Methylprednisolone succinate_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylprednisolone succinate perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylprednisolone succinate_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.128033
MYH9 myosin, heavy chain 9, non-muscle 0.0913134
RPL37A ribosomal protein L37a 0.0761207
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0686019
FNDC3B fibronectin type III domain containing 3B 0.0599848
COL5A2 collagen, type V, alpha 2 0.0567566
TRIO trio Rho guanine nucleotide exchange factor 0.0554373
POTEF POTE ankyrin domain family, member F 0.0542367
ANXA2 annexin A2 0.0540962
CD44 CD44 molecule (Indian blood group) 0.0529989
HLA-B major histocompatibility complex, class I, B 0.0520292
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0508734
COL6A1 collagen, type VI, alpha 1 0.0467107
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0454081
FN1 fibronectin 1 0.0453915
RUNX1 runt-related transcription factor 1 0.0445166
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0439127
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0433773
IQGAP1 IQ motif containing GTPase activating protein 1 0.0431356
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0410888
RPS12 ribosomal protein S12 0.0405619
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0383379
KMT2E lysine (K)-specific methyltransferase 2E 0.0383017
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.037879
SMAD3 SMAD family member 3 0.0378042
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0377036
KTN1 kinectin 1 (kinesin receptor) 0.0376836
AKAP9 A kinase (PRKA) anchor protein 9 0.0370515
HDLBP high density lipoprotein binding protein 0.0365757
CALR calreticulin 0.0360995
NFE2L1 nuclear factor, erythroid 2-like 1 0.0358749
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0356557
RPS27A ribosomal protein S27a 0.0352884
OGA O-GlcNAcase 0.034626
CANX calnexin 0.034552
NDRG1 N-myc downstream regulated 1 0.033357
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0329569
YEATS2 YEATS domain containing 2 0.0321119
ASPH aspartate beta-hydroxylase 0.0320792
FNBP4 formin binding protein 4 0.032026
NOTCH2 notch 2 0.0310288
APLP2 amyloid beta (A4) precursor-like protein 2 0.0308768
PLEC plectin 0.0306121
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0305595
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0305491
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0305411
MYO10 myosin X 0.030445
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0298015
SMYD3 SET and MYND domain containing 3 0.0296267
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0294874
PDE4D phosphodiesterase 4D, cAMP-specific 0.0294491
EPAS1 endothelial PAS domain protein 1 0.0293954
MYO1E myosin IE 0.0290667
COL5A1 collagen, type V, alpha 1 0.0289883
RAD51B RAD51 paralog B 0.0284624
MYO6 myosin VI 0.0276735
MMP12 matrix metallopeptidase 12 0.0276196
ENO1 enolase 1, (alpha) 0.0274925
EPS8 epidermal growth factor receptor pathway substrate 8 0.0271854
DST dystonin 0.026884
MTSS1 metastasis suppressor 1 0.0266991
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0266621
IGFBP3 insulin-like growth factor binding protein 3 0.0264915
TJP1 tight junction protein 1 0.0263669
TGFBI transforming growth factor, beta-induced, 68kDa 0.0263095
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0257465
ATXN1 ataxin 1 0.0255255
PTMA prothymosin, alpha 0.0252914
AKAP12 A kinase (PRKA) anchor protein 12 0.0249901
TIMP2 TIMP metallopeptidase inhibitor 2 0.0248695
DSTN destrin (actin depolymerizing factor) 0.0248169
KRT18 keratin 18, type I 0.0247648
TNS1 tensin 1 0.0247524
MSN moesin 0.0246074
ANKRD28 ankyrin repeat domain 28 0.0243852
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0241871
SPAG9 sperm associated antigen 9 0.0239644
ARHGAP10 Rho GTPase activating protein 10 0.023912
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.023717
DOCK5 dedicator of cytokinesis 5 0.0236355
DPY19L1 dpy-19-like 1 (C. elegans) 0.0236081
MEF2A myocyte enhancer factor 2A 0.0234866
ISG15 ISG15 ubiquitin-like modifier 0.0232275
TXNIP thioredoxin interacting protein 0.0232076
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0230496
ALCAM activated leukocyte cell adhesion molecule 0.0228996
ZEB2 zinc finger E-box binding homeobox 2 0.0228506
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0227482
RPS17 ribosomal protein S17 0.022747
ADAM9 ADAM metallopeptidase domain 9 0.0226595
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0225418
DSPP dentin sialophosphoprotein 0.0224553
VEGFA vascular endothelial growth factor A 0.0224547
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224231
RAB6A RAB6A, member RAS oncogene family 0.0222704
IFIH1 interferon induced with helicase C domain 1 0.0222279
NKTR natural killer cell triggering receptor 0.0222258
WSB1 WD repeat and SOCS box containing 1 0.0221863
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0220837
FNDC3A fibronectin type III domain containing 3A 0.0220399

decreased expression

Symbol Name Standardized Value
