Methyl aminolevulinate (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.120401
FTH1 ferritin, heavy polypeptide 1 0.105576
RPS3 ribosomal protein S3 0.0664689
MKI67 marker of proliferation Ki-67 0.0574975
B2M beta-2-microglobulin 0.0528009
SRRM2 serine/arginine repetitive matrix 2 0.0521411
TOP1 topoisomerase (DNA) I 0.0492371
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0478488
LAMC2 laminin, gamma 2 0.0446807
MYH9 myosin, heavy chain 9, non-muscle 0.0442235
RNF145 ring finger protein 145 0.0437785
FTL ferritin, light polypeptide 0.0421522
PRRC2C proline-rich coiled-coil 2C 0.0410103
GCLC glutamate-cysteine ligase, catalytic subunit 0.0392021
UBA6 ubiquitin-like modifier activating enzyme 6 0.0368446
RPS6 ribosomal protein S6 0.0355329
RPL37A ribosomal protein L37a 0.0354768
GSK3B glycogen synthase kinase 3 beta 0.0353058
RICTOR RPTOR independent companion of MTOR, complex 2 0.0343084
PABPC1 poly(A) binding protein, cytoplasmic 1 0.03397
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0333652
KTN1 kinectin 1 (kinesin receptor) 0.0326021
ZNF292 zinc finger protein 292 0.0314654
VEGFA vascular endothelial growth factor A 0.0310804
MCL1 myeloid cell leukemia 1 0.031068
CCNL1 cyclin L1 0.0305415
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0302605
ARGLU1 arginine and glutamate rich 1 0.0302
ADAM9 ADAM metallopeptidase domain 9 0.0300663
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0296635
EEF2 eukaryotic translation elongation factor 2 0.0296101
SETD5 SET domain containing 5 0.0295605
RPS8 ribosomal protein S8 0.0293511
ANKRD11 ankyrin repeat domain 11 0.02922
EGFR epidermal growth factor receptor 0.0289573
RPL35A ribosomal protein L35a 0.0288871
CAMTA1 calmodulin binding transcription activator 1 0.0287966
RPL7 ribosomal protein L7 0.028785
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0287432
ADAM17 ADAM metallopeptidase domain 17 0.0279216
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0275419
MCTP1 multiple C2 domains, transmembrane 1 0.0270369
KDM6A lysine (K)-specific demethylase 6A 0.02692
PCBP2 poly(rC) binding protein 2 0.0267445
MSN moesin 0.02592
RPS12 ribosomal protein S12 0.0257636
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0257562
RTN4 reticulon 4 0.0257372
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0256759
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0254938
KMT2E lysine (K)-specific methyltransferase 2E 0.0253724
ARRDC3 arrestin domain containing 3 0.0250741
PDE4D phosphodiesterase 4D, cAMP-specific 0.0249719
ENO1 enolase 1, (alpha) 0.0246661
RPLP1 ribosomal protein, large, P1 0.0245808
RPL11 ribosomal protein L11 0.0245276
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0243829
MACF1 microtubule-actin crosslinking factor 1 0.0242952
MATR3 matrin 3 0.0241733
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0237916
VMP1 vacuole membrane protein 1 0.0236286
RPS23 ribosomal protein S23 0.022313
RAB6A RAB6A, member RAS oncogene family 0.0222313
TFG TRK-fused gene 0.0222312
PNISR PNN-interacting serine/arginine-rich protein 0.0221829
PNN pinin, desmosome associated protein 0.0220416
CES1 carboxylesterase 1 0.0220051
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0219409
KDM2A lysine (K)-specific demethylase 2A 0.0219292
TPM3 tropomyosin 3 0.0217881
ANKRD10 ankyrin repeat domain 10 0.0213718
ANXA5 annexin A5 0.0213716
WAC WW domain containing adaptor with coiled-coil 0.0210616
AKAP13 A kinase (PRKA) anchor protein 13 0.0208437
UVRAG UV radiation resistance associated 0.0207559
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0206325
NAMPT nicotinamide phosphoribosyltransferase 0.020473
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0204311
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0203398
RNF149 ring finger protein 149 0.0203273
FNDC3B fibronectin type III domain containing 3B 0.0202353
NUP58 nucleoporin 58 0.0202322
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0197079
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0195678
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0195435
SMAD3 SMAD family member 3 0.019524
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0191702
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.019169
RPS25 ribosomal protein S25 0.0190826
CUL3 cullin 3 0.0188588
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0187461
EIF4B eukaryotic translation initiation factor 4B 0.0187399
RPS17 ribosomal protein S17 0.018701
TENT2 terminal nucleotidyltransferase 2 0.0186241
CAB39 calcium binding protein 39 0.0185389
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0185187
CTTN cortactin 0.0185151
ITCH itchy E3 ubiquitin protein ligase 0.0184977
WDR26 WD repeat domain 26 0.0184898
ZNF148 zinc finger protein 148 0.0183774

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10496
LMO7 LIM domain 7 -0.0999031
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.095307
