Methylthiouracil_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC38A2 solute carrier family 38, member 2 0.0835921
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0826051
AREG amphiregulin 0.0672929
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0646629
MED13L mediator complex subunit 13-like 0.0578938
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0569889
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0558741
TENM3 teneurin transmembrane protein 3 0.0551847
ZBTB20 zinc finger and BTB domain containing 20 0.0533061
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0508132
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0501577
MMP12 matrix metallopeptidase 12 0.0488064
YAP1 Yes-associated protein 1 0.048022
EEF2 eukaryotic translation elongation factor 2 0.0478621
CCN2 cellular communication network factor 2 0.0475241
PDE4D phosphodiesterase 4D, cAMP-specific 0.0473576
EPHA6 EPH receptor A6 0.0471628
PDGFC platelet derived growth factor C 0.0462875
CELF2 CUGBP, Elav-like family member 2 0.0460486
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0459451
POTEF POTE ankyrin domain family, member F 0.0449064
CCNL1 cyclin L1 0.0431042
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0427401
MGAT4C MGAT4 family, member C 0.0418826
HDAC9 histone deacetylase 9 0.0415439
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0412472
GSK3B glycogen synthase kinase 3 beta 0.0404172
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387424
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0379182
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0377794
DST dystonin 0.0363767
PCBP2 poly(rC) binding protein 2 0.0355901
CPOX coproporphyrinogen oxidase 0.035538
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0354252
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0349816
ADGRG6 adhesion G protein-coupled receptor G6 0.034737
VMP1 vacuole membrane protein 1 0.0341583
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0330655
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0324679
OXR1 oxidation resistance 1 0.0319525
ZSWIM6 zinc finger, SWIM-type containing 6 0.0311545
PLK2 polo-like kinase 2 0.0309103
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0308272
NEK7 NIMA-related kinase 7 0.0304692
FXR1 fragile X mental retardation, autosomal homolog 1 0.0303245
BRD2 bromodomain containing 2 0.0295396
AXIN2 axin 2 0.0292456
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0292366
CXADR coxsackie virus and adenovirus receptor 0.0287436
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0287139
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0280974
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0279059
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0278704
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0276213
BRWD1 bromodomain and WD repeat domain containing 1 0.0272866
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0271517
ATP11A ATPase, class VI, type 11A 0.027106
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.027085
MPG N-methylpurine-DNA glycosylase 0.0270657
WNK1 WNK lysine deficient protein kinase 1 0.0270326
TFG TRK-fused gene 0.0268303
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0266525
MARCHF4 membrane associated ring-CH-type finger 4 0.026461
ETNK1 ethanolamine kinase 1 0.0263535
PUM2 pumilio RNA-binding family member 2 0.0261074
MEMO1 mediator of cell motility 1 0.0261028
QKI QKI, KH domain containing, RNA binding 0.026073
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0260713
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0251795
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0249941
DSCAM Down syndrome cell adhesion molecule 0.0247367
USP34 ubiquitin specific peptidase 34 0.0247074
EXOC6B exocyst complex component 6B 0.0244855
ZFAND3 zinc finger, AN1-type domain 3 0.0244021
PICALM phosphatidylinositol binding clathrin assembly protein 0.0239321
NCKAP1 NCK-associated protein 1 0.0232601
GASK1B golgi associated kinase 1B 0.0232133
ERRFI1 ERBB receptor feedback inhibitor 1 0.0229425
CLDND1 claudin domain containing 1 0.022859
TBC1D5 TBC1 domain family, member 5 0.0228144
SETD5 SET domain containing 5 0.0227624
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0227253
PDE4B phosphodiesterase 4B, cAMP-specific 0.0223859
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0222525
COG5 component of oligomeric golgi complex 5 0.0221742
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0220401
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0218854
KMT2E lysine (K)-specific methyltransferase 2E 0.0218447
SRRM2 serine/arginine repetitive matrix 2 0.021753
ARHGAP12 Rho GTPase activating protein 12 0.0215139
GPBP1 GC-rich promoter binding protein 1 0.021398
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0213203
BIRC2 baculoviral IAP repeat containing 2 0.0211231
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0210981
