Methyl aminolevulinate (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methyl aminolevulinate (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methyl aminolevulinate (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ETNK1 ethanolamine kinase 1 0.0672145
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0490259
EEF2 eukaryotic translation elongation factor 2 0.042923
DIAPH3 diaphanous-related formin 3 0.0409606
CD46 CD46 molecule, complement regulatory protein 0.0405586
ESYT2 extended synaptotagmin-like protein 2 0.0367498
UBA6 ubiquitin-like modifier activating enzyme 6 0.0356708
RICTOR RPTOR independent companion of MTOR, complex 2 0.0349079
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0343948
ABHD2 abhydrolase domain containing 2 0.0339499
BCL2L1 BCL2-like 1 0.033556
OGA O-GlcNAcase 0.0331886
PDE8A phosphodiesterase 8A 0.0330127
SPRED2 sprouty-related, EVH1 domain containing 2 0.0318359
SNX9 sorting nexin 9 0.0317389
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0313693
BRWD3 bromodomain and WD repeat domain containing 3 0.0307783
ZNF292 zinc finger protein 292 0.0306011
PTEN phosphatase and tensin homolog 0.0305343
TXNIP thioredoxin interacting protein 0.0301401
BIRC6 baculoviral IAP repeat containing 6 0.029715
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0296223
SCAF11 SR-related CTD-associated factor 11 0.0294452
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0294341
AFDN afadin, adherens junction formation factor 0.0289754
VMP1 vacuole membrane protein 1 0.0289642
SETD5 SET domain containing 5 0.0281541
SBF2 SET binding factor 2 0.0278429
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0276585
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0275859
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0272993
NUP58 nucleoporin 58 0.0272548
COG5 component of oligomeric golgi complex 5 0.0272159
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0270159
USP9X ubiquitin specific peptidase 9, X-linked 0.0269332
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0265538
USP3 ubiquitin specific peptidase 3 0.0262157
NKTR natural killer cell triggering receptor 0.0261053
KDM6A lysine (K)-specific demethylase 6A 0.0259791
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0257527
AVL9 AVL9 homolog (S. cerevisiase) 0.0257134
ADAM17 ADAM metallopeptidase domain 17 0.0255019
GOLGA4 golgin A4 0.025396
WDFY2 WD repeat and FYVE domain containing 2 0.0251731
MARCHF6 membrane associated ring-CH-type finger 6 0.0249191
USP34 ubiquitin specific peptidase 34 0.0245893
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0238913
KMT2C lysine (K)-specific methyltransferase 2C 0.0231437
ARGLU1 arginine and glutamate rich 1 0.0231125
MYH9 myosin, heavy chain 9, non-muscle 0.0230902
CEMIP2 cell migration inducing hyaluronidase 2 0.0229947
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0228936
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0228119
PROX1 prospero homeobox 1 0.0227819
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0227532
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0225946
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0224971
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0224071
RB1CC1 RB1-inducible coiled-coil 1 0.0223293
TMEM41B transmembrane protein 41B 0.0220975
ADAM9 ADAM metallopeptidase domain 9 0.0219175
NCKAP1 NCK-associated protein 1 0.0218468
CEP95 centrosomal protein 95kDa 0.0216236
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0214353
ZDHHC20 zinc finger, DHHC-type containing 20 0.0214159
MSN moesin 0.0213512
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0212729
CKAP5 cytoskeleton associated protein 5 0.0211675
VGLL4 vestigial-like family member 4 0.021003
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0209236
GLG1 golgi glycoprotein 1 0.0206592
ZFAND3 zinc finger, AN1-type domain 3 0.0206375
AOPEP aminopeptidase O (putative) 0.0206042
YEATS2 YEATS domain containing 2 0.0204321
ITGA6 integrin, alpha 6 0.0203621
OXR1 oxidation resistance 1 0.020339
MIS18BP1 MIS18 binding protein 1 0.0202621
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0202526
XPO1 exportin 1 0.0201708
RNF43 ring finger protein 43 0.0200636
CARD16 caspase recruitment domain family, member 16 0.0200185
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0198214
RTN4 reticulon 4 0.0195231
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 0.0194585
RAB6A RAB6A, member RAS oncogene family 0.0193253
FAR1 fatty acyl CoA reductase 1 0.0192814
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0192052
PNN pinin, desmosome associated protein 0.0191848
PHIP pleckstrin homology domain interacting protein 0.0190827
FOXJ3 forkhead box J3 0.0189653
CUL3 cullin 3 0.0186863
WAC WW domain containing adaptor with coiled-coil 0.0186264
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0186222
