| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methyl aminolevulinate (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.112235 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.106283 |
| FN1 | fibronectin 1 | 0.101714 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0772222 |
| C3 | complement component 3 | 0.0638653 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0396422 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0362554 |
| TRIM26 | tripartite motif containing 26 | 0.0347408 |
| TF | transferrin | 0.0338316 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0321388 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0313757 |
| DSPP | dentin sialophosphoprotein | 0.0311644 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0296221 |
| A2M | alpha-2-macroglobulin | 0.0293763 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0288203 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.028691 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0278271 |
| VCL | vinculin | 0.0267118 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0260513 |
| MALT1 | MALT1 paracaspase | 0.0256187 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0250143 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.023996 |
| GPC3 | glypican 3 | 0.023403 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0226278 |
| VEGFA | vascular endothelial growth factor A | 0.0226194 |
| VMP1 | vacuole membrane protein 1 | 0.0224934 |
| AFDN | afadin, adherens junction formation factor | 0.0223395 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.021676 |
| ITGAV | integrin, alpha V | 0.0196323 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0195652 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0193724 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0193311 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.0187087 |
| MRTFA | myocardin related transcription factor A | 0.0183834 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0182689 |
| APOE | apolipoprotein E | 0.0181656 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0180152 |
| SMAD3 | SMAD family member 3 | 0.0177276 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0173249 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0173197 |
| JMJD1C | jumonji domain containing 1C | 0.0171859 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0170787 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0170267 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0162436 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0161386 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0159692 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0158764 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0158287 |
| MATR3 | matrin 3 | 0.0157932 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0157142 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0155341 |
| CTSB | cathepsin B | 0.015339 |
| PEG3 | paternally expressed 3 | 0.0152824 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0152675 |
| RTN4 | reticulon 4 | 0.0151036 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0148979 |
| ENO1 | enolase 1, (alpha) | 0.0147962 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0146901 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0144612 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0139594 |
| USP47 | ubiquitin specific peptidase 47 | 0.0138392 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0138307 |
| SERINC1 | serine incorporator 1 | 0.0136461 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0135386 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0134229 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0134088 |
| LRRC1 | leucine rich repeat containing 1 | 0.0133796 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0132981 |
| BCL2L1 | BCL2-like 1 | 0.0129665 |
| KIAA1217 | KIAA1217 | 0.0129361 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0128717 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0127498 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0126612 |
| PTMA | prothymosin, alpha | 0.01256 |
| RBM39 | RNA binding motif protein 39 | 0.0125465 |
| APP | amyloid beta (A4) precursor protein | 0.012537 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0123746 |
| TOP1 | topoisomerase (DNA) I | 0.0122972 |
| FOXN3 | forkhead box N3 | 0.0121785 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0121652 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0120337 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0119322 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0119012 |
| FOXO1 | forkhead box O1 | 0.0118473 |
| DNAH17 | dynein, axonemal, heavy chain 17 | 0.0118436 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0118253 |
| MED13L | mediator complex subunit 13-like | 0.0118002 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0116651 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0116634 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0115933 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0115677 |
| RAB1A | RAB1A, member RAS oncogene family | 0.01156 |
| RHOA | ras homolog family member A | 0.0114623 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0113452 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0112285 |
| MED13 | mediator complex subunit 13 | 0.0111891 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0111715 |
| PLAC8 | placenta-specific 8 | 0.0111444 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0111235 |
