Methylprednisolone succinate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.13251
LMO7 LIM domain 7 0.104456
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0679005
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0604289
PDLIM5 PDZ and LIM domain 5 0.0557177
KLF5 Kruppel-like factor 5 (intestinal) 0.0541641
WAC WW domain containing adaptor with coiled-coil 0.0517866
ESYT2 extended synaptotagmin-like protein 2 0.0510098
FAT1 FAT atypical cadherin 1 0.0489215
KRT18 keratin 18, type I 0.04782
RCOR1 REST corepressor 1 0.041952
MARK3 MAP/microtubule affinity-regulating kinase 3 0.041693
ITPRID2 ITPR interacting domain containing 2 0.0412407
RAB10 RAB10, member RAS oncogene family 0.0392663
LGALS3 lectin, galactoside-binding, soluble, 3 0.0390247
RRM2 ribonucleotide reductase M2 0.0390126
IGFBP3 insulin-like growth factor binding protein 3 0.0369661
LAMA4 laminin, alpha 4 0.0365646
RPLP0 ribosomal protein, large, P0 0.0353586
CLTC clathrin, heavy chain (Hc) 0.03454
ANXA2 annexin A2 0.0339345
TPT1 tumor protein, translationally-controlled 1 0.0324719
BAMBI BMP and activin membrane-bound inhibitor 0.0312613
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0309173
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0307805
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0306975
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0303016
ANXA1 annexin A1 0.029994
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.029425
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.028403
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0280628
NFIA nuclear factor I/A 0.0269016
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.026137
SAMD5 sterile alpha motif domain containing 5 0.0258892
SCFD1 sec1 family domain containing 1 0.0257598
PUM2 pumilio RNA-binding family member 2 0.0254694
KLF3 Kruppel-like factor 3 (basic) 0.0249482
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0247034
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0243783
RPL35A ribosomal protein L35a 0.0241747
FAR1 fatty acyl CoA reductase 1 0.0241227
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0239719
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0238699
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0234737
BBX bobby sox homolog (Drosophila) 0.0234281
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.023249
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0229702
RPS8 ribosomal protein S8 0.0229086
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0220393
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0219212
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.021636
RPL11 ribosomal protein L11 0.0214804
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0214799
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0214209
GARS1 glycyl-tRNA synthetase 1 0.0213288
CHD1 chromodomain helicase DNA binding protein 1 0.0212849
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0209785
SEC31A SEC31 homolog A (S. cerevisiae) 0.0209425
TBC1D4 TBC1 domain family, member 4 0.020883
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0207975
CTBP2 C-terminal binding protein 2 0.0207363
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0207298
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0207122
MAT2A methionine adenosyltransferase II, alpha 0.0207092
RREB1 ras responsive element binding protein 1 0.0205436
OXR1 oxidation resistance 1 0.0204933
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0203527
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0201618
RUNX2 runt-related transcription factor 2 0.0201426
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0200917
EFNB2 ephrin-B2 0.0200838
KPNB1 karyopherin (importin) beta 1 0.0194725
GNG4 guanine nucleotide binding protein (G protein), gamma 4 0.0194194
RPS2 ribosomal protein S2 0.0192695
TRIO trio Rho guanine nucleotide exchange factor 0.0188821
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0188818
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0188437
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.0187902
NCOR2 nuclear receptor corepressor 2 0.0187752
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0187659
OXSR1 oxidative stress responsive 1 0.0186538
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0184804
THSD4 thrombospondin, type I, domain containing 4 0.0183805
RUFY2 RUN and FYVE domain containing 2 0.0180936
RPL22L1 ribosomal protein L22-like 1 0.0180893
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0178896
SCAF4 SR-related CTD-associated factor 4 0.0178227
CDK13 cyclin-dependent kinase 13 0.0176975
LRRC58 leucine rich repeat containing 58 0.0176789
SFTPA2 surfactant protein A2 0.0175655
DSCAM Down syndrome cell adhesion molecule 0.0175516
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0175376
INSIG2 insulin induced gene 2 0.0174294
RPL9 ribosomal protein L9 0.0174167
KDM6A lysine (K)-specific demethylase 6A 0.0174113
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0174049
