Methylprednisolone succinate_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 0.182891
FAT1 FAT atypical cadherin 1 0.153736
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0967171
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0686385
FLNB filamin B, beta 0.054681
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0526514
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.051984
ITGA6 integrin, alpha 6 0.0502785
PRELID2 PRELI domain containing 2 0.0478972
SHROOM3 shroom family member 3 0.0470831
PTPRG protein tyrosine phosphatase, receptor type, G 0.0460179
TXNRD1 thioredoxin reductase 1 0.0456836
TRIM2 tripartite motif containing 2 0.045555
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0445921
CALB1 calbindin 1, 28kDa 0.0444922
PTPRK protein tyrosine phosphatase, receptor type, K 0.0440976
DSCAM Down syndrome cell adhesion molecule 0.0437577
THSD4 thrombospondin, type I, domain containing 4 0.0427838
FOXO1 forkhead box O1 0.0427105
GOLGA4 golgin A4 0.0413091
MYOF myoferlin 0.040865
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0402652
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0397988
AKAP13 A kinase (PRKA) anchor protein 13 0.0389081
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0372558
GARS1 glycyl-tRNA synthetase 1 0.0367509
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0366008
EEF2 eukaryotic translation elongation factor 2 0.0360469
PKP2 plakophilin 2 0.035616
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0352298
CANX calnexin 0.0347303
MSI2 musashi RNA-binding protein 2 0.034699
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0338974
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.033567
ANKRD11 ankyrin repeat domain 11 0.0335295
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0333975
FOXP1 forkhead box P1 0.0322905
PLAC8 placenta-specific 8 0.0321627
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0316453
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0315966
PCBP2 poly(rC) binding protein 2 0.0313337
KMT2C lysine (K)-specific methyltransferase 2C 0.0303856
LMO7 LIM domain 7 0.0302729
PCDHB16 protocadherin beta 16 0.0297209
TTC3 tetratricopeptide repeat domain 3 0.0290401
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0289055
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0282675
MYH9 myosin, heavy chain 9, non-muscle 0.0277323
RNF145 ring finger protein 145 0.0276133
AKAP9 A kinase (PRKA) anchor protein 9 0.0274544
MON2 MON2 homolog (S. cerevisiae) 0.0273307
EIF4B eukaryotic translation initiation factor 4B 0.0269839
ZNF292 zinc finger protein 292 0.0269436
ARHGAP26 Rho GTPase activating protein 26 0.0268054
RAD51B RAD51 paralog B 0.0266996
BIRC6 baculoviral IAP repeat containing 6 0.0266779
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0265561
ETNK1 ethanolamine kinase 1 0.0264
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0263513
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0262701
EXT1 exostosin glycosyltransferase 1 0.026236
SOS1 son of sevenless homolog 1 (Drosophila) 0.0262113
BTBD9 BTB (POZ) domain containing 9 0.026193
RBM39 RNA binding motif protein 39 0.0260877
ABHD17C abhydrolase domain containing 17C 0.0260748
COG5 component of oligomeric golgi complex 5 0.0260369
PDE4D phosphodiesterase 4D, cAMP-specific 0.0259951
PPARG peroxisome proliferator-activated receptor gamma 0.0259729
ZFC3H1 zinc finger, C3H1-type containing 0.0259267
SEC31A SEC31 homolog A (S. cerevisiae) 0.0257409
SLTM SAFB-like, transcription modulator 0.0252476
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0251435
MED13L mediator complex subunit 13-like 0.0250888
ZFAND3 zinc finger, AN1-type domain 3 0.0250804
CCPG1 cell cycle progression 1 0.0250633
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.025059
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.024587
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.024481
OGA O-GlcNAcase 0.0243434
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0241913
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0241835
AFDN afadin, adherens junction formation factor 0.0241659
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0241361
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0239333
UBA6 ubiquitin-like modifier activating enzyme 6 0.0239009
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0237202
SETD5 SET domain containing 5 0.023459
ESYT2 extended synaptotagmin-like protein 2 0.0234006
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.023227
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0231308
PTEN phosphatase and tensin homolog 0.02298
CEMIP cell migration inducing protein, hyaluronan binding 0.022617
CTNND1 catenin (cadherin-associated protein), delta 1 0.0220802
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0220741
