Methylprednisolone succinate_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.172407
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.141326
TENM1 teneurin transmembrane protein 1 0.0954108
NALF1 NALCN channel auxiliary factor 1 0.0859734
SMOC1 SPARC related modular calcium binding 1 0.0798631
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0760385
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0753145
TRIO trio Rho guanine nucleotide exchange factor 0.0746871
PDE4B phosphodiesterase 4B, cAMP-specific 0.0734096
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0685724
NKAIN2 Na+/K+ transporting ATPase interacting 2 0.0676404
CENPF centromere protein F, 350/400kDa 0.0667217
FAT1 FAT atypical cadherin 1 0.057262
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0568603
TENT5A terminal nucleotidyltransferase 5A 0.0558037
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0549508
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0548005
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0534684
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0506955
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0501131
JAZF1 JAZF zinc finger 1 0.0495133
PSD3 pleckstrin and Sec7 domain containing 3 0.0494547
PCM1 pericentriolar material 1 0.0491309
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0490934
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0486205
FGF14 fibroblast growth factor 14 0.046678
NCOR1 nuclear receptor corepressor 1 0.0462796
CHD7 chromodomain helicase DNA binding protein 7 0.0456681
CADM1 cell adhesion molecule 1 0.045187
SMC1A structural maintenance of chromosomes 1A 0.0442733
MED13L mediator complex subunit 13-like 0.0440882
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0437082
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0436848
CA8 carbonic anhydrase VIII 0.0428633
SMYD3 SET and MYND domain containing 3 0.0425405
DTNA dystrobrevin, alpha 0.0423936
GPC6 glypican 6 0.042009
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0419342
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0418671
NCAM1 neural cell adhesion molecule 1 0.0403379
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0401484
PUM1 pumilio RNA-binding family member 1 0.0398112
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0398077
XRN2 5'-3' exoribonuclease 2 0.0394874
MCL1 myeloid cell leukemia 1 0.0394713
NBAS neuroblastoma amplified sequence 0.0388323
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0385571
MACF1 microtubule-actin crosslinking factor 1 0.0384171
NUP58 nucleoporin 58 0.0377382
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0369639
ECT2 epithelial cell transforming 2 0.0368936
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0359202
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0358353
SFPQ splicing factor proline/glutamine-rich 0.0356876
NCKAP5 NCK-associated protein 5 0.0356127
MIS18BP1 MIS18 binding protein 1 0.0354364
SNAP25 synaptosomal-associated protein, 25kDa 0.0353933
JAM3 junctional adhesion molecule 3 0.0348097
RAD51B RAD51 paralog B 0.0347763
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0344283
MYH9 myosin, heavy chain 9, non-muscle 0.0340816
BCLAF1 BCL2-associated transcription factor 1 0.0338486
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0333013
NRXN1 neurexin 1 0.0332399
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0328936
NIPBL Nipped-B homolog (Drosophila) 0.0328714
RAD21 RAD21 homolog (S. pombe) 0.0325766
CCNY cyclin Y 0.032565
AUTS2 autism susceptibility candidate 2 0.0324655
TOX thymocyte selection-associated high mobility group box 0.0324184
ESRRG estrogen-related receptor gamma 0.0322882
NRG1 neuregulin 1 0.0320285
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0319256
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0318584
ADAM17 ADAM metallopeptidase domain 17 0.0316059
FAF1 Fas (TNFRSF6) associated factor 1 0.0315211
LINGO2 leucine rich repeat and Ig domain containing 2 0.0315024
MBNL1 muscleblind-like splicing regulator 1 0.0313186
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0310842
LCOR ligand dependent nuclear receptor corepressor 0.030991
TUSC3 tumor suppressor candidate 3 0.0307834
HMGB3 high mobility group box 3 0.0305089
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0303974
APLP2 amyloid beta (A4) precursor-like protein 2 0.0301376
PEG10 paternally expressed 10 0.0301369
MARCHF6 membrane associated ring-CH-type finger 6 0.0299587
ZMAT4 zinc finger, matrin-type 4 0.0299427
NFIA nuclear factor I/A 0.0299321
AFF1 AF4/FMR2 family, member 1 0.0299234
MBNL2 muscleblind-like splicing regulator 2 0.0298966
AOPEP aminopeptidase O (putative) 0.0295025
ADGRL3 adhesion G protein-coupled receptor L3 0.0293678
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0293069
FNDC3A fibronectin type III domain containing 3A 0.0292513
