Methylprednisolone succinate_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.180197
PM20D1 peptidase M20 domain containing 1 0.111157
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.111142
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.106669
MCL1 myeloid cell leukemia 1 0.0784514
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0782411
FTH1 ferritin, heavy polypeptide 1 0.0727757
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0668978
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0662501
PHF20 PHD finger protein 20 0.0631134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.062176
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0596604
TPM3 tropomyosin 3 0.0558088
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0537797
BRD2 bromodomain containing 2 0.0530856
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0514722
CALR calreticulin 0.0479515
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.047642
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0455522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0454606
AKAP13 A kinase (PRKA) anchor protein 13 0.0454268
DOCK4 dedicator of cytokinesis 4 0.0449179
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0445202
DOCK5 dedicator of cytokinesis 5 0.0430301
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0425355
GDA guanine deaminase 0.0408818
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0404625
MYOF myoferlin 0.0401234
CMIP c-Maf inducing protein 0.0399153
SMOC1 SPARC related modular calcium binding 1 0.03889
WAC WW domain containing adaptor with coiled-coil 0.0386202
SVIL supervillin 0.0383524
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0378318
EGFR epidermal growth factor receptor 0.0358176
UBASH3B ubiquitin associated and SH3 domain containing B 0.0356199
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0353211
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0353034
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.035161
LDHA lactate dehydrogenase A 0.0349409
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0347978
KYNU kynureninase 0.0346192
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0345015
SOD2 superoxide dismutase 2, mitochondrial 0.034254
PCBP2 poly(rC) binding protein 2 0.034226
PARD3 par-3 family cell polarity regulator 0.0337349
MEF2D myocyte enhancer factor 2D 0.0335646
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0330886
VIM vimentin 0.0323928
BCAR3 breast cancer anti-estrogen resistance 3 0.0323712
NUP58 nucleoporin 58 0.0322064
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.031791
USP36 ubiquitin specific peptidase 36 0.0317112
LMO7 LIM domain 7 0.0313931
DSCAM Down syndrome cell adhesion molecule 0.0310617
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0310202
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.030685
GLS2 glutaminase 2 (liver, mitochondrial) 0.0304612
FTO fat mass and obesity associated 0.0303583
FLNA filamin A, alpha 0.0296216
TTC28 tetratricopeptide repeat domain 28 0.0295724
MED13 mediator complex subunit 13 0.0293805
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0293553
CTBP2 C-terminal binding protein 2 0.0290545
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0289052
SIK3 SIK family kinase 3 0.0287656
WDR20 WD repeat domain 20 0.0287507
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0286082
INO80 INO80 complex subunit 0.0285544
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0283228
ECT2 epithelial cell transforming 2 0.0282495
MARCHF6 membrane associated ring-CH-type finger 6 0.0275981
EEF1G eukaryotic translation elongation factor 1 gamma 0.0270177
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0269597
ATF6 activating transcription factor 6 0.0269494
TPR translocated promoter region, nuclear basket protein 0.0269413
KMT2E lysine (K)-specific methyltransferase 2E 0.026708
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0266199
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0265603
SMAD3 SMAD family member 3 0.0263398
CIB1 calcium and integrin binding 1 (calmyrin) 0.0262343
PRR16 proline rich 16 0.0260388
IQGAP1 IQ motif containing GTPase activating protein 1 0.0258617
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0258468
KIF1B kinesin family member 1B 0.0258447
KAT6B K(lysine) acetyltransferase 6B 0.0256839
EEF2 eukaryotic translation elongation factor 2 0.0255457
RBMX RNA binding motif protein, X-linked 0.0254926
UHMK1 U2AF homology motif (UHM) kinase 1 0.0254886
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0251884
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0251374
PCNX4 pecanex 4 0.0250715
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.025056
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0247858
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0246268
MBNL1 muscleblind-like splicing regulator 1 0.0244662
MITF microphthalmia-associated transcription factor 0.0243434
