Methyl aminolevulinate (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.104533
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0566477
CCNL1 cyclin L1 0.0551051
ZNF292 zinc finger protein 292 0.0512687
FXR1 fragile X mental retardation, autosomal homolog 1 0.051215
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.048564
NAMPT nicotinamide phosphoribosyltransferase 0.047141
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0465486
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0443656
USP3 ubiquitin specific peptidase 3 0.0438548
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0418285
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0405415
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0400469
MATR3 matrin 3 0.0387392
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0383404
SNX9 sorting nexin 9 0.0377912
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0371611
NCKAP1 NCK-associated protein 1 0.0355176
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0353028
TMSB4X thymosin beta 4, X-linked 0.034013
VMP1 vacuole membrane protein 1 0.0339715
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0332918
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0324794
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0324325
KMT2E lysine (K)-specific methyltransferase 2E 0.0320262
MTMR3 myotubularin related protein 3 0.0319689
MYH9 myosin, heavy chain 9, non-muscle 0.0318438
UGCG UDP-glucose ceramide glucosyltransferase 0.0317621
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0314365
RNF145 ring finger protein 145 0.0312462
NPTN neuroplastin 0.0288701
BHLHE40 basic helix-loop-helix family, member e40 0.0288643
FTH1 ferritin, heavy polypeptide 1 0.0275062
RAD23B RAD23 homolog B (S. cerevisiae) 0.0273564
ZFAND6 zinc finger, AN1-type domain 6 0.0272509
FMR1 fragile X mental retardation 1 0.0271663
OLA1 Obg-like ATPase 1 0.025474
TRA2A transformer 2 alpha homolog (Drosophila) 0.0253147
AGFG1 ArfGAP with FG repeats 1 0.0251353
EPS8 epidermal growth factor receptor pathway substrate 8 0.0250467
MEF2A myocyte enhancer factor 2A 0.0247569
EEF2 eukaryotic translation elongation factor 2 0.0247475
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0239344
WAC WW domain containing adaptor with coiled-coil 0.0235241
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.023479
RBM39 RNA binding motif protein 39 0.0234144
TPM3 tropomyosin 3 0.0231474
KDM6A lysine (K)-specific demethylase 6A 0.0230157
TRA2B transformer 2 beta homolog (Drosophila) 0.0227658
EWSR1 EWS RNA-binding protein 1 0.022344
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.02233
CRY1 cryptochrome circadian clock 1 0.0220541
LMTK2 lemur tyrosine kinase 2 0.0218252
USP6NL USP6 N-terminal like 0.0207592
ANKRD28 ankyrin repeat domain 28 0.0207495
FOXJ3 forkhead box J3 0.0207064
PNN pinin, desmosome associated protein 0.0203304
RAB1A RAB1A, member RAS oncogene family 0.0202845
RTN4 reticulon 4 0.0202594
ARGLU1 arginine and glutamate rich 1 0.0202219
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0201389
RAB18 RAB18, member RAS oncogene family 0.0201369
TFG TRK-fused gene 0.0200898
TCERG1 transcription elongation regulator 1 0.0200634
MARCHF6 membrane associated ring-CH-type finger 6 0.0200366
TOP2B topoisomerase (DNA) II beta 180kDa 0.0199254
PELI1 pellino E3 ubiquitin protein ligase 1 0.0197908
AFDN afadin, adherens junction formation factor 0.0196496
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0195772
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0194322
DSPP dentin sialophosphoprotein 0.0193861
ZFAND3 zinc finger, AN1-type domain 3 0.0192056
SET SET nuclear proto-oncogene 0.0190201
ZNF148 zinc finger protein 148 0.0188312
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0186746
HSPA8 heat shock 70kDa protein 8 0.0186518
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0184497
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0183428
TEX10 testis expressed 10 0.0180523
GARS1 glycyl-tRNA synthetase 1 0.0180258
ATP13A3 ATPase type 13A3 0.0178583
CCNT2 cyclin T2 0.0178531
RAD21 RAD21 homolog (S. pombe) 0.0178513
BCLAF1 BCL2-associated transcription factor 1 0.0177568
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0175841
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0175692
SFPQ splicing factor proline/glutamine-rich 0.0174621
SMG7 SMG7 nonsense mediated mRNA decay factor 0.017406
FNBP1L formin binding protein 1-like 0.0172099
VEGFA vascular endothelial growth factor A 0.0171381
UBA6 ubiquitin-like modifier activating enzyme 6 0.0171167
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0169538
PPME1 protein phosphatase methylesterase 1 0.0169116
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0168539
ADAM17 ADAM metallopeptidase domain 17 0.0168122
MKRN1 makorin ring finger protein 1 0.0167467
XPO1 exportin 1 0.0167101
SF1 splicing factor 1 0.0166573
EIF4B eukaryotic translation initiation factor 4B 0.0165679
