Methylprednisolone succinate_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.292576
NLGN1 neuroligin 1 0.161798
FNDC3B fibronectin type III domain containing 3B 0.159334
LSAMP limbic system-associated membrane protein 0.137179
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.131233
VIM vimentin 0.106016
NRG3 neuregulin 3 0.0941829
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0927058
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0879287
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0870913
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0798508
DST dystonin 0.0783814
MSI2 musashi RNA-binding protein 2 0.0751495
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0728528
SLC39A11 solute carrier family 39, member 11 0.0691419
SFTPA2 surfactant protein A2 0.0653771
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0652336
FLNB filamin B, beta 0.0638355
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.061824
MSN moesin 0.0603318
LINGO2 leucine rich repeat and Ig domain containing 2 0.0594549
NOTCH2 notch 2 0.0586925
BBX bobby sox homolog (Drosophila) 0.05817
RAD51B RAD51 paralog B 0.0566305
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0545902
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0543538
PKM pyruvate kinase, muscle 0.0540375
NAV2 neuron navigator 2 0.0487817
FMNL2 formin-like 2 0.0486816
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0469033
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0463601
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0457636
AKAP12 A kinase (PRKA) anchor protein 12 0.0457396
PTK2 protein tyrosine kinase 2 0.0444109
SEPTIN9 septin 9 0.0435725
SETD5 SET domain containing 5 0.0434956
KMT2E lysine (K)-specific methyltransferase 2E 0.0430507
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0429955
CENPF centromere protein F, 350/400kDa 0.0425155
PRELID2 PRELI domain containing 2 0.0421994
LRMDA leucine rich melanocyte differentiation associated 0.0419532
YEATS2 YEATS domain containing 2 0.0415326
PCBP2 poly(rC) binding protein 2 0.0406369
PTPRG protein tyrosine phosphatase, receptor type, G 0.0402404
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0401584
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0397262
LEF1 lymphoid enhancer-binding factor 1 0.0396126
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0393452
CANX calnexin 0.0393413
MMP12 matrix metallopeptidase 12 0.0393334
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0390779
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0387802
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0386537
FHIT fragile histidine triad 0.0385617
LDHA lactate dehydrogenase A 0.0382561
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0380837
TPM3 tropomyosin 3 0.0376833
ICAM1 intercellular adhesion molecule 1 0.037629
ASPH aspartate beta-hydroxylase 0.0375709
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0371084
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0367026
CDH13 cadherin 13 0.0361485
PTPRM protein tyrosine phosphatase, receptor type, M 0.0352791
SOX10 SRY (sex determining region Y)-box 10 0.0349919
TNIK TRAF2 and NCK interacting kinase 0.0346501
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0345801
MBNL1 muscleblind-like splicing regulator 1 0.0343044
POTEF POTE ankyrin domain family, member F 0.0338037
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.03362
ATXN1 ataxin 1 0.0334469
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0332916
SBF2 SET binding factor 2 0.0332869
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.033127
CNKSR3 CNKSR family member 3 0.0328081
CTBP2 C-terminal binding protein 2 0.0326966
MAML3 mastermind-like 3 (Drosophila) 0.0324381
CADM1 cell adhesion molecule 1 0.0322807
BIRC6 baculoviral IAP repeat containing 6 0.0321547
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0319191
SMAD3 SMAD family member 3 0.0312454
ESYT2 extended synaptotagmin-like protein 2 0.0311755
CFAP20DC CFAP20 domain containing 0.0311149
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0310774
ENO1 enolase 1, (alpha) 0.0308562
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0305418
OGA O-GlcNAcase 0.0301793
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0298079
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0295474
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0292469
SREBF2 sterol regulatory element binding transcription factor 2 0.0288303
EXOC4 exocyst complex component 4 0.028678
NFE2L1 nuclear factor, erythroid 2-like 1 0.0285047
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0284556
HELZ helicase with zinc finger 0.0284378
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0282316
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0278897
PHF21A PHD finger protein 21A 0.0277174
