Methylprednisolone succinate_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in A498 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Methylprednisolone succinate_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0352263
ICAM1 intercellular adhesion molecule 1 0.0325554
GPC6 glypican 6 0.0315033
TRIO trio Rho guanine nucleotide exchange factor 0.0288352
VCAM1 vascular cell adhesion molecule 1 0.0278556
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0265107
FAT1 FAT atypical cadherin 1 0.0253328
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0249441
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0245411
EXT1 exostosin glycosyltransferase 1 0.0243074
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0228632
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0204952
BIRC6 baculoviral IAP repeat containing 6 0.0204874
ANKRD33B ankyrin repeat domain 33B 0.0188738
SPAG9 sperm associated antigen 9 0.0188173
ANKRD10 ankyrin repeat domain 10 0.0187874
PDLIM5 PDZ and LIM domain 5 0.0177376
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0176679
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0176611
CLTC clathrin, heavy chain (Hc) 0.0171867
RLIM ring finger protein, LIM domain interacting 0.0170691
SUCO SUN domain containing ossification factor 0.016969
TTC3 tetratricopeptide repeat domain 3 0.0169592
CPAP centrosome assembly and centriole elongation protein 0.0161484
UBQLN1 ubiquilin 1 0.015426
SHB Src homology 2 domain containing adaptor protein B 0.0153359
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0151859
CADM1 cell adhesion molecule 1 0.0146898
RUNX2 runt-related transcription factor 2 0.0146612
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0146271
RAB18 RAB18, member RAS oncogene family 0.0141646
CTBP2 C-terminal binding protein 2 0.0141476
ATP13A3 ATPase type 13A3 0.0140876
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0136209
TUFT1 tuftelin 1 0.0133471
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0132631
TSC22D2 TSC22 domain family, member 2 0.0131848
WAC WW domain containing adaptor with coiled-coil 0.0131393
NAV2 neuron navigator 2 0.0131249
UBA6 ubiquitin-like modifier activating enzyme 6 0.0131204
PLEC plectin 0.0129644
PBX1 pre-B-cell leukemia homeobox 1 0.0128015
TMED2 transmembrane emp24 domain trafficking protein 2 0.0127707
SBF2 SET binding factor 2 0.0126904
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0125906
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0125677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.01226
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 0.0121925
TJP1 tight junction protein 1 0.0121778
SOD2 superoxide dismutase 2, mitochondrial 0.0119585
SCFD2 sec1 family domain containing 2 0.0116904
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0116264
ANXA5 annexin A5 0.011542
SND1 staphylococcal nuclease and tudor domain containing 1 0.0114581
CXCL2 chemokine (C-X-C motif) ligand 2 0.0114543
OTULIN OTU deubiquitinase with linear linkage specificity 0.0114447
ELOVL5 ELOVL fatty acid elongase 5 0.0113649
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0113557
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0112921
SNX13 sorting nexin 13 0.011258
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0111904
TENT2 terminal nucleotidyltransferase 2 0.0111827
ARHGAP26 Rho GTPase activating protein 26 0.0111255
TGFB2 transforming growth factor, beta 2 0.0109628
FAM91A1 family with sequence similarity 91, member A1 0.0107542
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0106303
RNF220 ring finger protein 220 0.0106209
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0105413
ZCCHC7 zinc finger, CCHC domain containing 7 0.0104697
TENT4A terminal nucleotidyltransferase 4A 0.0104689
RBM39 RNA binding motif protein 39 0.0104688
KMT2C lysine (K)-specific methyltransferase 2C 0.0104002
FBXO32 F-box protein 32 0.0102576
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0102479
CRY1 cryptochrome circadian clock 1 0.0102298
ARHGAP17 Rho GTPase activating protein 17 0.0101594
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0101105
PRRC1 proline-rich coiled-coil 1 0.00999877
BZW1 basic leucine zipper and W2 domains 1 0.00995464
HP1BP3 heterochromatin protein 1, binding protein 3 0.0099054
SEC31A SEC31 homolog A (S. cerevisiae) 0.00981016
NDEL1 nudE neurodevelopment protein 1-like 1 0.00979956
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.00978146
MON2 MON2 homolog (S. cerevisiae) 0.00976995
TCEA1 transcription elongation factor A (SII), 1 0.00966268
ZNF460 zinc finger protein 460 0.00963374
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.00961345
BHLHE40 basic helix-loop-helix family, member e40 0.0095975
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit 0.00949179
FNDC3B fibronectin type III domain containing 3B 0.00945244
FAR1 fatty acyl CoA reductase 1 0.00933641
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.00929269
TPST1 tyrosylprotein sulfotransferase 1 0.00927296
