Methyl aminolevulinate (hydrochloride)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.108114
TMSB4X thymosin beta 4, X-linked 0.0719308
ZFAND3 zinc finger, AN1-type domain 3 0.0507619
ANKRD33B ankyrin repeat domain 33B 0.047388
THBS1 thrombospondin 1 0.0414405
TPM3 tropomyosin 3 0.0396141
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0391382
MYH9 myosin, heavy chain 9, non-muscle 0.0388581
PICALM phosphatidylinositol binding clathrin assembly protein 0.0384958
FNDC3B fibronectin type III domain containing 3B 0.0369648
ADAM9 ADAM metallopeptidase domain 9 0.0324925
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0324319
CKAP5 cytoskeleton associated protein 5 0.0315956
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0305686
RHEB Ras homolog enriched in brain 0.0304938
CALR calreticulin 0.0297831
CHD1 chromodomain helicase DNA binding protein 1 0.0281645
RHOA ras homolog family member A 0.0280252
TSC22D2 TSC22 domain family, member 2 0.0266853
APP amyloid beta (A4) precursor protein 0.0265973
CFL2 cofilin 2 (muscle) 0.0265259
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0264858
OSBPL9 oxysterol binding protein-like 9 0.0258432
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0253932
NCKAP1 NCK-associated protein 1 0.0251191
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0240296
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.023939
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0236439
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0235754
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0234123
THOC2 THO complex 2 0.0233702
CAMTA1 calmodulin binding transcription activator 1 0.0228859
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0227104
QKI QKI, KH domain containing, RNA binding 0.0226967
MTF2 metal response element binding transcription factor 2 0.0224371
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0224296
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.021787
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0215395
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0214005
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0212072
ADGRG6 adhesion G protein-coupled receptor G6 0.0210931
ANXA5 annexin A5 0.0209621
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0209344
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0209051
R3HDM1 R3H domain containing 1 0.0203969
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0203218
HDAC2 histone deacetylase 2 0.0202659
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0201964
FXR1 fragile X mental retardation, autosomal homolog 1 0.0200581
SPAG9 sperm associated antigen 9 0.019876
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0196435
ZBTB35 zinc finger and BTB domain containing 35 0.0195779
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.019529
KDM5B lysine (K)-specific demethylase 5B 0.0193979
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0193534
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0193389
NUP153 nucleoporin 153kDa 0.0193228
PGAP1 post-GPI attachment to proteins 1 0.0192494
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 0.0191642
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0191223
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0191152
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0189664
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.018919
MSL2 male-specific lethal 2 homolog (Drosophila) 0.0185705
OSBPL10 oxysterol binding protein-like 10 0.0185481
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0185279
ZNF326 zinc finger protein 326 0.018481
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0183928
MB21D2 Mab-21 domain containing 2 0.0183768
TPX2 TPX2, microtubule-associated 0.0183144
H1-4 H1.4 linker histone, cluster member 0.0183008
U2SURP U2 snRNP-associated SURP domain containing 0.0182183
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0180787
TMEM123 transmembrane protein 123 0.018077
ARHGAP12 Rho GTPase activating protein 12 0.0180372
NAMPT nicotinamide phosphoribosyltransferase 0.017882
KDM1A lysine (K)-specific demethylase 1A 0.0178008
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0177767
CAVIN1 caveolae associated protein 1 0.0177584
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0177218
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0176311
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.017462
GRB2 growth factor receptor-bound protein 2 0.0174461
MEMO1 mediator of cell motility 1 0.0174455
FAT1 FAT atypical cadherin 1 0.0174375
ELOVL5 ELOVL fatty acid elongase 5 0.0174079
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0171923
CCNL1 cyclin L1 0.0171699
TP53BP2 tumor protein p53 binding protein 2 0.0171157
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0170603
UBE2K ubiquitin-conjugating enzyme E2K 0.0166529
BRD2 bromodomain containing 2 0.016508
AGTPBP1 ATP/GTP binding protein 1 0.0164984
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0164811