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0276894
B2M beta-2-microglobulin 0.0276551
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0276402

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.128295
EIF1 eukaryotic translation initiation factor 1 -0.0553209
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0435182
TMSB10 thymosin beta 10 -0.0419816
FTL ferritin, light polypeptide -0.0407222
TPT1 tumor protein, translationally-controlled 1 -0.0342709
RPL35A ribosomal protein L35a -0.032316
LOC112694756 uncharaterized LOC112694756 -0.0305235
MT2A metallothionein 2A -0.0282514
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.0278534
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249203
TXNRD1 thioredoxin reductase 1 -0.0240742
ACTG1 actin gamma 1 -0.0224697
RACK1 receptor for activated C kinase 1 -0.0224097
RPL4 ribosomal protein L4 -0.0219346
RPLP1 ribosomal protein, large, P1 -0.0219119
VDAC1 voltage-dependent anion channel 1 -0.0210637
RPL32 ribosomal protein L32 -0.0204444
KLF6 Kruppel-like factor 6 -0.0200158
MT1X metallothionein 1X -0.0199048
IER3 immediate early response 3 -0.0187013
WNT2B wingless-type MMTV integration site family, member 2B -0.018571
RPL36A ribosomal protein L36a -0.0177851
RPS3 ribosomal protein S3 -0.0167664
FBXL2 F-box and leucine-rich repeat protein 2 -0.0165612
TP63 tumor protein p63 -0.0162627
RPL34 ribosomal protein L34 -0.015794
ATF4 activating transcription factor 4 -0.0156466
RPL31 ribosomal protein L31 -0.0155959
ARF1 ADP-ribosylation factor 1 -0.0154738
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0154001
EMP1 epithelial membrane protein 1 -0.0153992
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0146857
RPL38 ribosomal protein L38 -0.0146497
RPS21 ribosomal protein S21 -0.0145035
RPS24 ribosomal protein S24 -0.0142658
RPLP2 ribosomal protein, large, P2 -0.0142231
SENP5 SUMO1/sentrin specific peptidase 5 -0.0141831
RPS4X ribosomal protein S4, X-linked -0.0139939
RPL11 ribosomal protein L11 -0.0136567
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0135269
RPL23 ribosomal protein L23 -0.0133554
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0129821
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0129761
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0124279
BLZF1 basic leucine zipper nuclear factor 1 -0.0123601
MAPK8 mitogen-activated protein kinase 8 -0.0116932
SELENOK selenoprotein K -0.0116376
EGR1 early growth response 1 -0.0115911
RPS5 ribosomal protein S5 -0.0115726
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0115349
RPS6 ribosomal protein S6 -0.0114819
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0114221
RPS19 ribosomal protein S19 -0.0111342
RPL28 ribosomal protein L28 -0.0111226
GARS1 glycyl-tRNA synthetase 1 -0.010788
RPS27A ribosomal protein S27a -0.0106771
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0106328
SERINC5 serine incorporator 5 -0.0104892
RPL37A ribosomal protein L37a -0.0104337
ZNF655 zinc finger protein 655 -0.0103854
TMEM263 transmembrane protein 263 -0.0103734
NPR2 natriuretic peptide receptor 2 -0.0103133
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -0.0102774
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.010265
BZW1 basic leucine zipper and W2 domains 1 -0.00989754
AHNAK2 AHNAK nucleoprotein 2 -0.0098863
FADD Fas (TNFRSF6)-associated via death domain -0.00988112
DNAH14 dynein, axonemal, heavy chain 14 -0.00974786
SHTN1 shootin 1 -0.00973116
TUBB4B tubulin, beta 4B class IVb -0.0096999
MTAP methylthioadenosine phosphorylase -0.00961621
RPS23 ribosomal protein S23 -0.00953108
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.00950759
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.00947117
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.00940385
ULK4 unc-51 like kinase 4 -0.00937048
GNAS GNAS complex locus -0.00935368
GPATCH8 G patch domain containing 8 -0.00934919
KIAA0232 KIAA0232 -0.00929062
PMP22 peripheral myelin protein 22 -0.00921643
RPS14 ribosomal protein S14 -0.00916425
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00910065
RSL1D1 ribosomal L1 domain containing 1 -0.00908123
WBP2NL WBP2 N-terminal like -0.00907554
CSTB cystatin B (stefin B) -0.00898499
RPS27 ribosomal protein S27 -0.0089795
REEP3 receptor accessory protein 3 -0.00897011
RPL10A ribosomal protein L10a -0.0089198
CD63 CD63 molecule -0.00891655
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.008891
RIGI RNA sensor RIG-I -0.00861832
FRMD5 FERM domain containing 5 -0.00861673
RPS29 ribosomal protein S29 -0.00859387
CAVIN1 caveolae associated protein 1 -0.00857096
UBE2B ubiquitin-conjugating enzyme E2B -0.00856531
RPS13 ribosomal protein S13 -0.00852076
DCAF10 DDB1 and CUL4 associated factor 10 -0.0084552
PLSCR1 phospholipid scramblase 1 -0.00833044
OPHN1 oligophrenin 1 -0.00830138