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0220242
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0219038
CDK19 cyclin-dependent kinase 19 0.0218237
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.0217929
TCF12 transcription factor 12 0.0217917
MYO6 myosin VI 0.0216117

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.209142
RPLP1 ribosomal protein, large, P1 -0.131786
RPS6 ribosomal protein S6 -0.10469
RPL35A ribosomal protein L35a -0.0935861
TMSB10 thymosin beta 10 -0.0914084
RPL34 ribosomal protein L34 -0.0817738
RPS8 ribosomal protein S8 -0.0727984
RPLP2 ribosomal protein, large, P2 -0.070789
RPS19 ribosomal protein S19 -0.0695133
HLA-B major histocompatibility complex, class I, B -0.066351
RPL37A ribosomal protein L37a -0.0653829
RPL31 ribosomal protein L31 -0.0626945
RPS12 ribosomal protein S12 -0.0609097
RPS23 ribosomal protein S23 -0.0595574
PTMA prothymosin, alpha -0.0590272
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0557356
RPS13 ribosomal protein S13 -0.054289
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0508903
RPS24 ribosomal protein S24 -0.0508578
RPS29 ribosomal protein S29 -0.0495399
IFI6 interferon, alpha-inducible protein 6 -0.0476609
RPS25 ribosomal protein S25 -0.0472306
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0456943
RPS14 ribosomal protein S14 -0.0424357
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0423349
ACTG1 actin gamma 1 -0.0410293
RPL26 ribosomal protein L26 -0.040154
RPL38 ribosomal protein L38 -0.0398451
RPS27A ribosomal protein S27a -0.0393313
RPS21 ribosomal protein S21 -0.0387123
RPL36 ribosomal protein L36 -0.0363996
RPL11 ribosomal protein L11 -0.0361718
RPL9 ribosomal protein L9 -0.0360973
RPL37 ribosomal protein L37 -0.035677
RPS3 ribosomal protein S3 -0.0344653
RPL28 ribosomal protein L28 -0.0321634
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0315556
ISG15 ISG15 ubiquitin-like modifier -0.0311232
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0310414
RPL36A ribosomal protein L36a -0.0307399
RPL8 ribosomal protein L8 -0.0301953
RPL12 ribosomal protein L12 -0.030013
RPL19 ribosomal protein L19 -0.0300048
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0297293
RPS11 ribosomal protein S11 -0.0294805
IFI27 interferon, alpha-inducible protein 27 -0.0293472
RPS15 ribosomal protein S15 -0.0285601
S100A6 S100 calcium binding protein A6 -0.0284581
LRRC23 leucine rich repeat containing 23 -0.0279913
RPS17 ribosomal protein S17 -0.0276442
RPL23 ribosomal protein L23 -0.0275982
RPL32 ribosomal protein L32 -0.0271195
NPSR1 neuropeptide S receptor 1 -0.0265869
S100A9 S100 calcium binding protein A9 -0.0265808
RPS10 ribosomal protein S10 -0.0264314
INTS6 integrator complex subunit 6 -0.0253522
LOC102724023 ES1 protein homolog, mitochondrial -0.0253438
FRMD5 FERM domain containing 5 -0.0245326
SP100 SP100 nuclear antigen -0.0243818
IER3 immediate early response 3 -0.0241983
RPL7A ribosomal protein L7a -0.0241722
KRT18 keratin 18, type I -0.0240623
CATSPERB catsper channel auxiliary subunit beta -0.0237598
RPS5 ribosomal protein S5 -0.0236298
S100P S100 calcium binding protein P -0.0235721
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0232947
MYH14 myosin, heavy chain 14, non-muscle -0.0232326
RPS16 ribosomal protein S16 -0.0225758
RPL27A ribosomal protein L27a -0.0223926
RACK1 receptor for activated C kinase 1 -0.0221089
F3 coagulation factor III (thromboplastin, tissue factor) -0.0213793
IFITM3 interferon induced transmembrane protein 3 -0.0213788
FTL ferritin, light polypeptide -0.0207069
S100A11 S100 calcium binding protein A11 -0.0201957
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0200478
RPS27 ribosomal protein S27 -0.0199827
HLA-A major histocompatibility complex, class I, A -0.0191098
POTEF POTE ankyrin domain family, member F -0.018597
RPLP0 ribosomal protein, large, P0 -0.0185684
PKM pyruvate kinase, muscle -0.0182356
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0176523
XAF1 XIAP associated factor 1 -0.0176469
RPL30 ribosomal protein L30 -0.0176098
RPL10A ribosomal protein L10a -0.0172885
PERP PERP, TP53 apoptosis effector -0.017186
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0171446
S100A10 S100 calcium binding protein A10 -0.0169391
EIF5B eukaryotic translation initiation factor 5B -0.0169073
RPL35 ribosomal protein L35 -0.0167099
RPL36AL ribosomal protein L36a-like -0.0162678
AGR2 anterior gradient 2 -0.0160892
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0157985
NABP1 nucleic acid binding protein 1 -0.0157122
TUBB4B tubulin, beta 4B class IVb -0.0157048
TSPAN8 tetraspanin 8 -0.015563
NPR2 natriuretic peptide receptor 2 -0.015378
RPL27 ribosomal protein L27 -0.0152795
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4 -0.0151796
INHBA inhibin, beta A -0.0150732
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0149604