Methylprednisolone succinate_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.0890203
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0633242
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0575796
CDH13 cadherin 13 0.0562432
NAV2 neuron navigator 2 0.0559059
ATXN1 ataxin 1 0.0525067
ANXA2 annexin A2 0.0518646
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0503423
MAML2 mastermind-like 2 (Drosophila) 0.0460632
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0450117
ETNK1 ethanolamine kinase 1 0.0427367
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0426096
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.042469
DST dystonin 0.0400959
RAD51B RAD51 paralog B 0.0397012
MACF1 microtubule-actin crosslinking factor 1 0.0381355
ZBTB20 zinc finger and BTB domain containing 20 0.0373683
AXIN2 axin 2 0.0363908
RUNX1 runt-related transcription factor 1 0.0318495
ANLN anillin, actin binding protein 0.0318485
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.031663
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.031255
ESYT2 extended synaptotagmin-like protein 2 0.0303637
PLEC plectin 0.0298146
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0280288
NEBL nebulette 0.0279766
CD46 CD46 molecule, complement regulatory protein 0.027813
HDAC4 histone deacetylase 4 0.0275071
RLIM ring finger protein, LIM domain interacting 0.0248721
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0246191
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0242947
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0239027
AOPEP aminopeptidase O (putative) 0.0236582
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.02364
EXOC4 exocyst complex component 4 0.0230851
DSPP dentin sialophosphoprotein 0.0226399
YEATS2 YEATS domain containing 2 0.0224497
ANKRD10 ankyrin repeat domain 10 0.0219844
TBC1D22A TBC1 domain family, member 22A 0.0217313
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0216429
KIZ kizuna centrosomal protein 0.0201673
MED13 mediator complex subunit 13 0.019795
ABHD2 abhydrolase domain containing 2 0.0196291
MACC1 metastasis associated in colon cancer 1 0.0196055
TNS3 tensin 3 0.0194916
SMOC2 SPARC related modular calcium binding 2 0.019459
ANXA3 annexin A3 0.0194084
SDK1 sidekick cell adhesion molecule 1 0.0193849
IGFBP3 insulin-like growth factor binding protein 3 0.0192871
MRPS6 mitochondrial ribosomal protein S6 0.0192776
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187451
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0186728
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0186684
BIRC6 baculoviral IAP repeat containing 6 0.0184729
TNIK TRAF2 and NCK interacting kinase 0.018449
PROX1 prospero homeobox 1 0.0183903
CENPF centromere protein F, 350/400kDa 0.0183847
ECT2 epithelial cell transforming 2 0.0183765
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0178187
SNX9 sorting nexin 9 0.0177252
TBC1D5 TBC1 domain family, member 5 0.0173649
NCEH1 neutral cholesterol ester hydrolase 1 0.017204
FNIP1 folliculin interacting protein 1 0.0172022
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0171775
WNK1 WNK lysine deficient protein kinase 1 0.0170263
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0170193
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0169677
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0169562
GMDS GDP-mannose 4,6-dehydratase 0.0166464
SPATA13 spermatogenesis associated 13 0.0164117
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.0162874
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0161544
AFDN afadin, adherens junction formation factor 0.0161279
TNNC1 troponin C type 1 (slow) 0.0160274
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0159923
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0157826
FAT1 FAT atypical cadherin 1 0.0156145
KRT19 keratin 19, type I 0.0155564
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0154595
CDK8 cyclin-dependent kinase 8 0.0154361
MAT2A methionine adenosyltransferase II, alpha 0.0154319
OXR1 oxidation resistance 1 0.0153982
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0153429
TRA2B transformer 2 beta homolog (Drosophila) 0.0152858
CEP250 centrosomal protein 250kDa 0.0152743
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0151659
CTBP2 C-terminal binding protein 2 0.0151652
AKAP9 A kinase (PRKA) anchor protein 9 0.0150855
ANKRD28 ankyrin repeat domain 28 0.0149609
ANKRD36 ankyrin repeat domain 36 0.0148502
MTCL1 microtubule crosslinking factor 1 0.0148066
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0147201
LRMDA leucine rich melanocyte differentiation associated 0.0145875
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0145819
ITPRID2 ITPR interacting domain containing 2 0.0145751
