Methyl aminolevulinate (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.177513
PABPC1 poly(A) binding protein, cytoplasmic 1 0.175653
VEGFA vascular endothelial growth factor A 0.129747
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.12692
MYH9 myosin, heavy chain 9, non-muscle 0.125702
EEF2 eukaryotic translation elongation factor 2 0.0895423
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0813967
CCNL1 cyclin L1 0.0767611
NDRG1 N-myc downstream regulated 1 0.0763586
APLP2 amyloid beta (A4) precursor-like protein 2 0.0760682
FTH1 ferritin, heavy polypeptide 1 0.0742427
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0732522
RNF145 ring finger protein 145 0.0729413
CALR calreticulin 0.0715122
BHLHE40 basic helix-loop-helix family, member e40 0.0707543
FXR1 fragile X mental retardation, autosomal homolog 1 0.0689446
ADAM9 ADAM metallopeptidase domain 9 0.0652681
KMT2E lysine (K)-specific methyltransferase 2E 0.063368
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.063002
NAMPT nicotinamide phosphoribosyltransferase 0.0626904
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0617586
TPM3 tropomyosin 3 0.0611998
MYO6 myosin VI 0.0589815
MSN moesin 0.056891
GRB10 growth factor receptor-bound protein 10 0.0562083
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.055192
FNDC3B fibronectin type III domain containing 3B 0.0534977
POTEF POTE ankyrin domain family, member F 0.0533686
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0517083
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0505143
PCBP2 poly(rC) binding protein 2 0.0491682
RHOA ras homolog family member A 0.0481341
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.04766
P4HB prolyl 4-hydroxylase, beta polypeptide 0.04703
ALCAM activated leukocyte cell adhesion molecule 0.0458489
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0455696
PRRC2C proline-rich coiled-coil 2C 0.045321
PTK2 protein tyrosine kinase 2 0.0450368
PPARD peroxisome proliferator-activated receptor delta 0.0446787
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0445405
PAPOLA poly(A) polymerase alpha 0.0440653
UBA6 ubiquitin-like modifier activating enzyme 6 0.0411258
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406546
ARRDC3 arrestin domain containing 3 0.0406161
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.040471
COPA coatomer protein complex, subunit alpha 0.0402852
AKAP13 A kinase (PRKA) anchor protein 13 0.0399249
FAM13A family with sequence similarity 13, member A 0.0398371
CANX calnexin 0.0397233
MATR3 matrin 3 0.0388911
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0385892
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0380554
GPBP1 GC-rich promoter binding protein 1 0.037857
IGFBP3 insulin-like growth factor binding protein 3 0.0376912
MBNL1 muscleblind-like splicing regulator 1 0.0375051
ITCH itchy E3 ubiquitin protein ligase 0.0373781
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0370533
TFG TRK-fused gene 0.0365466
VMP1 vacuole membrane protein 1 0.0363402
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0362492
TRIO trio Rho guanine nucleotide exchange factor 0.0359446
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0359017
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0355517
SETD5 SET domain containing 5 0.0355419
PLEC plectin 0.0354412
DUSP10 dual specificity phosphatase 10 0.0349937
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0349191
KDM6A lysine (K)-specific demethylase 6A 0.0348836
SET SET nuclear proto-oncogene 0.0347949
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0338619
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0335654
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0327259
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0325218
TNIP1 TNFAIP3 interacting protein 1 0.0323779
PDLIM5 PDZ and LIM domain 5 0.0322501
AHDC1 AT hook, DNA binding motif, containing 1 0.0320202
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0320019
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0315548
SPAG9 sperm associated antigen 9 0.0315257
TMF1 TATA element modulatory factor 1 0.0314251
PUM1 pumilio RNA-binding family member 1 0.031321
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0312248
SRRM2 serine/arginine repetitive matrix 2 0.0311077
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0308822
ELL2 elongation factor, RNA polymerase II, 2 0.0308015
WAC WW domain containing adaptor with coiled-coil 0.0304859
HSPA8 heat shock 70kDa protein 8 0.0304794
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0300511
HDGF hepatoma-derived growth factor 0.0299426
RAD23B RAD23 homolog B (S. cerevisiae) 0.0298893
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0298156
RBM25 RNA binding motif protein 25 0.0293865
TRA2B transformer 2 beta homolog (Drosophila) 0.0292383
