Methylprednisolone succinate_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0832607
GRAMD1B GRAM domain containing 1B 0.0801017
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0780921
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0738012
RAD51B RAD51 paralog B 0.0616494
TRIO trio Rho guanine nucleotide exchange factor 0.0596762
XPO1 exportin 1 0.0547137
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0542642
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0541763
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0512699
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0504394
KDM2A lysine (K)-specific demethylase 2A 0.0467518
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0459869
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0435858
SMC4 structural maintenance of chromosomes 4 0.0420929
TFPI2 tissue factor pathway inhibitor 2 0.0396985
OGA O-GlcNAcase 0.03821
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0378271
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0366755
EXOC4 exocyst complex component 4 0.0351263
PHIP pleckstrin homology domain interacting protein 0.035067
ANKRD36 ankyrin repeat domain 36 0.0346036
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0341538
PCBP2 poly(rC) binding protein 2 0.0340653
RTN4 reticulon 4 0.0337626
PCNX1 pecanex 1 0.033585
NIPBL Nipped-B homolog (Drosophila) 0.0334661
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0329876
YBX3 Y box binding protein 3 0.0328772
ATP11A ATPase, class VI, type 11A 0.0328416
PTK2 protein tyrosine kinase 2 0.0327219
MED13L mediator complex subunit 13-like 0.0324966
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0323551
ZFAND3 zinc finger, AN1-type domain 3 0.0318725
BBX bobby sox homolog (Drosophila) 0.0318723
NCAPD2 non-SMC condensin I complex, subunit D2 0.0318091
ANO6 anoctamin 6 0.0317546
MKI67 marker of proliferation Ki-67 0.031437
CEP192 centrosomal protein 192kDa 0.0311
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0307309
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.03042
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0301386
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0300901
ANXA5 annexin A5 0.0300193
NCOR1 nuclear receptor corepressor 1 0.0299617
ZMYM2 zinc finger, MYM-type 2 0.0296234
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0293178
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0291171
USP34 ubiquitin specific peptidase 34 0.028879
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0281119
RICTOR RPTOR independent companion of MTOR, complex 2 0.027934
EIF4B eukaryotic translation initiation factor 4B 0.0279186
PPME1 protein phosphatase methylesterase 1 0.0274277
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0271895
PUM2 pumilio RNA-binding family member 2 0.027171
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271269
WNK1 WNK lysine deficient protein kinase 1 0.0271238
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0270756
NCKAP1 NCK-associated protein 1 0.0270214
KDM3A lysine (K)-specific demethylase 3A 0.0266328
CANX calnexin 0.026421
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0264026
TPM3 tropomyosin 3 0.0263158
SMAD3 SMAD family member 3 0.0260147
MIS18BP1 MIS18 binding protein 1 0.0256784
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.025528
ZNF638 zinc finger protein 638 0.0254371
ZNF292 zinc finger protein 292 0.0253782
ERBIN erbb2 interacting protein 0.0252278
CLTC clathrin, heavy chain (Hc) 0.0252223
CEP250 centrosomal protein 250kDa 0.025092
RLIM ring finger protein, LIM domain interacting 0.0250444
RRM2 ribonucleotide reductase M2 0.0248061
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0247641
MARCHF4 membrane associated ring-CH-type finger 4 0.024626
CSDE1 cold shock domain containing E1, RNA-binding 0.0245315
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0244995
NCAPG2 non-SMC condensin II complex, subunit G2 0.0244016
RASAL2 RAS protein activator like 2 0.0242368
ADGRG6 adhesion G protein-coupled receptor G6 0.0242001
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0238939
MSH6 mutS homolog 6 0.0238316
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.023652
GATAD2B GATA zinc finger domain containing 2B 0.0236052
NUP153 nucleoporin 153kDa 0.0234898
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0234614
SFPQ splicing factor proline/glutamine-rich 0.0233842
ADAR adenosine deaminase, RNA-specific 0.0233802
PGK1 phosphoglycerate kinase 1 0.0233186
RUSC2 RUN and SH3 domain containing 2 0.0231833
SINHCAF SIN3-HDAC complex associated factor 0.0231178
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0230561
MARCHF7 membrane associated ring-CH-type finger 7 0.0228024
LATS2 large tumor suppressor kinase 2 0.022667
