Methyl aminolevulinate (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.244487
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.15106
VCL vinculin 0.119647
ERRFI1 ERBB receptor feedback inhibitor 1 0.115009
ZFP36 ZFP36 ring finger protein 0.102694
MYH9 myosin, heavy chain 9, non-muscle 0.0931819
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0850733
ZCCHC7 zinc finger, CCHC domain containing 7 0.0848806
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0832205
ATP13A3 ATPase type 13A3 0.059772
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0582415
SRRM2 serine/arginine repetitive matrix 2 0.057746
EEF2 eukaryotic translation elongation factor 2 0.0532961
VMP1 vacuole membrane protein 1 0.052376
TMEM41B transmembrane protein 41B 0.0490251
FTH1 ferritin, heavy polypeptide 1 0.0482001
WDR43 WD repeat domain 43 0.047678
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.046458
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0440695
SUCO SUN domain containing ossification factor 0.0436645
SPRED2 sprouty-related, EVH1 domain containing 2 0.0423199
CALR calreticulin 0.0421788
VEGFA vascular endothelial growth factor A 0.041893
CTBP2 C-terminal binding protein 2 0.0417962
NUP58 nucleoporin 58 0.0414973
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0414417
FMNL2 formin-like 2 0.0411915
COPA coatomer protein complex, subunit alpha 0.040967
TPM1 tropomyosin 1 (alpha) 0.0399465
APP amyloid beta (A4) precursor protein 0.0396631
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0375622
ADAM17 ADAM metallopeptidase domain 17 0.0372997
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0368555
CCNL1 cyclin L1 0.0366837
SFTPA2 surfactant protein A2 0.0360431
GOLGA4 golgin A4 0.0359375
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0356785
EIF4B eukaryotic translation initiation factor 4B 0.0356015
ELL2 elongation factor, RNA polymerase II, 2 0.034852
MATR3 matrin 3 0.0347718
PDIA6 protein disulfide isomerase family A, member 6 0.0340756
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0335188
FXR1 fragile X mental retardation, autosomal homolog 1 0.0327146
ADM adrenomedullin 0.0319666
KDM3A lysine (K)-specific demethylase 3A 0.0318173
UBA2 ubiquitin-like modifier activating enzyme 2 0.0316742
DDIT4 DNA-damage-inducible transcript 4 0.0311911
TRIO trio Rho guanine nucleotide exchange factor 0.0306359
DCAF13 DDB1 and CUL4 associated factor 13 0.0304418
BRD2 bromodomain containing 2 0.0299917
MACF1 microtubule-actin crosslinking factor 1 0.0295614
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.029072
WAC WW domain containing adaptor with coiled-coil 0.0280691
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0275535
SRP54 signal recognition particle 54kDa 0.0274766
MSN moesin 0.027216
TBC1D23 TBC1 domain family, member 23 0.0268882
KDM6A lysine (K)-specific demethylase 6A 0.0268176
SEC24A SEC24 family member A 0.0266597
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0265845
DENND5A DENN/MADD domain containing 5A 0.0265038
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0264823
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0263993
ARF4 ADP-ribosylation factor 4 0.0257308
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0251216
GARS1 glycyl-tRNA synthetase 1 0.025068
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0249026
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0245432
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0245157
DGKD diacylglycerol kinase, delta 130kDa 0.024479
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0244097
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0243954
PTGES2 prostaglandin E synthase 2 0.0243085
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0241712
MYOF myoferlin 0.0241299
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0239493
RSL1D1 ribosomal L1 domain containing 1 0.0237664
TFG TRK-fused gene 0.0237172
TPM3 tropomyosin 3 0.0237172
RNF145 ring finger protein 145 0.0236994
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.023116
CHD1 chromodomain helicase DNA binding protein 1 0.0231065
JUN jun proto-oncogene 0.0230357
UBA6 ubiquitin-like modifier activating enzyme 6 0.0228316
BIRC6 baculoviral IAP repeat containing 6 0.0227355
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0226493
RHOA ras homolog family member A 0.0225999
GSPT1 G1 to S phase transition 1 0.0224423
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0223521
ELOVL5 ELOVL fatty acid elongase 5 0.0223418
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0221646
COPB1 coatomer protein complex, subunit beta 1 0.0221408
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0220933
TTC3 tetratricopeptide repeat domain 3 0.022058
SND1 staphylococcal nuclease and tudor domain containing 1 0.0220472
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.022032