ALCAM activated leukocyte cell adhesion molecule 0.0241634
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0241183
CFDP1 craniofacial development protein 1 0.0237772
ANXA5 annexin A5 0.0235948

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.254424
TXNRD1 thioredoxin reductase 1 -0.0880407
TMSB10 thymosin beta 10 -0.0768781
AKAP12 A kinase (PRKA) anchor protein 12 -0.0726882
IGF2 insulin-like growth factor 2 -0.0608531
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.058687
TPT1 tumor protein, translationally-controlled 1 -0.046235
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0412785
NRG1 neuregulin 1 -0.0403585
RAD51B RAD51 paralog B -0.0392404
TM4SF1 transmembrane 4 L six family member 1 -0.0380614
PDE4D phosphodiesterase 4D, cAMP-specific -0.0379908
STC1 stanniocalcin 1 -0.0377169
RPL4 ribosomal protein L4 -0.0375036
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0365959
RPL37A ribosomal protein L37a -0.0361625
C15ORF48 chromosome 15 open reading frame 48 -0.0358254
IER3 immediate early response 3 -0.0343044
EIF5B eukaryotic translation initiation factor 5B -0.0328187
KTN1 kinectin 1 (kinesin receptor) -0.0313839
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0311599
RPS12 ribosomal protein S12 -0.0303491
MKI67 marker of proliferation Ki-67 -0.0288743
KLF6 Kruppel-like factor 6 -0.0282599
RPL31 ribosomal protein L31 -0.0259316
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0257153
EFNA5 ephrin-A5 -0.0248255
RACK1 receptor for activated C kinase 1 -0.0242237
ZMYND8 zinc finger, MYND-type containing 8 -0.0240766
CAVIN1 caveolae associated protein 1 -0.0235424
RSL1D1 ribosomal L1 domain containing 1 -0.0232352
RPS16 ribosomal protein S16 -0.0230177
KPNB1 karyopherin (importin) beta 1 -0.0225106
RPS19 ribosomal protein S19 -0.022202
RPL5 ribosomal protein L5 -0.022114
RPS27A ribosomal protein S27a -0.0219721
PFDN2 prefoldin subunit 2 -0.0219315
PNISR PNN-interacting serine/arginine-rich protein -0.0218977
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0217316
NAV3 neuron navigator 3 -0.0213799
CENPF centromere protein F, 350/400kDa -0.0213548
RPS25 ribosomal protein S25 -0.0212215
MAPK8 mitogen-activated protein kinase 8 -0.0208561
THSD4 thrombospondin, type I, domain containing 4 -0.0208389
RPS23 ribosomal protein S23 -0.0204122
SLC38A1 solute carrier family 38, member 1 -0.0201978
RPS21 ribosomal protein S21 -0.0201892
GOLGA4 golgin A4 -0.0201667
WWOX WW domain containing oxidoreductase -0.0200058
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0197079
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0196981
CD44 CD44 molecule (Indian blood group) -0.0196074
LAMB1 laminin, beta 1 -0.0194468
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0190568
ACTG1 actin gamma 1 -0.0187356
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0186657
MT1X metallothionein 1X -0.0186293
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0185705
USP34 ubiquitin specific peptidase 34 -0.0185197
EPGN epithelial mitogen -0.0181118
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0178515
ZNF292 zinc finger protein 292 -0.017809
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0176694
RPL34 ribosomal protein L34 -0.0175346
MIS18BP1 MIS18 binding protein 1 -0.0175089
TUT4 terminal uridylyl transferase 4 -0.0173251
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0172844
UBE2K ubiquitin-conjugating enzyme E2K -0.0171636
GOLM2 golgi membrane protein 2 -0.0171507
CLTC clathrin, heavy chain (Hc) -0.0170762
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0168822
RPS2 ribosomal protein S2 -0.016695
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0166246
MAP1B microtubule-associated protein 1B -0.0164631
UPP1 uridine phosphorylase 1 -0.0164418
NDRG1 N-myc downstream regulated 1 -0.0164185
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0164178
DLG1 discs, large homolog 1 (Drosophila) -0.0163823
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0163352
RPS24 ribosomal protein S24 -0.0163009
ATXN10 ataxin 10 -0.0162821
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0162524
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0162409
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.016156
BABAM2 BRISC and BRCA1 A complex member 2 -0.0161065
ATXN1 ataxin 1 -0.0160137
GLIS3 GLIS family zinc finger 3 -0.015963
FAF1 Fas (TNFRSF6) associated factor 1 -0.0159504
MBTPS1 membrane-bound transcription factor peptidase, site 1 -0.015945
XPO1 exportin 1 -0.0159363
EHBP1 EH domain binding protein 1 -0.0158977
RPL9 ribosomal protein L9 -0.0158685
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0158671
GPC6 glypican 6 -0.0158643
NEGR1 neuronal growth regulator 1 -0.0157857
RPLP1 ribosomal protein, large, P1 -0.0157629
GPHN gephyrin -0.0157579
SPIDR scaffolding protein involved in DNA repair -0.0157417
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0156628
ZFAND6 zinc finger, AN1-type domain 6 -0.0155905