Methyl aminolevulinate (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0591791
AREG amphiregulin 0.0530549
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0496973
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.041869
KMT2C lysine (K)-specific methyltransferase 2C 0.0413503
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0401305
NUP58 nucleoporin 58 0.0398562
NDRG1 N-myc downstream regulated 1 0.0381647
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0378382
ESYT2 extended synaptotagmin-like protein 2 0.0367342
HSPA8 heat shock 70kDa protein 8 0.0339677
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0331047
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0327894
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0323125
UBA6 ubiquitin-like modifier activating enzyme 6 0.0299837
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0294578
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0293884
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0293715
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0293676
FTH1 ferritin, heavy polypeptide 1 0.0289755
ZNF292 zinc finger protein 292 0.0283469
BIRC3 baculoviral IAP repeat containing 3 0.028064
TXNIP thioredoxin interacting protein 0.0279815
GARS1 glycyl-tRNA synthetase 1 0.0274523
EREG epiregulin 0.0268687
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0265279
DDIT4 DNA-damage-inducible transcript 4 0.0265033
HILPDA hypoxia inducible lipid droplet-associated 0.0262902
ANXA2 annexin A2 0.0261065
ITPRID2 ITPR interacting domain containing 2 0.0259865
RAB6A RAB6A, member RAS oncogene family 0.0259518
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0258193
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0257188
COG5 component of oligomeric golgi complex 5 0.0256271
WAC WW domain containing adaptor with coiled-coil 0.0252877
TOP2B topoisomerase (DNA) II beta 180kDa 0.0251421
CPOX coproporphyrinogen oxidase 0.0240648
KDM6A lysine (K)-specific demethylase 6A 0.0239573
GOLGA4 golgin A4 0.0238248
NAMPT nicotinamide phosphoribosyltransferase 0.0236854
DSPP dentin sialophosphoprotein 0.0235937
TNPO1 transportin 1 0.0235687
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0230346
EIF4A2 eukaryotic translation initiation factor 4A2 0.0221969
RNF145 ring finger protein 145 0.0215815
RNF43 ring finger protein 43 0.021418
SLMAP sarcolemma associated protein 0.0212852
ADAM17 ADAM metallopeptidase domain 17 0.0210929
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0210022
NPEPPS aminopeptidase puromycin sensitive 0.0207978
EIF4B eukaryotic translation initiation factor 4B 0.0207361
GPBP1 GC-rich promoter binding protein 1 0.0207255
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0206124
LAMC2 laminin, gamma 2 0.0205815
SEC23A Sec23 homolog A (S. cerevisiae) 0.0205633
KDM3A lysine (K)-specific demethylase 3A 0.0205134
WDR43 WD repeat domain 43 0.0204142
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0203955
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0201937
SREBF2 sterol regulatory element binding transcription factor 2 0.0198927
ATP11B ATPase, class VI, type 11B 0.0198291
EEF2 eukaryotic translation elongation factor 2 0.0197756
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0197534
MYO1B myosin IB 0.0197299
PUM1 pumilio RNA-binding family member 1 0.0195664
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0194401
USP3 ubiquitin specific peptidase 3 0.0192747
PDE4B phosphodiesterase 4B, cAMP-specific 0.0192669
FBXO42 F-box protein 42 0.0192045
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0191467
MYH9 myosin, heavy chain 9, non-muscle 0.0188564
RPS18 ribosomal protein S18 0.0187789
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0186066
NCKAP1 NCK-associated protein 1 0.0185134
PLAUR plasminogen activator, urokinase receptor 0.0184431
SRPK1 SRSF protein kinase 1 0.0184158
TFRC transferrin receptor 0.018411
NAV2 neuron navigator 2 0.0179077
BBX bobby sox homolog (Drosophila) 0.017888
VEGFA vascular endothelial growth factor A 0.0177812
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0176995
RANBP9 RAN binding protein 9 0.0175766
AFDN afadin, adherens junction formation factor 0.0174571
ZC3H11A zinc finger CCCH-type containing 11A 0.0174091
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0171268
CCNL1 cyclin L1 0.0170358
ZMYM2 zinc finger, MYM-type 2 0.0169844
KDM1A lysine (K)-specific demethylase 1A 0.0168929
ABHD3 abhydrolase domain containing 3 0.0167796
RYBP RING1 and YY1 binding protein 0.016635
APP amyloid beta (A4) precursor protein 0.016376
LMAN1 lectin, mannose-binding, 1 0.016354
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0163506
OGA O-GlcNAcase 0.01625
TMOD3 tropomodulin 3 (ubiquitous) 0.016244
