| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methylprednisolone succinate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methylprednisolone succinate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.445359 |
| COL6A3 | collagen, type VI, alpha 3 | 0.161107 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0961002 |
| VIM | vimentin | 0.068845 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0666373 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.061169 |
| STC1 | stanniocalcin 1 | 0.0605104 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0552138 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0524941 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0519603 |
| TPM4 | tropomyosin 4 | 0.0516693 |
| LOXL2 | lysyl oxidase-like 2 | 0.0508428 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.049222 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0490498 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0481931 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0433562 |
| COL1A2 | collagen, type I, alpha 2 | 0.0425923 |
| HMGA2 | high mobility group AT-hook 2 | 0.0416035 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0410413 |
| LDHA | lactate dehydrogenase A | 0.0409054 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0404663 |
| CANX | calnexin | 0.0398905 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0376947 |
| ENO1 | enolase 1, (alpha) | 0.03739 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0369666 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0362462 |
| ANXA2 | annexin A2 | 0.0355837 |
| PTK2 | protein tyrosine kinase 2 | 0.0353267 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0345093 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0342011 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.033798 |
| MT2A | metallothionein 2A | 0.0326083 |
| ATP13A3 | ATPase type 13A3 | 0.0324481 |
| POSTN | periostin, osteoblast specific factor | 0.0317532 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0309697 |
| CD44 | CD44 molecule (Indian blood group) | 0.0309215 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0290105 |
| VCAN | versican | 0.0278665 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0263689 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0262691 |
| SMAD3 | SMAD family member 3 | 0.0260591 |
| FBN1 | fibrillin 1 | 0.0254476 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0253464 |
| NAV2 | neuron navigator 2 | 0.0247349 |
| CTSB | cathepsin B | 0.0246486 |
| FAT1 | FAT atypical cadherin 1 | 0.0244893 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0239138 |
| PTMA | prothymosin, alpha | 0.0237753 |
| CALR | calreticulin | 0.0234439 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0230641 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0230026 |
| RASA2 | RAS p21 protein activator 2 | 0.0229239 |
| SPAG9 | sperm associated antigen 9 | 0.0216027 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0215745 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0211273 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0211051 |
| ECE1 | endothelin converting enzyme 1 | 0.0208278 |
| APP | amyloid beta (A4) precursor protein | 0.0208196 |
| ASPH | aspartate beta-hydroxylase | 0.0207829 |
| OGA | O-GlcNAcase | 0.0205234 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0199573 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0199481 |
| VEGFC | vascular endothelial growth factor C | 0.0199237 |
| PLEC | plectin | 0.0195435 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0194035 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0193037 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0190706 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0189726 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0188717 |
| MAP1B | microtubule-associated protein 1B | 0.0186907 |
| ZNF148 | zinc finger protein 148 | 0.0186148 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0179666 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0175742 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0175553 |
| NRP1 | neuropilin 1 | 0.0174984 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0174958 |
| DST | dystonin | 0.0174865 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0173391 |
| CALU | calumenin | 0.0172556 |
| GLIS3 | GLIS family zinc finger 3 | 0.0171905 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0171326 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0170634 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0170214 |
| B2M | beta-2-microglobulin | 0.0168962 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0168895 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0168777 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0167476 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0165988 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0165566 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.016549 |
| MTSS1 | metastasis suppressor 1 | 0.0165079 |
| AXL | AXL receptor tyrosine kinase | 0.0162114 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0161549 |
| MX2 | MX dynamin-like GTPase 2 | 0.0158802 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0157435 |
| ARRDC3 | arrestin domain containing 3 | 0.0155704 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0155393 |
| RPS12 | ribosomal protein S12 | 0.0153235 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0153025 |
| RPS2 | ribosomal protein S2 | 0.0152923 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.106276 |
| CADM1 | cell adhesion molecule 1 | -0.090901 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0710784 |
| CDH13 | cadherin 13 | -0.0657954 |
| IER3 | immediate early response 3 | -0.0648001 |
| COL1A1 | collagen, type I, alpha 1 | -0.047083 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0462662 |
| TMSB10 | thymosin beta 10 | -0.0440743 |
| NDRG1 | N-myc downstream regulated 1 | -0.036761 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0309922 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0300307 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0256485 |
| RPS19 | ribosomal protein S19 | -0.0252426 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0236497 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0226731 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0209012 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0208083 |
| RPL18 | ribosomal protein L18 | -0.0204847 |
| FTL | ferritin, light polypeptide | -0.0200449 |
| EGR1 | early growth response 1 | -0.0192303 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0191073 |
| RPS6 | ribosomal protein S6 | -0.0186891 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0186071 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0178433 |
| HDAC9 | histone deacetylase 9 | -0.0174793 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0169866 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0169075 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0160587 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0154164 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0153926 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0152035 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0149991 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0148182 |
| EGFR | epidermal growth factor receptor | -0.0146515 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0140281 |
| STC2 | stanniocalcin 2 | -0.0138387 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0137658 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.013716 |
| GOLGA4 | golgin A4 | -0.0135363 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0132672 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0131767 |
| PFN1 | profilin 1 | -0.0130691 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0130499 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0129632 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | -0.0129302 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0128628 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0125708 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0125536 |
| CNTN5 | contactin 5 | -0.0125442 |
| ATF4 | activating transcription factor 4 | -0.0124555 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.0124441 |
| RTN3 | reticulon 3 | -0.0123869 |
| DGKI | diacylglycerol kinase, iota | -0.0122059 |
| JUN | jun proto-oncogene | -0.0121955 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0120978 |
| XBP1 | X-box binding protein 1 | -0.0119897 |
| HYOU1 | hypoxia up-regulated 1 | -0.0119802 |
| SNX14 | sorting nexin 14 | -0.0118656 |
| RND3 | Rho family GTPase 3 | -0.0118506 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0116634 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0115642 |
| RPL35A | ribosomal protein L35a | -0.0115035 |
| RRBP1 | ribosome binding protein 1 | -0.0114585 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0114344 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0114176 |
| TCF25 | transcription factor 25 (basic helix-loop-helix) | -0.0113048 |
| TMSB4X | thymosin beta 4, X-linked | -0.0112301 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0111539 |
| QKI | QKI, KH domain containing, RNA binding | -0.0110317 |
| HM13 | histocompatibility (minor) 13 | -0.0109009 |
| GPHN | gephyrin | -0.0108996 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0108471 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0107197 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0107035 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0105579 |
| SERP1 | stress-associated endoplasmic reticulum protein 1 | -0.0105335 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0105266 |
| FBXO11 | F-box protein 11 | -0.0103942 |
| NEK10 | NIMA-related kinase 10 | -0.0103131 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0103118 |
| JAK1 | Janus kinase 1 | -0.0103067 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0101217 |
| INTS6 | integrator complex subunit 6 | -0.0100503 |
| CLINT1 | clathrin interactor 1 | -0.0100124 |
| TLE4 | transducin-like enhancer of split 4 | -0.0100013 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.00996913 |
| HIPK2 | homeodomain interacting protein kinase 2 | -0.00991039 |
| KLF10 | Kruppel-like factor 10 | -0.00985929 |
| IL6 | interleukin 6 | -0.00985255 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.009813 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00981175 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.00956461 |
| NABP1 | nucleic acid binding protein 1 | -0.00956121 |
| ACTG1 | actin gamma 1 | -0.00949205 |
| SEC24D | SEC24 family member D | -0.00936449 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.00934958 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.00934555 |
| TPBG | trophoblast glycoprotein | -0.00934081 |
| MEF2A | myocyte enhancer factor 2A | -0.00926781 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | -0.00924532 |
