Methylprednisolone succinate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.159955
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.130414
TBC1D22A TBC1 domain family, member 22A 0.0752693
RAD51B RAD51 paralog B 0.0727553
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0616738
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.049405
PRELID2 PRELI domain containing 2 0.0470674
DSCAM Down syndrome cell adhesion molecule 0.0466154
YEATS2 YEATS domain containing 2 0.0460578
CTNND1 catenin (cadherin-associated protein), delta 1 0.0454296
TENM3 teneurin transmembrane protein 3 0.044551
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0442933
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0437525
KDM7A lysine (K)-specific demethylase 7A 0.0428118
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0396414
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0395408
MED13L mediator complex subunit 13-like 0.0391499
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0388932
KIAA1217 KIAA1217 0.0377391
ANKRD11 ankyrin repeat domain 11 0.0368153
BIRC6 baculoviral IAP repeat containing 6 0.0366531
NDRG1 N-myc downstream regulated 1 0.0357281
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0353678
LPP LIM domain containing preferred translocation partner in lipoma 0.0342345
ATXN1 ataxin 1 0.0338857
ESYT2 extended synaptotagmin-like protein 2 0.0338235
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0328676
ERRFI1 ERBB receptor feedback inhibitor 1 0.0324609
MYH9 myosin, heavy chain 9, non-muscle 0.0320083
AKAP9 A kinase (PRKA) anchor protein 9 0.0316962
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0315624
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0311746
KDM4C lysine (K)-specific demethylase 4C 0.0303324
LMO7 LIM domain 7 0.0298102
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0290979
OGA O-GlcNAcase 0.0289715
PATJ PATJ crumbs cell polarity complex component 0.0289066
PLEC plectin 0.0286126
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0282961
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0280188
PGK1 phosphoglycerate kinase 1 0.027715
NUP58 nucleoporin 58 0.0276833
SNX9 sorting nexin 9 0.0276135
SPIDR scaffolding protein involved in DNA repair 0.0266776
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0266381
TRA2B transformer 2 beta homolog (Drosophila) 0.0264773
GOLGB1 golgin B1 0.0262721
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0261531
NCOR1 nuclear receptor corepressor 1 0.0259197
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0259164
RARS1 arginyl-tRNA synthetase 1 0.0257952
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0257584
PFKP phosphofructokinase, platelet 0.0254589
PNISR PNN-interacting serine/arginine-rich protein 0.0252729
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0248435
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0248226
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0247164
NBAS neuroblastoma amplified sequence 0.0246636
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0244675
DSPP dentin sialophosphoprotein 0.0242347
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0241457
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0241214
EXOC4 exocyst complex component 4 0.0239687
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0238791
TMED2 transmembrane emp24 domain trafficking protein 2 0.0238371
ENSA endosulfine alpha 0.0237811
BCLAF1 BCL2-associated transcription factor 1 0.0234249
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0233903
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0233704
TENT2 terminal nucleotidyltransferase 2 0.0232654
HELZ helicase with zinc finger 0.023215
AKAP13 A kinase (PRKA) anchor protein 13 0.0231555
FNDC3B fibronectin type III domain containing 3B 0.0229762
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0229646
WDFY3 WD repeat and FYVE domain containing 3 0.0228783
ANXA2 annexin A2 0.0228626
AVL9 AVL9 homolog (S. cerevisiase) 0.0228043
SMC4 structural maintenance of chromosomes 4 0.0226535
PTBP3 polypyrimidine tract binding protein 3 0.0226094
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0225933
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0225694
FHIT fragile histidine triad 0.0225295
MED13 mediator complex subunit 13 0.0223164
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0222749
WWC2 WW and C2 domain containing 2 0.0220223
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0219568
SBF2 SET binding factor 2 0.0218579
JMJD1C jumonji domain containing 1C 0.0218086
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0217078
SERTAD2 SERTA domain containing 2 0.0217063
KIAA1328 KIAA1328 0.0216944
MBNL2 muscleblind-like splicing regulator 2 0.0216587
BLTP1 bridge-like lipid transfer protein family member 1 0.0216405
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0215444
