Methylprednisolone succinate_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0710973
GCLC glutamate-cysteine ligase, catalytic subunit 0.0505541
NDRG1 N-myc downstream regulated 1 0.0474221
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0441475
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0434102
ANXA2 annexin A2 0.0388637
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0361324
TSC22D2 TSC22 domain family, member 2 0.0324956
ERRFI1 ERBB receptor feedback inhibitor 1 0.030809
TJP1 tight junction protein 1 0.0296111
HELZ helicase with zinc finger 0.0295979
DST dystonin 0.0294452
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0291516
FAM91A1 family with sequence similarity 91, member A1 0.0287778
STK24 serine/threonine kinase 24 0.027388
DSPP dentin sialophosphoprotein 0.0272756
FAM135A family with sequence similarity 135, member A 0.0269812
BIRC6 baculoviral IAP repeat containing 6 0.0268229
ATXN1 ataxin 1 0.0265317
LMO7 LIM domain 7 0.0265305
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0258522
NUP58 nucleoporin 58 0.0257322
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0253206
LPIN2 lipin 2 0.0251319
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0245632
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0244208
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like 0.0239158
SRSF6 serine/arginine-rich splicing factor 6 0.0233653
SFTPA2 surfactant protein A2 0.022905
TRPS1 trichorhinophalangeal syndrome I 0.0227591
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0227355
EPS8 epidermal growth factor receptor pathway substrate 8 0.0225763
NAMPT nicotinamide phosphoribosyltransferase 0.0221884
SUCO SUN domain containing ossification factor 0.0219864
CLTC clathrin, heavy chain (Hc) 0.0211503
EPS8L1 EPS8-like 1 0.0208751
DMXL2 Dmx-like 2 0.0200406
DAND5 DAN domain family member 5, BMP antagonist 0.0197488
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0196885
TJP2 tight junction protein 2 0.0196426
NCKAP1 NCK-associated protein 1 0.0195986
ARHGAP42 Rho GTPase activating protein 42 0.0193651
TCEA1 transcription elongation factor A (SII), 1 0.0190929
BRD2 bromodomain containing 2 0.0190157
TRA2B transformer 2 beta homolog (Drosophila) 0.0189207
GRB10 growth factor receptor-bound protein 10 0.0186485
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0185503
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0184928
PTBP3 polypyrimidine tract binding protein 3 0.0184396
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0182788
WAC WW domain containing adaptor with coiled-coil 0.0182679
RPS2 ribosomal protein S2 0.0181361
SPRED2 sprouty-related, EVH1 domain containing 2 0.0180578
ANKRD10 ankyrin repeat domain 10 0.0180515
NFIB nuclear factor I/B 0.0178701
RICTOR RPTOR independent companion of MTOR, complex 2 0.0176838
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0171707
MIDEAS mitotic deacetylase associated SANT domain protein 0.0171372
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0170489
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0169646
WWC1 WW and C2 domain containing 1 0.0168459
USPL1 ubiquitin specific peptidase like 1 0.0166569
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0166223
UBA6 ubiquitin-like modifier activating enzyme 6 0.01658
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0164642
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0164358
CNOT12 CCR4-NOT transcription complex subunit 12 0.0162185
RLIM ring finger protein, LIM domain interacting 0.0161282
KLHL24 kelch-like family member 24 0.0161142
FAM13A family with sequence similarity 13, member A 0.016041
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0159104
DENND4C DENN/MADD domain containing 4C 0.015751
ATP11B ATPase, class VI, type 11B 0.0156255
ARHGAP17 Rho GTPase activating protein 17 0.0154989
TMEM65 transmembrane protein 65 0.0154752
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0154558
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0152787
HSPH1 heat shock 105kDa/110kDa protein 1 0.0152459
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0152296
SLMAP sarcolemma associated protein 0.0151743
WDR26 WD repeat domain 26 0.0151573
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0151458
ANXA11 annexin A11 0.0150417
CD58 CD58 molecule 0.0149513
ANXA3 annexin A3 0.014935
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0149177
UGDH UDP-glucose 6-dehydrogenase 0.0147738
CCNL1 cyclin L1 0.0147572
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0146325
FNBP4 formin binding protein 4 0.0145581
UBQLN1 ubiquilin 1 0.014493
KIAA0232 KIAA0232 0.0144905
LCOR ligand dependent nuclear receptor corepressor 0.0142589
IARS1 isoleucyl-tRNA synthetase 1 0.0142304
TMED2 transmembrane emp24 domain trafficking protein 2 0.0141633
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0141548
LCORL ligand dependent nuclear receptor corepressor-like 0.0140973