MMP1 matrix metallopeptidase 1 -0.309416
INHBA inhibin, beta A -0.250082
STC1 stanniocalcin 1 -0.179004
HMGA2 high mobility group AT-hook 2 -0.157946
VIM vimentin -0.152317
NALF1 NALCN channel auxiliary factor 1 -0.109451
GREM1 gremlin 1, DAN family BMP antagonist -0.0910279
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0889361
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0855442
NPTX1 neuronal pentraxin I -0.0804489
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0765534
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0680778
PRKG1 protein kinase, cGMP-dependent, type I -0.0669381
FTL ferritin, light polypeptide -0.0654
IER3 immediate early response 3 -0.0605693
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0564052
COL6A2 collagen, type VI, alpha 2 -0.0467057
TMSB10 thymosin beta 10 -0.0462256
EIF1 eukaryotic translation initiation factor 1 -0.0415644
CAVIN1 caveolae associated protein 1 -0.0401457
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0397548
NCKAP5 NCK-associated protein 5 -0.0394379
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0370901
SAMD3 sterile alpha motif domain containing 3 -0.0369719
RPL34 ribosomal protein L34 -0.0355127
DNER delta/notch-like EGF repeat containing -0.0349596
WNT2B wingless-type MMTV integration site family, member 2B -0.0339847
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0332761
EMP1 epithelial membrane protein 1 -0.033187
CEMIP cell migration inducing protein, hyaluronan binding -0.0327542
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0323383
MAP1B microtubule-associated protein 1B -0.0320764
TFPI2 tissue factor pathway inhibitor 2 -0.0318605
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0298021
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0275396
CDH13 cadherin 13 -0.0274894
CSDE1 cold shock domain containing E1, RNA-binding -0.0274612
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0273137
GPHN gephyrin -0.0271882
NUMB numb homolog (Drosophila) -0.0269142
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0268794
ARF1 ADP-ribosylation factor 1 -0.0244219
INSIG1 insulin induced gene 1 -0.0231654
CCND1 cyclin D1 -0.0230008
PRRX1 paired related homeobox 1 -0.0225524
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0223889
AHNAK AHNAK nucleoprotein -0.0221549
EXT1 exostosin glycosyltransferase 1 -0.0220054
PDIA4 protein disulfide isomerase family A, member 4 -0.0219921
RRBP1 ribosome binding protein 1 -0.0218795
PFN1 profilin 1 -0.0216082
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0215695
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0207336
KLF12 Kruppel-like factor 12 -0.0206611
EBF1 early B-cell factor 1 -0.0206417
PID1 phosphotyrosine interaction domain containing 1 -0.0203906
SAMD4A sterile alpha motif domain containing 4A -0.0203839
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0202624
TM4SF1 transmembrane 4 L six family member 1 -0.0201108
INTS6 integrator complex subunit 6 -0.020032
DGKI diacylglycerol kinase, iota -0.0199533
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0197171
GLG1 golgi glycoprotein 1 -0.0196311
SNX14 sorting nexin 14 -0.0194331
ZBTB38 zinc finger and BTB domain containing 38 -0.019363
PLPP3 phospholipid phosphatase 3 -0.0193627
HHIP hedgehog interacting protein -0.0193345
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0191635
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0190733
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0189028
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0187941
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0187155
EFCAB13 EF-hand calcium binding domain 13 -0.0186749
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0184054
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0182672
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0182451
NT5E 5'-nucleotidase, ecto (CD73) -0.0182169
HLA-E major histocompatibility complex, class I, E -0.0181527
ANKRD11 ankyrin repeat domain 11 -0.0181367
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0180187
PHACTR2 phosphatase and actin regulator 2 -0.0179437
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0178836
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0177839
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0176818
LDHA lactate dehydrogenase A -0.0175866
SRGN serglycin -0.0173866
MAGED1 melanoma antigen family D1 -0.0173812
SERF2 small EDRK-rich factor 2 -0.0172623
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.0171973
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0171669
NPAS2 neuronal PAS domain protein 2 -0.0171618
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0170494
RAB7A RAB7A, member RAS oncogene family -0.0168341
LMAN1 lectin, mannose-binding, 1 -0.01668
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0166543
FAM107B family with sequence similarity 107, member B -0.0164551
SENP5 SUMO1/sentrin specific peptidase 5 -0.0163023
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0162616
MCPH1 microcephalin 1 -0.0159942
RAI14 retinoic acid induced 14 -0.0159904