Methyl aminolevulinate (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.184939
FN1 fibronectin 1 0.143541
VEGFA vascular endothelial growth factor A 0.0934099
NAMPT nicotinamide phosphoribosyltransferase 0.0767885
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0637994
ZNF292 zinc finger protein 292 0.063593
TRIO trio Rho guanine nucleotide exchange factor 0.0618572
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0586056
SPAG9 sperm associated antigen 9 0.0580729
UGCG UDP-glucose ceramide glucosyltransferase 0.0580205
ELL2 elongation factor, RNA polymerase II, 2 0.0567882
ATP13A3 ATPase type 13A3 0.0557643
EEF2 eukaryotic translation elongation factor 2 0.0532467
OGA O-GlcNAcase 0.0530558
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0490647
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.047889
SOD2 superoxide dismutase 2, mitochondrial 0.0470167
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0461196
NAV2 neuron navigator 2 0.0459312
HELZ helicase with zinc finger 0.0456246
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0453694
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0452652
UBA6 ubiquitin-like modifier activating enzyme 6 0.0449265
USP9X ubiquitin specific peptidase 9, X-linked 0.0433499
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0396994
MYOF myoferlin 0.0392284
GOLGA4 golgin A4 0.0387956
APP amyloid beta (A4) precursor protein 0.0377709
TSC22D2 TSC22 domain family, member 2 0.0370773
THBS1 thrombospondin 1 0.0361109
ARRDC3 arrestin domain containing 3 0.036004
MSN moesin 0.0351862
KDM3A lysine (K)-specific demethylase 3A 0.0351852
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0351346
MXI1 MAX interactor 1, dimerization protein 0.0327743
ZFAND3 zinc finger, AN1-type domain 3 0.032198
VCAN versican 0.0318556
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0315856
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0313453
ZMIZ1 zinc finger, MIZ-type containing 1 0.0307579
ANLN anillin, actin binding protein 0.0306928
WAC WW domain containing adaptor with coiled-coil 0.0301707
APLP2 amyloid beta (A4) precursor-like protein 2 0.0300845
COL6A3 collagen, type VI, alpha 3 0.0294665
AFDN afadin, adherens junction formation factor 0.0293315
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0291252
DST dystonin 0.0291042
TENT5A terminal nucleotidyltransferase 5A 0.0287616
FTH1 ferritin, heavy polypeptide 1 0.0285975
DENND5A DENN/MADD domain containing 5A 0.0284491
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0280736
QKI QKI, KH domain containing, RNA binding 0.027761
CEP250 centrosomal protein 250kDa 0.0277134
NT5C2 5'-nucleotidase, cytosolic II 0.0275709
KMT2E lysine (K)-specific methyltransferase 2E 0.0274657
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0272918
RTN4 reticulon 4 0.0272387
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0270594
PICALM phosphatidylinositol binding clathrin assembly protein 0.0259103
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.025559
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0250303
WTAP Wilms tumor 1 associated protein 0.0250273
USP37 ubiquitin specific peptidase 37 0.0247044
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.024409
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0242574
SRRM2 serine/arginine repetitive matrix 2 0.0241943
FMNL2 formin-like 2 0.023934
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0236006
PPARD peroxisome proliferator-activated receptor delta 0.0234244
TNIP1 TNFAIP3 interacting protein 1 0.023369
RLF rearranged L-myc fusion 0.0232487
LAMP2 lysosomal-associated membrane protein 2 0.0230508
RYBP RING1 and YY1 binding protein 0.0229502
FXR1 fragile X mental retardation, autosomal homolog 1 0.0228972
EIF4B eukaryotic translation initiation factor 4B 0.0227726
UBE2H ubiquitin-conjugating enzyme E2H 0.0226218
NPEPPS aminopeptidase puromycin sensitive 0.022512
KDM6A lysine (K)-specific demethylase 6A 0.0225105
CCNL1 cyclin L1 0.0223787
MATR3 matrin 3 0.0221368
UVRAG UV radiation resistance associated 0.0220653
RB1CC1 RB1-inducible coiled-coil 1 0.0220294
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0220202
EPS8 epidermal growth factor receptor pathway substrate 8 0.0219792
RBM39 RNA binding motif protein 39 0.0219733
NCKAP1 NCK-associated protein 1 0.0218797
MARCHF6 membrane associated ring-CH-type finger 6 0.0218036
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0217472
RNF145 ring finger protein 145 0.021707
RICTOR RPTOR independent companion of MTOR, complex 2 0.021689
WDFY1 WD repeat and FYVE domain containing 1 0.0215786
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0215251
MACF1 microtubule-actin crosslinking factor 1 0.0215234
NUP153 nucleoporin 153kDa 0.0214147
CORO1C coronin, actin binding protein, 1C 0.021371
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0213385
ESYT2 extended synaptotagmin-like protein 2 0.0212663
