Methylprednisolone succinate_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.1304
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.122461
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.11479
ERBB4 erb-b2 receptor tyrosine kinase 4 0.110944
DST dystonin 0.0959276
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0915833
PGAP1 post-GPI attachment to proteins 1 0.0899926
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0801947
ADGRL2 adhesion G protein-coupled receptor L2 0.0741016
TSC22D2 TSC22 domain family, member 2 0.0689021
COL11A1 collagen, type XI, alpha 1 0.0677606
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0664016
FNDC3B fibronectin type III domain containing 3B 0.0659988
RERE arginine-glutamic acid dipeptide (RE) repeats 0.063385
ADAM9 ADAM metallopeptidase domain 9 0.0631871
HDAC9 histone deacetylase 9 0.0613143
NCAM2 neural cell adhesion molecule 2 0.0603807
PCDH9 protocadherin 9 0.0603211
TRIO trio Rho guanine nucleotide exchange factor 0.0544843
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0513103
KMT2E lysine (K)-specific methyltransferase 2E 0.0511463
NCKAP1 NCK-associated protein 1 0.0480162
ADGRV1 adhesion G protein-coupled receptor V1 0.0460796
ITGAV integrin, alpha V 0.0454316
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0453801
ZEB2 zinc finger E-box binding homeobox 2 0.0447222
MED13L mediator complex subunit 13-like 0.0446332
PRTG protogenin 0.0424272
STAG2 stromal antigen 2 0.0416949
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0416494
ZMYM2 zinc finger, MYM-type 2 0.04106
TCEA1 transcription elongation factor A (SII), 1 0.0408197
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0400887
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0398593
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0385421
ADGRL3 adhesion G protein-coupled receptor L3 0.0383083
PTK2 protein tyrosine kinase 2 0.0378388
TENM3 teneurin transmembrane protein 3 0.0376665
ZFAND3 zinc finger, AN1-type domain 3 0.0373773
NHSL1 NHS-like 1 0.0372069
CHD1 chromodomain helicase DNA binding protein 1 0.0367155
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0359195
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0354742
MACF1 microtubule-actin crosslinking factor 1 0.034904
ECT2 epithelial cell transforming 2 0.0343557
CFL2 cofilin 2 (muscle) 0.0339823
ANK2 ankyrin 2, neuronal 0.0338062
ZNF608 zinc finger protein 608 0.0337328
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0336704
FUBP1 far upstream element (FUSE) binding protein 1 0.0331231
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0331006
KMT2C lysine (K)-specific methyltransferase 2C 0.0329333
RAI1 retinoic acid induced 1 0.0328776
PPP4R1 protein phosphatase 4, regulatory subunit 1 0.0327857
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.032702
ANXA2 annexin A2 0.0325301
PDGFC platelet derived growth factor C 0.0324617
TRPS1 trichorhinophalangeal syndrome I 0.0323101
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0322781
STRN3 striatin, calmodulin binding protein 3 0.0316795
MYH9 myosin, heavy chain 9, non-muscle 0.0316713
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0312842
RASAL2 RAS protein activator like 2 0.0311778
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0307995
RREB1 ras responsive element binding protein 1 0.0307863
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.030356
METAP2 methionyl aminopeptidase 2 0.0301028
PCLO piccolo presynaptic cytomatrix protein 0.0290733
TTC28 tetratricopeptide repeat domain 28 0.0290346
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0289117
PUM1 pumilio RNA-binding family member 1 0.0285687
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0282957
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0282226
UBQLN1 ubiquilin 1 0.0282108
CENPE centromere protein E, 312kDa 0.0281168
AKAP13 A kinase (PRKA) anchor protein 13 0.0280975
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0278751
ENAH enabled homolog (Drosophila) 0.0276819
PRR16 proline rich 16 0.0276267
ANXA1 annexin A1 0.0275217
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0274708
RBM33 RNA binding motif protein 33 0.0274102
BIRC6 baculoviral IAP repeat containing 6 0.0270008
PRKD1 protein kinase D1 0.0267478
COLEC11 collectin sub-family member 11 0.0266046
SOX5 SRY (sex determining region Y)-box 5 0.0265655
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0262476
TOX thymocyte selection-associated high mobility group box 0.0260551
UTRN utrophin 0.0259717
CDC73 cell division cycle 73 0.0257266
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0255998
SMC4 structural maintenance of chromosomes 4 0.0255827
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0255636
ZNF217 zinc finger protein 217 0.0254848
SAMD4A sterile alpha motif domain containing 4A 0.0254359