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.086244
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0687025
ASPH aspartate beta-hydroxylase -0.0585776
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.050872
SLTM SAFB-like, transcription modulator -0.0457605
CXCL8 chemokine (C-X-C motif) ligand 8 -0.043339
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0422307
HDLBP high density lipoprotein binding protein -0.0414226
EGR1 early growth response 1 -0.0382486
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.037188
ACTG1 actin gamma 1 -0.0361967
CANX calnexin -0.0350635
AHNAK AHNAK nucleoprotein -0.0348293
NABP1 nucleic acid binding protein 1 -0.0346437
H1-0 H1.0 linker histone -0.0338991
GM2A GM2 ganglioside activator -0.0294136
OSMR oncostatin M receptor -0.028475
HBP1 HMG-box transcription factor 1 -0.0281622
SOD2 superoxide dismutase 2, mitochondrial -0.0265811
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0264774
BLZF1 basic leucine zipper nuclear factor 1 -0.0261026
MAML3 mastermind-like 3 (Drosophila) -0.0230336
AGR2 anterior gradient 2 -0.0225877
INTS6 integrator complex subunit 6 -0.0223164
EMP1 epithelial membrane protein 1 -0.0219827
MORF4L2 mortality factor 4 like 2 -0.0219228
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0211083
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0210878
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0208787
BMAL2 basic helix-loop-helix ARNT like 2 -0.0200818
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.019819
EFNA5 ephrin-A5 -0.0198049
S100A10 S100 calcium binding protein A10 -0.019625
CCND1 cyclin D1 -0.0195583
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0194686
TRIM56 tripartite motif containing 56 -0.0194158
SPDYA speedy/RINGO cell cycle regulator family member A -0.01932
MYOF myoferlin -0.0191668
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0191071
FOXP1 forkhead box P1 -0.0188036
EXT1 exostosin glycosyltransferase 1 -0.0186271
DOCK5 dedicator of cytokinesis 5 -0.0185973
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0185489
LOC112694756 uncharaterized LOC112694756 -0.0183523
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0182883
SLC38A2 solute carrier family 38, member 2 -0.0180366
RIN2 Ras and Rab interactor 2 -0.0178965
PER2 period circadian clock 2 -0.0178738
GOLGB1 golgin B1 -0.0177252
ARF1 ADP-ribosylation factor 1 -0.0174588
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0174331
TRAPPC9 trafficking protein particle complex 9 -0.0174246
RNF213 ring finger protein 213 -0.017136
TBC1D5 TBC1 domain family, member 5 -0.0171292
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0168872
MGAT4C MGAT4 family, member C -0.0168181
TES testin LIM domain protein -0.016652
CAV1 caveolin 1, caveolae protein, 22kDa -0.0164972
TAOK1 TAO kinase 1 -0.0164533
TJP1 tight junction protein 1 -0.0161499
DSCAM Down syndrome cell adhesion molecule -0.0159295
NCOA7 nuclear receptor coactivator 7 -0.0157626
SP100 SP100 nuclear antigen -0.0157354
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0155898
SMYD3 SET and MYND domain containing 3 -0.0153524
ZC3H11A zinc finger CCCH-type containing 11A -0.0152854
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0152488
RIMS2 regulating synaptic membrane exocytosis 2 -0.0151541
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0151364
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0150872
ARHGAP5 Rho GTPase activating protein 5 -0.0149932
FAAH2 fatty acid amide hydrolase 2 -0.0148524
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0148004
HYOU1 hypoxia up-regulated 1 -0.0147058
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0146896
LRP12 low density lipoprotein receptor-related protein 12 -0.0146654
ZMYND8 zinc finger, MYND-type containing 8 -0.014623
LDHA lactate dehydrogenase A -0.0145698
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0144763
SDC4 syndecan 4 -0.0143881
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0142029
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0141585
PATJ PATJ crumbs cell polarity complex component -0.0139895
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.013884
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0138438
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0137174
ZBTB20 zinc finger and BTB domain containing 20 -0.0136245
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0134461
IRF1 interferon regulatory factor 1 -0.0134401
EZR ezrin -0.0134226
DNAH14 dynein, axonemal, heavy chain 14 -0.0133021
IER3 immediate early response 3 -0.0131992
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0131938
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0131882
WSB1 WD repeat and SOCS box containing 1 -0.0131548
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0131411
CDK12 cyclin-dependent kinase 12 -0.0130744