Methyl aminolevulinate (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APP amyloid beta (A4) precursor protein 0.03515
MATR3 matrin 3 0.0326038
FTH1 ferritin, heavy polypeptide 1 0.0313318
MYH9 myosin, heavy chain 9, non-muscle 0.0311674
ZNF292 zinc finger protein 292 0.0303368
KDM3A lysine (K)-specific demethylase 3A 0.0240082
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0235479
RNF145 ring finger protein 145 0.0233812
USP9X ubiquitin specific peptidase 9, X-linked 0.0210553
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.020594
KMT2E lysine (K)-specific methyltransferase 2E 0.0204418
GOLGA4 golgin A4 0.0202248
BHLHE40 basic helix-loop-helix family, member e40 0.0196181
NCKAP1 NCK-associated protein 1 0.0194138
FXR1 fragile X mental retardation, autosomal homolog 1 0.0190722
HELZ helicase with zinc finger 0.018199
WAC WW domain containing adaptor with coiled-coil 0.0181217
RAD23B RAD23 homolog B (S. cerevisiae) 0.0177568
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0171323
AFDN afadin, adherens junction formation factor 0.017042
TOP2B topoisomerase (DNA) II beta 180kDa 0.0165575
ANKRD10 ankyrin repeat domain 10 0.0164049
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0163404
TMSB4X thymosin beta 4, X-linked 0.016259
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0154487
CCNL1 cyclin L1 0.0144578
KDM6A lysine (K)-specific demethylase 6A 0.0144115
PUM1 pumilio RNA-binding family member 1 0.0141554
QKI QKI, KH domain containing, RNA binding 0.0140953
CAMTA1 calmodulin binding transcription activator 1 0.0138615
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0137373
USP3 ubiquitin specific peptidase 3 0.0136507
NAMPT nicotinamide phosphoribosyltransferase 0.0134314
OGA O-GlcNAcase 0.0134144
WDR43 WD repeat domain 43 0.0133218
ZFAND3 zinc finger, AN1-type domain 3 0.0132036
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0130402
CLINT1 clathrin interactor 1 0.0128906
SLMAP sarcolemma associated protein 0.0127926
SMAD3 SMAD family member 3 0.012786
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0126692
CCNT2 cyclin T2 0.0125784
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0125764
AUH AU RNA binding protein/enoyl-CoA hydratase 0.012454
ANKRD36 ankyrin repeat domain 36 0.0123896
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0123357
RLF rearranged L-myc fusion 0.0122726
ANKRD28 ankyrin repeat domain 28 0.0121582
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0121036
TEX10 testis expressed 10 0.0118676
TFG TRK-fused gene 0.0117094
ZFC3H1 zinc finger, C3H1-type containing 0.0115122
MARCHF6 membrane associated ring-CH-type finger 6 0.0114972
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0113691
PTBP2 polypyrimidine tract binding protein 2 0.0113468
RANBP2 RAN binding protein 2 0.0112649
AHCTF1 AT hook containing transcription factor 1 0.0110835
AGFG1 ArfGAP with FG repeats 1 0.0109307
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0109206
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0109145
SETD2 SET domain containing 2 0.0108435
NRIP1 nuclear receptor interacting protein 1 0.0108373
AFF4 AF4/FMR2 family, member 4 0.0107803
RBM33 RNA binding motif protein 33 0.0107557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0106324
YTHDC1 YTH domain containing 1 0.0106162
BRWD1 bromodomain and WD repeat domain containing 1 0.0105278
SNX4 sorting nexin 4 0.0104516
CDC73 cell division cycle 73 0.010446
CASC3 cancer susceptibility candidate 3 0.0103334
EWSR1 EWS RNA-binding protein 1 0.0103202
FNBP1L formin binding protein 1-like 0.0102576
RYK receptor-like tyrosine kinase 0.0101461
PDS5B PDS5 cohesin associated factor B 0.00997363
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.00994161
ORC4 origin recognition complex, subunit 4 0.00985794
UIMC1 ubiquitin interaction motif containing 1 0.00983346
LCORL ligand dependent nuclear receptor corepressor-like 0.00982467
TRA2A transformer 2 alpha homolog (Drosophila) 0.00965032
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.00960908
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.00958918
SMG7 SMG7 nonsense mediated mRNA decay factor 0.00955833
RSRC2 arginine/serine-rich coiled-coil 2 0.0095561
SCAF4 SR-related CTD-associated factor 4 0.00946751
KDM1A lysine (K)-specific demethylase 1A 0.00946083
KMT2C lysine (K)-specific methyltransferase 2C 0.00941409
FUBP1 far upstream element (FUSE) binding protein 1 0.00939712
PRRC2C proline-rich coiled-coil 2C 0.0093887
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.00938284
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.00934553
CCNY cyclin Y 0.00932112
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00931861
USP24 ubiquitin specific peptidase 24 0.00930655
RBM27 RNA binding motif protein 27 0.00924722
ELP2 elongator acetyltransferase complex subunit 2 0.00923871
