| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5361918 |
| Similar Terms | |
| Downloads & Tools |
197 proteins with high or low expression in Methylnaltrexone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C11ORF95 | chromosome 11 open reading frame 95 | 1.09 |
| PKM | pyruvate kinase, muscle | 0.81 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.78 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.76 |
| DENND5A | DENN/MADD domain containing 5A | 0.66 |
| PALB2 | partner and localizer of BRCA2 | 0.65 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | 0.61 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.57 |
| COMMD2 | COMM domain containing 2 | 0.55 |
| RAD52 | RAD52 homolog (S. cerevisiae) | 0.53 |
| SH3D19 | SH3 domain containing 19 | 0.52 |
| RMI2 | RecQ mediated genome instability 2 | 0.52 |
| SDR16C5 | short chain dehydrogenase/reductase family 16C, member 5 | 0.5 |
| SLC2A4RG | SLC2A4 regulator | 0.5 |
| ACTBL2 | actin, beta-like 2 | 0.48 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.48 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.47 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.47 |
| HMGB2 | high mobility group box 2 | 0.47 |
| B2M | beta-2-microglobulin | 0.45 |
| NIPSNAP1 | nipsnap homolog 1 (C. elegans) | 0.42 |
| CLIC3 | chloride intracellular channel 3 | 0.42 |
| MED22 | mediator complex subunit 22 | 0.41 |
| LYST | lysosomal trafficking regulator | 0.41 |
| PIP | prolactin-induced protein | 0.41 |
| STMN2 | stathmin 2 | 0.4 |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.4 |
| ZNF296 | zinc finger protein 296 | 0.4 |
| DNAH1 | dynein, axonemal, heavy chain 1 | 0.39 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.39 |
| PRPF19 | pre-mRNA processing factor 19 | 0.39 |
| CST6 | cystatin E/M | 0.39 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.39 |
| AMZ2 | archaelysin family metallopeptidase 2 | 0.38 |
| GPR161 | G protein-coupled receptor 161 | 0.38 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.37 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 0.37 |
| HGH1 | HGH1 homolog (S. cerevisiae) | 0.37 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.37 |
| CDC26 | cell division cycle 26 | 0.37 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.36 |
| ATXN7L2 | ataxin 7-like 2 | 0.36 |
| SYN2 | synapsin II | 0.36 |
| RNF126 | ring finger protein 126 | 0.36 |
| PDE4DIP | phosphodiesterase 4D interacting protein | 0.35 |
| S100A4 | S100 calcium binding protein A4 | 0.35 |
| ZNF34 | zinc finger protein 34 | 0.35 |
| YBEY | ybeY metallopeptidase (putative) | 0.35 |
| TMEM104 | transmembrane protein 104 | 0.34 |
| CLTA | clathrin, light chain A | 0.34 |
| PAQR7 | progestin and adipoQ receptor family member VII | 0.34 |
| KSR2 | kinase suppressor of ras 2 | 0.34 |
| ZNF658 | zinc finger protein 658 | 0.34 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.34 |
| PAFAH1B2 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) | 0.34 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.33 |
| TMOD1 | tropomodulin 1 | 0.33 |
| OVCA2 | ovarian tumor suppressor candidate 2 | 0.33 |
| NCOA1 | nuclear receptor coactivator 1 | 0.33 |
| YBX3 | Y box binding protein 3 | 0.32 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.32 |
| PSME1 | proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) | 0.32 |
| VASN | vasorin | 0.32 |
| FZD1 | frizzled class receptor 1 | 0.31 |
| NDUFS6 | NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) | 0.31 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.31 |
| S100A14 | S100 calcium binding protein A14 | 0.31 |
| HYPK | huntingtin interacting protein K | 0.31 |
| FRMPD3 | FERM and PDZ domain containing 3 | 0.31 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.31 |
| XTBD1 | XRN2 binding domain containing 1 | 0.31 |
| SNX13 | sorting nexin 13 | 0.31 |
| C19ORF25 | chromosome 19 open reading frame 25 | 0.31 |
| MOB3A | MOB kinase activator 3A | 0.3 |
| TRIB3 | tribbles pseudokinase 3 | 0.3 |
| FKBP14 | FK506 binding protein 14, 22 kDa | 0.3 |
| AHI1 | Abelson helper integration site 1 | 0.3 |
| ZNF276 | zinc finger protein 276 | 0.3 |
| YTHDC1 | YTH domain containing 1 | 0.3 |
| KIAA1958 | KIAA1958 | 0.3 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.3 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.3 |
| MIF | macrophage migration inhibitory factor (glycosylation-inhibiting factor) | 0.3 |
| SHANK3 | SH3 and multiple ankyrin repeat domains 3 | 0.29 |
| GLRX5 | glutaredoxin 5 | 0.29 |
| TANK | TRAF family member-associated NFKB activator | 0.29 |
| LGALSL | lectin, galactoside-binding-like | 0.29 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.29 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.29 |
| VAMP8 | vesicle-associated membrane protein 8 | 0.29 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.29 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.29 |
| COL1A1 | collagen, type I, alpha 1 | 0.29 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | 0.28 |
| CNTN1 | contactin 1 | 0.28 |
| DCDC1 | doublecortin domain containing 1 | 0.28 |
| MAP3K12 | mitogen-activated protein kinase kinase kinase 12 | 0.28 |
| CHCHD6 | coiled-coil-helix-coiled-coil-helix domain containing 6 | 0.28 |
