Methylprednisolone succinate_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.207748
C3 complement component 3 0.145734
APOB apolipoprotein B 0.111084
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0933664
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0892486
DSPP dentin sialophosphoprotein 0.089004
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0880272
TF transferrin 0.0852229
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0783425
SAMD4A sterile alpha motif domain containing 4A 0.0763922
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0743366
FAT1 FAT atypical cadherin 1 0.0668572
FBF1 Fas (TNFRSF6) binding factor 1 0.0665097
FNDC3B fibronectin type III domain containing 3B 0.0593814
LRMDA leucine rich melanocyte differentiation associated 0.0589949
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0574131
EHBP1 EH domain binding protein 1 0.0553508
NKD1 naked cuticle homolog 1 (Drosophila) 0.0546168
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0544972
PEG3 paternally expressed 3 0.0512704
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0481588
MAML2 mastermind-like 2 (Drosophila) 0.0473355
DST dystonin 0.0462203
CFB complement factor B 0.0446357
AFDN afadin, adherens junction formation factor 0.0440772
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0436109
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0403036
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0392966
LMCD1 LIM and cysteine-rich domains 1 0.0382874
RPS12 ribosomal protein S12 0.0381501
CPE carboxypeptidase E 0.0364253
ATXN1 ataxin 1 0.0353886
A2M alpha-2-macroglobulin 0.0352858
SEPTIN9 septin 9 0.034615
TNS1 tensin 1 0.0344608
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.033488
TNS3 tensin 3 0.0333292
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.033261
SFTPA2 surfactant protein A2 0.033205
SLC38A2 solute carrier family 38, member 2 0.0331112
VMP1 vacuole membrane protein 1 0.0330777
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0330694
ARHGAP9 Rho GTPase activating protein 9 0.0328927
VEGFA vascular endothelial growth factor A 0.0325725
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0324897
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0321386
PTPRM protein tyrosine phosphatase, receptor type, M 0.0319553
DOCK4 dedicator of cytokinesis 4 0.031127
NPAS2 neuronal PAS domain protein 2 0.031008
VCL vinculin 0.030786
SMAD3 SMAD family member 3 0.0302817
GPC6 glypican 6 0.0300138
PEG10 paternally expressed 10 0.0295207
APLP2 amyloid beta (A4) precursor-like protein 2 0.0290177
DSCAM Down syndrome cell adhesion molecule 0.0289617
EEF2 eukaryotic translation elongation factor 2 0.0286977
PCBP2 poly(rC) binding protein 2 0.0282109
MBNL2 muscleblind-like splicing regulator 2 0.0280547
MYH9 myosin, heavy chain 9, non-muscle 0.0272178
ABTB3 ankyrin repeat and BTB domain containing 3 0.0269282
SESTD1 SEC14 and spectrin domains 1 0.0269249
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0263931
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0257759
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.025446
TUFT1 tuftelin 1 0.0254295
CCNY cyclin Y 0.025219
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0249726
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0249393
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0249281
EML4 echinoderm microtubule associated protein like 4 0.0248651
BIRC6 baculoviral IAP repeat containing 6 0.0246571
TRIO trio Rho guanine nucleotide exchange factor 0.0245926
UBASH3B ubiquitin associated and SH3 domain containing B 0.0242413
FLNB filamin B, beta 0.024113
PTCHD4 patched domain containing 4 0.0239524
PAWR PRKC, apoptosis, WT1, regulator 0.0238264
DOCK5 dedicator of cytokinesis 5 0.0238046
DNAH17 dynein, axonemal, heavy chain 17 0.0236729
HLF hepatic leukemia factor 0.0235878
ZNF644 zinc finger protein 644 0.0234171
IGF1R insulin-like growth factor 1 receptor 0.0233555
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0232653
PDLIM5 PDZ and LIM domain 5 0.0232354
GPC3 glypican 3 0.023223
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0230717
PARD3 par-3 family cell polarity regulator 0.023019
RBM39 RNA binding motif protein 39 0.0229076
WNK1 WNK lysine deficient protein kinase 1 0.0227769
RUNX1 runt-related transcription factor 1 0.0227558
FAM135A family with sequence similarity 135, member A 0.0225622
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0225586
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0223004
ZEB1 zinc finger E-box binding homeobox 1 0.0222245
TMEM181 transmembrane protein 181 0.0221987
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0220551
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.02203
MACF1 microtubule-actin crosslinking factor 1 0.0219913
