Methyl aminolevulinate (hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.340186
VIM vimentin 0.219143
TMSB10 thymosin beta 10 0.147891
DTNA dystrobrevin, alpha 0.121801
PABPC1 poly(A) binding protein, cytoplasmic 1 0.099315
LSAMP limbic system-associated membrane protein 0.0904158
RPS6 ribosomal protein S6 0.0848839
PTMA prothymosin, alpha 0.0820468
MT2A metallothionein 2A 0.0799191
RPL35A ribosomal protein L35a 0.07831
MMP12 matrix metallopeptidase 12 0.0766969
EEF2 eukaryotic translation elongation factor 2 0.0748709
BTG1 B-cell translocation gene 1, anti-proliferative 0.0680074
RPS19 ribosomal protein S19 0.0639425
FTH1 ferritin, heavy polypeptide 1 0.0516647
RPL11 ribosomal protein L11 0.0496194
RPL23 ribosomal protein L23 0.0488477
SRRM2 serine/arginine repetitive matrix 2 0.0482581
RPS3 ribosomal protein S3 0.0480666
RNF145 ring finger protein 145 0.0465213
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0460131
RPL26 ribosomal protein L26 0.0454399
RPLP2 ribosomal protein, large, P2 0.0444699
ADAM9 ADAM metallopeptidase domain 9 0.0437893
ANXA2 annexin A2 0.0427272
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0422804
TPT1 tumor protein, translationally-controlled 1 0.0417637
FTL ferritin, light polypeptide 0.0411147
VEGFA vascular endothelial growth factor A 0.0410026
RPLP1 ribosomal protein, large, P1 0.0407412
UBA6 ubiquitin-like modifier activating enzyme 6 0.0407404
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0395948
SETD5 SET domain containing 5 0.0389491
PBX3 pre-B-cell leukemia homeobox 3 0.0383923
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0378271
ERRFI1 ERBB receptor feedback inhibitor 1 0.0378208
EGR1 early growth response 1 0.0362013
RPL36 ribosomal protein L36 0.036085
RPL12 ribosomal protein L12 0.0356477
RPS17 ribosomal protein S17 0.0351343
HAS2 hyaluronan synthase 2 0.0343031
RPL31 ribosomal protein L31 0.0335776
FN1 fibronectin 1 0.0330414
PHACTR1 phosphatase and actin regulator 1 0.03273
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0325927
RPS13 ribosomal protein S13 0.0324313
EIF1 eukaryotic translation initiation factor 1 0.0323877
RACK1 receptor for activated C kinase 1 0.0320357
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0307267
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0287534
MYO10 myosin X 0.0285941
RPL37A ribosomal protein L37a 0.0285867
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0279855
RPL7A ribosomal protein L7a 0.0272615
RPS29 ribosomal protein S29 0.0270866
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0269642
NUP58 nucleoporin 58 0.0267528
ENO2 enolase 2 (gamma, neuronal) 0.0262562
IGFBP3 insulin-like growth factor binding protein 3 0.0257571
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0255245
EIF4B eukaryotic translation initiation factor 4B 0.0243961
RAB7A RAB7A, member RAS oncogene family 0.0243678
RPL10A ribosomal protein L10a 0.0242965
JUN jun proto-oncogene 0.0240754
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0240511
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.023904
B2M beta-2-microglobulin 0.0236639
RPL34 ribosomal protein L34 0.0234881
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.023361
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0232796
RPS25 ribosomal protein S25 0.0232396
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0229412
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0224013
LOC112694756 uncharaterized LOC112694756 0.022063
RPS23 ribosomal protein S23 0.0219607
RHOA ras homolog family member A 0.0218895
FGFR1 fibroblast growth factor receptor 1 0.0217186
HDAC9 histone deacetylase 9 0.0215336
HILPDA hypoxia inducible lipid droplet-associated 0.0213768
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0212163
PRRC2C proline-rich coiled-coil 2C 0.0205517
LGALS1 lectin, galactoside-binding, soluble, 1 0.0205352
RPS14 ribosomal protein S14 0.0203822
RPL35 ribosomal protein L35 0.0201223
ENKUR enkurin, TRPC channel interacting protein 0.0198387
CD47 CD47 molecule 0.0198055
FMNL2 formin-like 2 0.0197338
TRIO trio Rho guanine nucleotide exchange factor 0.0195055
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0192967
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0192034
CXCL8 chemokine (C-X-C motif) ligand 8 0.0186351
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0184193
RPL36A ribosomal protein L36a 0.0182928
SPRED2 sprouty-related, EVH1 domain containing 2 0.0182526
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0182479
NAV3 neuron navigator 3 0.0182409
QKI QKI, KH domain containing, RNA binding 0.0181985
CALD1 caldesmon 1 0.0180028
ADAM19 ADAM metallopeptidase domain 19 0.0179486
PRKCE protein kinase C, epsilon 0.0179286

decreased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase -0.119279
RPS2 ribosomal protein S2 -0.0794464
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0781127
