Methylprednisolone succinate_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Methylprednisolone succinate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.198965
FAM13A family with sequence similarity 13, member A 0.0886973
NDRG1 N-myc downstream regulated 1 0.0867643
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0807882
NAMPT nicotinamide phosphoribosyltransferase 0.0769851
TSC22D2 TSC22 domain family, member 2 0.0675591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0587061
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0563886
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0501653
IGFBP3 insulin-like growth factor binding protein 3 0.0477992
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0469554
ESYT2 extended synaptotagmin-like protein 2 0.045824
SPAG9 sperm associated antigen 9 0.0456242
CCNY cyclin Y 0.0445967
PGK1 phosphoglycerate kinase 1 0.0436168
KMT2E lysine (K)-specific methyltransferase 2E 0.0418356
WSB1 WD repeat and SOCS box containing 1 0.0415678
RBM39 RNA binding motif protein 39 0.0410942
INSIG2 insulin induced gene 2 0.0409847
AKAP9 A kinase (PRKA) anchor protein 9 0.0407873
HOOK2 hook microtubule-tethering protein 2 0.0391242
ANXA2 annexin A2 0.0387578
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0380254
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0376384
SRP54 signal recognition particle 54kDa 0.0371673
RAB1A RAB1A, member RAS oncogene family 0.0367249
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0363666
OGA O-GlcNAcase 0.0361999
MEF2A myocyte enhancer factor 2A 0.0361104
RAB6A RAB6A, member RAS oncogene family 0.0359392
ELL2 elongation factor, RNA polymerase II, 2 0.0356911
F3 coagulation factor III (thromboplastin, tissue factor) 0.0346182
NPEPPS aminopeptidase puromycin sensitive 0.0341921
UBA6 ubiquitin-like modifier activating enzyme 6 0.0324677
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0319851
BZW1 basic leucine zipper and W2 domains 1 0.0318924
HELZ helicase with zinc finger 0.0311509
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0308592
SEC31A SEC31 homolog A (S. cerevisiae) 0.0308411
BIRC3 baculoviral IAP repeat containing 3 0.0307759
RIOK3 RIO kinase 3 0.0305183
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0301008
FLNB filamin B, beta 0.0299643
SMAD3 SMAD family member 3 0.0298079
GRB10 growth factor receptor-bound protein 10 0.0295763
BACE2 beta-site APP-cleaving enzyme 2 0.0292462
YTHDC1 YTH domain containing 1 0.0288807
KDM5B lysine (K)-specific demethylase 5B 0.0288529
MYO1B myosin IB 0.0287313
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0286412
ADAM9 ADAM metallopeptidase domain 9 0.0277355
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0275928
SFTPA2 surfactant protein A2 0.0270857
KRT19 keratin 19, type I 0.0269547
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0268661
TTC3 tetratricopeptide repeat domain 3 0.0268571
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0267719
SUCO SUN domain containing ossification factor 0.0265496
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0260092
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.025671
IRAK3 interleukin-1 receptor-associated kinase 3 0.0255231
SEC23A Sec23 homolog A (S. cerevisiae) 0.0251897
CCNL1 cyclin L1 0.0247104
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0242656
PPARD peroxisome proliferator-activated receptor delta 0.0240742
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.024065
COPA coatomer protein complex, subunit alpha 0.0240319
NUP58 nucleoporin 58 0.0238861
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0235053
TRA2A transformer 2 alpha homolog (Drosophila) 0.0231962
RAB8B RAB8B, member RAS oncogene family 0.0227753
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0227611
COLEC11 collectin sub-family member 11 0.0226025
FNDC3B fibronectin type III domain containing 3B 0.0221058
DAPK1 death-associated protein kinase 1 0.0220066
CANX calnexin 0.021843
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0218291
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0217176
KDM3A lysine (K)-specific demethylase 3A 0.0217085
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0214624
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0213765
ITCH itchy E3 ubiquitin protein ligase 0.021003
ANXA5 annexin A5 0.0203628
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0203045
MARCHF6 membrane associated ring-CH-type finger 6 0.0199077
VEGFA vascular endothelial growth factor A 0.0197641
RLIM ring finger protein, LIM domain interacting 0.0197594
SHROOM3 shroom family member 3 0.0196593
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0195922
CERT1 ceramide transporter 1 0.0195716
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0195113
CD47 CD47 molecule 0.0193474
ARRDC3 arrestin domain containing 3 0.0192819
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0191359