EIF4A2 eukaryotic translation initiation factor 4A2 0.00921356
CLIP2 CAP-GLY domain containing linker protein 2 0.00920907
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.00920176
KCTD3 potassium channel tetramerization domain containing 3 0.00918353
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00917855

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.199567
TMSB10 thymosin beta 10 -0.158078
MT2A metallothionein 2A -0.121921
ACTG1 actin gamma 1 -0.0831899
ASPH aspartate beta-hydroxylase -0.0738756
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0723055
FTL ferritin, light polypeptide -0.0693971
PKM pyruvate kinase, muscle -0.0620592
TPM4 tropomyosin 4 -0.0588791
POTEF POTE ankyrin domain family, member F -0.0586645
ENO1 enolase 1, (alpha) -0.0558984
HMGA1 high mobility group AT-hook 1 -0.0558287
CCND1 cyclin D1 -0.053766
NDRG1 N-myc downstream regulated 1 -0.050159
RPL35A ribosomal protein L35a -0.0492113
RPS6 ribosomal protein S6 -0.0466701
LDHA lactate dehydrogenase A -0.0464219
PTMA prothymosin, alpha -0.0460919
RPS8 ribosomal protein S8 -0.0425993
ALCAM activated leukocyte cell adhesion molecule -0.0416584
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0413681
S100A10 S100 calcium binding protein A10 -0.0395507
KRT7 keratin 7, type II -0.0394892
RPL23 ribosomal protein L23 -0.0387157
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0382436
RAD51B RAD51 paralog B -0.0362766
S100A6 S100 calcium binding protein A6 -0.0356745
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0354682
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354261
CD44 CD44 molecule (Indian blood group) -0.0348039
TPT1 tumor protein, translationally-controlled 1 -0.0344294
RPS19 ribosomal protein S19 -0.0337158
PFN1 profilin 1 -0.0333419
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0326017
TPI1 triosephosphate isomerase 1 -0.0324224
DIAPH3 diaphanous-related formin 3 -0.031909
RPL19 ribosomal protein L19 -0.0317471
S100A9 S100 calcium binding protein A9 -0.0314189
RPL12 ribosomal protein L12 -0.0310654
RPLP0 ribosomal protein, large, P0 -0.0306787
HMGA2 high mobility group AT-hook 2 -0.0304051
RPLP1 ribosomal protein, large, P1 -0.0300995
EGR1 early growth response 1 -0.0300359
DLC1 DLC1 Rho GTPase activating protein -0.0299491
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0291114
BPTF bromodomain PHD finger transcription factor -0.0284329
FHIT fragile histidine triad -0.0281663
SVIL supervillin -0.0281076
RPL9 ribosomal protein L9 -0.0280622
PSD3 pleckstrin and Sec7 domain containing 3 -0.02765
ZBTB20 zinc finger and BTB domain containing 20 -0.0276153
RPL31 ribosomal protein L31 -0.0275206
PAX8 paired box 8 -0.0273507
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0269769
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0266894
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.026509
TBC1D5 TBC1 domain family, member 5 -0.0257818
RPS14 ribosomal protein S14 -0.025662
RPL34 ribosomal protein L34 -0.0255218
VCL vinculin -0.0255123
LAMC2 laminin, gamma 2 -0.0251248
BICD1 bicaudal D homolog 1 (Drosophila) -0.024951
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0238993
TUBA1B tubulin, alpha 1b -0.0236705
LAMA4 laminin, alpha 4 -0.023639
TUBB4B tubulin, beta 4B class IVb -0.0235933
CDCP1 CUB domain containing protein 1 -0.0235308
KRT19 keratin 19, type I -0.0229745
SMC4 structural maintenance of chromosomes 4 -0.0228869
RPLP2 ribosomal protein, large, P2 -0.0228214
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.022753
RPS24 ribosomal protein S24 -0.0223727
RPL32 ribosomal protein L32 -0.0221963
HMGB1 high mobility group box 1 -0.0220484
ITGA6 integrin, alpha 6 -0.0220118
VDAC1 voltage-dependent anion channel 1 -0.021872
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0217121
CBX3 chromobox homolog 3 -0.0216966
SH3KBP1 SH3-domain kinase binding protein 1 -0.0215926
RPL28 ribosomal protein L28 -0.0215485
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0214673
RPL11 ribosomal protein L11 -0.0208109
SEPTIN7 septin 7 -0.0203931
RPS11 ribosomal protein S11 -0.0202853
ACTN4 actinin, alpha 4 -0.0199179
EGFR epidermal growth factor receptor -0.0197782
RPS12 ribosomal protein S12 -0.0196447
WWOX WW domain containing oxidoreductase -0.0195369
MKI67 marker of proliferation Ki-67 -0.0192512
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0189984
ANXA2 annexin A2 -0.0188121
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0188075
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0188023
RPS27A ribosomal protein S27a -0.0187745
RPL5 ribosomal protein L5 -0.0187143
GNAS GNAS complex locus -0.0186448
TXNRD1 thioredoxin reductase 1 -0.0185819
RPS21 ribosomal protein S21 -0.018455
CAPN2 calpain 2, (m/II) large subunit -0.0183347
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0182861