Methylprednisolone succinate_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.332449
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0690807
LEF1 lymphoid enhancer-binding factor 1 0.0504726
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0483881
CD109 CD109 molecule 0.0429044
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0428206
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0421535
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0414091
NAMPT nicotinamide phosphoribosyltransferase 0.0402166
TMEM178B transmembrane protein 178B 0.0391229
SPRED1 sprouty-related, EVH1 domain containing 1 0.0383322
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0365863
ICAM1 intercellular adhesion molecule 1 0.0363367
PRELID2 PRELI domain containing 2 0.035733
ESYT2 extended synaptotagmin-like protein 2 0.0351092
DST dystonin 0.0339931
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0335282
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0328629
OGA O-GlcNAcase 0.0328501
NAV2 neuron navigator 2 0.0327442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0327388
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0321416
A2M alpha-2-macroglobulin 0.0316273
ASPH aspartate beta-hydroxylase 0.031131
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290984
RBM33 RNA binding motif protein 33 0.028792
EXOC4 exocyst complex component 4 0.0284614
NBAS neuroblastoma amplified sequence 0.0281823
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0276045
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0274704
APP amyloid beta (A4) precursor protein 0.0252826
UBE2H ubiquitin-conjugating enzyme E2H 0.0252087
TPR translocated promoter region, nuclear basket protein 0.0252015
FBXO7 F-box protein 7 0.0247824
ANXA2 annexin A2 0.0244896
EPS8 epidermal growth factor receptor pathway substrate 8 0.0241741
SETBP1 SET binding protein 1 0.0239744
NUP58 nucleoporin 58 0.0231148
CDC73 cell division cycle 73 0.0227424
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0224443
IVNS1ABP influenza virus NS1A binding protein 0.0220579
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.021962
STRIP2 striatin interacting protein 2 0.021435
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0214021
TNNC1 troponin C type 1 (slow) 0.0210671
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0206936
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0197619
KMT2C lysine (K)-specific methyltransferase 2C 0.0196831
SRPK2 SRSF protein kinase 2 0.0195229
NEK7 NIMA-related kinase 7 0.0193519
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0189293
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0188663
MED13L mediator complex subunit 13-like 0.0187967
AFDN afadin, adherens junction formation factor 0.0182837
SAMD4A sterile alpha motif domain containing 4A 0.0181896
ANXA5 annexin A5 0.0181657
PPME1 protein phosphatase methylesterase 1 0.0181646
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0179637
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0176106
FMNL2 formin-like 2 0.0174941
PI15 peptidase inhibitor 15 0.0171028
YEATS2 YEATS domain containing 2 0.017019
IL1RAP interleukin 1 receptor accessory protein 0.0169219
EXOC6B exocyst complex component 6B 0.016617
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0165725
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0165552
ARRDC3 arrestin domain containing 3 0.016262
ZYX zyxin 0.0161428
TENT4A terminal nucleotidyltransferase 4A 0.016072
KDM3A lysine (K)-specific demethylase 3A 0.0160134
IL6ST interleukin 6 signal transducer 0.0158686
MACF1 microtubule-actin crosslinking factor 1 0.0156026
PCBP2 poly(rC) binding protein 2 0.0155673
ZC3H11A zinc finger CCCH-type containing 11A 0.0155554
MYH9 myosin, heavy chain 9, non-muscle 0.0155214
UBA6 ubiquitin-like modifier activating enzyme 6 0.0154666
SUCO SUN domain containing ossification factor 0.0154205
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0153809
SNX13 sorting nexin 13 0.0153063
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0149787
DICER1 dicer 1, ribonuclease type III 0.0147969
STOM stomatin 0.0147849
UHMK1 U2AF homology motif (UHM) kinase 1 0.0147735
ETV6 ets variant 6 0.0147384
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0145244
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0145138
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0144922
TENT5A terminal nucleotidyltransferase 5A 0.0144799
ZFAND3 zinc finger, AN1-type domain 3 0.0144057
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0142879
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0142171
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0141356
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0140782
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0139262
HMCN1 hemicentin 1 0.0139085
CHSY1 chondroitin sulfate synthase 1 0.0138717
MBNL1 muscleblind-like splicing regulator 1 0.0138263