RUNX1 runt-related transcription factor 1 0.0140871
PDLIM5 PDZ and LIM domain 5 0.0140445
HP1BP3 heterochromatin protein 1, binding protein 3 0.0138864

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.180206
PTMA prothymosin, alpha -0.174594
TPT1 tumor protein, translationally-controlled 1 -0.165476
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.16098
TMSB10 thymosin beta 10 -0.159185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144285
RPS27A ribosomal protein S27a -0.137879
JUN jun proto-oncogene -0.125497
RPL23 ribosomal protein L23 -0.111162
PDIA4 protein disulfide isomerase family A, member 4 -0.102725
ACTG1 actin gamma 1 -0.101004
EEF2 eukaryotic translation elongation factor 2 -0.0851797
RPS3 ribosomal protein S3 -0.0822628
AHNAK AHNAK nucleoprotein -0.0818015
PDIA3 protein disulfide isomerase family A, member 3 -0.081718
KRT8 keratin 8, type II -0.0804187
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.072939
RPS6 ribosomal protein S6 -0.0716318
RPS19 ribosomal protein S19 -0.0704834
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0683158
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0665222
LOC102724023 ES1 protein homolog, mitochondrial -0.0645607
POTEF POTE ankyrin domain family, member F -0.0617891
ENO1 enolase 1, (alpha) -0.0614552
ASPH aspartate beta-hydroxylase -0.0611723
RPLP2 ribosomal protein, large, P2 -0.0607795
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0590901
ZMYND8 zinc finger, MYND-type containing 8 -0.0574095
FRY furry homolog (Drosophila) -0.0568974
RPS12 ribosomal protein S12 -0.0568365
MYH14 myosin, heavy chain 14, non-muscle -0.0563626
TRIB1 tribbles pseudokinase 1 -0.0562088
LMNA lamin A/C -0.055437
S100A10 S100 calcium binding protein A10 -0.0548799
RPS8 ribosomal protein S8 -0.0546508
ITPKC inositol-trisphosphate 3-kinase C -0.0525845
EGR1 early growth response 1 -0.0506332
ATAD2 ATPase family, AAA domain containing 2 -0.0495575
KRT20 keratin 20, type I -0.0494453
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.04904
RPLP1 ribosomal protein, large, P1 -0.0487548
RPS24 ribosomal protein S24 -0.0472534
RPL18 ribosomal protein L18 -0.047159
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0439938
RPL5 ribosomal protein L5 -0.0428222
PKM pyruvate kinase, muscle -0.042686
LAMA4 laminin, alpha 4 -0.0426169
LYZ lysozyme -0.0424126
SET SET nuclear proto-oncogene -0.0417716
CTNND1 catenin (cadherin-associated protein), delta 1 -0.041427
S100A6 S100 calcium binding protein A6 -0.0411245
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0406628
RPL4 ribosomal protein L4 -0.0400457
FTL ferritin, light polypeptide -0.0394817
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0392846
HMGB1 high mobility group box 1 -0.0390249
ANKRD11 ankyrin repeat domain 11 -0.0386822
EPCAM epithelial cell adhesion molecule -0.038577
SPDYA speedy/RINGO cell cycle regulator family member A -0.0377019
RPL7A ribosomal protein L7a -0.0375304
RPL31 ribosomal protein L31 -0.0374446
PRRC2C proline-rich coiled-coil 2C -0.0373167
CALR calreticulin -0.0372188
RPS17 ribosomal protein S17 -0.0371154
GOLGA4 golgin A4 -0.0367123
ETV6 ets variant 6 -0.036438
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0363799
RPL34 ribosomal protein L34 -0.035118
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0349087
RAB7A RAB7A, member RAS oncogene family -0.0348575
ZBTB20 zinc finger and BTB domain containing 20 -0.0347724
EIF1 eukaryotic translation initiation factor 1 -0.0345182
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0340224
EZR ezrin -0.0331997
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0329568
PRKN parkin RBR E3 ubiquitin protein ligase -0.0328671
ACTN4 actinin, alpha 4 -0.0322062
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0317324
RPL9 ribosomal protein L9 -0.031444
RRBP1 ribosome binding protein 1 -0.0313401
RPL37A ribosomal protein L37a -0.0311178
NECTIN2 nectin cell adhesion molecule 2 -0.0309803
TPM3 tropomyosin 3 -0.0309173
PCED1B PC-esterase domain containing 1B -0.030905
B2M beta-2-microglobulin -0.0308484
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0306587
CD63 CD63 molecule -0.0306295
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0302104
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0300261
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0299938
VMP1 vacuole membrane protein 1 -0.0296177
TRAPPC9 trafficking protein particle complex 9 -0.0295784
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0294948
RPS11 ribosomal protein S11 -0.0293552
MMP7 matrix metallopeptidase 7 -0.0291921
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0291192
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0288271
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0284355
RPL36A ribosomal protein L36a -0.0279252
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0279077