Methylprednisolone succinate_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.0903568
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0714322
PDGFC platelet derived growth factor C 0.0632898
SMC4 structural maintenance of chromosomes 4 0.0578991
NLGN1 neuroligin 1 0.0569708
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0562513
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0524853
CELF2 CUGBP, Elav-like family member 2 0.0510121
PCDH7 protocadherin 7 0.0496315
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0484003
MKI67 marker of proliferation Ki-67 0.0456937
CENPF centromere protein F, 350/400kDa 0.0423803
ADGRG6 adhesion G protein-coupled receptor G6 0.0421967
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0418634
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0397901
TENM3 teneurin transmembrane protein 3 0.0395792
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0393412
SPATS2 spermatogenesis associated, serine-rich 2 0.0375309
BCHE butyrylcholinesterase 0.037471
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0372708
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0355687
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0346564
MGAT4C MGAT4 family, member C 0.0330778
KIF5B kinesin family member 5B 0.0327924
RASAL2 RAS protein activator like 2 0.0324987
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0321197
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0302118
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0289565
NEBL nebulette 0.028607
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0285189
ANXA1 annexin A1 0.0284734
ECT2 epithelial cell transforming 2 0.0283634
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.028165
RABGAP1L RAB GTPase activating protein 1-like 0.0278541
GCG glucagon 0.0277298
TBC1D5 TBC1 domain family, member 5 0.0275959
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0274504
ERBIN erbb2 interacting protein 0.0272304
PDE4D phosphodiesterase 4D, cAMP-specific 0.027007
ZBTB20 zinc finger and BTB domain containing 20 0.0269617
BIRC6 baculoviral IAP repeat containing 6 0.0269141
EDARADD EDAR-associated death domain 0.0264485
BIRC3 baculoviral IAP repeat containing 3 0.0261697
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0258203
TPR translocated promoter region, nuclear basket protein 0.024313
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0242567
LMO7 LIM domain 7 0.0237145
CCDC88A coiled-coil domain containing 88A 0.0235626
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0235396
ANKRD28 ankyrin repeat domain 28 0.0233477
NCAPD2 non-SMC condensin I complex, subunit D2 0.0229665
WNK1 WNK lysine deficient protein kinase 1 0.0228589
YEATS2 YEATS domain containing 2 0.0225468
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0221659
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.021819
RPL37A ribosomal protein L37a 0.0215425
RRM2 ribonucleotide reductase M2 0.020878
FNDC3B fibronectin type III domain containing 3B 0.0207714
NEK7 NIMA-related kinase 7 0.0207394
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0206792
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.020616
EHBP1 EH domain binding protein 1 0.020487
BIRC2 baculoviral IAP repeat containing 2 0.020306
CARD16 caspase recruitment domain family, member 16 0.0200307
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0198619
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0198242
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0197746
P3H2 prolyl 3-hydroxylase 2 0.0197246
ANKRD11 ankyrin repeat domain 11 0.0195006
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0194937
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0193702
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.019347
AIG1 androgen-induced 1 0.019256
CCSER1 coiled-coil serine-rich protein 1 0.0191885
ZNF804A zinc finger protein 804A 0.0191767
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0187621
NBAS neuroblastoma amplified sequence 0.0187259
COL5A2 collagen, type V, alpha 2 0.0187205
UTRN utrophin 0.0185767
WDR43 WD repeat domain 43 0.0185122
NSD2 nuclear receptor binding SET domain protein 2 0.0184058
CAND1 cullin-associated and neddylation-dissociated 1 0.0183622
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0182742
KIF11 kinesin family member 11 0.0176987
RIMKLB ribosomal modification protein rimK-like family member B 0.0175297
SFTPA2 surfactant protein A2 0.0174539
CMIP c-Maf inducing protein 0.0173756
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0173475
VDAC1 voltage-dependent anion channel 1 0.0173226
PTK2 protein tyrosine kinase 2 0.0173148
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0173084
RAD51B RAD51 paralog B 0.0172672
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0172345
MTAP methylthioadenosine phosphorylase 0.0171438
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0170662
MPG N-methylpurine-DNA glycosylase 0.0169566
