Methyl aminolevulinate (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0838771
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0720452
FTH1 ferritin, heavy polypeptide 1 0.0701145
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0624592
SPAG9 sperm associated antigen 9 0.0622821
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0610858
MYH9 myosin, heavy chain 9, non-muscle 0.0605203
FAM13A family with sequence similarity 13, member A 0.0601673
TSC22D2 TSC22 domain family, member 2 0.0597958
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0494631
VEGFA vascular endothelial growth factor A 0.0488014
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0473965
CCNY cyclin Y 0.0449585
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0429756
RBM39 RNA binding motif protein 39 0.0429382
KMT2E lysine (K)-specific methyltransferase 2E 0.0418203
PTMA prothymosin, alpha 0.0416827
ADAM9 ADAM metallopeptidase domain 9 0.0399453
TMSB4X thymosin beta 4, X-linked 0.0393349
APP amyloid beta (A4) precursor protein 0.0391232
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0385322
ELL2 elongation factor, RNA polymerase II, 2 0.0377784
UBA6 ubiquitin-like modifier activating enzyme 6 0.0367859
AKAP12 A kinase (PRKA) anchor protein 12 0.0358196
CCNL1 cyclin L1 0.0353115
HELZ helicase with zinc finger 0.0351201
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0349258
NUP58 nucleoporin 58 0.0345076
OGA O-GlcNAcase 0.0342775
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0326876
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0326228
TOP1 topoisomerase (DNA) I 0.032622
MEF2A myocyte enhancer factor 2A 0.0320547
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0316276
ANKRD11 ankyrin repeat domain 11 0.0311044
FXR1 fragile X mental retardation, autosomal homolog 1 0.0308011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0298893
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297549
CDC73 cell division cycle 73 0.0295066
WAC WW domain containing adaptor with coiled-coil 0.0294413
MATR3 matrin 3 0.0281209
RTN4 reticulon 4 0.0280057
WSB1 WD repeat and SOCS box containing 1 0.027863
CTNND1 catenin (cadherin-associated protein), delta 1 0.027766
KDM3A lysine (K)-specific demethylase 3A 0.0274354
TFG TRK-fused gene 0.0272723
NPEPPS aminopeptidase puromycin sensitive 0.0272281
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0268783
RAB6A RAB6A, member RAS oncogene family 0.0263553
YTHDC1 YTH domain containing 1 0.0261426
MARCHF6 membrane associated ring-CH-type finger 6 0.0260055
USP3 ubiquitin specific peptidase 3 0.0254832
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0252759
BHLHE40 basic helix-loop-helix family, member e40 0.0250748
TRA2A transformer 2 alpha homolog (Drosophila) 0.0249478
RLF rearranged L-myc fusion 0.0248159
AKAP13 A kinase (PRKA) anchor protein 13 0.0245172
ZNF292 zinc finger protein 292 0.0241908
PRRC2C proline-rich coiled-coil 2C 0.0235162
ARRDC3 arrestin domain containing 3 0.0233628
RAB8B RAB8B, member RAS oncogene family 0.0232635
ABI1 abl-interactor 1 0.0231681
RAB1A RAB1A, member RAS oncogene family 0.0223781
DDIT4 DNA-damage-inducible transcript 4 0.0223276
FLNB filamin B, beta 0.0223243
PDIA6 protein disulfide isomerase family A, member 6 0.0222646
KDM6A lysine (K)-specific demethylase 6A 0.0221863
YME1L1 YME1-like 1 ATPase 0.0218434
NPTN neuroplastin 0.0215434
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0210073
CASC3 cancer susceptibility candidate 3 0.0207754
FAM162A family with sequence similarity 162, member A 0.0206623
CALR calreticulin 0.0205771
ERRFI1 ERBB receptor feedback inhibitor 1 0.0203396
SEC23A Sec23 homolog A (S. cerevisiae) 0.0199323
RIOK3 RIO kinase 3 0.0199118
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0197842
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.01971
FNBP1L formin binding protein 1-like 0.0196081
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.01936
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0193195
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0192152
G0S2 G0/G1 switch 2 0.0192076
QKI QKI, KH domain containing, RNA binding 0.0190347
ATP13A3 ATPase type 13A3 0.0190092
VEZT vezatin, adherens junctions transmembrane protein 0.0190044
ZFC3H1 zinc finger, C3H1-type containing 0.018694
GSK3B glycogen synthase kinase 3 beta 0.0186824
SUCO SUN domain containing ossification factor 0.018634
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186021
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0185249
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0182954
GARS1 glycyl-tRNA synthetase 1 0.0182134
HOOK2 hook microtubule-tethering protein 2 0.0181248
OSBPL9 oxysterol binding protein-like 9 0.018026
KMT2C lysine (K)-specific methyltransferase 2C 0.0177473
DSCAM Down syndrome cell adhesion molecule 0.0177281