PDE4D phosphodiesterase 4D, cAMP-specific 0.0137919
NHSL1 NHS-like 1 0.0137661
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.013664

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.193912
VIM vimentin -0.174422
IGFBP5 insulin-like growth factor binding protein 5 -0.144351
TMSB10 thymosin beta 10 -0.110597
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0977763
NLGN1 neuroligin 1 -0.0919439
HLA-B major histocompatibility complex, class I, B -0.074123
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0694772
S100A6 S100 calcium binding protein A6 -0.0636916
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0633803
ACTG1 actin gamma 1 -0.0594782
AKAP12 A kinase (PRKA) anchor protein 12 -0.0559443
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0541111
IGFBP3 insulin-like growth factor binding protein 3 -0.0530646
FRMD4A FERM domain containing 4A -0.0506416
GPC6 glypican 6 -0.048299
EGR1 early growth response 1 -0.0449667
FMN1 formin 1 -0.0433013
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.043203
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0406759
GDF15 growth differentiation factor 15 -0.0401888
CALD1 caldesmon 1 -0.0391983
PDIA3 protein disulfide isomerase family A, member 3 -0.0382961
HILPDA hypoxia inducible lipid droplet-associated -0.0382195
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0374832
FTL ferritin, light polypeptide -0.0368084
IER3 immediate early response 3 -0.0359245
LMNA lamin A/C -0.0353842
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0346999
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343847
RPLP1 ribosomal protein, large, P1 -0.0341397
PTMA prothymosin, alpha -0.0335015
RPS19 ribosomal protein S19 -0.03287
LOC102724023 ES1 protein homolog, mitochondrial -0.0320051
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0315858
S100A9 S100 calcium binding protein A9 -0.0312918
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0312701
CTSD cathepsin D -0.0312088
POTEF POTE ankyrin domain family, member F -0.030526
GNAS GNAS complex locus -0.0300249
MFSD12 major facilitator superfamily domain containing 12 -0.0281933
EHBP1 EH domain binding protein 1 -0.0275675
RPLP2 ribosomal protein, large, P2 -0.0273816
IFITM3 interferon induced transmembrane protein 3 -0.0271817
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0267515
CALU calumenin -0.0267335
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0266823
PTPRD protein tyrosine phosphatase, receptor type, D -0.0251715
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0251712
CALR calreticulin -0.0248517
TAGLN2 transgelin 2 -0.0245875
PLIN2 perilipin 2 -0.0244443
PDIA4 protein disulfide isomerase family A, member 4 -0.0240363
IFI6 interferon, alpha-inducible protein 6 -0.0237105
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0236427
TPI1 triosephosphate isomerase 1 -0.023545
PKM pyruvate kinase, muscle -0.023474
CUX1 cut-like homeobox 1 -0.0233451
RPL35A ribosomal protein L35a -0.0232737
COL19A1 collagen, type XIX, alpha 1 -0.0222914
RRBP1 ribosome binding protein 1 -0.0219057
BSG basigin (Ok blood group) -0.0218961
TPT1 tumor protein, translationally-controlled 1 -0.0216552
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0215337
RPL34 ribosomal protein L34 -0.0214704
ENO2 enolase 2 (gamma, neuronal) -0.0213987
DCT dopachrome tautomerase -0.0213286
NPAS2 neuronal PAS domain protein 2 -0.0212686
RPS6 ribosomal protein S6 -0.0209336
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.020738
PFN1 profilin 1 -0.0205372
NAV3 neuron navigator 3 -0.0203626
VGF VGF nerve growth factor inducible -0.0198895
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0197444
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0196998
PTCHD4 patched domain containing 4 -0.0194365
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0193297
RPS8 ribosomal protein S8 -0.0193183
ATF4 activating transcription factor 4 -0.0193157
RUNX1 runt-related transcription factor 1 -0.0192695
CTTNBP2 cortactin binding protein 2 -0.0192025
SCFD2 sec1 family domain containing 2 -0.0190693
RHEB Ras homolog enriched in brain -0.0190323
HSPB1 heat shock 27kDa protein 1 -0.0187813
RAB7A RAB7A, member RAS oncogene family -0.0186321
NPC1 Niemann-Pick disease, type C1 -0.0183817
RNF24 ring finger protein 24 -0.0183654
CD63 CD63 molecule -0.0182221
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0181663
S100A10 S100 calcium binding protein A10 -0.0181032
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0174171
RPL8 ribosomal protein L8 -0.0171792
INSIG1 insulin induced gene 1 -0.0170781
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.016904
B2M beta-2-microglobulin -0.0168837
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0166296
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0165291
FBXO11 F-box protein 11 -0.0164656
MYO1E myosin IE -0.0163212
HMGA2 high mobility group AT-hook 2 -0.0162698