DPYD dihydropyrimidine dehydrogenase -0.0720873
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0686272
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0644979
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0620219
TXNRD1 thioredoxin reductase 1 -0.0559308
GPC6 glypican 6 -0.0558715
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0531016
LDHA lactate dehydrogenase A -0.0526525
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.052306
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0515275
HSPA8 heat shock 70kDa protein 8 -0.0512791
ALCAM activated leukocyte cell adhesion molecule -0.0494954
TMPRSS15 transmembrane protease, serine 15 -0.0493138
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0491702
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0484934
ANO6 anoctamin 6 -0.0465438
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0460872
PKM pyruvate kinase, muscle -0.0448728
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0437111
AHNAK AHNAK nucleoprotein -0.0412892
EFNA5 ephrin-A5 -0.0403203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0398223
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0387967
PDE4D phosphodiesterase 4D, cAMP-specific -0.0380774
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0375826
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0368365
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0360961
RBM39 RNA binding motif protein 39 -0.0359628
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0358457
FNDC3B fibronectin type III domain containing 3B -0.0352922
TRPS1 trichorhinophalangeal syndrome I -0.0348712
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0347001
NDRG1 N-myc downstream regulated 1 -0.0344881
GLS2 glutaminase 2 (liver, mitochondrial) -0.0344377
MBNL1 muscleblind-like splicing regulator 1 -0.0340564
ACTG1 actin gamma 1 -0.033848
SMAD3 SMAD family member 3 -0.0330888
USP34 ubiquitin specific peptidase 34 -0.0330589
CSNK1A1 casein kinase 1, alpha 1 -0.0329809
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0322139
PEG10 paternally expressed 10 -0.0317435
PTPRG protein tyrosine phosphatase, receptor type, G -0.0316641
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0315496
RIGI RNA sensor RIG-I -0.0314701
NAMPT nicotinamide phosphoribosyltransferase -0.0312697
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0311576
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0309657
ARL15 ADP-ribosylation factor-like 15 -0.0301452
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0300939
NCKAP1 NCK-associated protein 1 -0.0296068
EXOC6B exocyst complex component 6B -0.0295902
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0295855
PAX3 paired box 3 -0.0290917
IPO7 importin 7 -0.0287393
HMGA1 high mobility group AT-hook 1 -0.0286385
MBD5 methyl-CpG binding domain protein 5 -0.0285696
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0285
KLF12 Kruppel-like factor 12 -0.028292
RPL4 ribosomal protein L4 -0.0282394
BDNF brain-derived neurotrophic factor -0.0281477
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0281094
ZBTB20 zinc finger and BTB domain containing 20 -0.0277476
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0273948
BBX bobby sox homolog (Drosophila) -0.0273153
NBEA neurobeachin -0.026845
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0265921
PGK1 phosphoglycerate kinase 1 -0.0265203
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0265098
TNPO1 transportin 1 -0.0264697
SMYD3 SET and MYND domain containing 3 -0.0262832
RPL38 ribosomal protein L38 -0.0257904
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0257383
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0255936
TLE4 transducin-like enhancer of split 4 -0.0254327
MYOF myoferlin -0.0254032
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0253266
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0249378
ITSN1 intersectin 1 (SH3 domain protein) -0.0248692
NALF1 NALCN channel auxiliary factor 1 -0.0247826
GOLT1B golgi transport 1B -0.0246174
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0245312
CCDC91 coiled-coil domain containing 91 -0.0244684
MCTP1 multiple C2 domains, transmembrane 1 -0.0240753
SPIDR scaffolding protein involved in DNA repair -0.0240265
PRKG1 protein kinase, cGMP-dependent, type I -0.0239072
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0235998
NLGN1 neuroligin 1 -0.0235587
MAP1B microtubule-associated protein 1B -0.0235305
TBC1D5 TBC1 domain family, member 5 -0.0232541
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0230708
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0230445
PHF3 PHD finger protein 3 -0.022984
ANTXR2 anthrax toxin receptor 2 -0.0229568
NRIP1 nuclear receptor interacting protein 1 -0.0228302
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0228296
IL6ST interleukin 6 signal transducer -0.0225274
PCBP2 poly(rC) binding protein 2 -0.0224613