NUP58 nucleoporin 58 0.0292032
ZNF292 zinc finger protein 292 0.0289092
ANXA5 annexin A5 0.0289053
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0289044
LDHA lactate dehydrogenase A 0.0284013
KTN1 kinectin 1 (kinesin receptor) 0.0281778
CDC73 cell division cycle 73 0.0281575

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.248831
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187897
FTL ferritin, light polypeptide -0.180458
TMSB10 thymosin beta 10 -0.117096
TPT1 tumor protein, translationally-controlled 1 -0.107348
S100A6 S100 calcium binding protein A6 -0.0870735
ACTG1 actin gamma 1 -0.0792121
RPLP1 ribosomal protein, large, P1 -0.0756085
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0690967
RPL35A ribosomal protein L35a -0.0664387
RPL34 ribosomal protein L34 -0.0618333
RPL23 ribosomal protein L23 -0.0592613
RPLP0 ribosomal protein, large, P0 -0.0590099
IFI27 interferon, alpha-inducible protein 27 -0.0569179
S100A10 S100 calcium binding protein A10 -0.0548749
RPS8 ribosomal protein S8 -0.0521309
RPLP2 ribosomal protein, large, P2 -0.0512028
RPS19 ribosomal protein S19 -0.04428
WSB1 WD repeat and SOCS box containing 1 -0.0420951
IFI16 interferon, gamma-inducible protein 16 -0.0410603
HMGA1 high mobility group AT-hook 1 -0.0409839
RPS24 ribosomal protein S24 -0.0405212
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0394951
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0394633
IFI6 interferon, alpha-inducible protein 6 -0.03871
RPS23 ribosomal protein S23 -0.0380996
MT2A metallothionein 2A -0.037667
PTMA prothymosin, alpha -0.0376152
RPS13 ribosomal protein S13 -0.0364362
TM4SF1 transmembrane 4 L six family member 1 -0.0359853
RPL12 ribosomal protein L12 -0.0349342
IFITM3 interferon induced transmembrane protein 3 -0.0344887
AHNAK AHNAK nucleoprotein -0.0332799
CSTB cystatin B (stefin B) -0.0325736
ISG15 ISG15 ubiquitin-like modifier -0.0318213
RPL8 ribosomal protein L8 -0.031674
RPL9 ribosomal protein L9 -0.0313036
GNAS GNAS complex locus -0.0306854
C15ORF48 chromosome 15 open reading frame 48 -0.0305727
RPL32 ribosomal protein L32 -0.0304046
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0290436
RPS25 ribosomal protein S25 -0.0276125
RPS21 ribosomal protein S21 -0.0273453
RPS14 ribosomal protein S14 -0.0273158
RPL19 ribosomal protein L19 -0.0270876
RPS27A ribosomal protein S27a -0.0268929
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0268607
RPL28 ribosomal protein L28 -0.0260923
H1-0 H1.0 linker histone -0.0253056
RPS29 ribosomal protein S29 -0.0251579
RPL30 ribosomal protein L30 -0.0247909
RPL38 ribosomal protein L38 -0.0242503
S100A9 S100 calcium binding protein A9 -0.0230736
VIM vimentin -0.0230688
LAMB3 laminin, beta 3 -0.0225957
HMGB1 high mobility group box 1 -0.0225916
TMEM263 transmembrane protein 263 -0.0225528
RPL27A ribosomal protein L27a -0.0222787
LGALS1 lectin, galactoside-binding, soluble, 1 -0.022213
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0220097
RPS5 ribosomal protein S5 -0.021949
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0218505
UPP1 uridine phosphorylase 1 -0.0218042
RPS10 ribosomal protein S10 -0.0215092
RPL18 ribosomal protein L18 -0.0214678
RPS15 ribosomal protein S15 -0.0210208
RPL31 ribosomal protein L31 -0.0207164
DUSP6 dual specificity phosphatase 6 -0.0200273
ZBTB20 zinc finger and BTB domain containing 20 -0.0197597
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0197206
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0196959
TMEM123 transmembrane protein 123 -0.019303
RPS27 ribosomal protein S27 -0.0192433
RPL36 ribosomal protein L36 -0.0192135
LY6E lymphocyte antigen 6 complex, locus E -0.019111
MX2 MX dynamin-like GTPase 2 -0.0190503
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0188878
FAM162A family with sequence similarity 162, member A -0.0185957
MYL12B myosin, light chain 12B, regulatory -0.0184253
RPS11 ribosomal protein S11 -0.0183122
NPC2 Niemann-Pick disease, type C2 -0.0178279
SP100 SP100 nuclear antigen -0.0171559
RPS6 ribosomal protein S6 -0.0170386
IFITM1 interferon induced transmembrane protein 1 -0.0169863
TKT transketolase -0.0169492
RPS20 ribosomal protein S20 -0.0168762
FHIT fragile histidine triad -0.0168758
KRT19 keratin 19, type I -0.0165779
RPS16 ribosomal protein S16 -0.0164373
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0163814
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0160668
NAV2 neuron navigator 2 -0.016008
RPL27 ribosomal protein L27 -0.015769
RAB1B RAB1B, member RAS oncogene family -0.0157675
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0153907
RPL23A ribosomal protein L23a -0.01525
IER3 immediate early response 3 -0.0151056
SQSTM1 sequestosome 1 -0.0149097
IFIH1 interferon induced with helicase C domain 1 -0.0147734
PGK1 phosphoglycerate kinase 1 -0.0145271