Methyl aminolevulinate (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.113968
CALCA calcitonin-related polypeptide alpha 0.111406
STC1 stanniocalcin 1 0.0789205
PTMA prothymosin, alpha 0.0683191
MAP1B microtubule-associated protein 1B 0.068027
TENT5A terminal nucleotidyltransferase 5A 0.0657307
CPE carboxypeptidase E 0.0654446
RPS3 ribosomal protein S3 0.0607718
ENO1 enolase 1, (alpha) 0.0552342
SMOC1 SPARC related modular calcium binding 1 0.0531417
TMSB4X thymosin beta 4, X-linked 0.0474412
RPL26 ribosomal protein L26 0.0467817
FGF14 fibroblast growth factor 14 0.0463763
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.0410108
DSTN destrin (actin depolymerizing factor) 0.0404376
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0398249
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0389601
PHF14 PHD finger protein 14 0.0376811
SASH1 SAM and SH3 domain containing 1 0.0361199
B2M beta-2-microglobulin 0.0359425
RPL30 ribosomal protein L30 0.0358199
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0355812
RPL7A ribosomal protein L7a 0.0354354
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0350024
RPL5 ribosomal protein L5 0.0342596
PDE4D phosphodiesterase 4D, cAMP-specific 0.0340857
RIMS2 regulating synaptic membrane exocytosis 2 0.0340055
SCG2 secretogranin II 0.0336896
RPL7 ribosomal protein L7 0.0336497
NIPSNAP2 nipsnap homolog 2 0.0333406
S100A9 S100 calcium binding protein A9 0.0330482
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0328818
RPS6 ribosomal protein S6 0.0328804
MT2A metallothionein 2A 0.0326422
BMERB1 bMERB domain containing 1 0.032555
MED13L mediator complex subunit 13-like 0.0325021
ADNP activity-dependent neuroprotector homeobox 0.0321283
RPS27A ribosomal protein S27a 0.0320153
CHGB chromogranin B 0.0319939
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0318252
DOCK5 dedicator of cytokinesis 5 0.0309931
SMC1A structural maintenance of chromosomes 1A 0.03083
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0304171
NCKAP5 NCK-associated protein 5 0.0302232
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0297786
IFI6 interferon, alpha-inducible protein 6 0.0295729
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0294851
RPL31 ribosomal protein L31 0.0283315
ATP5F1E ATP synthase F1 subunit epsilon 0.0282444
FNDC3A fibronectin type III domain containing 3A 0.0282241
RPL37 ribosomal protein L37 0.0276439
RPL8 ribosomal protein L8 0.027473
RPS12 ribosomal protein S12 0.0274692
PAEP progestagen-associated endometrial protein 0.0273112
ELL2 elongation factor, RNA polymerase II, 2 0.0268253
SCG3 secretogranin III 0.0265922
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0265445
ARHGAP26 Rho GTPase activating protein 26 0.0264838
KIF5B kinesin family member 5B 0.0264793
COL22A1 collagen, type XXII, alpha 1 0.0261833
STMN1 stathmin 1 0.0261552
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0260427
RPS16 ribosomal protein S16 0.0259711
RPS8 ribosomal protein S8 0.0259621
RPS17 ribosomal protein S17 0.0258219
NAV2 neuron navigator 2 0.0255408
CKAP5 cytoskeleton associated protein 5 0.0253435
PSD3 pleckstrin and Sec7 domain containing 3 0.0252972
EIF1 eukaryotic translation initiation factor 1 0.0250456
RPS19 ribosomal protein S19 0.0249298
RPL23 ribosomal protein L23 0.0245942
RTN4 reticulon 4 0.024561
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0245217
RIT2 Ras-like without CAAX 2 0.0244761
VGF VGF nerve growth factor inducible 0.0244511
GNAS GNAS complex locus 0.024192
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0241567
TPM3 tropomyosin 3 0.0240478
PA2G4 proliferation-associated 2G4, 38kDa 0.0239786
SINHCAF SIN3-HDAC complex associated factor 0.0234823
RPS21 ribosomal protein S21 0.0234758
RPLP0 ribosomal protein, large, P0 0.0234476
RPL19 ribosomal protein L19 0.0231931
RPL35 ribosomal protein L35 0.0230892
LOC112694756 uncharaterized LOC112694756 0.023026
RPS25 ribosomal protein S25 0.023026
RPL36A ribosomal protein L36a 0.0228566
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0228101
TPT1 tumor protein, translationally-controlled 1 0.0227926
RPLP1 ribosomal protein, large, P1 0.0227472
MARCHF6 membrane associated ring-CH-type finger 6 0.0226869
EEF2 eukaryotic translation elongation factor 2 0.0226549
SETD5 SET domain containing 5 0.022388
CENPF centromere protein F, 350/400kDa 0.0223115
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.022263
FOXC1 forkhead box C1 0.0222511
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.0222445
ACTG1 actin gamma 1 0.0222328
EGR1 early growth response 1 0.0222141
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0220885

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.137135
GPC6 glypican 6 -0.0926368
DTNA dystrobrevin, alpha -0.0795878
SMYD3 SET and MYND domain containing 3 -0.0688132
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0634155
