Methylprednisolone succinate_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.153659
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.147601
PTK2 protein tyrosine kinase 2 0.119958
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0746904
PBX3 pre-B-cell leukemia homeobox 3 0.068297
BIRC6 baculoviral IAP repeat containing 6 0.0679711
SRPK2 SRSF protein kinase 2 0.0672822
TRIO trio Rho guanine nucleotide exchange factor 0.0672362
UBA6 ubiquitin-like modifier activating enzyme 6 0.0643152
DLC1 DLC1 Rho GTPase activating protein 0.0635817
OGA O-GlcNAcase 0.0629513
FLNB filamin B, beta 0.0606115
MCL1 myeloid cell leukemia 1 0.0592524
NUP58 nucleoporin 58 0.0585059
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.058445
ZFAND3 zinc finger, AN1-type domain 3 0.0561518
CALD1 caldesmon 1 0.0540492
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0524785
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0511053
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0509985
MAST4 microtubule associated serine/threonine kinase family member 4 0.0508156
PCBP2 poly(rC) binding protein 2 0.0497175
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0491599
DSCAM Down syndrome cell adhesion molecule 0.0489297
NCKAP1 NCK-associated protein 1 0.0486104
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0482791
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0480541
MYH9 myosin, heavy chain 9, non-muscle 0.0479165
ANO6 anoctamin 6 0.0474494
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0457917
WAC WW domain containing adaptor with coiled-coil 0.0454986
BBX bobby sox homolog (Drosophila) 0.0453487
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0445048
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0443416
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0436735
ECPAS Ecm29 proteasome adaptor and scaffold 0.0432635
ATP13A3 ATPase type 13A3 0.0427504
RASA2 RAS p21 protein activator 2 0.0423598
CANX calnexin 0.0413625
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0410293
PCNX1 pecanex 1 0.0408115
TPM4 tropomyosin 4 0.0401781
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0401542
KDM2A lysine (K)-specific demethylase 2A 0.0399171
YEATS2 YEATS domain containing 2 0.0397878
SFPQ splicing factor proline/glutamine-rich 0.0390964
ANTXR2 anthrax toxin receptor 2 0.0386302
NCOR1 nuclear receptor corepressor 1 0.0378346
MACF1 microtubule-actin crosslinking factor 1 0.0377817
FMNL2 formin-like 2 0.0376295
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0371033
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0370037
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0367078
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0364839
UBE3C ubiquitin protein ligase E3C 0.0364494
SETD5 SET domain containing 5 0.0361557
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0360592
MTDH metadherin 0.0359609
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0359344
ZEB1 zinc finger E-box binding homeobox 1 0.0358865
SAMD4A sterile alpha motif domain containing 4A 0.0357032
FNBP4 formin binding protein 4 0.0355885
PGK1 phosphoglycerate kinase 1 0.0353911
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0352448
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0352095
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0350761
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0340663
ADAM9 ADAM metallopeptidase domain 9 0.0340385
FAM91A1 family with sequence similarity 91, member A1 0.0339926
CD274 CD274 molecule 0.0339288
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338989
RBM33 RNA binding motif protein 33 0.0338406
AXL AXL receptor tyrosine kinase 0.0337747
ANXA5 annexin A5 0.0336184
KMT2E lysine (K)-specific methyltransferase 2E 0.0335572
CHD7 chromodomain helicase DNA binding protein 7 0.0332317
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0331999
ERBIN erbb2 interacting protein 0.0331392
PICALM phosphatidylinositol binding clathrin assembly protein 0.0331002
CAPRIN2 caprin family member 2 0.0330004
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0328716
FNDC3B fibronectin type III domain containing 3B 0.0327017
APP amyloid beta (A4) precursor protein 0.0326837
USP9X ubiquitin specific peptidase 9, X-linked 0.0326431
KTN1 kinectin 1 (kinesin receptor) 0.0323787
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0323444
RB1CC1 RB1-inducible coiled-coil 1 0.0322534
RUNX1 runt-related transcription factor 1 0.0319719
SNX9 sorting nexin 9 0.0319633
EEF1G eukaryotic translation elongation factor 1 gamma 0.0318118
MED13L mediator complex subunit 13-like 0.0317554
NBAS neuroblastoma amplified sequence 0.031418
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0313864
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.031177
VMP1 vacuole membrane protein 1 0.0309416
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0308165