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0290649
TENT4A terminal nucleotidyltransferase 4A 0.0288683
MATR3 matrin 3 0.0287614
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.028746
FOXJ3 forkhead box J3 0.0284043
APP amyloid beta (A4) precursor protein 0.0282504

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.123161
FTL ferritin, light polypeptide -0.104316
STC1 stanniocalcin 1 -0.0780762
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0584177
RPLP1 ribosomal protein, large, P1 -0.0521018
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0498349
RPS3 ribosomal protein S3 -0.0482748
RPS8 ribosomal protein S8 -0.0482503
RPS6 ribosomal protein S6 -0.0481445
RPS19 ribosomal protein S19 -0.0432855
TMSB10 thymosin beta 10 -0.0432521
S100A9 S100 calcium binding protein A9 -0.0422718
DOCK5 dedicator of cytokinesis 5 -0.0422256
RPS21 ribosomal protein S21 -0.0421624
TPT1 tumor protein, translationally-controlled 1 -0.0411663
RPL23 ribosomal protein L23 -0.0403907
TMSB4X thymosin beta 4, X-linked -0.0401301
RPL37A ribosomal protein L37a -0.0399276
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0386146
RPL12 ribosomal protein L12 -0.0382239
RPL26 ribosomal protein L26 -0.0381946
RPS12 ribosomal protein S12 -0.0377864
RPS16 ribosomal protein S16 -0.0375414
RPL11 ribosomal protein L11 -0.036586
ENO1 enolase 1, (alpha) -0.0359673
RPLP2 ribosomal protein, large, P2 -0.0359567
IGFBP5 insulin-like growth factor binding protein 5 -0.0356687
RPL37 ribosomal protein L37 -0.0354198
GNAS GNAS complex locus -0.0352881
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0351221
NDRG1 N-myc downstream regulated 1 -0.0344233
RPL38 ribosomal protein L38 -0.0342426
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0326251
LOC112694756 uncharaterized LOC112694756 -0.0325887
RPL32 ribosomal protein L32 -0.0325462
MT1X metallothionein 1X -0.0323627
IFI6 interferon, alpha-inducible protein 6 -0.0310962
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0305132
ATP5F1E ATP synthase F1 subunit epsilon -0.0304879
RPL31 ribosomal protein L31 -0.0301175
RPL35A ribosomal protein L35a -0.0294941
RPL36 ribosomal protein L36 -0.0293907
RPS5 ribosomal protein S5 -0.0289946
RPL19 ribosomal protein L19 -0.028953
RPS27A ribosomal protein S27a -0.028738
RPL36A ribosomal protein L36a -0.0285752
RPL5 ribosomal protein L5 -0.0285384
RPS14 ribosomal protein S14 -0.0282218
RPL8 ribosomal protein L8 -0.0279628
RPS17 ribosomal protein S17 -0.0275323
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0267984
RPS20 ribosomal protein S20 -0.0265826
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0261839
RPL7A ribosomal protein L7a -0.0260262
DGKD diacylglycerol kinase, delta 130kDa -0.0259625
RPS11 ribosomal protein S11 -0.0252056
TUBB4B tubulin, beta 4B class IVb -0.0249953
RPS4X ribosomal protein S4, X-linked -0.0248211
SOX4 SRY (sex determining region Y)-box 4 -0.0247615
RPL35 ribosomal protein L35 -0.0236787
RRBP1 ribosome binding protein 1 -0.0235645
ZCCHC2 zinc finger, CCHC domain containing 2 -0.0235031
B2M beta-2-microglobulin -0.0230828
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0229088
RPS29 ribosomal protein S29 -0.0226529
RIMS2 regulating synaptic membrane exocytosis 2 -0.0220917
RPL34 ribosomal protein L34 -0.0217796
AKAP12 A kinase (PRKA) anchor protein 12 -0.021616
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0215805
RPLP0 ribosomal protein, large, P0 -0.0214241
ST18 suppression of tumorigenicity 18, zinc finger -0.0209958
SCG2 secretogranin II -0.0207618
RPL4 ribosomal protein L4 -0.02007
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0200245
FTH1 ferritin, heavy polypeptide 1 -0.0199942
FOXC1 forkhead box C1 -0.01951
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0193746
RPL15 ribosomal protein L15 -0.0193619
RPS10 ribosomal protein S10 -0.0191894
FKBP3 FK506 binding protein 3, 25kDa -0.0191783
RPL28 ribosomal protein L28 -0.0191507
ACTG1 actin gamma 1 -0.0191313
FGF9 fibroblast growth factor 9 -0.0189933
ISG15 ISG15 ubiquitin-like modifier -0.0189341
EIF1 eukaryotic translation initiation factor 1 -0.0189032
RPS25 ribosomal protein S25 -0.0185358
GABARAP GABA(A) receptor-associated protein -0.0184611
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.01836
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) -0.0177616
KIF26B kinesin family member 26B -0.0174746
TFF3 trefoil factor 3 (intestinal) -0.0173892
BACE2 beta-site APP-cleaving enzyme 2 -0.0171549
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0169115
PFN1 profilin 1 -0.01669
RACK1 receptor for activated C kinase 1 -0.0165993
HMGB1 high mobility group box 1 -0.0165841
EEF2 eukaryotic translation elongation factor 2 -0.0162949
RPL30 ribosomal protein L30 -0.0162362
RPS27 ribosomal protein S27 -0.0160464
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0159962