KDM6A lysine (K)-specific demethylase 6A 0.0145012
UBA6 ubiquitin-like modifier activating enzyme 6 0.0144921
LRP6 low density lipoprotein receptor-related protein 6 0.0143792
GLI3 GLI family zinc finger 3 0.0143733
DAND5 DAN domain family member 5, BMP antagonist 0.0143293

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.219836
TMSB10 thymosin beta 10 -0.210164
RPS27A ribosomal protein S27a -0.134823
UBC ubiquitin C -0.122648
EEF2 eukaryotic translation elongation factor 2 -0.120655
ENO1 enolase 1, (alpha) -0.0968068
PTMA prothymosin, alpha -0.0886577
RPS6 ribosomal protein S6 -0.0880348
RPL23 ribosomal protein L23 -0.0879899
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0864164
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0826833
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0800246
RPS12 ribosomal protein S12 -0.0688293
RPS19 ribosomal protein S19 -0.0679438
AHNAK AHNAK nucleoprotein -0.0674668
LOC102724023 ES1 protein homolog, mitochondrial -0.0670021
ACTG1 actin gamma 1 -0.0639176
RPS24 ribosomal protein S24 -0.0627627
RPS3 ribosomal protein S3 -0.0620682
SYT1 synaptotagmin I -0.0615231
KRT8 keratin 8, type II -0.0607891
RPL32 ribosomal protein L32 -0.0578711
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0575177
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0555589
VIM vimentin -0.0553315
RPLP2 ribosomal protein, large, P2 -0.054455
RPS8 ribosomal protein S8 -0.0536895
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0530276
RPLP1 ribosomal protein, large, P1 -0.0527424
RPL36A ribosomal protein L36a -0.0507377
RPL5 ribosomal protein L5 -0.0502026
JUN jun proto-oncogene -0.0485038
RPS4X ribosomal protein S4, X-linked -0.0484297
PKM pyruvate kinase, muscle -0.0482309
PCBP2 poly(rC) binding protein 2 -0.0481158
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0472023
MT2A metallothionein 2A -0.0463515
TPT1 tumor protein, translationally-controlled 1 -0.0433864
EIF1 eukaryotic translation initiation factor 1 -0.0431809
EGR1 early growth response 1 -0.0428187
NAP1L1 nucleosome assembly protein 1-like 1 -0.0415897
TMSB4X thymosin beta 4, X-linked -0.0412347
RPL18 ribosomal protein L18 -0.0404933
RPS23 ribosomal protein S23 -0.0403517
S100A10 S100 calcium binding protein A10 -0.0399854
RPS5 ribosomal protein S5 -0.0396798
RPS13 ribosomal protein S13 -0.0391797
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0389829
RPL35A ribosomal protein L35a -0.0389254
RPL26 ribosomal protein L26 -0.0379717
LOC112694756 uncharaterized LOC112694756 -0.0371266
RACK1 receptor for activated C kinase 1 -0.0371158
LDHA lactate dehydrogenase A -0.0365047
PRRC2C proline-rich coiled-coil 2C -0.0363867
RPL37 ribosomal protein L37 -0.0361947
RPL8 ribosomal protein L8 -0.0344669
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0344016
RPL4 ribosomal protein L4 -0.034297
IPO7 importin 7 -0.0338436
DUSP6 dual specificity phosphatase 6 -0.0332053
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0331962
S100A6 S100 calcium binding protein A6 -0.0328332
IER3 immediate early response 3 -0.0325991
RPL36 ribosomal protein L36 -0.0320054
RPL7A ribosomal protein L7a -0.0317191
PDIA3 protein disulfide isomerase family A, member 3 -0.0317173
SLC38A2 solute carrier family 38, member 2 -0.0314668
RPL37A ribosomal protein L37a -0.0312114
H3-3B H3.3 histone B -0.0307206
PFN1 profilin 1 -0.0305812
RPS15 ribosomal protein S15 -0.0301645
RPL19 ribosomal protein L19 -0.0300964
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0294261
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0293355
UBB ubiquitin B -0.0291115
RPL31 ribosomal protein L31 -0.028677
SRRM2 serine/arginine repetitive matrix 2 -0.0285762
SOX4 SRY (sex determining region Y)-box 4 -0.0280447
EIF3M eukaryotic translation initiation factor 3, subunit M -0.0274299
RPS21 ribosomal protein S21 -0.0271327
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0270657
RPL34 ribosomal protein L34 -0.0268476
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0262485
PGK1 phosphoglycerate kinase 1 -0.0259684
RPL28 ribosomal protein L28 -0.0259249
POTEF POTE ankyrin domain family, member F -0.0258196
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0253626
MYL12B myosin, light chain 12B, regulatory -0.025346
CBX3 chromobox homolog 3 -0.0252301
GARS1 glycyl-tRNA synthetase 1 -0.0251462
EMP1 epithelial membrane protein 1 -0.0247848
PERP PERP, TP53 apoptosis effector -0.0246047
RPS17 ribosomal protein S17 -0.0245099
RPL9 ribosomal protein L9 -0.0242419
GLG1 golgi glycoprotein 1 -0.0239034
EIF5B eukaryotic translation initiation factor 5B -0.0238717
AKAP12 A kinase (PRKA) anchor protein 12 -0.0238457
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0238442
ACTN4 actinin, alpha 4 -0.0237511
CBFB core-binding factor, beta subunit -0.0235932