Methylprednisolone succinate_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.152622
ANXA2 annexin A2 0.141365
PDE4D phosphodiesterase 4D, cAMP-specific 0.133459
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.11442
FNDC3B fibronectin type III domain containing 3B 0.103236
SMAD3 SMAD family member 3 0.0921906
ARHGAP26 Rho GTPase activating protein 26 0.0907285
SPAG9 sperm associated antigen 9 0.089711
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0779053
FAM107B family with sequence similarity 107, member B 0.0741373
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0728847
GRB10 growth factor receptor-bound protein 10 0.0728296
FLNB filamin B, beta 0.0716374
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0693348
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0682275
EFNA5 ephrin-A5 0.066973
FMNL2 formin-like 2 0.0630845
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0621386
BIRC6 baculoviral IAP repeat containing 6 0.0595445
PDE10A phosphodiesterase 10A 0.057916
IQGAP1 IQ motif containing GTPase activating protein 1 0.0546293
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0532292
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0531686
TRIO trio Rho guanine nucleotide exchange factor 0.0530446
RICTOR RPTOR independent companion of MTOR, complex 2 0.0525361
SOD2 superoxide dismutase 2, mitochondrial 0.0499581
MYO1E myosin IE 0.0489741
HELZ helicase with zinc finger 0.0487671
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0484
AUTS2 autism susceptibility candidate 2 0.0470887
KCTD9 potassium channel tetramerization domain containing 9 0.0468086
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0464321
CANX calnexin 0.0464105
IGF1R insulin-like growth factor 1 receptor 0.0462496
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0455675
SBF2 SET binding factor 2 0.0454183
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0454092
DGKD diacylglycerol kinase, delta 130kDa 0.0451586
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0448734
ADAM17 ADAM metallopeptidase domain 17 0.0448355
OGA O-GlcNAcase 0.0439659
THSD4 thrombospondin, type I, domain containing 4 0.0432389
USP34 ubiquitin specific peptidase 34 0.042908
ASPH aspartate beta-hydroxylase 0.0428469
AHNAK AHNAK nucleoprotein 0.0419241
KYNU kynureninase 0.04183
NAV2 neuron navigator 2 0.0409631
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0403845
PTK2 protein tyrosine kinase 2 0.0399311
MCL1 myeloid cell leukemia 1 0.0397973
RNF213 ring finger protein 213 0.0395361
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0393445
RAB1A RAB1A, member RAS oncogene family 0.0390906
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0390852
KDM3A lysine (K)-specific demethylase 3A 0.0387632
TNIP1 TNFAIP3 interacting protein 1 0.0380499
PDE8A phosphodiesterase 8A 0.0380139
ANKRD11 ankyrin repeat domain 11 0.0379419
RB1CC1 RB1-inducible coiled-coil 1 0.0375777
ACTN4 actinin, alpha 4 0.0375247
PDLIM5 PDZ and LIM domain 5 0.037307
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0372297
GOLGA4 golgin A4 0.0371679
AKAP13 A kinase (PRKA) anchor protein 13 0.0366978
USP3 ubiquitin specific peptidase 3 0.0364716
WAC WW domain containing adaptor with coiled-coil 0.0364352
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0363022
VMP1 vacuole membrane protein 1 0.036094
ECT2 epithelial cell transforming 2 0.0355527
EXT1 exostosin glycosyltransferase 1 0.0355442
AKAP12 A kinase (PRKA) anchor protein 12 0.0354105
LDHA lactate dehydrogenase A 0.0344265
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0343367
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0335338
UBA6 ubiquitin-like modifier activating enzyme 6 0.0332992
NRIP1 nuclear receptor interacting protein 1 0.0332076
CMIP c-Maf inducing protein 0.0326672
NBAS neuroblastoma amplified sequence 0.0324734
MYH9 myosin, heavy chain 9, non-muscle 0.0318173
PCBP2 poly(rC) binding protein 2 0.0314774
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0314764
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0313617
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0310879
VCL vinculin 0.0310795
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0305736
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0304801
ELL2 elongation factor, RNA polymerase II, 2 0.0303464
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0302087
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0301115
PGK1 phosphoglycerate kinase 1 0.0300037
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0299523
ZSWIM6 zinc finger, SWIM-type containing 6 0.0298769
CA12 carbonic anhydrase XII 0.0298421
NAMPT nicotinamide phosphoribosyltransferase 0.0298416
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0297959
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0296305