SEPTIN9 septin 9 0.00925515
ARRDC3 arrestin domain containing 3 0.00924689
TRA2B transformer 2 beta homolog (Drosophila) 0.00919288
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.00914561
ACO1 aconitase 1, soluble 0.00910384
USP36 ubiquitin specific peptidase 36 0.00906186
ERBIN erbb2 interacting protein 0.00905402

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.239505
ASPH aspartate beta-hydroxylase -0.22265
TMSB10 thymosin beta 10 -0.222422
FTL ferritin, light polypeptide -0.173801
IGFBP3 insulin-like growth factor binding protein 3 -0.152114
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128004
UBC ubiquitin C -0.110427
B2M beta-2-microglobulin -0.106727
RPS27A ribosomal protein S27a -0.0930715
POTEF POTE ankyrin domain family, member F -0.0900551
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0873612
CD44 CD44 molecule (Indian blood group) -0.0842909
HLA-B major histocompatibility complex, class I, B -0.0794113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0787837
RPL23 ribosomal protein L23 -0.0704536
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0701624
CA12 carbonic anhydrase XII -0.0695264
PTMA prothymosin, alpha -0.0664352
TXNRD1 thioredoxin reductase 1 -0.0622088
EEF2 eukaryotic translation elongation factor 2 -0.0610091
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0604097
RPS6 ribosomal protein S6 -0.0595895
JUN jun proto-oncogene -0.0570895
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0559495
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0553289
PFN1 profilin 1 -0.0530406
CALR calreticulin -0.0519205
RPS8 ribosomal protein S8 -0.0517292
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0514506
HSPB1 heat shock 27kDa protein 1 -0.0514281
PKM pyruvate kinase, muscle -0.0513596
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0511566
MT2A metallothionein 2A -0.0506869
EIF4A1 eukaryotic translation initiation factor 4A1 -0.048165
EIF1 eukaryotic translation initiation factor 1 -0.0470071
CP ceruloplasmin (ferroxidase) -0.0463582
PDIA3 protein disulfide isomerase family A, member 3 -0.0462258
RPS19 ribosomal protein S19 -0.0442139
CTSD cathepsin D -0.043998
CALU calumenin -0.0439237
TPT1 tumor protein, translationally-controlled 1 -0.0436006
RPLP1 ribosomal protein, large, P1 -0.0425119
RPL31 ribosomal protein L31 -0.0414083
S100A6 S100 calcium binding protein A6 -0.0409499
RPLP2 ribosomal protein, large, P2 -0.0407794
S100A10 S100 calcium binding protein A10 -0.0403292
LOC112694756 uncharaterized LOC112694756 -0.0400876
APOL1 apolipoprotein L, 1 -0.0399879
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0398722
RPL34 ribosomal protein L34 -0.0392167
RPL28 ribosomal protein L28 -0.0391279
RPS4X ribosomal protein S4, X-linked -0.0390814
NAP1L1 nucleosome assembly protein 1-like 1 -0.0384144
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0381795
PDIA6 protein disulfide isomerase family A, member 6 -0.0381639
RPS5 ribosomal protein S5 -0.0376211
RPL35A ribosomal protein L35a -0.0372182
NDRG1 N-myc downstream regulated 1 -0.0368078
PLIN2 perilipin 2 -0.0354653
RPL19 ribosomal protein L19 -0.0353081
ACTG1 actin gamma 1 -0.0349655
ENO1 enolase 1, (alpha) -0.0343917
PRRC2C proline-rich coiled-coil 2C -0.0340547
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0339177
RPL8 ribosomal protein L8 -0.033571
MGST1 microsomal glutathione S-transferase 1 -0.0316173
RPL37A ribosomal protein L37a -0.0315513
PDIA4 protein disulfide isomerase family A, member 4 -0.0312178
MAP1B microtubule-associated protein 1B -0.0309285
FTH1 ferritin, heavy polypeptide 1 -0.0307467
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0303918
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0293839
LITAF lipopolysaccharide-induced TNF factor -0.0292873
APP amyloid beta (A4) precursor protein -0.029267
CXXC1 CXXC finger protein 1 -0.0285859
TKT transketolase -0.0284822
CBX3 chromobox homolog 3 -0.0280013
RPS13 ribosomal protein S13 -0.0277843
LMNA lamin A/C -0.0275906
RPL36A ribosomal protein L36a -0.0272617
RPS24 ribosomal protein S24 -0.0270259
HLA-E major histocompatibility complex, class I, E -0.0269607
HLA-A major histocompatibility complex, class I, A -0.0267882
RTN4 reticulon 4 -0.0265837
RACK1 receptor for activated C kinase 1 -0.0265388
SPDYA speedy/RINGO cell cycle regulator family member A -0.0263659
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0262142
GNAS GNAS complex locus -0.026201
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.02603
CD63 CD63 molecule -0.0258496
IFITM3 interferon induced transmembrane protein 3 -0.025732
S100A11 S100 calcium binding protein A11 -0.025165
LDHA lactate dehydrogenase A -0.0250835
HLA-C major histocompatibility complex, class I, C -0.0249462
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0245343
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0243475
AHNAK AHNAK nucleoprotein -0.0242275
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0241935
TUBA1B tubulin, alpha 1b -0.0241819
SERF2 small EDRK-rich factor 2 -0.0237794