FILIP1L filamin A interacting protein 1-like 0.0217219
LCOR ligand dependent nuclear receptor corepressor 0.0216694
MATN3 matrilin 3 0.0215773

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.376179
AKAP12 A kinase (PRKA) anchor protein 12 -0.156008
TPT1 tumor protein, translationally-controlled 1 -0.108883
IGFBP1 insulin-like growth factor binding protein 1 -0.0926593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0879779
TMSB10 thymosin beta 10 -0.0786623
MT2A metallothionein 2A -0.0780694
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0757602
FTL ferritin, light polypeptide -0.0697098
APOA2 apolipoprotein A-II -0.0696306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0683174
RPL35A ribosomal protein L35a -0.0554762
RPL34 ribosomal protein L34 -0.0533426
RPS6 ribosomal protein S6 -0.0464528
HMGA1 high mobility group AT-hook 1 -0.0447688
RPS19 ribosomal protein S19 -0.044349
RPS24 ribosomal protein S24 -0.0425208
DTNA dystrobrevin, alpha -0.042408
RPL23 ribosomal protein L23 -0.0400268
RPLP1 ribosomal protein, large, P1 -0.0377219
CCL20 chemokine (C-C motif) ligand 20 -0.0357625
RPLP2 ribosomal protein, large, P2 -0.0347787
RPL5 ribosomal protein L5 -0.0329625
RPS23 ribosomal protein S23 -0.031229
RPS27A ribosomal protein S27a -0.0309789
RPS21 ribosomal protein S21 -0.0306791
RPL12 ribosomal protein L12 -0.030171
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0292972
NDRG1 N-myc downstream regulated 1 -0.0290494
EIF1 eukaryotic translation initiation factor 1 -0.0288474
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0286944
H1-0 H1.0 linker histone -0.0279952
RPL31 ribosomal protein L31 -0.0264913
RPS14 ribosomal protein S14 -0.0243535
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0242856
KMT2E lysine (K)-specific methyltransferase 2E -0.0239876
IER3 immediate early response 3 -0.0239654
PLIN2 perilipin 2 -0.0236066
GNAS GNAS complex locus -0.0234904
BHLHE40 basic helix-loop-helix family, member e40 -0.0234208
RPL32 ribosomal protein L32 -0.0232829
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0227838
RPS15 ribosomal protein S15 -0.0223332
KIF21A kinesin family member 21A -0.0219437
RPS29 ribosomal protein S29 -0.0215811
RPL19 ribosomal protein L19 -0.0211855
RAB7A RAB7A, member RAS oncogene family -0.0208934
SBF2 SET binding factor 2 -0.0205524
NAP1L1 nucleosome assembly protein 1-like 1 -0.0202586
RPS4X ribosomal protein S4, X-linked -0.0200796
S100A10 S100 calcium binding protein A10 -0.0200429
KDM3A lysine (K)-specific demethylase 3A -0.0199509
PFN1 profilin 1 -0.0196264
GARS1 glycyl-tRNA synthetase 1 -0.0194029
GDF15 growth differentiation factor 15 -0.0193885
STAU1 staufen double-stranded RNA binding protein 1 -0.019004
RPLP0 ribosomal protein, large, P0 -0.0188936
SLC38A1 solute carrier family 38, member 1 -0.0187045
S100A9 S100 calcium binding protein A9 -0.0186289
RPL37 ribosomal protein L37 -0.0184877
ARF1 ADP-ribosylation factor 1 -0.0182154
RPS5 ribosomal protein S5 -0.0181477
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0177474
RPL28 ribosomal protein L28 -0.017585
WDR45B WD repeat domain 45B -0.0173565
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0171855
RPS10 ribosomal protein S10 -0.0171187
ZNF292 zinc finger protein 292 -0.0170781
VIM vimentin -0.0170142
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0170097
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0167041
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0166396
FBXO42 F-box protein 42 -0.0162665
RPL37A ribosomal protein L37a -0.0161746
APOE apolipoprotein E -0.0160167
RPL26 ribosomal protein L26 -0.0160058
RPL7A ribosomal protein L7a -0.0156341
MYL12B myosin, light chain 12B, regulatory -0.0155463
TM4SF1 transmembrane 4 L six family member 1 -0.0154562
RPL8 ribosomal protein L8 -0.0154528
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0151362
RPS11 ribosomal protein S11 -0.014927
S100A6 S100 calcium binding protein A6 -0.0148518
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0148506
PDIA3 protein disulfide isomerase family A, member 3 -0.0146005
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0145202
FBXO11 F-box protein 11 -0.0142565
RPL23A ribosomal protein L23a -0.0141775
UBB ubiquitin B -0.0140989
NFE2L2 nuclear factor, erythroid 2-like 2 -0.014089
UGCG UDP-glucose ceramide glucosyltransferase -0.0140511
SERF2 small EDRK-rich factor 2 -0.014034
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0139178
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0138981
RPL27 ribosomal protein L27 -0.0136815
SETD5 SET domain containing 5 -0.0136644
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0136568
APOC1 apolipoprotein C-I -0.0135007
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0134419
TOP1 topoisomerase (DNA) I -0.0134228