OPTN optineurin 0.019079
KMT2C lysine (K)-specific methyltransferase 2C 0.0189121
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0188777
TMED2 transmembrane emp24 domain trafficking protein 2 0.0188166
ANKRD11 ankyrin repeat domain 11 0.0187875
HPCAL1 hippocalcin-like 1 0.0187621

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.314769
UBC ubiquitin C -0.240595
MT2A metallothionein 2A -0.144144
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127403
ASPH aspartate beta-hydroxylase -0.12696
PTMA prothymosin, alpha -0.106352
RPL23 ribosomal protein L23 -0.0903651
MT1X metallothionein 1X -0.0861675
RPS27A ribosomal protein S27a -0.0794665
VIM vimentin -0.0781654
FTL ferritin, light polypeptide -0.0713314
EIF1 eukaryotic translation initiation factor 1 -0.0711265
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0675212
AHNAK AHNAK nucleoprotein -0.0662645
ENO1 enolase 1, (alpha) -0.0618337
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0609016
HLA-B major histocompatibility complex, class I, B -0.0602825
LOC112694756 uncharaterized LOC112694756 -0.059939
JUN jun proto-oncogene -0.0578403
S100A6 S100 calcium binding protein A6 -0.0564194
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0561592
RNF213 ring finger protein 213 -0.0542725
IFI27 interferon, alpha-inducible protein 27 -0.0542636
NRG3 neuregulin 3 -0.0542435
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0494297
C15ORF48 chromosome 15 open reading frame 48 -0.0476
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0466579
ACTG1 actin gamma 1 -0.0463357
RPLP1 ribosomal protein, large, P1 -0.0441861
TMSB4X thymosin beta 4, X-linked -0.0435542
RPL19 ribosomal protein L19 -0.0417495
ALCAM activated leukocyte cell adhesion molecule -0.0411777
RPS19 ribosomal protein S19 -0.0408614
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0404368
ISG15 ISG15 ubiquitin-like modifier -0.0396478
RPS3 ribosomal protein S3 -0.0394823
S100A10 S100 calcium binding protein A10 -0.039261
ARHGAP26 Rho GTPase activating protein 26 -0.0390659
B2M beta-2-microglobulin -0.0383128
PKM pyruvate kinase, muscle -0.0379924
POTEF POTE ankyrin domain family, member F -0.037946
PCDH7 protocadherin 7 -0.0378342
KRT8 keratin 8, type II -0.0359991
EEF2 eukaryotic translation elongation factor 2 -0.0350932
MX2 MX dynamin-like GTPase 2 -0.0347767
LAMC2 laminin, gamma 2 -0.034576
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0342588
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0327142
SLC38A1 solute carrier family 38, member 1 -0.0325291
PDE4D phosphodiesterase 4D, cAMP-specific -0.0320565
RPS8 ribosomal protein S8 -0.0318039
TXNIP thioredoxin interacting protein -0.0309187
SP100 SP100 nuclear antigen -0.0308698
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0306063
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0297308
RPL34 ribosomal protein L34 -0.0291907
ITGA6 integrin, alpha 6 -0.0286005
PDIA6 protein disulfide isomerase family A, member 6 -0.0283878
MX1 MX dynamin-like GTPase 1 -0.0280565
RPS21 ribosomal protein S21 -0.0280153
PDIA4 protein disulfide isomerase family A, member 4 -0.028015
PMP22 peripheral myelin protein 22 -0.0280023
AREG amphiregulin -0.0278557
EGR1 early growth response 1 -0.0271498
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0271348
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0267685
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0267181
NABP1 nucleic acid binding protein 1 -0.0264784
MMP7 matrix metallopeptidase 7 -0.0264256
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0262968
RPS24 ribosomal protein S24 -0.0262072
RPS14 ribosomal protein S14 -0.0262005
RASAL2 RAS protein activator like 2 -0.0261864
RAB10 RAB10, member RAS oncogene family -0.0258961
SVIL supervillin -0.0257458
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0255431
RPS29 ribosomal protein S29 -0.02532
DST dystonin -0.0250719
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0250665
ZBTB20 zinc finger and BTB domain containing 20 -0.0250068
EFNA5 ephrin-A5 -0.0247671
RPS6 ribosomal protein S6 -0.0247279
CATSPERB catsper channel auxiliary subunit beta -0.0243551
TPT1 tumor protein, translationally-controlled 1 -0.0243397
OSMR oncostatin M receptor -0.0241087
ACTN4 actinin, alpha 4 -0.0240905
RPS23 ribosomal protein S23 -0.0238312
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0238055
DOCK5 dedicator of cytokinesis 5 -0.0237892
RPL28 ribosomal protein L28 -0.0235416
PDIA3 protein disulfide isomerase family A, member 3 -0.0233837
RPS5 ribosomal protein S5 -0.0233599
PCBP2 poly(rC) binding protein 2 -0.0233322
RPS25 ribosomal protein S25 -0.0223414
PRKCA protein kinase C, alpha -0.0221018
RPLP2 ribosomal protein, large, P2 -0.0220869
LY6E lymphocyte antigen 6 complex, locus E -0.0220581
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0218926
SDC4 syndecan 4 -0.0217838
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0215973