MCTP1 multiple C2 domains, transmembrane 1 0.0176836
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0174637
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0174581

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.122718
MMP7 matrix metallopeptidase 7 -0.0979175
TMSB10 thymosin beta 10 -0.0939343
MT2A metallothionein 2A -0.0917497
IFI27 interferon, alpha-inducible protein 27 -0.073889
KRT19 keratin 19, type I -0.0716555
HLA-B major histocompatibility complex, class I, B -0.0627509
FTL ferritin, light polypeptide -0.0514057
CP ceruloplasmin (ferroxidase) -0.0499841
ISG15 ISG15 ubiquitin-like modifier -0.0478704
APOL1 apolipoprotein L, 1 -0.0449393
S100A6 S100 calcium binding protein A6 -0.0447581
MAML2 mastermind-like 2 (Drosophila) -0.044053
HMGA1 high mobility group AT-hook 1 -0.0432623
IGFBP3 insulin-like growth factor binding protein 3 -0.0426758
EFNA5 ephrin-A5 -0.0425152
RPLP1 ribosomal protein, large, P1 -0.0408494
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0406997
RPL19 ribosomal protein L19 -0.0400388
IFI6 interferon, alpha-inducible protein 6 -0.0393815
RPL23 ribosomal protein L23 -0.0362523
RNF213 ring finger protein 213 -0.0353169
RPS8 ribosomal protein S8 -0.034101
LCN2 lipocalin 2 -0.0323512
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0318892
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0305025
VIM vimentin -0.0301868
TM4SF1 transmembrane 4 L six family member 1 -0.0301688
RAD51B RAD51 paralog B -0.0300892
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0286267
PKM pyruvate kinase, muscle -0.0283488
RPS29 ribosomal protein S29 -0.0283043
SLC38A1 solute carrier family 38, member 1 -0.0277825
S100A10 S100 calcium binding protein A10 -0.0271547
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0270173
C15ORF48 chromosome 15 open reading frame 48 -0.0265258
RPL35A ribosomal protein L35a -0.0263757
RPL34 ribosomal protein L34 -0.0263328
IFITM1 interferon induced transmembrane protein 1 -0.0263242
MX2 MX dynamin-like GTPase 2 -0.0260556
TPT1 tumor protein, translationally-controlled 1 -0.0260493
RPS19 ribosomal protein S19 -0.0256162
LAMA4 laminin, alpha 4 -0.025318
EGR1 early growth response 1 -0.0248906
F3 coagulation factor III (thromboplastin, tissue factor) -0.0245437
STAT1 signal transducer and activator of transcription 1, 91kDa -0.024022
SP100 SP100 nuclear antigen -0.0237446
NRG3 neuregulin 3 -0.0236908
IFITM3 interferon induced transmembrane protein 3 -0.0234089
ENO1 enolase 1, (alpha) -0.0232566
PDE4D phosphodiesterase 4D, cAMP-specific -0.0227172
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0222629
PLAT plasminogen activator, tissue -0.0220317
MX1 MX dynamin-like GTPase 1 -0.0219713
PCDH7 protocadherin 7 -0.0218604
RPL31 ribosomal protein L31 -0.0217628
TPM4 tropomyosin 4 -0.0216566
OSMR oncostatin M receptor -0.0214276
BPTF bromodomain PHD finger transcription factor -0.0213299
PMP22 peripheral myelin protein 22 -0.0213206
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0212135
ACTG1 actin gamma 1 -0.0211075
RPS21 ribosomal protein S21 -0.0209755
ZFP36L1 ZFP36 ring finger protein-like 1 -0.020973
ZBTB20 zinc finger and BTB domain containing 20 -0.0209077
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0206533
IFI16 interferon, gamma-inducible protein 16 -0.0204391
ALCAM activated leukocyte cell adhesion molecule -0.0201776
HMGA2 high mobility group AT-hook 2 -0.0198977
RPS24 ribosomal protein S24 -0.0197942
EXT1 exostosin glycosyltransferase 1 -0.0195258
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0194815
CDCP1 CUB domain containing protein 1 -0.0192235
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.019152
RPL9 ribosomal protein L9 -0.0187794
RPL37A ribosomal protein L37a -0.0187094
RSAD2 radical S-adenosyl methionine domain containing 2 -0.018306
RPS23 ribosomal protein S23 -0.0182627
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0179307
SAMD9 sterile alpha motif domain containing 9 -0.0177453
RPS14 ribosomal protein S14 -0.017685
ANXA4 annexin A4 -0.0175415
NABP1 nucleic acid binding protein 1 -0.0175212
RPS25 ribosomal protein S25 -0.0174606
TMC5 transmembrane channel-like 5 -0.0172152
RIGI RNA sensor RIG-I -0.0171794
ARHGAP26 Rho GTPase activating protein 26 -0.0170848
S100A11 S100 calcium binding protein A11 -0.0169842
EGFR epidermal growth factor receptor -0.0163998
CDK6 cyclin-dependent kinase 6 -0.0162946
CNRIP1 cannabinoid receptor interacting protein 1 -0.0162287
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0162094
MT1E metallothionein 1E -0.0161149
HDAC9 histone deacetylase 9 -0.0160889
ZMYND8 zinc finger, MYND-type containing 8 -0.0160304
TAGLN2 transgelin 2 -0.0160175
NCKAP5 NCK-associated protein 5 -0.0159844
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0159732
MT1X metallothionein 1X -0.0158883
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0158123