Methylprednisolone succinate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NEBL nebulette 0.128325
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.118954
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.10984
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0889223
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0876762
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0774053
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0766873
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0692747
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0688763
TENM3 teneurin transmembrane protein 3 0.0658504
FMNL2 formin-like 2 0.0619996
KMT2C lysine (K)-specific methyltransferase 2C 0.060091
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0578641
SMYD3 SET and MYND domain containing 3 0.0576719
TTC28 tetratricopeptide repeat domain 28 0.0568329
PTK2 protein tyrosine kinase 2 0.0566958
NUP58 nucleoporin 58 0.0562745
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0555679
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0551941
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0545975
PCBP2 poly(rC) binding protein 2 0.0513496
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0506679
TRIO trio Rho guanine nucleotide exchange factor 0.0506499
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0503155
HELZ helicase with zinc finger 0.0501506
USP34 ubiquitin specific peptidase 34 0.0495718
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0494071
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0479589
PARD3 par-3 family cell polarity regulator 0.0468391
ATRN attractin 0.0461245
PIAS2 protein inhibitor of activated STAT, 2 0.045607
ZNF638 zinc finger protein 638 0.0449432
SLIT2 slit homolog 2 (Drosophila) 0.044177
ZNF292 zinc finger protein 292 0.043648
APLP2 amyloid beta (A4) precursor-like protein 2 0.0433872
KDM6A lysine (K)-specific demethylase 6A 0.0432731
YEATS2 YEATS domain containing 2 0.0429457
CHD7 chromodomain helicase DNA binding protein 7 0.042736
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0423848
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0422969
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0419877
BIRC6 baculoviral IAP repeat containing 6 0.0413837
P4HB prolyl 4-hydroxylase, beta polypeptide 0.041363
JARID2 jumonji, AT rich interactive domain 2 0.0411588
FAT1 FAT atypical cadherin 1 0.0402957
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0402118
NGLY1 N-glycanase 1 0.0400756
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0391599
AUTS2 autism susceptibility candidate 2 0.0385578
SRPK2 SRSF protein kinase 2 0.03851
CAMTA1 calmodulin binding transcription activator 1 0.037826
DST dystonin 0.0376089
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0368203
DENND1A DENN/MADD domain containing 1A 0.0365469
NFIA nuclear factor I/A 0.036375
PSPC1 paraspeckle component 1 0.0349714
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0345852
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0343041
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0339738
PTPRG protein tyrosine phosphatase, receptor type, G 0.0339723
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0337368
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0336067
ZMYM2 zinc finger, MYM-type 2 0.0335501
TENT4A terminal nucleotidyltransferase 4A 0.0334247
SEC31A SEC31 homolog A (S. cerevisiae) 0.0331296
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.033064
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.033009
ANKRD36 ankyrin repeat domain 36 0.0328947
SFPQ splicing factor proline/glutamine-rich 0.0327229
CABIN1 calcineurin binding protein 1 0.0325348
ZNF608 zinc finger protein 608 0.0321629
KDM2A lysine (K)-specific demethylase 2A 0.0320929
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0318298
NBAS neuroblastoma amplified sequence 0.0317795
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0314031
NCOR1 nuclear receptor corepressor 1 0.0312068
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0306547
WNK1 WNK lysine deficient protein kinase 1 0.030654
NCKAP1 NCK-associated protein 1 0.0306385
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0302556
RBM33 RNA binding motif protein 33 0.0298519
FOXO3 forkhead box O3 0.0298148
CEP192 centrosomal protein 192kDa 0.0297251
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0296475
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0295101
ARFGEF3 ARFGEF family member 3 0.0288683
CCNY cyclin Y 0.0288636
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0288162
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0279545
DEK DEK proto-oncogene 0.0279241
PCM1 pericentriolar material 1 0.0278295
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0277507
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0275872
MDN1 MDN1, midasin homolog (yeast) 0.0273109
