Methyl aminolevulinate (hydrochloride)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.18567
ERRFI1 ERBB receptor feedback inhibitor 1 0.0838183
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0829784
EEF2 eukaryotic translation elongation factor 2 0.0796538
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0745754
TPM3 tropomyosin 3 0.0717056
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0716475
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0672155
P4HB prolyl 4-hydroxylase, beta polypeptide 0.059914
SAMD4A sterile alpha motif domain containing 4A 0.0591048
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0568845
AKAP12 A kinase (PRKA) anchor protein 12 0.0559332
MACF1 microtubule-actin crosslinking factor 1 0.0545738
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0545727
UBASH3B ubiquitin associated and SH3 domain containing B 0.0543618
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526213
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0505825
PDLIM5 PDZ and LIM domain 5 0.0502314
VMP1 vacuole membrane protein 1 0.0490656
ERBIN erbb2 interacting protein 0.0478563
CCNL1 cyclin L1 0.0472677
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0465436
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0453252
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0445786
PDIA6 protein disulfide isomerase family A, member 6 0.0441369
MYH9 myosin, heavy chain 9, non-muscle 0.043268
BRD2 bromodomain containing 2 0.0430523
ZFAND3 zinc finger, AN1-type domain 3 0.0420825
COPA coatomer protein complex, subunit alpha 0.0412212
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0412185
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0406275
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0396404
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0389438
SMOC1 SPARC related modular calcium binding 1 0.0382443
PLS3 plastin 3 0.0376403
DOCK4 dedicator of cytokinesis 4 0.0359592
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0353732
FNDC3B fibronectin type III domain containing 3B 0.0350702
RNF145 ring finger protein 145 0.0348834
MCL1 myeloid cell leukemia 1 0.0346136
KTN1 kinectin 1 (kinesin receptor) 0.0340696
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0338244
SRRM2 serine/arginine repetitive matrix 2 0.0337266
HSPA8 heat shock 70kDa protein 8 0.0336024
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0334902
APP amyloid beta (A4) precursor protein 0.0333821
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0333309
WDR43 WD repeat domain 43 0.0330841
AKAP13 A kinase (PRKA) anchor protein 13 0.0327832
CALR calreticulin 0.0327424
RPL3 ribosomal protein L3 0.0322543
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0317123
MSN moesin 0.0314628
HDGF hepatoma-derived growth factor 0.0311477
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.031147
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0306782
WAC WW domain containing adaptor with coiled-coil 0.030483
RASAL2 RAS protein activator like 2 0.0303257
PRRC2C proline-rich coiled-coil 2C 0.029959
RTN4 reticulon 4 0.029804
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0295161
ELL2 elongation factor, RNA polymerase II, 2 0.0291192
TFG TRK-fused gene 0.0290609
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0284797
DSCAM Down syndrome cell adhesion molecule 0.0280648
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0278331
FGB fibrinogen beta chain 0.0272192
POTEF POTE ankyrin domain family, member F 0.0271391
CUL3 cullin 3 0.0271371
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0268824
BCLAF1 BCL2-associated transcription factor 1 0.0263725
EIF3A eukaryotic translation initiation factor 3, subunit A 0.026262
PNN pinin, desmosome associated protein 0.0261944
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0258234
ANKRD11 ankyrin repeat domain 11 0.0258109
ZSWIM6 zinc finger, SWIM-type containing 6 0.0248753
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248418
CSNK1A1 casein kinase 1, alpha 1 0.0247834
UBAP2L ubiquitin associated protein 2-like 0.0246911
PRPF8 pre-mRNA processing factor 8 0.0246516
APLP2 amyloid beta (A4) precursor-like protein 2 0.0246394
KMT2E lysine (K)-specific methyltransferase 2E 0.0245828
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0245489
SPRED2 sprouty-related, EVH1 domain containing 2 0.0245421
SETD5 SET domain containing 5 0.0244117
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0243227
RPS18 ribosomal protein S18 0.0242829
RICTOR RPTOR independent companion of MTOR, complex 2 0.0241846
YAP1 Yes-associated protein 1 0.0239977
ADAM17 ADAM metallopeptidase domain 17 0.023953
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) 0.0239382
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0237248
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0236888
MBNL1 muscleblind-like splicing regulator 1 0.0231084
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0230573