PAWR PRKC, apoptosis, WT1, regulator 0.0208426
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.020783
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0201424

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.227708
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178219
HLA-B major histocompatibility complex, class I, B -0.107089
FTL ferritin, light polypeptide -0.0986083
TMSB10 thymosin beta 10 -0.09417
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0894473
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0769875
MT2A metallothionein 2A -0.068007
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0653159
HMGA2 high mobility group AT-hook 2 -0.0599859
IGFBP3 insulin-like growth factor binding protein 3 -0.046516
GLIS3 GLIS family zinc finger 3 -0.0464667
HLA-A major histocompatibility complex, class I, A -0.0459839
IER3 immediate early response 3 -0.0455908
RPS8 ribosomal protein S8 -0.0454351
RPL23 ribosomal protein L23 -0.0435809
RPS6 ribosomal protein S6 -0.0430822
TPT1 tumor protein, translationally-controlled 1 -0.0421255
LDHA lactate dehydrogenase A -0.0415371
RPLP1 ribosomal protein, large, P1 -0.0406792
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0406212
RPS19 ribosomal protein S19 -0.0383975
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0378957
RPL35A ribosomal protein L35a -0.0375023
EGR1 early growth response 1 -0.0369918
CD44 CD44 molecule (Indian blood group) -0.0366647
IFITM3 interferon induced transmembrane protein 3 -0.0365847
RPLP2 ribosomal protein, large, P2 -0.035698
RPS23 ribosomal protein S23 -0.0345462
IFI6 interferon, alpha-inducible protein 6 -0.0341334
RPS24 ribosomal protein S24 -0.0331675
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0331076
CTSD cathepsin D -0.0330518
CDH13 cadherin 13 -0.0326187
IFI16 interferon, gamma-inducible protein 16 -0.0317575
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0312863
ACTG1 actin gamma 1 -0.0304229
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0303434
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0301591
RPL31 ribosomal protein L31 -0.029618
ZMYND8 zinc finger, MYND-type containing 8 -0.0293406
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0288313
EXT1 exostosin glycosyltransferase 1 -0.0287858
RPL9 ribosomal protein L9 -0.02862
RPL37A ribosomal protein L37a -0.0284143
RPS12 ribosomal protein S12 -0.0278626
EIF1 eukaryotic translation initiation factor 1 -0.0275374
RPS4X ribosomal protein S4, X-linked -0.0268845
PLIN2 perilipin 2 -0.0268403
SQSTM1 sequestosome 1 -0.0264832
RPS13 ribosomal protein S13 -0.0264734
ZBTB20 zinc finger and BTB domain containing 20 -0.0264149
RPL12 ribosomal protein L12 -0.0257278
RPL19 ribosomal protein L19 -0.0250384
BICC1 BicC family RNA binding protein 1 -0.0248604
SLC38A2 solute carrier family 38, member 2 -0.0246978
RPL36 ribosomal protein L36 -0.0246291
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0245895
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0244628
RPL36A ribosomal protein L36a -0.0242596
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0241717
RPLP0 ribosomal protein, large, P0 -0.0240084
ATXN1 ataxin 1 -0.0236966
LOC112694756 uncharaterized LOC112694756 -0.023425
RPS25 ribosomal protein S25 -0.0231915
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.023191
S100A9 S100 calcium binding protein A9 -0.02317
RPS14 ribosomal protein S14 -0.023068
IFITM1 interferon induced transmembrane protein 1 -0.0229941
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0229827
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0229285
RPL34 ribosomal protein L34 -0.0229235
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0226498
EGFR epidermal growth factor receptor -0.0224068
RPS21 ribosomal protein S21 -0.0221093
GNAS GNAS complex locus -0.0215365
TMEM132D transmembrane protein 132D -0.021261
DIAPH2 diaphanous-related formin 2 -0.0211066
FRMPD4 FERM and PDZ domain containing 4 -0.0209263
RPL38 ribosomal protein L38 -0.0206932
ENO1 enolase 1, (alpha) -0.0203753
RPL27A ribosomal protein L27a -0.0201249
RPL32 ribosomal protein L32 -0.0200965
ISG15 ISG15 ubiquitin-like modifier -0.020035
SMYD3 SET and MYND domain containing 3 -0.019898
ENO2 enolase 2 (gamma, neuronal) -0.0198609
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0197129
PDE4D phosphodiesterase 4D, cAMP-specific -0.0196662
RPS11 ribosomal protein S11 -0.0195991
HMGA1 high mobility group AT-hook 1 -0.0192499
RPL28 ribosomal protein L28 -0.0188214
RPS27 ribosomal protein S27 -0.0188087
ASTN2 astrotactin 2 -0.0188037
RPL5 ribosomal protein L5 -0.0187836
PMP22 peripheral myelin protein 22 -0.0187435
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0187225
LOX lysyl oxidase -0.0185519
HM13 histocompatibility (minor) 13 -0.0183151
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0181154
ZBTB38 zinc finger and BTB domain containing 38 -0.018024