636
BCAS3 breast carcinoma amplified sequence 3 -0.027367
NLGN1 neuroligin 1 -0.0268361
NRCAM neuronal cell adhesion molecule -0.0267584
PAX3 paired box 3 -0.026719
NCOA7 nuclear receptor coactivator 7 -0.0266914
MT1X metallothionein 1X -0.0266261
SMYD3 SET and MYND domain containing 3 -0.0265561
EHBP1 EH domain binding protein 1 -0.0263406
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0262287
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0255936
NPR2 natriuretic peptide receptor 2 -0.0254252
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0251525
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0250786
DOCK4 dedicator of cytokinesis 4 -0.02497
HMGA2 high mobility group AT-hook 2 -0.0248588
ATF6 activating transcription factor 6 -0.0247736
IGF1R insulin-like growth factor 1 receptor -0.0242569
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0242186
RPLP1 ribosomal protein, large, P1 -0.0240072
RUNX1 runt-related transcription factor 1 -0.0239015
TAS2R14 taste receptor, type 2, member 14 -0.023541
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0232777
HLA-E major histocompatibility complex, class I, E -0.0232289
GNAS GNAS complex locus -0.023187
MITF microphthalmia-associated transcription factor -0.0231161
ETV6 ets variant 6 -0.0230206
AFAP1 actin filament associated protein 1 -0.0229704
ZBTB20 zinc finger and BTB domain containing 20 -0.0229525
CDH19 cadherin 19, type 2 -0.0228521
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0226003
HBP1 HMG-box transcription factor 1 -0.0223412
INPP5F inositol polyphosphate-5-phosphatase F -0.0221723
ATXN1 ataxin 1 -0.0221611
PTCHD4 patched domain containing 4 -0.0219785
ARHGAP5 Rho GTPase activating protein 5 -0.0219139
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0211997
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0207546
PDE4D phosphodiesterase 4D, cAMP-specific -0.0207486
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0207003
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0206924
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0206909
COL1A2 collagen, type I, alpha 2 -0.0205272