AFF1 AF4/FMR2 family, member 1 0.0306898
CEP250 centrosomal protein 250kDa 0.0304958
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0302182
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0301053

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.10917
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0986907
MT2A metallothionein 2A -0.0828026
TPT1 tumor protein, translationally-controlled 1 -0.0795628
ACTG1 actin gamma 1 -0.0775749
ZNF438 zinc finger protein 438 -0.0754263
TMSB10 thymosin beta 10 -0.0657899
RPLP1 ribosomal protein, large, P1 -0.0575143
RPS24 ribosomal protein S24 -0.0563787
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0553223
RPS6 ribosomal protein S6 -0.0550234
RPS19 ribosomal protein S19 -0.0542758
RPL35A ribosomal protein L35a -0.0527866
RRBP1 ribosome binding protein 1 -0.046401
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0451696
RPL34 ribosomal protein L34 -0.0428531
SP100 SP100 nuclear antigen -0.0421357
FRMD4A FERM domain containing 4A -0.0419185
EIF1 eukaryotic translation initiation factor 1 -0.0398985
RPS21 ribosomal protein S21 -0.0395779
RPS12 ribosomal protein S12 -0.0377456
RPL4 ribosomal protein L4 -0.0371372
RPL8 ribosomal protein L8 -0.0370783
RPL7A ribosomal protein L7a -0.036981
ARHGAP22 Rho GTPase activating protein 22 -0.0358549
RPLP2 ribosomal protein, large, P2 -0.0355377
RPL32 ribosomal protein L32 -0.0353724
RPS4X ribosomal protein S4, X-linked -0.0347721
EGR1 early growth response 1 -0.0347238
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0329551
FTL ferritin, light polypeptide -0.0328681
RPL23 ribosomal protein L23 -0.0325179
RAB7A RAB7A, member RAS oncogene family -0.0313173
FHIT fragile histidine triad -0.0307306
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305607
RPL30 ribosomal protein L30 -0.0295982
NABP1 nucleic acid binding protein 1 -0.0290277
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0289725
NAV3 neuron navigator 3 -0.028745
SGMS2 sphingomyelin synthase 2 -0.0272454
ARF1 ADP-ribosylation factor 1 -0.0270513
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0269051
EEF2 eukaryotic translation elongation factor 2 -0.0267278
MT1X metallothionein 1X -0.0262031
RPL36 ribosomal protein L36 -0.0260668
HDAC9 histone deacetylase 9 -0.0248716
LOC112694756 uncharaterized LOC112694756 -0.0247497
HMGA1 high mobility group AT-hook 1 -0.0246614
GLRX glutaredoxin (thioltransferase) -0.0246395
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0246199
RPS20 ribosomal protein S20 -0.0241481
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0237843
CREB5 cAMP responsive element binding protein 5 -0.0231163
WNT2B wingless-type MMTV integration site family, member 2B -0.023061
RPS15 ribosomal protein S15 -0.0230457
RPLP0 ribosomal protein, large, P0 -0.0224679
RPL12 ribosomal protein L12 -0.0224027
RPL38 ribosomal protein L38 -0.0223451
GARS1 glycyl-tRNA synthetase 1 -0.0220232
IFI16 interferon, gamma-inducible protein 16 -0.0219381
INTS6 integrator complex subunit 6 -0.0218351
RPL6 ribosomal protein L6 -0.0218215
MTAP methylthioadenosine phosphorylase -0.0214779
RACK1 receptor for activated C kinase 1 -0.0209977
ATF4 activating transcription factor 4 -0.0206368
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0205557
UBB ubiquitin B -0.0202817
RPS27A ribosomal protein S27a -0.0200391
RPL26 ribosomal protein L26 -0.0198885
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -0.0196482
SPRY4 sprouty homolog 4 (Drosophila) -0.0185699
RPL35 ribosomal protein L35 -0.0185531
MSH4 mutS homolog 4 -0.0182444
RPL23A ribosomal protein L23a -0.0181941
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0175889
MYRFL myelin regulatory factor-like -0.0173872
GNAS GNAS complex locus -0.017134
SAMD9 sterile alpha motif domain containing 9 -0.0169794
RPL19 ribosomal protein L19 -0.0169714
BLZF1 basic leucine zipper nuclear factor 1 -0.0169503
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.016805
RPS10 ribosomal protein S10 -0.0166463
PFN1 profilin 1 -0.0165532
RPS8 ribosomal protein S8 -0.0165236
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2 -0.0164683
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0163959
RSL24D1 ribosomal L24 domain containing 1 -0.0163288
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0162769
RPL36A ribosomal protein L36a -0.0162025
HMGB1 high mobility group box 1 -0.0161948
RPL31 ribosomal protein L31 -0.0158484
RPL36AL ribosomal protein L36a-like -0.0157299
ERCC1 excision repair cross-complementation group 1 -0.0157241
ZC3H12B zinc finger CCCH-type containing 12B -0.0156402
S100A9 S100 calcium binding protein A9 -0.0149583
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0146763
RPS16 ribosomal protein S16 -0.0143671
RPS3 ribosomal protein S3 -0.014349
IFITM2 interferon induced transmembrane protein 2 -0.0143125
IER2 immediate early response 2 -0.0142392