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.018622
NEK7 NIMA-related kinase 7 0.0185959
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0185014
HELZ helicase with zinc finger 0.018475
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0184427
SREBF2 sterol regulatory element binding transcription factor 2 0.0184228
SP3 Sp3 transcription factor 0.018385

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.1606
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.152806
PTMA prothymosin, alpha -0.123429
TPT1 tumor protein, translationally-controlled 1 -0.115741
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0917746
NAV2 neuron navigator 2 -0.088629
INTS6 integrator complex subunit 6 -0.0878144
EZR ezrin -0.0855377
TMSB10 thymosin beta 10 -0.0847731
CCND1 cyclin D1 -0.0833281
RPL35A ribosomal protein L35a -0.0808251
VCL vinculin -0.078741
CDH13 cadherin 13 -0.0777987
SDK1 sidekick cell adhesion molecule 1 -0.0768596
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0757923
RPS6 ribosomal protein S6 -0.0704429
ACTG1 actin gamma 1 -0.0671769
RPL23 ribosomal protein L23 -0.0599095
RPS8 ribosomal protein S8 -0.0587493
RPS24 ribosomal protein S24 -0.0542314
ASPH aspartate beta-hydroxylase -0.0532934
MRPS6 mitochondrial ribosomal protein S6 -0.0514942
NKD1 naked cuticle homolog 1 (Drosophila) -0.0506478
RPLP1 ribosomal protein, large, P1 -0.0504152
ANXA2 annexin A2 -0.0489042
ADGRL2 adhesion G protein-coupled receptor L2 -0.0486847
VIM vimentin -0.0486395
LDHA lactate dehydrogenase A -0.0485868
EMP1 epithelial membrane protein 1 -0.0468102
ANO1 anoctamin 1, calcium activated chloride channel -0.0465527
SLC38A2 solute carrier family 38, member 2 -0.0455388
SKAP1 src kinase associated phosphoprotein 1 -0.045039
KRT18 keratin 18, type I -0.0444359
RPS12 ribosomal protein S12 -0.0444249
SQSTM1 sequestosome 1 -0.0442105
RPL26 ribosomal protein L26 -0.0439252
S100A10 S100 calcium binding protein A10 -0.0433397
RAD51B RAD51 paralog B -0.043054
WWOX WW domain containing oxidoreductase -0.0413863
CDK6 cyclin-dependent kinase 6 -0.0412415
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0406507
PDE4D phosphodiesterase 4D, cAMP-specific -0.0390507
RPL12 ribosomal protein L12 -0.0382007
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0375412
AHNAK AHNAK nucleoprotein -0.0374461
ZBTB20 zinc finger and BTB domain containing 20 -0.0366617
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.035749
LOC102724023 ES1 protein homolog, mitochondrial -0.0357433
RPL37A ribosomal protein L37a -0.0357337
RPS19 ribosomal protein S19 -0.035415
BACE2 beta-site APP-cleaving enzyme 2 -0.0353262
EXOC4 exocyst complex component 4 -0.0350904
RPL19 ribosomal protein L19 -0.0349094
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0347462
RPS27A ribosomal protein S27a -0.0343488
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0333599
MAML2 mastermind-like 2 (Drosophila) -0.0332786
RPL34 ribosomal protein L34 -0.0332316
RPL9 ribosomal protein L9 -0.032811
MT2A metallothionein 2A -0.0327707
RPS25 ribosomal protein S25 -0.0326392
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0321343
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.03188
LMNA lamin A/C -0.0318722
RPL31 ribosomal protein L31 -0.0315056
LRMDA leucine rich melanocyte differentiation associated -0.0305717
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0302056
UBAP2 ubiquitin associated protein 2 -0.030158
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0294774
FRMD5 FERM domain containing 5 -0.0294497
KRT8 keratin 8, type II -0.0293075
FTL ferritin, light polypeptide -0.0293052
RPL38 ribosomal protein L38 -0.0291329
CUX1 cut-like homeobox 1 -0.0287957
SERINC5 serine incorporator 5 -0.0287871
GMDS GDP-mannose 4,6-dehydratase -0.0287496
TPM4 tropomyosin 4 -0.0282596
RPS23 ribosomal protein S23 -0.0280612
MYOF myoferlin -0.0277876
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0277832
FHIT fragile histidine triad -0.0277426
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0276091
RPL11 ribosomal protein L11 -0.0275064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0275001
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0272578
RPL36A ribosomal protein L36a -0.0272468
NPAS2 neuronal PAS domain protein 2 -0.0271461
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.02684
HMGB1 high mobility group box 1 -0.026832
RACK1 receptor for activated C kinase 1 -0.0261293
SPDYA speedy/RINGO cell cycle regulator family member A -0.0260077
TAS2R14 taste receptor, type 2, member 14 -0.0259978
EGR1 early growth response 1 -0.0259522
NAP1L1 nucleosome assembly protein 1-like 1 -0.0258784
MSI2 musashi RNA-binding protein 2 -0.0258329
RPS3 ribosomal protein S3 -0.0256941
RPLP2 ribosomal protein, large, P2 -0.0256641
RPL5 ribosomal protein L5 -0.0250029
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 -0.0250006
RPL27A ribosomal protein L27a -0.0249875