PRRC2C proline-rich coiled-coil 2C 0.0219891
CASC3 cancer susceptibility candidate 3 0.021802
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.021794
COL18A1 collagen, type XVIII, alpha 1 0.0216424

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.344783
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131912
RPLP1 ribosomal protein, large, P1 -0.0860771
RPLP2 ribosomal protein, large, P2 -0.0797508
TMSB10 thymosin beta 10 -0.0789631
RPS8 ribosomal protein S8 -0.0668238
RPLP0 ribosomal protein, large, P0 -0.06221
RPL35A ribosomal protein L35a -0.0615011
RPS12 ribosomal protein S12 -0.0609354
RPS24 ribosomal protein S24 -0.0600126
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0587011
TM4SF1 transmembrane 4 L six family member 1 -0.0561655
ASPH aspartate beta-hydroxylase -0.0555631
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0489495
CARD18 caspase recruitment domain family, member 18 -0.0469639
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0457793
MT2A metallothionein 2A -0.0437385
RPL36A ribosomal protein L36a -0.0436196
S100A6 S100 calcium binding protein A6 -0.0433718
RPL38 ribosomal protein L38 -0.0430276
ANKRD12 ankyrin repeat domain 12 -0.042167
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0420194
RPL28 ribosomal protein L28 -0.0420193
ATXN1 ataxin 1 -0.0408492
RPS2 ribosomal protein S2 -0.0405731
RPL12 ribosomal protein L12 -0.0405058
RPS6 ribosomal protein S6 -0.0403501
RPL9 ribosomal protein L9 -0.0402797
RPL27A ribosomal protein L27a -0.039602
RPL23 ribosomal protein L23 -0.039129
SLC38A2 solute carrier family 38, member 2 -0.0387037
SDK1 sidekick cell adhesion molecule 1 -0.0383135
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0375277
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0370932
RPL37A ribosomal protein L37a -0.0369514
RPS25 ribosomal protein S25 -0.036946
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0368995
RPL34 ribosomal protein L34 -0.036607
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0354128
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347446
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0339918
ZBTB20 zinc finger and BTB domain containing 20 -0.033351
ODF2L outer dense fiber of sperm tails 2-like -0.0330423
RPS27A ribosomal protein S27a -0.0330315
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.033024
CENPF centromere protein F, 350/400kDa -0.032648
AHNAK AHNAK nucleoprotein -0.032434
RPL30 ribosomal protein L30 -0.0321926
ZNF780B zinc finger protein 780B -0.032191
RPS13 ribosomal protein S13 -0.0318854
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0316867
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0312202
TAS2R14 taste receptor, type 2, member 14 -0.0312059
MYO9A myosin IXA -0.0311905
VIM vimentin -0.0304331
TPT1 tumor protein, translationally-controlled 1 -0.030329
FTL ferritin, light polypeptide -0.030319
HMGB1 high mobility group box 1 -0.0301798
NF1 neurofibromin 1 -0.0301338
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0297552
EFNA5 ephrin-A5 -0.0296109
RPL39 ribosomal protein L39 -0.0295912
RPS5 ribosomal protein S5 -0.0294214
ACTG1 actin gamma 1 -0.0294162
TXNRD1 thioredoxin reductase 1 -0.0291665
MBD5 methyl-CpG binding domain protein 5 -0.029099
RPL31 ribosomal protein L31 -0.028917
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0287918
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0287173
GLCCI1 glucocorticoid induced 1 -0.0285385
DST dystonin -0.028473
BIRC2 baculoviral IAP repeat containing 2 -0.0283902
PRELID2 PRELI domain containing 2 -0.0282267
RPL19 ribosomal protein L19 -0.0280605
RPS19 ribosomal protein S19 -0.0277553
ACTN4 actinin, alpha 4 -0.0277156
EIF1 eukaryotic translation initiation factor 1 -0.0267865
ZC3H12B zinc finger CCCH-type containing 12B -0.0266129
CTSD cathepsin D -0.0263571
RPS21 ribosomal protein S21 -0.0262155
RAD51B RAD51 paralog B -0.0261296
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0259343
SPIDR scaffolding protein involved in DNA repair -0.0256142
RPS20 ribosomal protein S20 -0.0253158
SEPTIN7 septin 7 -0.025091
PERP PERP, TP53 apoptosis effector -0.0249441
EXOC6B exocyst complex component 6B -0.0248266
RPS17 ribosomal protein S17 -0.024625
CD44 CD44 molecule (Indian blood group) -0.0246173
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0245947
RPL36 ribosomal protein L36 -0.0243046
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0242937
ARB2A ARB2 cotranscriptional regulator A -0.02428
BABAM2 BRISC and BRCA1 A complex member 2 -0.0242468
RPS23 ribosomal protein S23 -0.0241989
S100A10 S100 calcium binding protein A10 -0.0238932
ATG10 autophagy related 10 -0.0238747
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0238276
SQSTM1 sequestosome 1 -0.0236258
OSMR oncostatin M receptor -0.0235352