Methylprednisolone succinate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Methylprednisolone succinate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.120069
AKAP12 A kinase (PRKA) anchor protein 12 0.0841205
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0626348
PODXL podocalyxin-like 0.061889
THBS2 thrombospondin 2 0.0505628
COL8A1 collagen, type VIII, alpha 1 0.0465901
TRIO trio Rho guanine nucleotide exchange factor 0.0436232
DST dystonin 0.0421406
LOXL2 lysyl oxidase-like 2 0.0394099
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0393123
SEPTIN9 septin 9 0.0357191
NAV1 neuron navigator 1 0.0356407
PLAT plasminogen activator, tissue 0.0348042
VEGFC vascular endothelial growth factor C 0.033317
RSAD2 radical S-adenosyl methionine domain containing 2 0.0322477
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0322284
ZBTB20 zinc finger and BTB domain containing 20 0.028682
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0280015
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0271679
EFNA5 ephrin-A5 0.0270782
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0266586
SLC39A11 solute carrier family 39, member 11 0.0266152
SFTPA2 surfactant protein A2 0.0264267
FBN1 fibrillin 1 0.0264065
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0252096
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0248508
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0246617
MRPS6 mitochondrial ribosomal protein S6 0.0242335
ELL2 elongation factor, RNA polymerase II, 2 0.0240337
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0239896
DLG1 discs, large homolog 1 (Drosophila) 0.023951
PSD3 pleckstrin and Sec7 domain containing 3 0.0226868
AKAP9 A kinase (PRKA) anchor protein 9 0.0215976
GLIS3 GLIS family zinc finger 3 0.021132
RAD51B RAD51 paralog B 0.0211153
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0209944
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0206626
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0199346
SUCNR1 succinate receptor 1 0.019876
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.019681
AFDN afadin, adherens junction formation factor 0.0185505
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0184234
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0182307
AUTS2 autism susceptibility candidate 2 0.0176654
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0174067
GPC6 glypican 6 0.0173839
LINGO2 leucine rich repeat and Ig domain containing 2 0.0172839
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0171713
ZEB2 zinc finger E-box binding homeobox 2 0.0165494
N4BP1 NEDD4 binding protein 1 0.0160354
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0156676
WARS1 tryptophanyl-tRNA synthetase 1 0.0154807
EGFR epidermal growth factor receptor 0.0153503
GOLGA2 golgin A2 0.0152143
PRSS23 protease, serine, 23 0.0146891
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0145317
FRMD4A FERM domain containing 4A 0.0144239
SP3 Sp3 transcription factor 0.0143557
JAZF1 JAZF zinc finger 1 0.0142783
VEGFA vascular endothelial growth factor A 0.0142392
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0141911
NEK7 NIMA-related kinase 7 0.0140227
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.013882
ITCH itchy E3 ubiquitin protein ligase 0.0136899
EXOC6B exocyst complex component 6B 0.0134714
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0134376
EHBP1 EH domain binding protein 1 0.0133551
FRMD5 FERM domain containing 5 0.013296
CD109 CD109 molecule 0.0130866
CALD1 caldesmon 1 0.0130264
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.0129829
UBQLN1 ubiquilin 1 0.0129421
ANKRD36 ankyrin repeat domain 36 0.0125158
ESYT2 extended synaptotagmin-like protein 2 0.0124497
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0123995
SENP6 SUMO1/sentrin specific peptidase 6 0.0123148
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0122991
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0122715
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0122209
DNAAF9 dynein axonemal assembly factor 9 0.0121242
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 0.0121078
GRB10 growth factor receptor-bound protein 10 0.0119824
TNNT1 troponin T type 1 (skeletal, slow) 0.011961
ZBTB7C zinc finger and BTB domain containing 7C 0.0118254
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0118254
YEATS2 YEATS domain containing 2 0.0117478
BLTP1 bridge-like lipid transfer protein family member 1 0.0115762
L1CAM L1 cell adhesion molecule 0.0114766
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0114746
FN1 fibronectin 1 0.011452
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.011298
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0112793
TMEM39A transmembrane protein 39A 0.0112317
TDRD7 tudor domain containing 7 0.0111814
FLNB filamin B, beta 0.0110307
KIF13A kinesin family member 13A 0.0110007