RREB1 ras responsive element binding protein 1 0.0161819
CKAP5 cytoskeleton associated protein 5 0.0161329
PPARD peroxisome proliferator-activated receptor delta 0.0161264
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0160887
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.0160328

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.137347
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.11234
RAD51B RAD51 paralog B -0.0836376
EGR1 early growth response 1 -0.0830201
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0818147
ACTG1 actin gamma 1 -0.0734731
HMGA2 high mobility group AT-hook 2 -0.0723252
RPS6 ribosomal protein S6 -0.0638758
TMSB10 thymosin beta 10 -0.0616106
VCL vinculin -0.0593977
RPLP1 ribosomal protein, large, P1 -0.0563807
LAMA4 laminin, alpha 4 -0.0545491
EGFR epidermal growth factor receptor -0.0545152
RPL35A ribosomal protein L35a -0.0512987
RPS24 ribosomal protein S24 -0.0508361
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0501823
RPS8 ribosomal protein S8 -0.0491914
LOC102724023 ES1 protein homolog, mitochondrial -0.0483485
FHIT fragile histidine triad -0.0477739
RCOR1 REST corepressor 1 -0.047668
RPS19 ribosomal protein S19 -0.0473493
RPL23 ribosomal protein L23 -0.0468289
CD36 CD36 molecule (thrombospondin receptor) -0.0459031
GPHN gephyrin -0.0449731
PHF14 PHD finger protein 14 -0.0427724
ATXN1 ataxin 1 -0.04063
RPS4X ribosomal protein S4, X-linked -0.0403879
TPT1 tumor protein, translationally-controlled 1 -0.0388967
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0386298
RPLP2 ribosomal protein, large, P2 -0.0379142
RPLP0 ribosomal protein, large, P0 -0.0369215
EEF1G eukaryotic translation elongation factor 1 gamma -0.0363676
RPL12 ribosomal protein L12 -0.035901
FHL2 four and a half LIM domains 2 -0.0355341
RPL34 ribosomal protein L34 -0.0352859
PTMA prothymosin, alpha -0.0349185
ACTN4 actinin, alpha 4 -0.0340145
S100A10 S100 calcium binding protein A10 -0.0332843
RPS29 ribosomal protein S29 -0.0319052
RPL19 ribosomal protein L19 -0.0317143
TNS3 tensin 3 -0.031348
EXOC4 exocyst complex component 4 -0.0312186
CCSER1 coiled-coil serine-rich protein 1 -0.0309764
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0308945
RPS21 ribosomal protein S21 -0.0303827
RPL11 ribosomal protein L11 -0.0302066
RPL9 ribosomal protein L9 -0.0299432
RPS23 ribosomal protein S23 -0.0294963
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0287586
BMP4 bone morphogenetic protein 4 -0.0285232
RPS14 ribosomal protein S14 -0.027106
FAF1 Fas (TNFRSF6) associated factor 1 -0.0266676
CUX1 cut-like homeobox 1 -0.0265884
EHBP1 EH domain binding protein 1 -0.0258922
RPS15 ribosomal protein S15 -0.0256592
S100A6 S100 calcium binding protein A6 -0.0252078
ITPKC inositol-trisphosphate 3-kinase C -0.0250937
LAMB3 laminin, beta 3 -0.024298
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.024193
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0241588
RPL13A ribosomal protein L13a -0.024158
RAB10 RAB10, member RAS oncogene family -0.0233472
PERP PERP, TP53 apoptosis effector -0.02325
RPL8 ribosomal protein L8 -0.0229926
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0226075
PATJ PATJ crumbs cell polarity complex component -0.0225664
BPTF bromodomain PHD finger transcription factor -0.022551
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0224895
RPS12 ribosomal protein S12 -0.0222864
RPL32 ribosomal protein L32 -0.0221137
RPS13 ribosomal protein S13 -0.0220145
NCEH1 neutral cholesterol ester hydrolase 1 -0.0217311
MTAP methylthioadenosine phosphorylase -0.0216588
RPL36 ribosomal protein L36 -0.0215374
RPL31 ribosomal protein L31 -0.0210672
HMGA1 high mobility group AT-hook 1 -0.0206141
RPL27 ribosomal protein L27 -0.0205819
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0205607
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0205488
RPL37 ribosomal protein L37 -0.0205055
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.020334
MBNL1 muscleblind-like splicing regulator 1 -0.0201973
DOCK5 dedicator of cytokinesis 5 -0.0201327
RPS5 ribosomal protein S5 -0.0199767
ANKRD17 ankyrin repeat domain 17 -0.0198042
BCL2L1 BCL2-like 1 -0.0197284
ABR active BCR-related -0.019505
FRMD8 FERM domain containing 8 -0.019474
RPS17 ribosomal protein S17 -0.0193987
RPL28 ribosomal protein L28 -0.0189957
NFIA nuclear factor I/A -0.0185498
FER fer (fps/fes related) tyrosine kinase -0.0182481
TENM3 teneurin transmembrane protein 3 -0.0181552
RPL5 ribosomal protein L5 -0.0181373
BICD1 bicaudal D homolog 1 (Drosophila) -0.0180339
CDK13 cyclin-dependent kinase 13 -0.0179748
PKP4 plakophilin 4 -0.0177667
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0177367
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0177203
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.017677