Methyl aminolevulinate (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.170144
P4HB prolyl 4-hydroxylase, beta polypeptide 0.108567
MYH9 myosin, heavy chain 9, non-muscle 0.0948566
ERRFI1 ERBB receptor feedback inhibitor 1 0.088765
VEGFA vascular endothelial growth factor A 0.0804541
EEF2 eukaryotic translation elongation factor 2 0.0800376
DSCAM Down syndrome cell adhesion molecule 0.0737764
HELZ helicase with zinc finger 0.0717027
GOLGA4 golgin A4 0.0702855
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0646038
SRRM2 serine/arginine repetitive matrix 2 0.0624747
PRELID2 PRELI domain containing 2 0.0597796
SEC31A SEC31 homolog A (S. cerevisiae) 0.0585275
ARF4 ADP-ribosylation factor 4 0.055775
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0557479
SETD5 SET domain containing 5 0.0533435
TBC1D22A TBC1 domain family, member 22A 0.0498858
UBA6 ubiquitin-like modifier activating enzyme 6 0.0488161
ZNF292 zinc finger protein 292 0.0485498
VMP1 vacuole membrane protein 1 0.0484746
YEATS2 YEATS domain containing 2 0.0455354
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0449118
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0445967
TMF1 TATA element modulatory factor 1 0.0419856
KDM4C lysine (K)-specific demethylase 4C 0.0402529
DSPP dentin sialophosphoprotein 0.0390253
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0390187
GOLGB1 golgin B1 0.03788
KDM2A lysine (K)-specific demethylase 2A 0.0373718
MCL1 myeloid cell leukemia 1 0.037296
TPR translocated promoter region, nuclear basket protein 0.0371525
SUCO SUN domain containing ossification factor 0.0368873
WDR26 WD repeat domain 26 0.0366144
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0360855
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0346761
RHOA ras homolog family member A 0.0343984
KMT2C lysine (K)-specific methyltransferase 2C 0.0335278
ZNF638 zinc finger protein 638 0.0328953
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0327317
INSIG2 insulin induced gene 2 0.0325776
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.032555
EP300 E1A binding protein p300 0.0325074
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0323131
NUP58 nucleoporin 58 0.0314749
SMAD4 SMAD family member 4 0.0311399
TXNRD1 thioredoxin reductase 1 0.0305622
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0305421
COPA coatomer protein complex, subunit alpha 0.0304025
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0303919
BCLAF1 BCL2-associated transcription factor 1 0.0303755
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0303286
ZFC3H1 zinc finger, C3H1-type containing 0.030193
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0301138
MATR3 matrin 3 0.0299317
ENO1 enolase 1, (alpha) 0.0298049
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0294563
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0293958
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0293898
RPS18 ribosomal protein S18 0.0291385
KDM6A lysine (K)-specific demethylase 6A 0.0290712
SPRED2 sprouty-related, EVH1 domain containing 2 0.02868
YTHDC1 YTH domain containing 1 0.0282325
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) 0.0281954
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0281371
RPL3 ribosomal protein L3 0.0281228
SNX9 sorting nexin 9 0.0279551
GIGYF2 GRB10 interacting GYF protein 2 0.0279192
KIAA1217 KIAA1217 0.0277812
PCBP2 poly(rC) binding protein 2 0.0274032
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.027348
MED13L mediator complex subunit 13-like 0.0273048
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272841
CCNL1 cyclin L1 0.0270887
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.027052
DIAPH1 diaphanous-related formin 1 0.0268488
SFPQ splicing factor proline/glutamine-rich 0.0266371
PGM3 phosphoglucomutase 3 0.0265553
USP34 ubiquitin specific peptidase 34 0.0263676
ARL5B ADP-ribosylation factor-like 5B 0.0263235
EIF4B eukaryotic translation initiation factor 4B 0.0262757
APLP2 amyloid beta (A4) precursor-like protein 2 0.0260596
TMEM41B transmembrane protein 41B 0.0259016
RBM5 RNA binding motif protein 5 0.0259001
CDK19 cyclin-dependent kinase 19 0.0258826
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256525
NBAS neuroblastoma amplified sequence 0.0256507
USP9X ubiquitin specific peptidase 9, X-linked 0.0255519
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0253032
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0251986
TMEM39A transmembrane protein 39A 0.0251375
FAT1 FAT atypical cadherin 1 0.0249765
CTNND1 catenin (cadherin-associated protein), delta 1 0.0249749
SREBF2 sterol regulatory element binding transcription factor 2 0.0246973
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.024685