ECT2 epithelial cell transforming 2 0.0209779
ARL5B ADP-ribosylation factor-like 5B 0.0208537
KDM6A lysine (K)-specific demethylase 6A 0.0208298
TXNRD1 thioredoxin reductase 1 0.0207341
LCOR ligand dependent nuclear receptor corepressor 0.0207337
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0205496

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.362585
TMSB10 thymosin beta 10 -0.186936
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146496
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.145546
PTMA prothymosin, alpha -0.102075
TPT1 tumor protein, translationally-controlled 1 -0.0920334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0814828
ACTG1 actin gamma 1 -0.0783599
MYL12B myosin, light chain 12B, regulatory -0.0751579
RPL35A ribosomal protein L35a -0.073532
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0698906
IFIH1 interferon induced with helicase C domain 1 -0.0572679
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0534586
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0528414
NAP1L1 nucleosome assembly protein 1-like 1 -0.0522454
RPLP1 ribosomal protein, large, P1 -0.0516223
KPNB1 karyopherin (importin) beta 1 -0.0506014
FTL ferritin, light polypeptide -0.0485972
RPS6 ribosomal protein S6 -0.0482842
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0470116
RPS8 ribosomal protein S8 -0.0462726
NLGN1 neuroligin 1 -0.0462063
RPS27A ribosomal protein S27a -0.0454303
AKAP12 A kinase (PRKA) anchor protein 12 -0.0450818
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0435317
RPL26 ribosomal protein L26 -0.0433563
RPL23 ribosomal protein L23 -0.0415118
MKI67 marker of proliferation Ki-67 -0.0406302
S100A10 S100 calcium binding protein A10 -0.0390466
RPL34 ribosomal protein L34 -0.0383291
RPS3 ribosomal protein S3 -0.0381056
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.037696
RPL37A ribosomal protein L37a -0.0343527
GNAS GNAS complex locus -0.0340818
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0339979
RPL38 ribosomal protein L38 -0.0337942
S100A6 S100 calcium binding protein A6 -0.0336626
RPS12 ribosomal protein S12 -0.0329521
CAVIN1 caveolae associated protein 1 -0.032069
RPL37 ribosomal protein L37 -0.0318698
RPS24 ribosomal protein S24 -0.0317671
CCND1 cyclin D1 -0.031486
CANX calnexin -0.0314822
PRDX1 peroxiredoxin 1 -0.0313585
RPL19 ribosomal protein L19 -0.0311347
TM4SF1 transmembrane 4 L six family member 1 -0.0311063
TPM4 tropomyosin 4 -0.0309178
PA2G4 proliferation-associated 2G4, 38kDa -0.0296274
RPS29 ribosomal protein S29 -0.0294008
HMGB1 high mobility group box 1 -0.0289751
ANKRD12 ankyrin repeat domain 12 -0.0284823
VDAC1 voltage-dependent anion channel 1 -0.0284593
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0284165
ENO1 enolase 1, (alpha) -0.0281459
BRI3BP BRI3 binding protein -0.0279252
RPS19 ribosomal protein S19 -0.0271219
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0269597
TMEM41B transmembrane protein 41B -0.0266891
RPLP2 ribosomal protein, large, P2 -0.0258825
RSL1D1 ribosomal L1 domain containing 1 -0.0253631
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0251801
RPL36A ribosomal protein L36a -0.0249877
KLF6 Kruppel-like factor 6 -0.0248485
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0246994
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0246522
YBX3 Y box binding protein 3 -0.0246335
CLDN1 claudin 1 -0.0246262
RPL12 ribosomal protein L12 -0.0241373
RPS27 ribosomal protein S27 -0.0241137
RPL11 ribosomal protein L11 -0.0238746
SLC38A1 solute carrier family 38, member 1 -0.0236454
TMEM123 transmembrane protein 123 -0.0235711
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0234507
LOC112694756 uncharaterized LOC112694756 -0.0226856
SMC4 structural maintenance of chromosomes 4 -0.0226505
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0226296
LOC102724023 ES1 protein homolog, mitochondrial -0.022345
TUBA1B tubulin, alpha 1b -0.0214019
RPL9 ribosomal protein L9 -0.0212833
RPS13 ribosomal protein S13 -0.0212462
TUBB tubulin, beta class I -0.0208411
RPS21 ribosomal protein S21 -0.0206503
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0204605
HMGA1 high mobility group AT-hook 1 -0.0201226
AHNAK AHNAK nucleoprotein -0.0199885
PDIA3 protein disulfide isomerase family A, member 3 -0.0198785
RACK1 receptor for activated C kinase 1 -0.0196461
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0193101
DEK DEK proto-oncogene -0.0193072
HSPB1 heat shock 27kDa protein 1 -0.0192891
RPLP0 ribosomal protein, large, P0 -0.0192304
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0191648
FUS FUS RNA binding protein -0.019064
SEPTIN7 septin 7 -0.0187488
CENPF centromere protein F, 350/400kDa -0.0185961
RPS14 ribosomal protein S14 -0.0182348
RPL31 ribosomal protein L31 -0.0181283
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.017923
GCG glucagon -0.0179124
NAV3 neuron navigator 3 -0.0178014