SCAF4 SR-related CTD-associated factor 4 0.0164489
CAPRIN1 cell cycle associated protein 1 0.0163785
ANXA2 annexin A2 0.016342
CRLF3 cytokine receptor-like factor 3 0.0163125
CANX calnexin 0.0163103
ECT2 epithelial cell transforming 2 0.0162835

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.212639
COL11A1 collagen, type XI, alpha 1 -0.146593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13823
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.119185
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.104918
TMSB10 thymosin beta 10 -0.10224
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0964806
CADM2 cell adhesion molecule 2 -0.0910347
ADGRL2 adhesion G protein-coupled receptor L2 -0.0902454
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0824211
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.076315
RPS8 ribosomal protein S8 -0.0757155
RPS16 ribosomal protein S16 -0.0709312
PCDH9 protocadherin 9 -0.0650875
ANKRD12 ankyrin repeat domain 12 -0.062023
RPS6 ribosomal protein S6 -0.0618277
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0594754
RPL19 ribosomal protein L19 -0.0580818
PDE4D phosphodiesterase 4D, cAMP-specific -0.0571407
RPLP1 ribosomal protein, large, P1 -0.0556794
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0552091
NTM neurotrimin -0.0547634
ACTG1 actin gamma 1 -0.0504153
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0470232
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0468236
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0459261
EIF1 eukaryotic translation initiation factor 1 -0.0454983
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.044812
RPLP2 ribosomal protein, large, P2 -0.0447574
GPC3 glypican 3 -0.0445749
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0443652
NPAS3 neuronal PAS domain protein 3 -0.0438881
TENM3 teneurin transmembrane protein 3 -0.0437898
RPS12 ribosomal protein S12 -0.0436759
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.043019
RPS19 ribosomal protein S19 -0.0429143
CDH19 cadherin 19, type 2 -0.0426471
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0423654
RPL23 ribosomal protein L23 -0.0421939
JMJD1C jumonji domain containing 1C -0.0414518
RPL11 ribosomal protein L11 -0.0404363
ENO1 enolase 1, (alpha) -0.0401811
SYT1 synaptotagmin I -0.0400222
WSB1 WD repeat and SOCS box containing 1 -0.0392741
SLIT2 slit homolog 2 (Drosophila) -0.0369452
RPS23 ribosomal protein S23 -0.0362379
RPS13 ribosomal protein S13 -0.0360534
RACK1 receptor for activated C kinase 1 -0.0359371
RPL30 ribosomal protein L30 -0.0357111
RPL9 ribosomal protein L9 -0.0356981
FST follistatin -0.0356194
RPLP0 ribosomal protein, large, P0 -0.0355972
PLPP1 phospholipid phosphatase 1 -0.0351206
AKAP9 A kinase (PRKA) anchor protein 9 -0.0350615
HMGB1 high mobility group box 1 -0.0349484
RPL34 ribosomal protein L34 -0.0349233
RPL35A ribosomal protein L35a -0.0339446
BIRC6 baculoviral IAP repeat containing 6 -0.0330807
NCAM2 neural cell adhesion molecule 2 -0.0327794
MDK midkine (neurite growth-promoting factor 2) -0.0326204
RPL31 ribosomal protein L31 -0.032442
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0323508
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0320682
COL3A1 collagen, type III, alpha 1 -0.0318694
LOC112694756 uncharaterized LOC112694756 -0.0317218
RPS4X ribosomal protein S4, X-linked -0.0317163
SLC38A2 solute carrier family 38, member 2 -0.0315516
MBD5 methyl-CpG binding domain protein 5 -0.0313998
RPS21 ribosomal protein S21 -0.0311309
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.03098
RAD51B RAD51 paralog B -0.0309567
RPL37A ribosomal protein L37a -0.0308586
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0308165
RPL37 ribosomal protein L37 -0.0307453
TNRC6B trinucleotide repeat containing 6B -0.0306376
PRR16 proline rich 16 -0.030498
FTL ferritin, light polypeptide -0.0303832
DLG1 discs, large homolog 1 (Drosophila) -0.0303026
CSMD3 CUB and Sushi multiple domains 3 -0.0303022
TRIM2 tripartite motif containing 2 -0.0301702
RPL12 ribosomal protein L12 -0.0292648
PCLO piccolo presynaptic cytomatrix protein -0.0291296
PCDH7 protocadherin 7 -0.0289629
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0288973
TRPS1 trichorhinophalangeal syndrome I -0.0288089
CEP350 centrosomal protein 350kDa -0.0287735
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0286789
SORBS2 sorbin and SH3 domain containing 2 -0.0286428
DMD dystrophin -0.0280783
FN1 fibronectin 1 -0.0277686
RPS10 ribosomal protein S10 -0.0275761
ANK2 ankyrin 2, neuronal -0.0275391
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0271264
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0270819
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0270041
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0268465
FOXP2 forkhead box P2 -0.0265317
GNAS GNAS complex locus -0.0265252
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0256748
PGK1 phosphoglycerate kinase 1 -0.0256406