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0227461
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0227171
PAWR PRKC, apoptosis, WT1, regulator 0.0224112
PAPOLA poly(A) polymerase alpha 0.0223237
SPAG9 sperm associated antigen 9 0.022297

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.348369
TMSB10 thymosin beta 10 -0.165325
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.156424
FTL ferritin, light polypeptide -0.15473
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.137158
VIM vimentin -0.0911031
RPL23 ribosomal protein L23 -0.077418
RPL19 ribosomal protein L19 -0.0702108
TFPI2 tissue factor pathway inhibitor 2 -0.0695958
TM4SF1 transmembrane 4 L six family member 1 -0.06606
TPT1 tumor protein, translationally-controlled 1 -0.0655501
RPLP1 ribosomal protein, large, P1 -0.0630033
IER3 immediate early response 3 -0.0602615
C15ORF48 chromosome 15 open reading frame 48 -0.0571735
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0560994
RPS8 ribosomal protein S8 -0.0526593
PTMA prothymosin, alpha -0.0515392
GRAMD1B GRAM domain containing 1B -0.0489134
RPS21 ribosomal protein S21 -0.0477119
ACTG1 actin gamma 1 -0.0475702
RPL35A ribosomal protein L35a -0.0438971
S100A10 S100 calcium binding protein A10 -0.0431419
S100A6 S100 calcium binding protein A6 -0.041945
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0409854
RPLP0 ribosomal protein, large, P0 -0.039571
EIF1 eukaryotic translation initiation factor 1 -0.0388334
RPS24 ribosomal protein S24 -0.0387842
HMGB1 high mobility group box 1 -0.0369751
RPL34 ribosomal protein L34 -0.0364742
CAVIN1 caveolae associated protein 1 -0.0357778
RPL31 ribosomal protein L31 -0.0346318
TXNRD1 thioredoxin reductase 1 -0.0338752
RPL36 ribosomal protein L36 -0.0325113
RPS19 ribosomal protein S19 -0.0319055
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0317214
MT1X metallothionein 1X -0.0316921
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0316174
MYL12B myosin, light chain 12B, regulatory -0.0300783
RPS25 ribosomal protein S25 -0.0299767
GNAS GNAS complex locus -0.0293142
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269949
RPS29 ribosomal protein S29 -0.026775
RPL8 ribosomal protein L8 -0.0264928
RPS15 ribosomal protein S15 -0.0262381
RPL38 ribosomal protein L38 -0.0260266
RPS23 ribosomal protein S23 -0.0254302
RPS5 ribosomal protein S5 -0.0253095
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0249538
HMGA1 high mobility group AT-hook 1 -0.0241006
RPS11 ribosomal protein S11 -0.0232927
RPL30 ribosomal protein L30 -0.0229732
RPS20 ribosomal protein S20 -0.0228105
ATP5F1E ATP synthase F1 subunit epsilon -0.0228075
RPL12 ribosomal protein L12 -0.0227878
VDAC1 voltage-dependent anion channel 1 -0.0225263
HLA-E major histocompatibility complex, class I, E -0.0222432
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0222316
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0217606
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0216225
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0212283
BICC1 BicC family RNA binding protein 1 -0.0210318
RPL36AL ribosomal protein L36a-like -0.0197412
SERF2 small EDRK-rich factor 2 -0.0195902
GSTP1 glutathione S-transferase pi 1 -0.0194382
PFN1 profilin 1 -0.0193572
RPL9 ribosomal protein L9 -0.0190111
EFNA5 ephrin-A5 -0.0180771
UQCRB ubiquinol-cytochrome c reductase binding protein -0.017859
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0177645
IGF2 insulin-like growth factor 2 -0.017735
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0175086
PDE4D phosphodiesterase 4D, cAMP-specific -0.0173373
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0172687
BASP1 brain abundant, membrane attached signal protein 1 -0.0172064
BTG3 BTG family, member 3 -0.0171224
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0169982
TUBA1B tubulin, alpha 1b -0.016951
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0168407
TUBB tubulin, beta class I -0.0167378
PARK7 parkinson protein 7 -0.0165737
SLC38A1 solute carrier family 38, member 1 -0.0164327
H1-0 H1.0 linker histone -0.0163521
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0161377
RAN RAN, member RAS oncogene family -0.016114
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0160726
OSMR oncostatin M receptor -0.0159054
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0155509
S100A9 S100 calcium binding protein A9 -0.0152912
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0148579
RAD21 RAD21 homolog (S. pombe) -0.0147973
NRG1 neuregulin 1 -0.0147895
RPL32 ribosomal protein L32 -0.0147262
RPL27A ribosomal protein L27a -0.0145906
FKBP10 FK506 binding protein 10, 65 kDa -0.0142673
DEK DEK proto-oncogene -0.0142535
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0141934
ROMO1 reactive oxygen species modulator 1 -0.0141629
NNMT nicotinamide N-methyltransferase -0.0140992
RPL27 ribosomal protein L27 -0.0138796
AHNAK AHNAK nucleoprotein -0.0137397