RB1CC1 RB1-inducible coiled-coil 1 0.0173892
FRAS1 Fraser extracellular matrix complex subunit 1 0.0173853
KDM6B lysine (K)-specific demethylase 6B 0.0173492
PARD3 par-3 family cell polarity regulator 0.0173134

decreased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 -0.17334
TMSB10 thymosin beta 10 -0.159952
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157138
UBC ubiquitin C -0.132669
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.117472
AHNAK AHNAK nucleoprotein -0.108142
IER3 immediate early response 3 -0.106126
HMGA2 high mobility group AT-hook 2 -0.106058
RPS27A ribosomal protein S27a -0.102358
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0959498
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0867529
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0812906
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0776773
ENO1 enolase 1, (alpha) -0.0718163
RAD51B RAD51 paralog B -0.0707351
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0606861
ITPKC inositol-trisphosphate 3-kinase C -0.0534545
RPS3 ribosomal protein S3 -0.0533396
EIF1 eukaryotic translation initiation factor 1 -0.0526294
ATXN1 ataxin 1 -0.0524498
RPL4 ribosomal protein L4 -0.0523271
LAMC2 laminin, gamma 2 -0.0491584
EGFR epidermal growth factor receptor -0.0474993
AREG amphiregulin -0.0474001
VMP1 vacuole membrane protein 1 -0.0468904
ZNF292 zinc finger protein 292 -0.0468525
RPL23 ribosomal protein L23 -0.0446818
RPS19 ribosomal protein S19 -0.0445981
PDE4B phosphodiesterase 4B, cAMP-specific -0.0428903
CD36 CD36 molecule (thrombospondin receptor) -0.0427722
RPS4X ribosomal protein S4, X-linked -0.0410592
SDC4 syndecan 4 -0.0407104
PKM pyruvate kinase, muscle -0.038138
LAMB3 laminin, beta 3 -0.0378652
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0371709
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0367155
PCBP2 poly(rC) binding protein 2 -0.036568
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0360182
LOC112694756 uncharaterized LOC112694756 -0.0356991
PHF14 PHD finger protein 14 -0.035055
RPL3 ribosomal protein L3 -0.0345723
PNISR PNN-interacting serine/arginine-rich protein -0.0333907
FLNA filamin A, alpha -0.0331635
USP9X ubiquitin specific peptidase 9, X-linked -0.0331552
CD44 CD44 molecule (Indian blood group) -0.0328671
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0328108
PDIA3 protein disulfide isomerase family A, member 3 -0.0324592
PRRC2C proline-rich coiled-coil 2C -0.0324076
YAP1 Yes-associated protein 1 -0.0321719
AKAP12 A kinase (PRKA) anchor protein 12 -0.0319897
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.031904
SCLT1 sodium channel and clathrin linker 1 -0.0315475
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0310833
PDIA4 protein disulfide isomerase family A, member 4 -0.0309797
RPL15 ribosomal protein L15 -0.030325
RPL32 ribosomal protein L32 -0.0301964
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0298227
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0292766
RPL31 ribosomal protein L31 -0.0281502
EHBP1 EH domain binding protein 1 -0.0280926
KTN1 kinectin 1 (kinesin receptor) -0.0278099
HDAC2 histone deacetylase 2 -0.0277391
SEPTIN7 septin 7 -0.0277038
FBXL17 F-box and leucine-rich repeat protein 17 -0.0276716
RPL14 ribosomal protein L14 -0.027556
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.027146
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0270831
FHL2 four and a half LIM domains 2 -0.0266248
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0265269
NAV2 neuron navigator 2 -0.0261844
MT1X metallothionein 1X -0.0256659
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0255904
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0252517
SOS1 son of sevenless homolog 1 (Drosophila) -0.0249087
JUN jun proto-oncogene -0.0248996
SET SET nuclear proto-oncogene -0.0246649
S100A10 S100 calcium binding protein A10 -0.0246359
RPS6 ribosomal protein S6 -0.0245045
KDM3A lysine (K)-specific demethylase 3A -0.0244037
CPOX coproporphyrinogen oxidase -0.0243896
RPS29 ribosomal protein S29 -0.0242104
RPS12 ribosomal protein S12 -0.0239529
ASPH aspartate beta-hydroxylase -0.0237843
HSPA8 heat shock 70kDa protein 8 -0.023702
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0235962
PLAUR plasminogen activator, urokinase receptor -0.0234559
RPL5 ribosomal protein L5 -0.0232808
SMC1A structural maintenance of chromosomes 1A -0.0229852
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0229233
BICD1 bicaudal D homolog 1 (Drosophila) -0.0227889
FAF1 Fas (TNFRSF6) associated factor 1 -0.0227512
SRRM2 serine/arginine repetitive matrix 2 -0.0227243
RPS5 ribosomal protein S5 -0.0226532
EZR ezrin -0.0224509
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0224195
EMP1 epithelial membrane protein 1 -0.0222793
DOCK5 dedicator of cytokinesis 5 -0.0222317
MYH9 myosin, heavy chain 9, non-muscle -0.0222244
ABR active BCR-related -0.022199
EXOC4 exocyst complex component 4 -0.0221855