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0245736
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0244893
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0244838
SRRM1 serine/arginine repetitive matrix 1 0.0244576
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0243664
RNF24 ring finger protein 24 0.0242107

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.316985
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.242623
TMSB10 thymosin beta 10 -0.122832
TPT1 tumor protein, translationally-controlled 1 -0.119499
PTMA prothymosin, alpha -0.112613
RPS8 ribosomal protein S8 -0.0889826
FTL ferritin, light polypeptide -0.0866988
LOC112694756 uncharaterized LOC112694756 -0.0849034
RPL35A ribosomal protein L35a -0.0817746
RPLP1 ribosomal protein, large, P1 -0.0797147
AHNAK AHNAK nucleoprotein -0.0754929
RPL34 ribosomal protein L34 -0.070184
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0683979
RPLP0 ribosomal protein, large, P0 -0.0642317
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0622962
RPS24 ribosomal protein S24 -0.0619749
S100A10 S100 calcium binding protein A10 -0.0595935
RPS6 ribosomal protein S6 -0.0497539
RPL19 ribosomal protein L19 -0.0480061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0471164
RPL30 ribosomal protein L30 -0.0465098
RPS19 ribosomal protein S19 -0.0456946
RPL23 ribosomal protein L23 -0.0432204
RPLP2 ribosomal protein, large, P2 -0.0430727
RPL12 ribosomal protein L12 -0.0421736
RACK1 receptor for activated C kinase 1 -0.0401329
RPS13 ribosomal protein S13 -0.0398365
ARF1 ADP-ribosylation factor 1 -0.038625
GNAS GNAS complex locus -0.0385132
RPL32 ribosomal protein L32 -0.038041
RPS3 ribosomal protein S3 -0.0380329
RPS27A ribosomal protein S27a -0.0374769
EIF1 eukaryotic translation initiation factor 1 -0.0371614
RPL27A ribosomal protein L27a -0.0363689
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0362471
RPL18 ribosomal protein L18 -0.0356852
ACTG1 actin gamma 1 -0.0354606
RPL31 ribosomal protein L31 -0.035422
RPS29 ribosomal protein S29 -0.034292
RPL26 ribosomal protein L26 -0.034277
RPL11 ribosomal protein L11 -0.0340068
RPS16 ribosomal protein S16 -0.0336213
RPL38 ribosomal protein L38 -0.0324873
RPL28 ribosomal protein L28 -0.0324607
RPS15 ribosomal protein S15 -0.0320341
RPS25 ribosomal protein S25 -0.0314121
RPS5 ribosomal protein S5 -0.0312699
RPS10 ribosomal protein S10 -0.0307894
RPL8 ribosomal protein L8 -0.0306307
RPL5 ribosomal protein L5 -0.0304097
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0302313
RPS11 ribosomal protein S11 -0.0302309
RPL9 ribosomal protein L9 -0.029933
RPL36 ribosomal protein L36 -0.0298333
RPS27 ribosomal protein S27 -0.0290605
RPS14 ribosomal protein S14 -0.0287838
KRT19 keratin 19, type I -0.028535
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0284548
CCNI cyclin I -0.0281997
RPL37A ribosomal protein L37a -0.027962
HMGB1 high mobility group box 1 -0.0275066
RPL13A ribosomal protein L13a -0.0270794
TKT transketolase -0.0270485
PERP PERP, TP53 apoptosis effector -0.0267397
RPS20 ribosomal protein S20 -0.0262784
RPS12 ribosomal protein S12 -0.0260673
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0256758
EPCAM epithelial cell adhesion molecule -0.0256364
SPDYA speedy/RINGO cell cycle regulator family member A -0.0247416
RPL37 ribosomal protein L37 -0.0246442
KPNB1 karyopherin (importin) beta 1 -0.024624
MTDH metadherin -0.0245967
RPL27 ribosomal protein L27 -0.0245208
LMNA lamin A/C -0.0242265
SEC61G Sec61 gamma subunit -0.0239942
RPS21 ribosomal protein S21 -0.0239734
TPI1 triosephosphate isomerase 1 -0.0238753
RPS4X ribosomal protein S4, X-linked -0.0238039
HMGA1 high mobility group AT-hook 1 -0.0235854
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0234017
RPL4 ribosomal protein L4 -0.023367
S100A9 S100 calcium binding protein A9 -0.0229217
MYL12B myosin, light chain 12B, regulatory -0.0226769
CCND1 cyclin D1 -0.0224567
VDAC1 voltage-dependent anion channel 1 -0.0219247
RPL35 ribosomal protein L35 -0.0216159
LMAN1 lectin, mannose-binding, 1 -0.0214897
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0214305
HDLBP high density lipoprotein binding protein -0.0212126
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0211362
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0211089
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0210734
CCDC47 coiled-coil domain containing 47 -0.0202766
RPS23 ribosomal protein S23 -0.0201459
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0200927
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0198068
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0197597
RPS28 ribosomal protein S28 -0.0197254
MT2A metallothionein 2A -0.0196529
LDHA lactate dehydrogenase A -0.0194416