NCKAP1 NCK-associated protein 1 0.0168897
ANKRD36 ankyrin repeat domain 36 0.0168033
EPHA6 EPH receptor A6 0.0168003
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0167825

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.229196
VIM vimentin -0.201732
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114318
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.108913
UBC ubiquitin C -0.0858756
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0655189
EEF2 eukaryotic translation elongation factor 2 -0.0564548
RPS27A ribosomal protein S27a -0.0554912
EGR1 early growth response 1 -0.0533158
AREG amphiregulin -0.0511982
RPL23 ribosomal protein L23 -0.0502999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0482565
EIF1 eukaryotic translation initiation factor 1 -0.0462259
RAB7A RAB7A, member RAS oncogene family -0.042265
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0405027
PFN1 profilin 1 -0.0403027
FTL ferritin, light polypeptide -0.0399797
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0381068
PCBP2 poly(rC) binding protein 2 -0.0357799
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0357632
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.035665
S100A6 S100 calcium binding protein A6 -0.0349218
ACTG1 actin gamma 1 -0.0348106
LOC102724023 ES1 protein homolog, mitochondrial -0.0342144
TXNRD1 thioredoxin reductase 1 -0.0326559
TMEM41B transmembrane protein 41B -0.032611
RPS19 ribosomal protein S19 -0.0298668
PTMS parathymosin -0.0295221
GARS1 glycyl-tRNA synthetase 1 -0.0286814
RPL8 ribosomal protein L8 -0.0276295
VMP1 vacuole membrane protein 1 -0.0257315
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0256315
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0252203
CNRIP1 cannabinoid receptor interacting protein 1 -0.024914
PDIA6 protein disulfide isomerase family A, member 6 -0.0248557
AHNAK AHNAK nucleoprotein -0.0240159
MYL12B myosin, light chain 12B, regulatory -0.0239211
HSPB1 heat shock 27kDa protein 1 -0.0232261
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0220911
RPLP2 ribosomal protein, large, P2 -0.0220379
RPL32 ribosomal protein L32 -0.0218908
CALR calreticulin -0.0218329
LOC112694756 uncharaterized LOC112694756 -0.0206262
DUSP6 dual specificity phosphatase 6 -0.0205414
RPS8 ribosomal protein S8 -0.0196418
PDIA4 protein disulfide isomerase family A, member 4 -0.0192039
DDIT3 DNA-damage-inducible transcript 3 -0.0190055
RPL19 ribosomal protein L19 -0.0186153
RPS4X ribosomal protein S4, X-linked -0.0185042
RPS23 ribosomal protein S23 -0.0179827
RPL28 ribosomal protein L28 -0.0178071
CBX3 chromobox homolog 3 -0.0168707
IPO7 importin 7 -0.0165607
RPS5 ribosomal protein S5 -0.0165441
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0165379
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0161776
NIPBL Nipped-B homolog (Drosophila) -0.0161408
RPLP1 ribosomal protein, large, P1 -0.0160979
RPL5 ribosomal protein L5 -0.015663
CCNI cyclin I -0.015551
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0154649
MATR3 matrin 3 -0.0153598
POTEF POTE ankyrin domain family, member F -0.0152707
RHOA ras homolog family member A -0.015172
SESN2 sestrin 2 -0.0148141
S100A10 S100 calcium binding protein A10 -0.0145042
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0144562
GPX4 glutathione peroxidase 4 -0.0144328
DSCAM Down syndrome cell adhesion molecule -0.0143738
RPL4 ribosomal protein L4 -0.0143674
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0142765
RPL18 ribosomal protein L18 -0.0142511
SYAP1 synapse associated protein 1 -0.0142436
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0141283
YBX1 Y box binding protein 1 -0.0138561
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0136939
NARS1 asparaginyl-tRNA synthetase 1 -0.0136926
NCOA1 nuclear receptor coactivator 1 -0.0132495
SLC38A1 solute carrier family 38, member 1 -0.0132347
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0130965
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0130755
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0128916
RBBP6 retinoblastoma binding protein 6 -0.0127036
RPL12 ribosomal protein L12 -0.0124711
NPR2 natriuretic peptide receptor 2 -0.0124544
SON SON DNA binding protein -0.0123937
SF3B6 splicing factor 3b, subunit 6, 14kDa -0.0122961
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0122774
ENO1 enolase 1, (alpha) -0.0121289
SPDYA speedy/RINGO cell cycle regulator family member A -0.0120558
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0119646
PTPN6 protein tyrosine phosphatase, non-receptor type 6 -0.0119557
RPS15 ribosomal protein S15 -0.011909
HTATSF1 HIV-1 Tat specific factor 1 -0.0118186
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0117984
PAX6 paired box 6 -0.0117967
RPS3 ribosomal protein S3 -0.0115225
RNF10 ring finger protein 10 -0.0114542
PRRC2C proline-rich coiled-coil 2C -0.0114322
RBM6 RNA binding motif protein 6 -0.0112349