ANXA5 annexin A5 0.0251704
SHROOM3 shroom family member 3 0.0250433
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0250413
GPBP1 GC-rich promoter binding protein 1 0.0248614
ANKRD17 ankyrin repeat domain 17 0.0248343

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.185984
VIM vimentin -0.182327
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.135933
RPS16 ribosomal protein S16 -0.0852875
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0799631
RPS19 ribosomal protein S19 -0.0716779
ACTG1 actin gamma 1 -0.0716264
RPS27A ribosomal protein S27a -0.0689094
RPS8 ribosomal protein S8 -0.0662309
RPL23 ribosomal protein L23 -0.0643399
RPL35A ribosomal protein L35a -0.0639089
RPLP1 ribosomal protein, large, P1 -0.0636794
RPS12 ribosomal protein S12 -0.0624585
RPS3 ribosomal protein S3 -0.0573314
RPS6 ribosomal protein S6 -0.0526552
UBC ubiquitin C -0.0517219
EEF2 eukaryotic translation elongation factor 2 -0.0510095
TPT1 tumor protein, translationally-controlled 1 -0.0502422
RPL37A ribosomal protein L37a -0.0438838
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.043489
PTMA prothymosin, alpha -0.0427681
RPL19 ribosomal protein L19 -0.0427507
RPL31 ribosomal protein L31 -0.0413269
MDK midkine (neurite growth-promoting factor 2) -0.0408694
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0402198
ENO1 enolase 1, (alpha) -0.0400818
RPLP2 ribosomal protein, large, P2 -0.0382864
EIF1 eukaryotic translation initiation factor 1 -0.0373804
GNAS GNAS complex locus -0.0365471
CNRIP1 cannabinoid receptor interacting protein 1 -0.0354174
RPL5 ribosomal protein L5 -0.0344623
RPL12 ribosomal protein L12 -0.0343715
RACK1 receptor for activated C kinase 1 -0.0341464
RPS13 ribosomal protein S13 -0.0340118
RPS25 ribosomal protein S25 -0.0339443
RPL26 ribosomal protein L26 -0.0339273
RPL37 ribosomal protein L37 -0.0321651
LOC112694756 uncharaterized LOC112694756 -0.0313094
RPS21 ribosomal protein S21 -0.0311544
TMSB4X thymosin beta 4, X-linked -0.030981
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309639
NAP1L1 nucleosome assembly protein 1-like 1 -0.0303364
RPL9 ribosomal protein L9 -0.0302464
FTL ferritin, light polypeptide -0.0299784
PFN1 profilin 1 -0.0294616
CDK6 cyclin-dependent kinase 6 -0.0292596
RPL36 ribosomal protein L36 -0.0289928
S100A10 S100 calcium binding protein A10 -0.0286593
RPS14 ribosomal protein S14 -0.0285485
RPL36A ribosomal protein L36a -0.0283268
RPL11 ribosomal protein L11 -0.0280677
RPS4X ribosomal protein S4, X-linked -0.0279398
POTEF POTE ankyrin domain family, member F -0.0278448
RPL15 ribosomal protein L15 -0.0274197
APOE apolipoprotein E -0.0271956
EAPP E2F-associated phosphoprotein -0.0261195
RPS24 ribosomal protein S24 -0.025638
ATF4 activating transcription factor 4 -0.0249894
RPS17 ribosomal protein S17 -0.0248375
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0247634
RPL32 ribosomal protein L32 -0.0246569
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0245305
RPL38 ribosomal protein L38 -0.0243896
RPS20 ribosomal protein S20 -0.0243191
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0242784
RPS29 ribosomal protein S29 -0.0237487
SPDYA speedy/RINGO cell cycle regulator family member A -0.0235757
JUN jun proto-oncogene -0.0233848
HSPB1 heat shock 27kDa protein 1 -0.0231804
RPS5 ribosomal protein S5 -0.0231676
PDIA3 protein disulfide isomerase family A, member 3 -0.0230494
RPL34 ribosomal protein L34 -0.0229077
B2M beta-2-microglobulin -0.0226065
RSL1D1 ribosomal L1 domain containing 1 -0.0225128
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0224804
PRRC2C proline-rich coiled-coil 2C -0.022418
RAB7A RAB7A, member RAS oncogene family -0.0223687
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0218707
GARS1 glycyl-tRNA synthetase 1 -0.0217349
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0215257
RCC1 regulator of chromosome condensation 1 -0.0213889
LOC102724023 ES1 protein homolog, mitochondrial -0.0213087
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0210614
EIF5B eukaryotic translation initiation factor 5B -0.0209146
RPLP0 ribosomal protein, large, P0 -0.0208054
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.020781
MYL12B myosin, light chain 12B, regulatory -0.020333
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.019904
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0196874
RPL23A ribosomal protein L23a -0.0196044
RPL7A ribosomal protein L7a -0.0195562
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0195327
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0192733
CDK12 cyclin-dependent kinase 12 -0.0191543
RPS10 ribosomal protein S10 -0.019097
FTH1 ferritin, heavy polypeptide 1 -0.0189244
RPS28 ribosomal protein S28 -0.0189131
PA2G4 proliferation-associated 2G4, 38kDa -0.0184241
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0184072
UBB ubiquitin B -0.0182152