| ARHGAP22 | Rho GTPase activating protein 22 | 0.28 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IL17RB | interleukin 17 receptor B | -0.91 |
| PJA1 | praja ring finger 1, E3 ubiquitin protein ligase | -0.73 |
| SELENOF | selenoprotein F | -0.73 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.7 |
| EHF | ets homologous factor | -0.69 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | -0.68 |
| PHF1 | PHD finger protein 1 | -0.66 |
| LACC1 | laccase (multicopper oxidoreductase) domain containing 1 | -0.61 |
| TC2N | tandem C2 domains, nuclear | -0.58 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.56 |
| ALDH1L1 | aldehyde dehydrogenase 1 family, member L1 | -0.54 |
| BHLHA15 | basic helix-loop-helix family, member a15 | -0.53 |
| ANKRD36 | ankyrin repeat domain 36 | -0.47 |
| CLASP1 | cytoplasmic linker associated protein 1 | -0.45 |
| ZNF3 | zinc finger protein 3 | -0.45 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | -0.44 |
| NDST2 | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 | -0.42 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.42 |
| NPTXR | neuronal pentraxin receptor | -0.42 |
| DENND4A | DENN/MADD domain containing 4A | -0.41 |
| ZNF624 | zinc finger protein 624 | -0.41 |
| CRYBG2 | crystallin beta-gamma domain containing 2 | -0.41 |
| SUCO | SUN domain containing ossification factor | -0.4 |
| ZNF430 | zinc finger protein 430 | -0.39 |
| DOLK | dolichol kinase | -0.38 |
| KALRN | kalirin, RhoGEF kinase | -0.37 |
| ZG16B | zymogen granule protein 16B | -0.37 |
| RGL2 | ral guanine nucleotide dissociation stimulator-like 2 | -0.37 |
| SNX11 | sorting nexin 11 | -0.36 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | -0.36 |
| NAPEPLD | N-acyl phosphatidylethanolamine phospholipase D | -0.36 |
| MSH5 | mutS homolog 5 | -0.36 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.36 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.36 |
| SH3BP5L | SH3-binding domain protein 5-like | -0.35 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.35 |
| CDON | cell adhesion associated, oncogene regulated | -0.33 |
| SCAMP4 | secretory carrier membrane protein 4 | -0.33 |
| FBXW8 | F-box and WD repeat domain containing 8 | -0.33 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.32 |
| WNK2 | WNK lysine deficient protein kinase 2 | -0.32 |
| RAB28 | RAB28, member RAS oncogene family | -0.32 |
| PRSS23 | protease, serine, 23 | -0.32 |
| KLK7 | kallikrein-related peptidase 7 | -0.32 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.32 |
| PYGM | phosphorylase, glycogen, muscle | -0.31 |
| SPPL2A | signal peptide peptidase like 2A | -0.31 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.31 |
| KDELR3 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 | -0.3 |
| NOS3 | nitric oxide synthase 3 (endothelial cell) | -0.3 |
| TMEM106C | transmembrane protein 106C | -0.3 |
| ABHD14A | abhydrolase domain containing 14A | -0.3 |
| CBY1 | chibby homolog 1 (Drosophila) | -0.3 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.29 |
| SCAND1 | SCAN domain containing 1 | -0.29 |
| GK5 | glycerol kinase 5 (putative) | -0.29 |
| LATS2 | large tumor suppressor kinase 2 | -0.29 |
| PLGRKT | plasminogen receptor, C-terminal lysine transmembrane protein | -0.29 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.29 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | -0.29 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.29 |
| TPPP | tubulin polymerization promoting protein | -0.29 |
| FN1 | fibronectin 1 | -0.29 |
| TMC7 | transmembrane channel-like 7 | -0.29 |
| TMEM160 | transmembrane protein 160 | -0.29 |
| EFNB2 | ephrin-B2 | -0.28 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | -0.28 |
| ZNF580 | zinc finger protein 580 | -0.28 |
| USP27X | ubiquitin specific peptidase 27, X-linked | -0.28 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.27 |
| TRAF5 | TNF receptor-associated factor 5 | -0.27 |
| ZNF205 | zinc finger protein 205 | -0.27 |
| FGB | fibrinogen beta chain | -0.27 |
| RBAK | RB-associated KRAB zinc finger | -0.27 |
| GATA2 | GATA binding protein 2 | -0.27 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.27 |
| CTSL | cathepsin L | -0.26 |
| CENPP | centromere protein P | -0.26 |
| ARHGEF6 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 | -0.26 |
| FBXO46 | F-box protein 46 | -0.25 |
| FAT3 | FAT atypical cadherin 3 | -0.25 |
| HLA-F | major histocompatibility complex, class I, F | -0.25 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | -0.25 |
| LRATD2 | LRAT domain containing 2 | -0.25 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.25 |
| CC2D2A | coiled-coil and C2 domain containing 2A | -0.24 |
| RUSC2 | RUN and SH3 domain containing 2 | -0.24 |
| TIMM23B | translocase of inner mitochondrial membrane 23 homolog B (yeast) | -0.24 |
| DEAF1 | DEAF1 transcription factor | -0.24 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.24 |
| OTX1 | orthodenticle homeobox 1 | -0.24 |
| ARHGEF39 | Rho guanine nucleotide exchange factor (GEF) 39 | -0.24 |
| ZNF485 | zinc finger protein 485 | -0.24 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.24 |
| EMB | embigin | -0.23 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | -0.23 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | -0.23 |
| DMD | dystrophin | -0.23 |