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0214264
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0214175
ITCH itchy E3 ubiquitin protein ligase 0.021358
PCM1 pericentriolar material 1 0.021223
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0211495
ARHGAP12 Rho GTPase activating protein 12 0.0209941

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.372673
TMSB10 thymosin beta 10 -0.185419
AHNAK AHNAK nucleoprotein -0.12435
UBC ubiquitin C -0.0990151
RPS6 ribosomal protein S6 -0.0870747
EEF2 eukaryotic translation elongation factor 2 -0.0842293
FTL ferritin, light polypeptide -0.0839005
TPT1 tumor protein, translationally-controlled 1 -0.0752691
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0740587
RPL35A ribosomal protein L35a -0.0650456
EIF1 eukaryotic translation initiation factor 1 -0.064718
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0614583
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.061384
S100A10 S100 calcium binding protein A10 -0.0603936
RPS27A ribosomal protein S27a -0.0596534
LOC112694756 uncharaterized LOC112694756 -0.0552669
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0505149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0500614
RPL18 ribosomal protein L18 -0.0497456
ATF4 activating transcription factor 4 -0.0491834
KRT8 keratin 8, type II -0.0482847
JUN jun proto-oncogene -0.0477056
PTMA prothymosin, alpha -0.0476876
MT2A metallothionein 2A -0.0448942
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0446104
RPL34 ribosomal protein L34 -0.0442898
RPS8 ribosomal protein S8 -0.0437545
RPL23 ribosomal protein L23 -0.0433774
EPCAM epithelial cell adhesion molecule -0.0398874
EGR1 early growth response 1 -0.039388
RPLP0 ribosomal protein, large, P0 -0.0392744
ENO1 enolase 1, (alpha) -0.0388798
RPL8 ribosomal protein L8 -0.0385181
LDHA lactate dehydrogenase A -0.0372271
ACTG1 actin gamma 1 -0.0351887
RACK1 receptor for activated C kinase 1 -0.0351151
RPS19 ribosomal protein S19 -0.0341969
PDIA4 protein disulfide isomerase family A, member 4 -0.0339566
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0334028
PKM pyruvate kinase, muscle -0.0332182
SDC4 syndecan 4 -0.0320582
RPS24 ribosomal protein S24 -0.0320388
MIDN midnolin -0.0319626
DDIT4 DNA-damage-inducible transcript 4 -0.0319358
PDIA6 protein disulfide isomerase family A, member 6 -0.0299794
VMP1 vacuole membrane protein 1 -0.0295953
RPL19 ribosomal protein L19 -0.0293227
RPL32 ribosomal protein L32 -0.028793
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0285197
RPS15 ribosomal protein S15 -0.0284332
S100A9 S100 calcium binding protein A9 -0.0282627
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0282197
IER3 immediate early response 3 -0.0280227
RPL7A ribosomal protein L7a -0.0280177
RPS21 ribosomal protein S21 -0.0278684
RPL36AL ribosomal protein L36a-like -0.0271332
SEPTIN2 septin 2 -0.0268665
RPL36A ribosomal protein L36a -0.0262999
HMGA1 high mobility group AT-hook 1 -0.0259508
RPS29 ribosomal protein S29 -0.0255522
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0254666
TKT transketolase -0.0249519
PDIA3 protein disulfide isomerase family A, member 3 -0.0248228
LOC102724023 ES1 protein homolog, mitochondrial -0.0244896
RRBP1 ribosome binding protein 1 -0.0242944
RPS5 ribosomal protein S5 -0.023988
TPI1 triosephosphate isomerase 1 -0.0235771
RPL4 ribosomal protein L4 -0.023274
PCBP2 poly(rC) binding protein 2 -0.0231714
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0231625
FBXO11 F-box protein 11 -0.0229718
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0229651
LMNA lamin A/C -0.0229302
TPM4 tropomyosin 4 -0.0229266
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0225642
VDAC1 voltage-dependent anion channel 1 -0.022093
PFN1 profilin 1 -0.0218621
IFITM3 interferon induced transmembrane protein 3 -0.0216976
RPS3 ribosomal protein S3 -0.021659
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0215382
RPL15 ribosomal protein L15 -0.0215367
YBX3 Y box binding protein 3 -0.0214561
HLA-E major histocompatibility complex, class I, E -0.020964
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0206786
KLF6 Kruppel-like factor 6 -0.0206691
RPL37A ribosomal protein L37a -0.0205752
RPL35 ribosomal protein L35 -0.0204302
RPS4X ribosomal protein S4, X-linked -0.0204142
RAB7A RAB7A, member RAS oncogene family -0.02039
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0202569
S100A6 S100 calcium binding protein A6 -0.0202308
RPS14 ribosomal protein S14 -0.0200331
RPL26 ribosomal protein L26 -0.0198694
UBB ubiquitin B -0.0195793
SPDYA speedy/RINGO cell cycle regulator family member A -0.0193711
KMT2A lysine (K)-specific methyltransferase 2A -0.019281
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0190839
SEC61G Sec61 gamma subunit -0.0190829
TMEM263 transmembrane protein 263 -0.0190142
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0182999