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0271192
AKAP13 A kinase (PRKA) anchor protein 13 0.027085
BRWD1 bromodomain and WD repeat domain containing 1 0.0269225
MED13L mediator complex subunit 13-like 0.0268122
BMPR1A bone morphogenetic protein receptor, type IA 0.0267213

decreased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.101606
TMSB10 thymosin beta 10 -0.070769
ACTG1 actin gamma 1 -0.0575098
RPLP1 ribosomal protein, large, P1 -0.0523119
SOX4 SRY (sex determining region Y)-box 4 -0.0495571
RPS6 ribosomal protein S6 -0.0421134
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0410904
CADM2 cell adhesion molecule 2 -0.0390026
SHROOM3 shroom family member 3 -0.0387333
SOX2 SRY (sex determining region Y)-box 2 -0.0386234
STAT1 signal transducer and activator of transcription 1, 91kDa -0.038256
MCTP1 multiple C2 domains, transmembrane 1 -0.038174
EIF1 eukaryotic translation initiation factor 1 -0.0360159
HMGB1 high mobility group box 1 -0.0359819
RPS19 ribosomal protein S19 -0.0351404
RPS5 ribosomal protein S5 -0.035092
RPL34 ribosomal protein L34 -0.0340038
RIGI RNA sensor RIG-I -0.0340012
EGR1 early growth response 1 -0.0324437
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0314679
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0310228
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.030691
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0306318
TOX thymocyte selection-associated high mobility group box -0.0303784
RBBP6 retinoblastoma binding protein 6 -0.0303297
RPS28 ribosomal protein S28 -0.0294969
VDAC1 voltage-dependent anion channel 1 -0.0294184
RPL32 ribosomal protein L32 -0.0288254
RPL12 ribosomal protein L12 -0.0288102
EIF5B eukaryotic translation initiation factor 5B -0.0282581
RPS4X ribosomal protein S4, X-linked -0.0277151
RPL18 ribosomal protein L18 -0.0276361
LOC112694756 uncharaterized LOC112694756 -0.0271926
VCL vinculin -0.0267759
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.026195
RPL4 ribosomal protein L4 -0.0261186
RPS21 ribosomal protein S21 -0.0259958
RPL31 ribosomal protein L31 -0.0259782
IFI6 interferon, alpha-inducible protein 6 -0.0256992
B2M beta-2-microglobulin -0.0254907
RPS24 ribosomal protein S24 -0.0250115
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0241985
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0237064
RPS27A ribosomal protein S27a -0.0236584
RPL23 ribosomal protein L23 -0.0234391
RPL36A ribosomal protein L36a -0.0233565
RPL35A ribosomal protein L35a -0.0232347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0231491
PFN1 profilin 1 -0.0227301
RPS12 ribosomal protein S12 -0.0226781
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0214451
RPL19 ribosomal protein L19 -0.0213977
H1-0 H1.0 linker histone -0.0213832
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0213796
RACK1 receptor for activated C kinase 1 -0.0206377
ADGRG6 adhesion G protein-coupled receptor G6 -0.0204524
RPS8 ribosomal protein S8 -0.0203722
RPL10A ribosomal protein L10a -0.0203445
TMEM41B transmembrane protein 41B -0.0201939
RPLP0 ribosomal protein, large, P0 -0.0201065
AKAP6 A kinase (PRKA) anchor protein 6 -0.0199014
RPLP2 ribosomal protein, large, P2 -0.0195797
RPL36 ribosomal protein L36 -0.0192682
PTMA prothymosin, alpha -0.0190328
RPL38 ribosomal protein L38 -0.0185338
DNAH14 dynein, axonemal, heavy chain 14 -0.018464
RAB7A RAB7A, member RAS oncogene family -0.0183477
MYL12B myosin, light chain 12B, regulatory -0.0182856
ATF4 activating transcription factor 4 -0.0181713
RHOA ras homolog family member A -0.0180125
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0178045
RPL6 ribosomal protein L6 -0.0177365
FTL ferritin, light polypeptide -0.0174711
RPL8 ribosomal protein L8 -0.0174565
CBX3 chromobox homolog 3 -0.0171468
GRID2 glutamate receptor, ionotropic, delta 2 -0.0169923
BTG3 BTG family, member 3 -0.0167819
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0167374
RPS25 ribosomal protein S25 -0.01666
RPL7A ribosomal protein L7a -0.0164117
GCC2 GRIP and coiled-coil domain containing 2 -0.0160868
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0159616
MAP1B microtubule-associated protein 1B -0.0156125
ZNF33A zinc finger protein 33A -0.0155755
RPS16 ribosomal protein S16 -0.0154589
ARF1 ADP-ribosylation factor 1 -0.0154198
ATP5F1E ATP synthase F1 subunit epsilon -0.0149598
RPS14 ribosomal protein S14 -0.0148397
MAPK8 mitogen-activated protein kinase 8 -0.014799
SETX senataxin -0.0146801
CAVIN1 caveolae associated protein 1 -0.0146469
PCNX4 pecanex 4 -0.0146407
TUBB4B tubulin, beta 4B class IVb -0.0146202
NRG1 neuregulin 1 -0.0146029
RPL5 ribosomal protein L5 -0.014595
GARS1 glycyl-tRNA synthetase 1 -0.0145536
ZNFX1 zinc finger, NFX1-type containing 1 -0.0145221
BICD1 bicaudal D homolog 1 (Drosophila) -0.0144767
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0144601
TPT1 tumor protein, translationally-controlled 1 -0.014401