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0165436

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.132446
FTL ferritin, light polypeptide -0.118778
MAML2 mastermind-like 2 (Drosophila) -0.111046
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0793087
TMSB10 thymosin beta 10 -0.0775265
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0763391
RPLP1 ribosomal protein, large, P1 -0.0636561
SDK1 sidekick cell adhesion molecule 1 -0.0626698
EHBP1 EH domain binding protein 1 -0.0604989
PTMA prothymosin, alpha -0.0593844
RPL35A ribosomal protein L35a -0.0588412
EGR1 early growth response 1 -0.0582746
NCEH1 neutral cholesterol ester hydrolase 1 -0.0559315
HM13 histocompatibility (minor) 13 -0.0512942
ZBTB20 zinc finger and BTB domain containing 20 -0.0489217
RPL23 ribosomal protein L23 -0.0489133
CEMIP cell migration inducing protein, hyaluronan binding -0.0484701
ZMYND8 zinc finger, MYND-type containing 8 -0.0480799
BCL2L1 BCL2-like 1 -0.0478068
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.047728
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0471974
ACTG1 actin gamma 1 -0.0467029
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0464275
RPLP2 ribosomal protein, large, P2 -0.046102
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0460497
VCL vinculin -0.042536
RPS19 ribosomal protein S19 -0.0416162
GMDS GDP-mannose 4,6-dehydratase -0.0414824
RPL31 ribosomal protein L31 -0.0406419
LDHA lactate dehydrogenase A -0.0398879
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0398572
GNAS GNAS complex locus -0.0393857
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0386871
TPT1 tumor protein, translationally-controlled 1 -0.038656
RPL28 ribosomal protein L28 -0.0384729
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0383915
RPS8 ribosomal protein S8 -0.0382814
RPL12 ribosomal protein L12 -0.0380898
CUX1 cut-like homeobox 1 -0.0376229
NEBL nebulette -0.0374475
RPS6 ribosomal protein S6 -0.0373208
LOC102724023 ES1 protein homolog, mitochondrial -0.0372636
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0369775
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0369189
RPS25 ribosomal protein S25 -0.0367991
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0366237
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.036271
MYO1E myosin IE -0.0359725
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0356506
GOLGB1 golgin B1 -0.0355902
CDK13 cyclin-dependent kinase 13 -0.0354865
FNDC3B fibronectin type III domain containing 3B -0.0350832
IER3 immediate early response 3 -0.0349738
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0348146
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0346361
RPL19 ribosomal protein L19 -0.0345493
RPL37A ribosomal protein L37a -0.0345437
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0341558
IFITM1 interferon induced transmembrane protein 1 -0.0338161
DLG1 discs, large homolog 1 (Drosophila) -0.0333979
RPS21 ribosomal protein S21 -0.0331025
RPS13 ribosomal protein S13 -0.0327828
ZBTB38 zinc finger and BTB domain containing 38 -0.0320172
GCC2 GRIP and coiled-coil domain containing 2 -0.0317272
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0315705
NF1 neurofibromin 1 -0.0313918
NFIA nuclear factor I/A -0.0312596
PERP PERP, TP53 apoptosis effector -0.0301915
SOX4 SRY (sex determining region Y)-box 4 -0.0300737
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0300586
RPS14 ribosomal protein S14 -0.030025
ZNFX1 zinc finger, NFX1-type containing 1 -0.0299537
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0298383
BBX bobby sox homolog (Drosophila) -0.0297842
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0296781
PTPRK protein tyrosine phosphatase, receptor type, K -0.0295975
SLC38A1 solute carrier family 38, member 1 -0.0295817
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0295043
PCLO piccolo presynaptic cytomatrix protein -0.0294942
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0292724
LPP LIM domain containing preferred translocation partner in lipoma -0.0290993
TAS2R14 taste receptor, type 2, member 14 -0.0290989
FRMD5 FERM domain containing 5 -0.0290614
PATJ PATJ crumbs cell polarity complex component -0.0290302
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0290254
TGFA transforming growth factor, alpha -0.0290057
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0289175
HDLBP high density lipoprotein binding protein -0.0287566
LOC112694756 uncharaterized LOC112694756 -0.0286709
RPS11 ribosomal protein S11 -0.0285619
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0285201
SP100 SP100 nuclear antigen -0.0282346
RPL32 ribosomal protein L32 -0.0280425
TMEM123 transmembrane protein 123 -0.0279479
S100A6 S100 calcium binding protein A6 -0.027937
RPLP0 ribosomal protein, large, P0 -0.027573
RPS24 ribosomal protein S24 -0.0275524
NKD1 naked cuticle homolog 1 (Drosophila) -0.0275241
NDRG1 N-myc downstream regulated 1 -0.0273786
RAD51B RAD51 paralog B -0.0272461