Methylprednisolone succinate_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

105 genes differentially expressed following the Methylprednisolone succinate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.279225
FNDC3B fibronectin type III domain containing 3B 0.216559
ASPH aspartate beta-hydroxylase 0.18486
NAMPT nicotinamide phosphoribosyltransferase 0.168562
MYH9 myosin, heavy chain 9, non-muscle 0.167844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.151266
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.149624
NALF1 NALCN channel auxiliary factor 1 0.131163
PDE4D phosphodiesterase 4D, cAMP-specific 0.116657
FLNB filamin B, beta 0.111675
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.108463
EFNA5 ephrin-A5 0.106475
GOLGA4 golgin A4 0.100468
GPC6 glypican 6 0.0948899
TRIO trio Rho guanine nucleotide exchange factor 0.0944705
NAP1L1 nucleosome assembly protein 1-like 1 0.0783487
EXT1 exostosin glycosyltransferase 1 0.0740448
SMAD3 SMAD family member 3 0.0698513
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0585115
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0549153
PKM pyruvate kinase, muscle 0.0529251
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0521542
B2M beta-2-microglobulin 0.0520151
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0494249
SETD5 SET domain containing 5 0.045095
SPAG9 sperm associated antigen 9 0.038483
RPS6 ribosomal protein S6 0.0344526
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0339503
LDHA lactate dehydrogenase A 0.030459
FTL ferritin, light polypeptide 0.0297158
EZR ezrin 0.0275544
MYO1E myosin IE 0.0252963
DSCAM Down syndrome cell adhesion molecule 0.022417
MON2 MON2 homolog (S. cerevisiae) 0.0177329
AKAP12 A kinase (PRKA) anchor protein 12 0.0158338
ANXA2 annexin A2 0.0144824
RPS12 ribosomal protein S12 0.0144761
LMO7 LIM domain 7 0.0139764
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.00912623
PRRC2C proline-rich coiled-coil 2C 0.00847834
PDLIM5 PDZ and LIM domain 5 0.00797287
MAML3 mastermind-like 3 (Drosophila) 0.00732404
EGFR epidermal growth factor receptor 0.00695967
TTC3 tetratricopeptide repeat domain 3 0.00560339
PALM2AKAP2 PALM2 and AKAP2 fusion 0.00437503
RPL37A ribosomal protein L37a 0.00280681
NPAS2 neuronal PAS domain protein 2 0.00266659
OGA O-GlcNAcase 0.00246396
KMT2E lysine (K)-specific methyltransferase 2E 0.00169725

decreased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) -0.234576
SNX9 sorting nexin 9 -0.166005
MAML2 mastermind-like 2 (Drosophila) -0.130248
RPS16 ribosomal protein S16 -0.129782
MACF1 microtubule-actin crosslinking factor 1 -0.128222
RBM25 RNA binding motif protein 25 -0.124538
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.118299
CARD16 caspase recruitment domain family, member 16 -0.112286
RPL26 ribosomal protein L26 -0.102745
VIM vimentin -0.0989071
LAMB3 laminin, beta 3 -0.0908982
NAV2 neuron navigator 2 -0.0786634
RPS8 ribosomal protein S8 -0.0749708
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0724216
RPLP2 ribosomal protein, large, P2 -0.0708948
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0672882
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.06549
RPLP1 ribosomal protein, large, P1 -0.0624557
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0595523
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0584048
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0565985
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0539859
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0539256
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0537227
ZBTB20 zinc finger and BTB domain containing 20 -0.053709
FN1 fibronectin 1 -0.052098
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0516178
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.049777
SRRM2 serine/arginine repetitive matrix 2 -0.048288
PGK1 phosphoglycerate kinase 1 -0.046167
STAG2 stromal antigen 2 -0.0458925
HDLBP high density lipoprotein binding protein -0.0450311
ITGA6 integrin, alpha 6 -0.044873
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0441084
JMJD1C jumonji domain containing 1C -0.0431842
BIRC6 baculoviral IAP repeat containing 6 -0.0390278
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0378883
MYOF myoferlin -0.0320122
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0307057
RPL35A ribosomal protein L35a -0.0291866
SBF2 SET binding factor 2 -0.0290524
TPT1 tumor protein, translationally-controlled 1 -0.0283051
IGFBP5 insulin-like growth factor binding protein 5 -0.0266376
ZFR zinc finger RNA binding protein -0.0258605
WASF2 WAS protein family, member 2 -0.0256758
PTMA prothymosin, alpha -0.0196669
TMSB10 thymosin beta 10 -0.0177821
ZNF292 zinc finger protein 292 -0.0173232
NDRG1 N-myc downstream regulated 1 -0.0169327
ENO1 enolase 1, (alpha) -0.0158059
PARD3 par-3 family cell polarity regulator -0.0149388
GMDS GDP-mannose 4,6-dehydratase -0.0115521
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0100457
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.00980797
RPS3 ribosomal protein S3 -0.00755191
FTH1 ferritin, heavy polypeptide 1 -0.00421378