GRB10 growth factor receptor-bound protein 10 -0.059258
NALF1 NALCN channel auxiliary factor 1 -0.058397
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0572183
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0552915
TENM1 teneurin transmembrane protein 1 -0.0552471
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0543133
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0538914
FAM13A family with sequence similarity 13, member A -0.0483176
CA8 carbonic anhydrase VIII -0.0482513
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0477863
CADM1 cell adhesion molecule 1 -0.0418754
NDRG1 N-myc downstream regulated 1 -0.0411391
GMDS GDP-mannose 4,6-dehydratase -0.0410762
ESRRG estrogen-related receptor gamma -0.0393999
DENND1A DENN/MADD domain containing 1A -0.0392775
RORA RAR-related orphan receptor A -0.03755
NRG1 neuregulin 1 -0.0369859
MBNL2 muscleblind-like splicing regulator 2 -0.0347814
MCTP1 multiple C2 domains, transmembrane 1 -0.0332068
JAM3 junctional adhesion molecule 3 -0.03309
MSI2 musashi RNA-binding protein 2 -0.0324922
ZNF292 zinc finger protein 292 -0.0322346
RALYL RALY RNA binding protein-like -0.0316924
TRIO trio Rho guanine nucleotide exchange factor -0.0314012
CHD7 chromodomain helicase DNA binding protein 7 -0.0311324
AFF1 AF4/FMR2 family, member 1 -0.0303598
BCL2 B-cell CLL/lymphoma 2 -0.029871
FNDC3B fibronectin type III domain containing 3B -0.0287425
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0282001
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0279639
ASPH aspartate beta-hydroxylase -0.027528
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0269301
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0266785
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0260245
PDE4B phosphodiesterase 4B, cAMP-specific -0.0259281
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0255856
TBC1D22A TBC1 domain family, member 22A -0.0253755
PSPC1 paraspeckle component 1 -0.0243643
INSIG2 insulin induced gene 2 -0.0241522
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) -0.0240754
EXOC4 exocyst complex component 4 -0.0240513
NLGN1 neuroligin 1 -0.0231469
GPC5 glypican 5 -0.0230738
RNF213 ring finger protein 213 -0.0230463
GOLGB1 golgin B1 -0.0229975
PIAS2 protein inhibitor of activated STAT, 2 -0.0228936
MAP2K1 mitogen-activated protein kinase kinase 1 -0.0228088
NGLY1 N-glycanase 1 -0.0227813
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0224432
SCFD2 sec1 family domain containing 2 -0.022344
ADGRV1 adhesion G protein-coupled receptor V1 -0.0221554
IQSEC1 IQ motif and Sec7 domain 1 -0.0218477
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0216466
MYH10 myosin, heavy chain 10, non-muscle -0.0215118
SPDYA speedy/RINGO cell cycle regulator family member A -0.021331
CCNY cyclin Y -0.0210459
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0209928
CNTNAP2 contactin associated protein-like 2 -0.0205643
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0204638
ADGRL3 adhesion G protein-coupled receptor L3 -0.0203533
NRXN1 neurexin 1 -0.0201669
ACIN1 apoptotic chromatin condensation inducer 1 -0.0200341
DOT1L DOT1-like histone H3K79 methyltransferase -0.0199015
ZMAT4 zinc finger, matrin-type 4 -0.0197684
SDK1 sidekick cell adhesion molecule 1 -0.0196314
SETX senataxin -0.0191557
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0190603
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0187276
ZFHX3 zinc finger homeobox 3 -0.0185204
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0184569
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0184007
TRA2A transformer 2 alpha homolog (Drosophila) -0.0183988
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0183853
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0181461
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0178967
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0178635
CSMD3 CUB and Sushi multiple domains 3 -0.0178453
KLHL29 kelch-like family member 29 -0.0177612
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0171559
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.017029
HDAC4 histone deacetylase 4 -0.0170254
TTC3 tetratricopeptide repeat domain 3 -0.0170173
NIPBL Nipped-B homolog (Drosophila) -0.0170127
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0169915
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0169426
SQSTM1 sequestosome 1 -0.0168846
BCLAF1 BCL2-associated transcription factor 1 -0.0167628
ZNF804A zinc finger protein 804A -0.0166447
KDM3A lysine (K)-specific demethylase 3A -0.0166176
MAML3 mastermind-like 3 (Drosophila) -0.0165681
POU6F2 POU class 6 homeobox 2 -0.0165347
EPHA6 EPH receptor A6 -0.0165079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0164468
TOX3 TOX high mobility group box family member 3 -0.0163581
CTBP2 C-terminal binding protein 2 -0.0163222