BACE2 beta-site APP-cleaving enzyme 2 0.0109754
ANO6 anoctamin 6 0.0109214
CEP170 centrosomal protein 170kDa 0.0109039
KDM6A lysine (K)-specific demethylase 6A 0.010861

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.322308
UBC ubiquitin C -0.23249
VIM vimentin -0.224594
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.205994
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.166993
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.139476
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.109479
COL3A1 collagen, type III, alpha 1 -0.108845
AHNAK AHNAK nucleoprotein -0.108211
PTMA prothymosin, alpha -0.100508
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0922248
S100A10 S100 calcium binding protein A10 -0.0900796
CD44 CD44 molecule (Indian blood group) -0.0788477
S100A6 S100 calcium binding protein A6 -0.0761293
MT2A metallothionein 2A -0.0698939
POTEF POTE ankyrin domain family, member F -0.0652234
PKM pyruvate kinase, muscle -0.0639339
EEF2 eukaryotic translation elongation factor 2 -0.0622443
CALR calreticulin -0.0596297
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.059249
LMNA lamin A/C -0.0591102
RHOBTB3 Rho-related BTB domain containing 3 -0.0578982
RPS27A ribosomal protein S27a -0.0562734
LDHA lactate dehydrogenase A -0.0521863
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.051264
ENO1 enolase 1, (alpha) -0.0509488
TMSB4X thymosin beta 4, X-linked -0.0494551
SQSTM1 sequestosome 1 -0.0479057
NAP1L1 nucleosome assembly protein 1-like 1 -0.0470064
LOC112694756 uncharaterized LOC112694756 -0.0457693
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0447567
PDIA3 protein disulfide isomerase family A, member 3 -0.043418
PRRC2C proline-rich coiled-coil 2C -0.0428399
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0378792
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0371085
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0360863
PFN1 profilin 1 -0.0360768
RPL23 ribosomal protein L23 -0.0352171
JUN jun proto-oncogene -0.0345558
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0345152
EIF1 eukaryotic translation initiation factor 1 -0.0338277
RPS3 ribosomal protein S3 -0.033459
GARS1 glycyl-tRNA synthetase 1 -0.0328012
SRRM2 serine/arginine repetitive matrix 2 -0.0323159
APP amyloid beta (A4) precursor protein -0.0322845
ASPH aspartate beta-hydroxylase -0.0321079
TPT1 tumor protein, translationally-controlled 1 -0.0310291
CD99 CD99 molecule -0.0303321
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0297128
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0293098
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0292585
CSTB cystatin B (stefin B) -0.0291118
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0285299
TAGLN2 transgelin 2 -0.0280666
RPS24 ribosomal protein S24 -0.0275918
RPS19 ribosomal protein S19 -0.0274526
B2M beta-2-microglobulin -0.0272408
CERS2 ceramide synthase 2 -0.0271158
RPS8 ribosomal protein S8 -0.0270296
VMP1 vacuole membrane protein 1 -0.0267852
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0263106
PDIA4 protein disulfide isomerase family A, member 4 -0.0260541
OGA O-GlcNAcase -0.0257754
MT1X metallothionein 1X -0.0256628
PDIA6 protein disulfide isomerase family A, member 6 -0.0255155
RPLP1 ribosomal protein, large, P1 -0.0254405
SPDYA speedy/RINGO cell cycle regulator family member A -0.0253574
FTL ferritin, light polypeptide -0.0248449
HMGB2 high mobility group box 2 -0.0247989
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.024633
RPS5 ribosomal protein S5 -0.0245423
PCBP2 poly(rC) binding protein 2 -0.0244475
RACK1 receptor for activated C kinase 1 -0.0243728
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.024217
RPL28 ribosomal protein L28 -0.0241554
CALU calumenin -0.0241296
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0240992
ACTG1 actin gamma 1 -0.023667
RPS6 ribosomal protein S6 -0.0236199
CENPF centromere protein F, 350/400kDa -0.023229
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0231628
RPLP2 ribosomal protein, large, P2 -0.0230142
HDAC9 histone deacetylase 9 -0.0228436
SON SON DNA binding protein -0.0227998
SEPTIN7 septin 7 -0.0227197
SET SET nuclear proto-oncogene -0.0224474
TPM3 tropomyosin 3 -0.0219429
SP100 SP100 nuclear antigen -0.0217615
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0217277
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0217099
MYH9 myosin, heavy chain 9, non-muscle -0.0215755
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0215273
TAOK1 TAO kinase 1 -0.0214867
RRBP1 ribosome binding protein 1 -0.0211355
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0209364
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0208868
SEC61G Sec61 gamma subunit -0.0205622
FLNA filamin A, alpha -0.0205069
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0203766
CDK6 cyclin-dependent kinase 6 -0.0202045