CLTC clathrin, heavy chain (Hc) 0.0292085
RTN4 reticulon 4 0.0288984
TM4SF1 transmembrane 4 L six family member 1 0.0287422
MORF4L2 mortality factor 4 like 2 0.0286067

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0827744
RPS19 ribosomal protein S19 -0.0696005
FTH1 ferritin, heavy polypeptide 1 -0.063948
RPL37A ribosomal protein L37a -0.051596
VIM vimentin -0.050371
RPS6 ribosomal protein S6 -0.0415182
RPS12 ribosomal protein S12 -0.0407137
MT2A metallothionein 2A -0.04048
RPS3 ribosomal protein S3 -0.03687
RPS27A ribosomal protein S27a -0.0356601
RPL31 ribosomal protein L31 -0.0338272
RPL23 ribosomal protein L23 -0.0336244
EIF1 eukaryotic translation initiation factor 1 -0.0323202
RPS17 ribosomal protein S17 -0.0309738
RPLP1 ribosomal protein, large, P1 -0.0280946
FTL ferritin, light polypeptide -0.0277056
RPL35A ribosomal protein L35a -0.027271
RPLP2 ribosomal protein, large, P2 -0.02616
TPT1 tumor protein, translationally-controlled 1 -0.0260981
RPS24 ribosomal protein S24 -0.0251262
RPL7A ribosomal protein L7a -0.0230017
RPL26 ribosomal protein L26 -0.0225743
RPS16 ribosomal protein S16 -0.0221424
RPL36A ribosomal protein L36a -0.0220199
RPL38 ribosomal protein L38 -0.0217531
RPL28 ribosomal protein L28 -0.0215736
RPS14 ribosomal protein S14 -0.0213415
RPL12 ribosomal protein L12 -0.021049
RPS25 ribosomal protein S25 -0.0204626
RPL9 ribosomal protein L9 -0.0198195
RPL13A ribosomal protein L13a -0.0188792
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0187338
RPL4 ribosomal protein L4 -0.0182585
RPS29 ribosomal protein S29 -0.0177774
POTEF POTE ankyrin domain family, member F -0.016597
RACK1 receptor for activated C kinase 1 -0.0161849
RPS4X ribosomal protein S4, X-linked -0.0161347
PDCD5 programmed cell death 5 -0.0160889
RPS8 ribosomal protein S8 -0.0156607
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0156583
RPL36 ribosomal protein L36 -0.0155084
ATF4 activating transcription factor 4 -0.0151755
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0151027
NFE2L2 nuclear factor, erythroid 2-like 2 -0.01505
RPL27 ribosomal protein L27 -0.0147527
BHLHE40 basic helix-loop-helix family, member e40 -0.0145256
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0144545
RPL37 ribosomal protein L37 -0.0140415
B2M beta-2-microglobulin -0.013852
IGFBP1 insulin-like growth factor binding protein 1 -0.0136264
RPL5 ribosomal protein L5 -0.0117008
ENO2 enolase 2 (gamma, neuronal) -0.0113941
DSTN destrin (actin depolymerizing factor) -0.0112707
RPS10 ribosomal protein S10 -0.011221
HLA-B major histocompatibility complex, class I, B -0.0103632
RPS23 ribosomal protein S23 -0.00992948
RPL11 ribosomal protein L11 -0.00987038
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.00982232
UBB ubiquitin B -0.00964601
LOC102724023 ES1 protein homolog, mitochondrial -0.00953279
RPL36AL ribosomal protein L36a-like -0.00920503
RPL35 ribosomal protein L35 -0.00905533
RPS27L ribosomal protein S27-like -0.00903344
RPS27 ribosomal protein S27 -0.00902839
RSPO3 R-spondin 3 -0.00887616
PTMA prothymosin, alpha -0.0088279
EIF5B eukaryotic translation initiation factor 5B -0.00876979
RPL10A ribosomal protein L10a -0.00869887
TSC22D1 TSC22 domain family, member 1 -0.00857059
MCFD2 multiple coagulation factor deficiency 2 -0.00849293
CST3 cystatin C -0.008269
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.00823267
RPL23A ribosomal protein L23a -0.0080056
LAMA5 laminin, alpha 5 -0.00792535
RPL19 ribosomal protein L19 -0.00789641
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.00783563
RPS21 ribosomal protein S21 -0.00781649
IFI6 interferon, alpha-inducible protein 6 -0.00780143
RPL15 ribosomal protein L15 -0.00767187
S100A11 S100 calcium binding protein A11 -0.00760118
ANGPTL4 angiopoietin-like 4 -0.00747164
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.00730654
RPL18 ribosomal protein L18 -0.00719804
RPL34 ribosomal protein L34 -0.0071779
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.00714708
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.00706809
ISG15 ISG15 ubiquitin-like modifier -0.0070331
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00697769
ATP5MG ATP synthase membrane subunit g -0.00668839
RPS15 ribosomal protein S15 -0.00658103
C19ORF33 chromosome 19 open reading frame 33 -0.0065775
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.00652791
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.00648309
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.00648205
PRR13 proline rich 13 -0.00646779
LRRC75A leucine rich repeat containing 75A -0.00640285
ATP5MK ATP synthase membrane subunit k -0.00632757
NACA nascent polypeptide-associated complex alpha subunit -0.00626877
IER3 immediate early response 3 -0.00625484
RPS20 ribosomal protein S20 -0.00624602