| OSMR | oncostatin M receptor | 0.0111154 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.290591 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0787817 |
| HMGA1 | high mobility group AT-hook 1 | -0.0265897 |
| PLIN2 | perilipin 2 | -0.0239238 |
| RPS8 | ribosomal protein S8 | -0.0214494 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.019826 |
| FRMD5 | FERM domain containing 5 | -0.0187074 |
| AHSG | alpha-2-HS-glycoprotein | -0.0186429 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0175589 |
| RPLP1 | ribosomal protein, large, P1 | -0.0173626 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0172084 |
| RPLP0 | ribosomal protein, large, P0 | -0.0170966 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.015336 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0150425 |
| RPS6 | ribosomal protein S6 | -0.0146329 |
| EHBP1 | EH domain binding protein 1 | -0.0139748 |
| STK17A | serine/threonine kinase 17a | -0.0136821 |
| GK | glycerol kinase | -0.0134556 |
| TMEM123 | transmembrane protein 123 | -0.0126636 |
| APOA2 | apolipoprotein A-II | -0.0116337 |
| FAM135A | family with sequence similarity 135, member A | -0.0114143 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0111668 |
| RACK1 | receptor for activated C kinase 1 | -0.0111125 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0109898 |
| RPL39 | ribosomal protein L39 | -0.010394 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.010338 |
| RPL23 | ribosomal protein L23 | -0.0100488 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0100476 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00999979 |
| TMSB10 | thymosin beta 10 | -0.00998769 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00928228 |
| RPL12 | ribosomal protein L12 | -0.00924552 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.00923067 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0091659 |
| RPS14 | ribosomal protein S14 | -0.00914896 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.00914481 |
| RPS25 | ribosomal protein S25 | -0.00910176 |
| GLRX | glutaredoxin (thioltransferase) | -0.00905134 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.00893037 |
| CMIP | c-Maf inducing protein | -0.00881972 |
| RPS24 | ribosomal protein S24 | -0.00876833 |
| DOK6 | docking protein 6 | -0.00851467 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.00846305 |
| DUSP6 | dual specificity phosphatase 6 | -0.00845004 |
| PERP | PERP, TP53 apoptosis effector | -0.0083524 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.008313 |
| RPL7 | ribosomal protein L7 | -0.00826184 |
| MAPK6 | mitogen-activated protein kinase 6 | -0.00811766 |
| RPL28 | ribosomal protein L28 | -0.00793476 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00787125 |
| BSG | basigin (Ok blood group) | -0.00776395 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00771968 |
| NDRG1 | N-myc downstream regulated 1 | -0.00764021 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.00762248 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00751826 |
| RPS12 | ribosomal protein S12 | -0.00733358 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.00730046 |
| RPL9 | ribosomal protein L9 | -0.00715801 |
| DTNA | dystrobrevin, alpha | -0.00703944 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.00699505 |
| HLA-A | major histocompatibility complex, class I, A | -0.00698426 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.00679643 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00672878 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0066374 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.00658843 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.00640117 |
| MAP1B | microtubule-associated protein 1B | -0.00632602 |
| RPL27A | ribosomal protein L27a | -0.00629085 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.00626492 |
| RPS19 | ribosomal protein S19 | -0.00626306 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.00622559 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.00621727 |
| PFN1 | profilin 1 | -0.00621243 |
| VKORC1 | vitamin K epoxide reductase complex, subunit 1 | -0.00619781 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.00611416 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.00609476 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.00603022 |
| EGR1 | early growth response 1 | -0.00602228 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | -0.00599588 |
| GOLGA4 | golgin A4 | -0.00597981 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.00597934 |
| POTEF | POTE ankyrin domain family, member F | -0.00592077 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.00588724 |
| RPL4 | ribosomal protein L4 | -0.00587791 |
| RPS27 | ribosomal protein S27 | -0.00585983 |
| CHD7 | chromodomain helicase DNA binding protein 7 | -0.00585579 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.00580965 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | -0.00579647 |
| HM13 | histocompatibility (minor) 13 | -0.0057484 |
| HOMER1 | homer scaffolding protein 1 | -0.00572827 |
| RPL8 | ribosomal protein L8 | -0.0057213 |
| DYNLRB1 | dynein, light chain, roadblock-type 1 | -0.00571451 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.00569683 |
| NRP1 | neuropilin 1 | -0.00567448 |
| SHTN1 | shootin 1 | -0.00566939 |
| RPS23 | ribosomal protein S23 | -0.00555885 |
| KLF10 | Kruppel-like factor 10 | -0.00552772 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.00550539 |
| KYNU | kynureninase | -0.00546286 |
| S100A6 | S100 calcium binding protein A6 | -0.00546088 |