TPX2 TPX2, microtubule-associated 0.022657
KCMF1 potassium channel modulatory factor 1 0.0225667
STAG2 stromal antigen 2 0.0222602
DIAPH3 diaphanous-related formin 3 0.0221944
ANKRD36C ankyrin repeat domain 36C 0.0221594
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022112

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194437
TMSB10 thymosin beta 10 -0.15054
AKAP12 A kinase (PRKA) anchor protein 12 -0.142331
EGR1 early growth response 1 -0.0819415
PTMA prothymosin, alpha -0.0777427
RPL35A ribosomal protein L35a -0.0555683
HLA-B major histocompatibility complex, class I, B -0.0544575
ACTG1 actin gamma 1 -0.0543123
MCL1 myeloid cell leukemia 1 -0.0530415
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.052406
VIM vimentin -0.0521402
MT2A metallothionein 2A -0.0498989
RPS3 ribosomal protein S3 -0.0473991
RPS8 ribosomal protein S8 -0.0471128
RPL37A ribosomal protein L37a -0.0469168
TPT1 tumor protein, translationally-controlled 1 -0.0443281
IER3 immediate early response 3 -0.0439851
RPS21 ribosomal protein S21 -0.0438831
RPS19 ribosomal protein S19 -0.0418066
RPLP1 ribosomal protein, large, P1 -0.0409727
RPL31 ribosomal protein L31 -0.0402007
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0401652
LOC102724023 ES1 protein homolog, mitochondrial -0.0341754
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338084
IFI6 interferon, alpha-inducible protein 6 -0.0334542
RAB7A RAB7A, member RAS oncogene family -0.0333629
RPL36 ribosomal protein L36 -0.0329666
RPS15 ribosomal protein S15 -0.0324126
FTL ferritin, light polypeptide -0.0323645
INTS6 integrator complex subunit 6 -0.0322319
RPS6 ribosomal protein S6 -0.0320465
RPL34 ribosomal protein L34 -0.0316542
WNT2B wingless-type MMTV integration site family, member 2B -0.0313131
RPL32 ribosomal protein L32 -0.0310371
PFN1 profilin 1 -0.0310032
POTEF POTE ankyrin domain family, member F -0.0299031
RPS29 ribosomal protein S29 -0.0284691
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0284585
RPL19 ribosomal protein L19 -0.0279343
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0278865
RPL8 ribosomal protein L8 -0.0277269
RPLP2 ribosomal protein, large, P2 -0.0270109
RPL23 ribosomal protein L23 -0.0267076
PRH1 proline-rich protein HaeIII subfamily 1 -0.0266406
S100A10 S100 calcium binding protein A10 -0.0261969
RPS24 ribosomal protein S24 -0.0260058
CAVIN1 caveolae associated protein 1 -0.025876
RPS10 ribosomal protein S10 -0.0254931
RPL37 ribosomal protein L37 -0.0254107
EIF5B eukaryotic translation initiation factor 5B -0.0250766
RPL38 ribosomal protein L38 -0.0248593
NCOA7 nuclear receptor coactivator 7 -0.0243118
RPS13 ribosomal protein S13 -0.0232579
EIF1 eukaryotic translation initiation factor 1 -0.0232355
RPL26 ribosomal protein L26 -0.0226144
S100A6 S100 calcium binding protein A6 -0.0219903
AEBP2 AE binding protein 2 -0.0219859
RPS4X ribosomal protein S4, X-linked -0.021926
RPS12 ribosomal protein S12 -0.0215153
VCL vinculin -0.0211909
RPL7A ribosomal protein L7a -0.0210943
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.020214
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0198213
RPS17 ribosomal protein S17 -0.0196384
LRRC23 leucine rich repeat containing 23 -0.0193042
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0188581
RPS27A ribosomal protein S27a -0.0186517
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0185546
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.018152
RPS27 ribosomal protein S27 -0.0178797
RPL9 ribosomal protein L9 -0.0178485
RPL18 ribosomal protein L18 -0.0177703
RPL5 ribosomal protein L5 -0.0171787
UBB ubiquitin B -0.0170726
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0169082
TCIM transcriptional and immune response regulator -0.0168137
TPM4 tropomyosin 4 -0.0167079
SEC61G Sec61 gamma subunit -0.0167067
HMGA2 high mobility group AT-hook 2 -0.0165825
RPS14 ribosomal protein S14 -0.016418
GNAS GNAS complex locus -0.016383
RPS25 ribosomal protein S25 -0.0160713
IGF2 insulin-like growth factor 2 -0.0159088
NEK10 NIMA-related kinase 10 -0.0158399
S100A11 S100 calcium binding protein A11 -0.0155745
OSMR oncostatin M receptor -0.0155256
C15ORF48 chromosome 15 open reading frame 48 -0.0154809
GSTP1 glutathione S-transferase pi 1 -0.0152236
NAP1L1 nucleosome assembly protein 1-like 1 -0.0152181
ATP5F1E ATP synthase F1 subunit epsilon -0.0150932
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0150436
TRIM59 tripartite motif containing 59 -0.0150054
RPS16 ribosomal protein S16 -0.0149747
RPL28 ribosomal protein L28 -0.014645
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0144975
JUN jun proto-oncogene -0.0142466
MIDN midnolin -0.0141629
DDIT3 DNA-damage-inducible transcript 3 -0.0141257
CALR calreticulin -0.0140857
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0140049